IJMS, Vol. 21, Pages 5860: Structural Characterization of Covalently Stabilized Human Cystatin C Oligomers International Journal of Molecular Sciences doi: 10.3390/ijms21165860 Authors: Magdalena Chrabąszczewska Adam K. Sieradzan Sylwia Rodziewicz-Motowidło Anders Grubb Christopher M. Dobson Janet R. Kumita Maciej Kozak Human cystatin C (HCC), a cysteine-protease inhibitor, exists as a folded monomer under physiological conditions but has the ability to self-assemble...
Sat Aug 15, 2020 03:00
IJMS, Vol. 21, Pages 5859: Structural Insights into the Mechanism of a Nanobody That Stabilizes PAI-1 and Modulates Its Activity International Journal of Molecular Sciences doi: 10.3390/ijms21165859 Authors: Machteld Sillen Stephen D. Weeks Sergei V. Strelkov Paul J. Declerck Plasminogen activator inhibitor-1 (PAI-1) is the main physiological inhibitor of tissue-type (tPA) and urokinase-type (uPA) plasminogen activators (PAs). Apart from being critically involved in fibrinolysis...
Sat Aug 15, 2020 03:00
IJMS, Vol. 21, Pages 5858: Revisiting the Amyloid Cascade Hypothesis: From Anti-Aβ Therapeutics to Auspicious New Ways for Alzheimer’s Disease International Journal of Molecular Sciences doi: 10.3390/ijms21165858 Authors: Uddin Kabir Rahman Behl Jeandet Ashraf Najda Bin-Jumah El-Seedi Abdel-Daim Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder related to age, characterized by the cerebral deposition of fibrils, which...
Fri Aug 14, 2020 03:00
IJMS, Vol. 21, Pages 5857: In Silico Structural and Biochemical Functional Analysis of a Novel CYP21A2 Pathogenic Variant International Journal of Molecular Sciences doi: 10.3390/ijms21165857 Authors: Michal Cohen Emanuele Pignatti Monica Dines Adi Mory Nina Ekhilevitch Rachel Kolodny Christa E. Flück Dov Tiosano Classical congenital adrenal hyperplasia (CAH) caused by pathogenic variants in the steroid 21-hydroxylase gene (CYP21A2) is a severe life-threatening condition....
Fri Aug 14, 2020 03:00
IJMS, Vol. 21, Pages 5855: Association between Acrylamide Metabolites and Cardiovascular Risk in Children With Early Stages of Chronic Kidney Disease International Journal of Molecular Sciences doi: 10.3390/ijms21165855 Authors: Chien-Ning Hsu Chih-Yao Hou Pei-Chen Lu Guo-Ping Chang-Chien Sufan Lin You-Lin Tain Cardiovascular disease (CVD) begins early in children with chronic kidney disease (CKD). Reduced nitric oxide (NO) bioavailability has been associated with increased...
Fri Aug 14, 2020 03:00
IJMS, Vol. 21, Pages 5856: New Anti SARS-Cov-2 Targets for Quinoline Derivatives Chloroquine and Hydroxychloroquine International Journal of Molecular Sciences doi: 10.3390/ijms21165856 Authors: Davide Gentile Virginia Fuochi Antonio Rescifina Pio Maria Furneri The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created a severe global health crisis. In this paper, we used docking and simulation methods to identify potential targets and the mechanism...
Fri Aug 14, 2020 03:00
IJMS, Vol. 21, Pages 5854: Low Dose Radiation Therapy, Particularly with 0.5 Gy, Improves Pain in Degenerative Joint Disease of the Fingers: Results of a Retrospective Analysis International Journal of Molecular Sciences doi: 10.3390/ijms21165854 Authors: Anna-Jasmina Donaubauer Jian-Guo Zhou Oliver J. Ott Florian Putz Rainer Fietkau Ludwig Keilholz Udo S. Gaipl Benjamin Frey Thomas Weissmann Low-dose radiation therapy (LDRT) has been successfully established...
Fri Aug 14, 2020 03:00
IJMS, Vol. 21, Pages 5852: The Role of ABA in Plant Immunity is Mediated through the PYR1 Receptor International Journal of Molecular Sciences doi: 10.3390/ijms21165852 Authors: Javier García-Andrade Beatriz González Miguel Gonzalez-Guzman Pedro L. Rodriguez Pablo Vera ABA is involved in plant responses to a broad range of pathogens and exhibits complex antagonistic and synergistic relationships with salicylic acid (SA) and ethylene (ET) signaling pathways, respectively....
