IJMS, Vol. 21, Pages 5537: Social Fear Memory Requires Two Stages of Protein Synthesis in Mice International Journal of Molecular Sciences doi: 10.3390/ijms21155537 Authors: Johannes Kornhuber Iulia Zoicas It is well known that long-term consolidation of newly acquired information, including information related to social fear, require de novo protein synthesis. However, the temporal dynamics of protein synthesis during the consolidation of social fear memories is unclear. To address...
Sun Aug 02, 2020 03:00
IJMS, Vol. 21, Pages 5534: Identification of New Potential LncRNA Biomarkers in Hirschsprung Disease
IJMS, Vol. 21, Pages 5534: Identification of New Potential LncRNA Biomarkers in Hirschsprung Disease International Journal of Molecular Sciences doi: 10.3390/ijms21155534 Authors: Ana Torroglosa Leticia Villalba-Benito Raquel María Fernández Berta Luzón-Toro María José Moya-Jiménez Guillermo Antiñolo Salud Borrego Hirschsprung disease (HSCR) is a neurocristopathy defined by intestinal aganglionosis due to alterations during the development of the Enteric Nervous System...
Sun Aug 02, 2020 03:00
IJMS, Vol. 21, Pages 5533: Cytotoxic Effects of Cannabinoids on Human HT-29 Colorectal Adenocarcinoma Cells: Different Mechanisms of THC, CBD, and CB83 International Journal of Molecular Sciences doi: 10.3390/ijms21155533 Authors: Daniela Cerretani Giulia Collodel Antonella Brizzi Anna Ida Fiaschi Andrea Menchiari Elena Moretti Laura Moltoni Lucia Micheli In this study, we investigated the effects of exposition to IC50 dose for 24 h of a new synthetic cannabinoid...
Sat Aug 01, 2020 03:00
IJMS, Vol. 21, Pages 5527: NR2F6 as a Prognostic Biomarker in HNSCC International Journal of Molecular Sciences doi: 10.3390/ijms21155527 Authors: Luise Klapper Julika Ribbat-Idel Patrick Kuppler Finn-Ole Paulsen Karl-Ludwig Bruchhage Dirk Rades Anne Offermann Jutta Kirfel Barbara Wollenberg Christian Idel Sven Perner Head and neck squamous cell carcinoma (HNSCC)is the 6th most common cancer in humans worldwide and is associated with a poor prognosis for...
Sat Aug 01, 2020 03:00
IJMS, Vol. 21, Pages 5525: Anti-Epileptic Effects of FABP3 Ligand MF1 through the Benzodiazepine Recognition Site of the GABAA Receptor International Journal of Molecular Sciences doi: 10.3390/ijms21155525 Authors: Yasushi Yabuki Jiaqi Liu Ichiro Kawahata Hisanao Izumi Yasuharu Shinoda Kohei Koga Shinya Ueno Norifumi Shioda Kohji Fukunaga Recently, we developed the fatty acid-binding protein 3 (FABP3) ligand MF1 (4-(2-(1-(2-chlorophenyl)-5-phenyl-1H-pyrazol-3-yl)phenoxy)...
Sat Aug 01, 2020 03:00
IJMS, Vol. 21, Pages 5523: Emerging Role of Extracellular Vesicles in Embryo–Maternal Communication throughout Implantation Processes International Journal of Molecular Sciences doi: 10.3390/ijms21155523 Authors: Keigo Nakamura Kazuya Kusama Yoshihito Suda Hiroshi Fujiwara Masatoshi Hori Kazuhiko Imakawa In ruminants, the establishment of proper conceptus–endometrial communication is essential for conceptus implantation and subsequent successful placentation....
Sat Aug 01, 2020 03:00
IJMS, Vol. 21, Pages 5531: Roles of Membrane Domains in Integrin-Mediated Cell Adhesion International Journal of Molecular Sciences doi: 10.3390/ijms21155531 Authors: Daniel Lietha Tina Izard The composition and organization of the plasma membrane play important functional and regulatory roles in integrin signaling, which direct many physiological and pathological processes, such as development, wound healing, immunity, thrombosis, and cancer metastasis. Membranes are comprised of...