Fri Aug 14, 2020 03:00
IJMS, Vol. 21, Pages 5851: Comparison of Monovalent and Divalent Ions Removal from Aqueous Solutions Using Agricultural Waste Biochars Prepared at Different Temperatures—Experimental and Model Study International Journal of Molecular Sciences doi: 10.3390/ijms21165851 Authors: Agnieszka Tomczyk Zofia Sokołowska Patrycja Boguta Katarzyna Szewczuk-Karpisz Copper (Cu) and silver (Ag) occur naturally in the environment but have toxic effects on organisms at elevated concentrations....
Fri Aug 14, 2020 03:00
IJMS, Vol. 21, Pages 5850: Gestational Factors throughout Fetal Neurodevelopment: The Serotonin Link
IJMS, Vol. 21, Pages 5850: Gestational Factors throughout Fetal Neurodevelopment: The Serotonin Link International Journal of Molecular Sciences doi: 10.3390/ijms21165850 Authors: Sabrina I. Hanswijk Marcia Spoelder Ling Shan Michel M. M. Verheij Otto G. Muilwijk Weizhuo Li Chunqing Liu Sharon M. Kolk Judith R. Homberg Serotonin (5-HT) is a critical player in brain development and neuropsychiatric disorders. Fetal 5-HT levels can be influenced by several gestational...
Fri Aug 14, 2020 03:00
IJMS, Vol. 21, Pages 5853: Expression, Distribution and Role of Aquaporins in Various Rhinologic Conditions International Journal of Molecular Sciences doi: 10.3390/ijms21165853 Authors: Su Young Jung Dong Choon Park Sung Su Kim Seung Geun Yeo Aquaporins (AQPs) are water-specific membrane channel proteins that regulate cellular and organismal water homeostasis. The nose, an organ with important respiratory and olfactory functions, is the first organ exposed to external stimuli....
Fri Aug 14, 2020 03:00
IJMS, Vol. 21, Pages 5840: Exosomes in Angiogenesis and Anti-angiogenic Therapy in Cancers International Journal of Molecular Sciences doi: 10.3390/ijms21165840 Authors: Wioletta Olejarz Grażyna Kubiak-Tomaszewska Alicja Chrzanowska Tomasz Lorenc Angiogenesis is the process through which new blood vessels are formed from pre-existing ones. Exosomes are involved in angiogenesis in cancer progression by transporting numerous pro-angiogenic biomolecules like vascular endothelial...
Fri Aug 14, 2020 03:00
IJMS, Vol. 21, Pages 5848: NME/NM23/NDPK and Histidine Phosphorylation International Journal of Molecular Sciences doi: 10.3390/ijms21165848 Authors: Kevin Adam Jia Ning Jeffrey Reina Tony Hunter The NME (Non-metastatic) family members, also known as NDPKs (nucleoside diphosphate kinases), were originally identified and studied for their nucleoside diphosphate kinase activities. This family of kinases is extremely well conserved through evolution, being found in prokaryotes...
Fri Aug 14, 2020 03:00
IJMS, Vol. 21, Pages 5849: Hypothermically Stored Adipose-Derived Mesenchymal Stromal Cell Alginate Bandages Facilitate Use of Paracrine Molecules for Corneal Wound Healing International Journal of Molecular Sciences doi: 10.3390/ijms21165849 Authors: Olla Al-Jaibaji Stephen Swioklo Alex Shortt Francisco C. Figueiredo Che J. Connon Adipose-derived mesenchymal stromal cells (Ad-MSCs) may alleviate corneal injury through the secretion of therapeutic factors delivered at the...
Fri Aug 14, 2020 03:00
IJMS, Vol. 21, Pages 5846: Contribution of Predictive and Prognostic Biomarkers to Clinical Research on Chronic Kidney Disease International Journal of Molecular Sciences doi: 10.3390/ijms21165846 Authors: Michele Provenzano Salvatore Rotundo Paolo Chiodini Ida Gagliardi Ashour Michael Elvira Angotti Silvio Borrelli Raffaele Serra Daniela Foti Giovambattista De Sarro Michele Andreucci Chronic kidney disease (CKD), defined as the presence of albuminuria and/or...
Fri Aug 14, 2020 03:00
IJMS, Vol. 21, Pages 5847: Deep Learning Modeling of Androgen Receptor Responses to Prostate Cancer Therapies International Journal of Molecular Sciences doi: 10.3390/ijms21165847 Authors: Oliver Snow Nada Lallous Martin Ester Artem Cherkasov Gain-of-function mutations in human androgen receptor (AR) are among the major causes of drug resistance in prostate cancer (PCa). Identifying mutations that cause resistant phenotype is of critical importance for guiding treatment protocols,...
Fri Aug 14, 2020 03:00
IJMS, Vol. 21, Pages 5844: Propofol Affects Cortico-Hippocampal Interactions via β3 Subunit-Containing GABAA Receptors International Journal of Molecular Sciences doi: 10.3390/ijms21165844 Authors: Matthias Kreuzer Sergejus Butovas Paul S García Gerhard Schneider Cornelius Schwarz Uwe Rudolph Bernd Antkowiak Berthold Drexler Background: General anesthetics depress neuronal activity. The depression and uncoupling of cortico-hippocampal activity may contribute to anesthetic-induced...
Fri Aug 14, 2020 03:00
IJMS, Vol. 21, Pages 5843: Multicopy Suppressor Analysis of Strains Lacking Cytoplasmic Peptidyl-Prolyl cis/trans Isomerases Identifies Three New PPIase Activities in Escherichia coli That Includes the DksA Transcription Factor International Journal of Molecular Sciences doi: 10.3390/ijms21165843 Authors: Pawel Wojtkiewicz Daria Biernacka Patrycja Gorzelak Anna Stupak Gracjana Klein Satish Raina Consistent with a role in catalyzing rate-limiting step of protein folding,...
Fri Aug 14, 2020 03:00
IJMS, Vol. 21, Pages 5841: Evidence for Enhanced Exosome Production in Aromatase Inhibitor-Resistant Breast Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21165841 Authors: Giuseppina Augimeri Giusi La Camera Luca Gelsomino Cinzia Giordano Salvatore Panza Diego Sisci Catia Morelli Balázs Győrffy Daniela Bonofiglio Sebastiano Andò Ines Barone Stefania Catalano Aromatase inhibitors (AIs) represent the standard anti-hormonal therapy...
Fri Aug 14, 2020 03:00
IJMS, Vol. 21, Pages 5842: Effects of Aerobic Exercise on Tau and Related Proteins in Rats with the Middle Cerebral Artery Occlusion International Journal of Molecular Sciences doi: 10.3390/ijms21165842 Authors: Sakulrat Mankhong Sujin Kim Sohee Moon Kyoung-Hee Lee Hyeong-Eun Jeon Byeong-Hun Hwang Jong-Won Beak Kyung-Lim Joa Ju-Hee Kang Although Alzheimer’s disease (AD)-like pathology is frequently found in patients with post-stroke dementia, little...
Fri Aug 14, 2020 03:00
IJMS, Vol. 21, Pages 5839: Recent Advances in Porphyrin-Based Materials for Metal Ions Detection International Journal of Molecular Sciences doi: 10.3390/ijms21165839 Authors: Zhen-Li Qi Yun-Hui Cheng Zhou Xu Mao-Long Chen Porphyrins have planar and conjugated structures, good optical properties, and other special functional properties. Owing to these excellent properties, in recent years, porphyrins and their analogues have emerged as a multifunctional platform for chemical...
Fri Aug 14, 2020 03:00
IJMS, Vol. 21, Pages 5845: Lipid Metabolism and Cancer Immunotherapy: Immunosuppressive Myeloid Cells at the Crossroad International Journal of Molecular Sciences doi: 10.3390/ijms21165845 Authors: Augusto Bleve Barbara Durante Antonio Sica Francesca Maria Consonni Cancer progression generates a chronic inflammatory state that dramatically influences hematopoiesis, originating different subsets of immune cells that can exert pro- or anti-tumor roles. Commitment towards one of...
Fri Aug 14, 2020 03:00
IJMS, Vol. 21, Pages 5838: CAIX Regulates GBM Motility and TAM Adhesion and Polarization through EGFR/STAT3 under Hypoxic Conditions International Journal of Molecular Sciences doi: 10.3390/ijms21165838 Authors: Bor-Ren Huang Yu-Shu Liu Sheng-Wei Lai Hui-Jung Lin Ching-Kai Shen Liang-Yo Yang Dah-Yuu Lu Carbonic anhydrases (CAs) are acid–base regulatory proteins that modulate a variety of physiological functions. Recent findings have shown that CAIX is particularly...