Sat Aug 01, 2020 03:00
IJMS, Vol. 21, Pages 5530: Goat’s Milk Intake Prevents Obesity, Hepatic Steatosis and Insulin Resistance in Mice Fed A High-Fat Diet by Reducing Inflammatory Markers and Increasing Energy Expenditure and Mitochondrial Content in Skeletal Muscle International Journal of Molecular Sciences doi: 10.3390/ijms21155530 Authors: Claudia Delgadillo-Puga Lilia G. Noriega Aurora M. Morales-Romero Antonio Nieto-Camacho Omar Granados-Portillo Leonardo A. Rodríguez-López Gabriela Alemán...
Sat Aug 01, 2020 03:00
IJMS, Vol. 21, Pages 5532: Impact of Nucleic Acid Sequencing on Viroid Biology International Journal of Molecular Sciences doi: 10.3390/ijms21155532 Authors: Adkar-Purushothama Perreault The early 1970s marked two breakthroughs in the field of biology: (i) The development of nucleotide sequencing technology; and, (ii) the discovery of the viroids. The first DNA sequences were obtained by two-dimensional chromatography which was later replaced by sequencing using electrophoresis...
Sat Aug 01, 2020 03:00
IJMS, Vol. 21, Pages 5528: Vitamins and Uterine Fibroids: Current Data on Pathophysiology and Possible Clinical Relevance International Journal of Molecular Sciences doi: 10.3390/ijms21155528 Authors: Michał Ciebiera Mohamed Ali Magdalena Zgliczyńska Maciej Skrzypczak Ayman Al-Hendy Uterine fibroid (UF) is the most common benign tumor pathology of the female reproductive organs. UFs constitute the main reason for a hysterectomy and hospitalization due to gynecological conditions....
Sat Aug 01, 2020 03:00
IJMS, Vol. 21, Pages 5524: Exploring the Potential of Mesenchymal Stem Cell-Based Therapy in Mouse Models of Vascular Cognitive Impairment International Journal of Molecular Sciences doi: 10.3390/ijms21155524 Authors: Lee Kim Chang Jang Kim Yang Kim Son Na Closely linked to Alzheimer’s disease (AD), the pathological spectrum of vascular cognitive impairment (VCI) is known to be wide and complex. Considering that multiple instead of a single...
Sat Aug 01, 2020 03:00
IJMS, Vol. 21, Pages 5526: Surfactin as a Green Agent Controlling the Growth of Porous Calcite Microstructures International Journal of Molecular Sciences doi: 10.3390/ijms21155526 Authors: Anna Bastrzyk Marta Fiedot-Toboła Halina Maniak Izabela Polowczyk Grażyna Płaza This study presents a new, simple way to obtain mesoporous calcite structures via a green method using an eco-friendly surface-active compound, surfactin, as a controlling agent. The effects of synthesis time...
Sat Aug 01, 2020 03:00
IJMS, Vol. 21, Pages 5529: Iron Metabolism in Obesity and Metabolic Syndrome International Journal of Molecular Sciences doi: 10.3390/ijms21155529 Authors: González-Domínguez Visiedo-García Domínguez-Riscart González-Domínguez Mateos Lechuga-Sancho Obesity is an excessive adipose tissue accumulation that may have detrimental effects on health. Particularly, childhood obesity has become one of the main public health problems in the 21st century, since its prevalence...
Sat Aug 01, 2020 03:00
IJMS, Vol. 21, Pages 5520: Noradrenergic Components of Locomotor Recovery Induced by Intraspinal Grafting of the Embryonic Brainstem in Adult Paraplegic Rats International Journal of Molecular Sciences doi: 10.3390/ijms21155520 Authors: Anna Kwaśniewska Krzysztof Miazga Henryk Majczyński Larry M. Jordan Małgorzata Zawadzka Urszula Sławińska Intraspinal grafting of serotonergic (5-HT) neurons was shown to restore plantar stepping in paraplegic rats. Here we asked whether...
Sat Aug 01, 2020 03:00
IJMS, Vol. 21, Pages 5519: Inherited Metabolic Disorders Presenting with Ataxia International Journal of Molecular Sciences doi: 10.3390/ijms21155519 Authors: Grace Silver Saadet Mercimek-Andrews Ataxia is a common clinical feature in inherited metabolic disorders. There are more than 150 inherited metabolic disorders in patients presenting with ataxia in addition to global developmental delay, encephalopathy episodes, a history of developmental regression, coarse facial features,...