Fri Aug 14, 2020 03:00
IJMS, Vol. 21, Pages 5837: Association of Maternal Regulatory Single Nucleotide Polymorphic CD99 Genotype with Preeclampsia in Pregnancies Carrying Male Fetuses in Ethiopian Women International Journal of Molecular Sciences doi: 10.3390/ijms21165837 Authors: Tsehayneh Kelemu Lena Erlandsson Daniel Seifu Markos Abebe Sisay Teklu Jill Storry Stefan Hansson Preeclampsia (PE) is a human specific syndrome with unknown etiology causing maternal and fetal morbidities and mortalities....
Fri Aug 14, 2020 03:00
IJMS, Vol. 21, Pages 5835: Critical Analysis of Genome-Wide Association Studies: Triple Negative Breast Cancer Quae Exempli Causa International Journal of Molecular Sciences doi: 10.3390/ijms21165835 Authors: Maria-Ancuta Jurj Mihail Buse Alina-Andreea Zimta Angelo Paradiso Schuyler S. Korban Laura-Ancuta Pop Ioana Berindan-Neagoe Genome-wide association studies (GWAS) are useful in assessing and analyzing either differences or variations in DNA sequences across the...
Fri Aug 14, 2020 03:00
IJMS, Vol. 21, Pages 5836: Current Progress in Understanding and Recovering the Wheat Genes Lost in Evolution and Domestication International Journal of Molecular Sciences doi: 10.3390/ijms21165836 Authors: Rahman Islam Yu She Nevo Ma The modern cultivated wheat has passed a long evolution involving origin of wild emmer (WEM), development of cultivated emmer, formation of spelt wheat and finally establishment of modern bread wheat and durum wheat. During this evolutionary...
Fri Aug 14, 2020 03:00
IJMS, Vol. 21, Pages 5834: Prognostic and Clinicopathological Significance of MiR-155 in Breast Cancer: A Systematic Review International Journal of Molecular Sciences doi: 10.3390/ijms21165834 Authors: Anna Maria Grimaldi Silvia Nuzzo Gerolama Condorelli Marco Salvatore Mariarosaria Incoronato There is an unmet need for novel non-invasive prognostic molecular tumour markers for breast cancer (BC). Accumulating evidence shows that miR-155 plays a pivotal role in tumorigenesis....
Fri Aug 14, 2020 03:00
IJMS, Vol. 21, Pages 5833: In Vitro Cell Sensitivity to Palytoxin Correlates with High Gene Expression of the Na+/K+-ATPase β2 Subunit Isoform International Journal of Molecular Sciences doi: 10.3390/ijms21165833 Authors: Marco Pelin Gabriele Stocco Chiara Florio Silvio Sosa Aurelia Tubaro The marine polyether palytoxin (PLTX) is one of the most toxic natural compounds, and is involved in human poisonings after oral, inhalation, skin and/or ocular exposure. Epidemiological...
Fri Aug 14, 2020 03:00
IJNS, Vol. 6, Pages 65: The Impact of Post-Analytical Tools on New York Screening for Krabbe Disease and Pompe Disease International Journal of Neonatal Screening doi: 10.3390/ijns6030065 Authors: Monica M. Martin Ryan Wilson Michele Caggana Joseph J. Orsini New York uses a two-tier assay to screen newborns for Krabbe disease and Pompe disease. Individual enzyme activities are measured in the first-tier, and specimens from newborns with low activity are reflexed to second tier...
Fri Aug 14, 2020 03:00
IJNS, Vol. 6, Pages 64: Landscape of Congenital Adrenal Hyperplasia Newborn Screening in the United States International Journal of Neonatal Screening doi: 10.3390/ijns6030064 Authors: Sari Edelman Hiral Desai Trey Pigg Careema Yusuf Jelili Ojodu Newborn screening (NBS) is a state-based public health program that aims to identify newborns at risk of certain disorders in the first days after birth to prevent permanent disability or death. Disorders on the Health and Human...
Fri Aug 14, 2020 03:00
JCM, Vol. 9, Pages 2654: Pattern of Recurrence and Patient Survival after Perioperative Chemotherapy with 5-FU, Leucovorin, Oxaliplatin and Docetaxel (FLOT) for Locally Advanced Esophagogastric Adenocarcinoma in Patients Treated Outside Clinical Trials Journal of Clinical Medicine doi: 10.3390/jcm9082654 Authors: Torben Glatz Rasmus Verst Jasmina Kuvendjiska Peter Bronsert Heiko Becker Jens Hoeppner Birte Kulemann Background: The 5-FU, Leucovorin, Oxaliplatin and Docetaxel...
Sun Aug 16, 2020 03:00
JCM, Vol. 9, Pages 2653: Notching and Pulsatility Index of the Uterine Arteries and Preeclampsia in Twin Pregnancies Journal of Clinical Medicine doi: 10.3390/jcm9082653 Authors: Stephanie Springer Mariella Polterauer Maria Stammler-Safar Harald Zeisler Heinz Leipold Christof Worda Katharina Worda Increased uterine artery Doppler indices have been shown to be associated with preeclampsia and adverse pregnancy outcomes in singleton and twin pregnancies. At 20–22...
Sat Aug 15, 2020 03:00
JCM, Vol. 9, Pages 2652: Short-Term Effects of a Myofunctional Appliance on Atypical Swallowing and Lip Strength: A Prospective Study Journal of Clinical Medicine doi: 10.3390/jcm9082652 Authors: Vincenzo Quinzi Alessandro Nota Eleonora Caggiati Sabina Saccomanno Giuseppe Marzo Simona Tecco Atypical swallowing needs treatment in order to eliminate harmful interferences of the tongue, which prevent the harmonious growth of the stomatognathic system. The purpose of this...
Sat Aug 15, 2020 03:00
JCM, Vol. 9, Pages 2651: Effect of Children’s Weight Status on Physical Activity and Sedentary Behavior during Physical Education, Recess, and After School Journal of Clinical Medicine doi: 10.3390/jcm9082651 Authors: Zachary C. Pope Charles Huang David Stodden Daniel J. McDonough Zan Gao Children’s body mass index may affect physical activity (PA) participation. Therefore, this study examined the effect of children’s weight status on underserved elementary...
Sat Aug 15, 2020 03:00
JCM, Vol. 9, Pages 2649: Retinal Response of Low Myopes during Orthokeratology Treatment Journal of Clinical Medicine doi: 10.3390/jcm9082649 Authors: António Queirós Ana F. Pereira-da-Mota Jéssica Costa Ana Amorim-de-Sousa Paulo R. B. Fernandes José M. González-Méijome The aim of this study was to evaluate the changes in retinal activity during orthokeratology (OK) treatment in 20 myopic eyes. Pattern electroretinography (PERG) and visual evoked potential (VEP) were assessed...
Fri Aug 14, 2020 03:00
JCM, Vol. 9, Pages 2650: Recent Advances in Mycobacterial Research Journal of Clinical Medicine doi: 10.3390/jcm9082650 Authors: Venketaraman Worldwide, tuberculosis (TB) remains the most frequent and important infectious disease that is responsible for causing significant morbidity and death [1,2] [...]
Fri Aug 14, 2020 03:00
JCM, Vol. 9, Pages 2648: Liver Steatosis, Gut-Liver Axis, Microbiome and Environmental Factors. A Never-Ending Bidirectional Cross-Talk Journal of Clinical Medicine doi: 10.3390/jcm9082648 Authors: Agostino Di Ciaula Jacek Baj Gabriella Garruti Giuseppe Celano Maria De Angelis Helen H. Wang Domenica Maria Di Palo Leonilde Bonfrate David Q-H Wang Piero Portincasa The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide and parallels...
Fri Aug 14, 2020 03:00
JCM, Vol. 9, Pages 2646: Early Intervention in Ulcerative Colitis: Ready for Prime Time? Journal of Clinical Medicine doi: 10.3390/jcm9082646 Authors: Virginia Solitano Ferdinando D’Amico Eirini Zacharopoulou Laurent Peyrin-Biroulet Silvio Danese Growing evidence shows that ulcerative colitis (UC) is a progressive disease similar to Crohn’s disease (CD). The UC-related burden is often underestimated by physicians and a standard step-up therapeutic approach is preferred....
Fri Aug 14, 2020 03:00
JCM, Vol. 9, Pages 2645: The Value of Morphometric Measurements in Risk Assessment for Donor-Site Complications after Microsurgical Breast Reconstruction Journal of Clinical Medicine doi: 10.3390/jcm9082645 Authors: Muriel O. Meyer Tristan M. Handschin Daniel T. Boll Frédérique Chammartin Dirk J. Schaefer Martin D. Haug Elisabeth A. Kappos Microsurgical abdominally-based reconstruction is considered the gold standard in autologous breast reconstruction. Despite refined...
Fri Aug 14, 2020 03:00
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