Sat Aug 01, 2020 03:00
IJMS, Vol. 21, Pages 5518: Aesculetin Attenuates Alveolar Injury and Fibrosis Induced by Close Contact of Alveolar Epithelial Cells with Blood-Derived Macrophages via IL-8 Signaling International Journal of Molecular Sciences doi: 10.3390/ijms21155518 Authors: Su Yeon Oh Yun-Ho Kim Min-Kyung Kang Eun-Jung Lee Dong Yeon Kim Hyeongjoo Oh Soo-Il Kim Woojin Na Young-Hee Kang Pulmonary fibrosis is a disease in which lung tissues become fibrous and thereby causes severe...
Sat Aug 01, 2020 03:00
IJMS, Vol. 21, Pages 5522: N-Glycoproteins Have a Major Role in MGL Binding to Colorectal Cancer Cell Lines: Associations with Overall Proteome Diversity International Journal of Molecular Sciences doi: 10.3390/ijms21155522 Authors: Martina Pirro Yassene Mohammed Sandra J. van Vliet Yoann Rombouts Agnese Sciacca Arnoud H. de Ru George M. C. Janssen Rayman T. N. Tjokrodirijo Manfred Wuhrer Peter A. van Veelen Paul J. Hensbergen Colorectal cancer (CRC) is...
Sat Aug 01, 2020 03:00
IJMS, Vol. 21, Pages 5521: Immune Landscape in Tumor Microenvironment: Implications for Biomarker Development and Immunotherapy International Journal of Molecular Sciences doi: 10.3390/ijms21155521 Authors: Karim Pérez-Romero Ramón M. Rodríguez Amedeo Amedei Gwendolyn Barceló-Coblijn Daniel H. Lopez Integration of the tumor microenvironment as a fundamental part of the tumorigenic process has undoubtedly revolutionized our understanding of cancer biology. Increasing evidence...
Sat Aug 01, 2020 03:00
IJMS, Vol. 21, Pages 5516: A Small Molecule, 4-Phenylbutyric Acid, Suppresses HCV Replication via Epigenetically Induced Hepatic Hepcidin International Journal of Molecular Sciences doi: 10.3390/ijms21155516 Authors: Kiyoon Kim Young-seok Lee Suyun Jeong Daehong Kim Suk Chon Youngmi Kim Pak Sungsoo Kim Joohun Ha Insug Kang Wonchae Choe Hepatic hepcidin is a well-known major iron regulator and has been reported to be closely related to hepatitis C virus (HCV)...
Sat Aug 01, 2020 03:00
IJMS, Vol. 21, Pages 5517: Selectivity of Transport Processes in Ion-Exchange Membranes: Relationship with the Structure and Methods for Its Improvement International Journal of Molecular Sciences doi: 10.3390/ijms21155517 Authors: Irina Stenina Daniel Golubenko Victor Nikonenko Andrey Yaroslavtsev Nowadays, ion-exchange membranes have numerous applications in water desalination, electrolysis, chemistry, food, health, energy, environment and other fields. All of these applications...
Sat Aug 01, 2020 03:00
IJMS, Vol. 21, Pages 5515: Indoleamine 2,3-Dioxygenase 2 Deficiency Exacerbates Imiquimod-Induced Psoriasis-Like Skin Inflammation International Journal of Molecular Sciences doi: 10.3390/ijms21155515 Authors: Kento Fujii Yasuko Yamamoto Yoko Mizutani Kuniaki Saito Mariko Seishima Indoleamine 2,3-dioxygenase 1 (IDO1) is an enzyme known to suppress immune responses, and several reports have showed that it is associated with psoriasis. IDO2 is an isoform of IDO1, recently identified...
Sat Aug 01, 2020 03:00
IJMS, Vol. 21, Pages 5514: Update on Cuticular Wax Biosynthesis and Its Roles in Plant Disease Resistance International Journal of Molecular Sciences doi: 10.3390/ijms21155514 Authors: Xiaoyu Wang Lingyao Kong Pengfei Zhi Cheng Chang The aerial surface of higher plants is covered by a hydrophobic layer of cuticular waxes to protect plant tissues against enormous environmental challenges including the infection of various pathogens. As the first contact site between plants and...
Sat Aug 01, 2020 03:00
IJMS, Vol. 21, Pages 5512: Chemical Screening of Nuclear Receptor Modulators International Journal of Molecular Sciences doi: 10.3390/ijms21155512 Authors: Mari Ishigami-Yuasa Hiroyuki Kagechika Nuclear receptors are ligand-inducible transcriptional factors that control multiple biological phenomena, including proliferation, differentiation, reproduction, metabolism, and the maintenance of homeostasis. Members of the nuclear receptor superfamily have marked structural and functional...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5511: Ablation of Galectin-12 Inhibits Atherosclerosis through Enhancement of M2 Macrophage Polarization International Journal of Molecular Sciences doi: 10.3390/ijms21155511 Authors: En-Shyh Lin Yu-An Hsu Ching-Yao Chang Hui-Ju Lin Chih Sheng Chen Lei Wan The formation of foam cells, which are macrophages that have engulfed oxidized low-density lipoprotein (OxLDL), constitutes the first stage in the development of atherosclerosis. Previously, we found...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5510: Antibody-Drug Conjugates: The New Frontier of Chemotherapy International Journal of Molecular Sciences doi: 10.3390/ijms21155510 Authors: Sara Ponziani Giulia Di Di Vittorio Giuseppina Pitari Anna Maria Cimini Matteo Ardini Roberta Gentile Stefano Iacobelli Gianluca Sala Emily Capone David J. Flavell Rodolfo Ippoliti Francesco Giansanti In recent years, antibody-drug conjugates (ADCs) have become promising antitumor agents to...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5513: Tobacco, but Not Nicotine and Flavor-Less Electronic Cigarettes, Induces ACE2 and Immune Dysregulation International Journal of Molecular Sciences doi: 10.3390/ijms21155513 Authors: Abby C. Lee Jaideep Chakladar Wei Tse Li Chengyu Chen Eric Y. Chang Jessica Wang-Rodriguez Weg M. Ongkeko The COVID-19 pandemic caused by the SARS-CoV-2 virus, overlaps with the ongoing epidemics of cigarette smoking and electronic cigarette (e-cig) vaping. However,...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5509: Flexible NAD+ Binding in Deoxyhypusine Synthase Reflects the Dynamic Hypusine Modification of Translation Factor IF5A International Journal of Molecular Sciences doi: 10.3390/ijms21155509 Authors: Meirong Chen Zuoqi Gai Chiaki Okada Yuxin Ye ‖ Jian Yu Min Yao The eukaryotic and archaeal translation factor IF5A requires a post-translational hypusine modification, which is catalyzed by deoxyhypusine synthase (DHS) at a single lysine residue of...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5507: Pyrazoline Hybrids as Promising Anticancer Agents: An Up-to-Date Overview
IJMS, Vol. 21, Pages 5507: Pyrazoline Hybrids as Promising Anticancer Agents: An Up-to-Date Overview International Journal of Molecular Sciences doi: 10.3390/ijms21155507 Authors: Dimitris Matiadis Marina Sagnou Pyrazolines are five-membered heterocycles possessing two adjacent nitrogens. They have attracted significant attention from organic and medicinal chemists due to their potent biological activities and the numerous possibilities for structural diversification. In the last...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5508: CDK19 as a Potential HPV-Independent Biomarker for Recurrent Disease in HNSCC International Journal of Molecular Sciences doi: 10.3390/ijms21155508 Authors: Finn-Ole Paulsen Christian Idel Julika Ribbat-Idel Patrick Kuppler Luise Klapper Dirk Rades Karl-Ludwig Bruchhage Barbara Wollenberg Johannes Brägelmann Sven Perner Anne Offermann The Mediator complex is a central integrator of transcription and a hub for the regulation of...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5506: Results from a Genome-Wide Association Study (GWAS) in Mastocytosis Reveal New Gene Polymorphisms Associated with WHO Subgroups International Journal of Molecular Sciences doi: 10.3390/ijms21155506 Authors: Bogusław Nedoszytko Marta Sobalska-Kwapis Dominik Strapagiel Magdalena Lange Aleksandra Górska Joanne N. G. Oude Elberink Jasper van van Doormaal Marcin Słomka Leszek Kalinowski Marta Gruchała-Niedoszytko Roman J. Nowicki Peter...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5493: Oxygenated Water Inhibits Adipogenesis and Attenuates Hepatic Steatosis in High-Fat Diet-Induced Obese Mice International Journal of Molecular Sciences doi: 10.3390/ijms21155493 Authors: Yuh-Jen Cheng Chao-Chi Liu Fang-Yeh Chu Ching-Ping Yang Chiao-Wan Hsiao Cheng-Wei Chuang Ming-Yuh Shiau Hsueh-Te Lee Jen-Ning Tsai Yih-Hsin Chang The expansion of adipose tissue mass is the primary characteristic of the process of becoming obesity,...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5504: Localization of the Elastic Proteins in the Flight Muscle of Manduca sexta International Journal of Molecular Sciences doi: 10.3390/ijms21155504 Authors: Henry Gong Weikang Ma Shaoshuai Chen Geng Wang Ramzi Khairallah Thomas Irving The flight muscle of Manduca sexta (DLM1) is an emerging model system for biophysical studies of muscle contraction. Unlike the well-studied indirect flight muscle of Lethocerus and Drosophila, the DLM1 of Manduca...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5503: Persistent Human KIT Receptor Signaling Disposes Murine Placenta to Premature Differentiation Resulting in Severely Disrupted Placental Structure and Functionality International Journal of Molecular Sciences doi: 10.3390/ijms21155503 Authors: Franziska Kaiser Julia Hartweg Selina Jansky Natalie Pelusi Caroline Kubaczka Neha Sharma Dominik Nitsche Jan Langkabel Hubert Schorle Activating mutations in the human KIT receptor is known to...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5502: Induction of Apoptosis by Coptisine in Hep3B Hepatocellular Carcinoma Cells through Activation of the ROS-Mediated JNK Signaling Pathway International Journal of Molecular Sciences doi: 10.3390/ijms21155502 Authors: So Young Kim Hyun Hwangbo Hyesook Lee Cheol Park Gi-Young Kim Sung-Kwon Moon Seok Joong Yun Wun-Jae Kim Jaehun Cheong Yung Hyun Choi Hepatocellular carcinoma (HCC) has a high mortality rate worldwide, and treatment is...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5505: Rewiring of Lipid Metabolism in Adipose Tissue Macrophages in Obesity: Impact on Insulin Resistance and Type 2 Diabetes International Journal of Molecular Sciences doi: 10.3390/ijms21155505 Authors: Veronica D. Dahik Eric Frisdal Wilfried Le Goff Obesity and its two major comorbidities, insulin resistance and type 2 diabetes, represent worldwide health issues whose incidence is predicted to steadily rise in the coming years. Obesity is characterized by...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5500: Epigenetic Mechanisms in Gastric Cancer: Potential New Therapeutic Opportunities International Journal of Molecular Sciences doi: 10.3390/ijms21155500 Authors: Matteo Canale Andrea Casadei-Gardini Paola Ulivi Maria Arechederra Carmen Berasain Pier-Luigi Lollini Maite G. Fernández-Barrena Matías A. Avila Gastric cancer (GC) is one of the deadliest malignancies worldwide. Complex disease heterogeneity, late diagnosis, and suboptimal therapies...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5498: Mechanisms Protecting Acinetobacter baumannii against Multiple Stresses Triggered by the Host Immune Response, Antibiotics, and outside Host Environment International Journal of Molecular Sciences doi: 10.3390/ijms21155498 Authors: Soroosh Monem Beata Furmanek-Blaszk Adrianna Łupkowska Dorota Kuczyńska-Wiśnik Karolina Stojowska-Swędrzyńska Ewa Laskowska Acinetobacter baumannii is considered one of the most persistent pathogens responsible for...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5499: The Role of Pre-Clinical 3-Dimensional Models of Osteosarcoma International Journal of Molecular Sciences doi: 10.3390/ijms21155499 Authors: Hannah L. Smith Stephen A. Beers Juliet C. Gray Janos M. Kanczler Treatment for osteosarcoma (OS) has been largely unchanged for several decades, with typical therapies being a mixture of chemotherapy and surgery. Although therapeutic targets and products against cancer are being continually developed, only a...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5497: Targeting of CD163+ Macrophages in Inflammatory and Malignant Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21155497 Authors: Maria K. Skytthe Jonas Heilskov Graversen Søren K. Moestrup The macrophage is a key cell in the pro- and anti-inflammatory response including that of the inflammatory microenvironment of malignant tumors. Much current drug development in chronic inflammatory diseases and cancer therefore focuses on the macrophage...
Fri Jul 31, 2020 03:00
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