IJERPH, Vol. 17, Pages 5903: The Physiological Experimental Study on the Effect of Different Color of Safety Signs on a Virtual Subway Fire Escape—An Exploratory Case Study of Zijing Mountain Subway Station International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17165903 Authors: Na Chen Ming Zhao Kun Gao Jun Zhao Safety signs play a very important role in people’s evacuation during emergencies. In order to explore the appropriate color...
Fri Aug 14, 2020 03:00
IJERPH, Vol. 17, Pages 5900: Pretreatment of Grape Stalks by Fungi: Effect on Bioactive Compounds, Fiber Composition, Saccharification Kinetics and Monosaccharides Ratio International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17165900 Authors: Joana M.C. Fernandes Irene Fraga Rose M.O.F. Sousa Miguel A.M. Rodrigues Ana Sampaio Rui M.F. Bezerra Albino A. Dias Grape stalks, an inedible lignocellulosic residue from winemaking and agro-industrial...
Fri Aug 14, 2020 03:00
IJERPH, Vol. 17, Pages 5899: Animal-Assisted Therapy Improves Communication and Mobility among Institutionalized People with Cognitive Impairment International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17165899 Authors: Maylos Rodrigo-Claverol Belén Malla-Clua Carme Marquilles-Bonet Joaquim Sol Júlia Jové-Naval Meritxell Sole-Pujol Marta Ortega-Bravo Disorders of communication, social relationships, and psychomotricity are often characterized...
Fri Aug 14, 2020 03:00
IJERPH, Vol. 17, Pages 5898: Allocation Efficiency, Influencing Factors and Optimization Path of Rural Land Resources: A Case Study in Fang County of Hubei Province, China International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17165898 Authors: Bin Yang Zhanqi Wang Bo Zhang Di Zhang Land resource allocation efficiency (LRAE) is a significant indicator in weighing regional socioeconomic development. The study of LRAE can provide useful references...
Fri Aug 14, 2020 03:00
IJMS, Vol. 21, Pages 5893: Regulation of Female Folliculogenesis by Tsp1a in Nile Tilapia (Oreochromis niloticus) International Journal of Molecular Sciences doi: 10.3390/ijms21165893 Authors: Jie Ma Zhou Wu Li Liu Wang TSP1 was reported to be involved in multiple biological processes including the activation of TGF-β signaling pathways and the regulation of angiogenesis during wound repair and tumor growth, while its role in ovarian folliculogenesis...
Sun Aug 16, 2020 03:00
IJMS, Vol. 21, Pages 5894: Downregulation of ORP3 Correlates with Reduced Survival of Colon Cancer Patients with Advanced Nodal Metastasis and of Female Patients with Grade 3 Colon Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21165894 Authors: Pengfei Xu Julia Richter Annette Blatz Fabian Gärtner Roland Alberts Anca Azoitei Wycliffe Arika Makori Sabine Meessen Uwe Knippschild Cagatay Günes Genome instability is an essential hallmark in...
Sun Aug 16, 2020 03:00
IJMS, Vol. 21, Pages 5892: Combinational Analyses with Multiple Methods Reveal the Existence of Several Forms of Polysialylated Neural Cell Adhesion Molecule in Mouse Developing Brains International Journal of Molecular Sciences doi: 10.3390/ijms21165892 Authors: Airi Mori Yi Yang Yuka Takahashi Masaya Hane Ken Kitajima Chihiro Sato Polysialic acid (polySia/PSA) is an anionic glycan polymer of sialic acid, and it mostly modifies the neural cell adhesion molecule (NCAM)...
Sun Aug 16, 2020 03:00
IJMS, Vol. 21, Pages 5895: Possible Neuroprotective Mechanisms of Physical Exercise in Neurodegeneration International Journal of Molecular Sciences doi: 10.3390/ijms21165895 Authors: B. Mahalakshmi Nancy Maurya Shin-Da Lee V. Bharath Kumar Physical exercise (PE) improves physical performance, mental status, general health, and well-being. It does so by affecting many mechanisms at the cellular and molecular level. PE is beneficial for people suffering from neuro-degenerative...
Sun Aug 16, 2020 03:00
IJMS, Vol. 21, Pages 5891: NECTIN4 Expression in Extramammary Paget’s Disease: Implication of a New Therapeutic Target International Journal of Molecular Sciences doi: 10.3390/ijms21165891 Authors: Maho Murata Takamichi Ito Yuka Tanaka Yumiko Kaku-Ito Masutaka Furue Extramammary Paget’s disease (EMPD) is a rare skin cancer arising in the anogenital area. Most EMPD tumors remain dormant as in situ lesions, but the outcomes of patients with metastatic EMPD are poor...
Sun Aug 16, 2020 03:00
IJMS, Vol. 21, Pages 5888: History of Nonalcoholic Fatty Liver Disease International Journal of Molecular Sciences doi: 10.3390/ijms21165888 Authors: Amedeo Lonardo Simona Leoni Khalid A. Alswat Yasser Fouad Based on the assumption that characterizing the history of a disease will help in improving practice while offering a clue to research, this article aims at reviewing the history of nonalcoholic fatty liver disease (NAFLD) in adults and children. To this end, we address...
Sun Aug 16, 2020 03:00
IJMS, Vol. 21, Pages 5890: Heterologous Hydrogenase Overproduction Systems for Biotechnology—An Overview International Journal of Molecular Sciences doi: 10.3390/ijms21165890 Authors: Qin Fan Peter Neubauer Oliver Lenz Matthias Gimpel Hydrogenases are complex metalloenzymes, showing tremendous potential as H2-converting redox catalysts for application in light-driven H2 production, enzymatic fuel cells and H2-driven cofactor regeneration. They catalyze the reversible oxidation...
Sun Aug 16, 2020 03:00
IJMS, Vol. 21, Pages 5889: Molecular Effects of Silver Nanoparticles on Monogenean Parasites: Lessons from Caenorhabditis elegans International Journal of Molecular Sciences doi: 10.3390/ijms21165889 Authors: Citlalic A. Pimentel-Acosta Jorge Ramírez-Salcedo Francisco Neptalí Morales-Serna Emma J. Fajer-Ávila Cristina Chávez-Sánchez Humberto H. Lara Alejandra García-Gasca The mechanisms of action of silver nanoparticles (AgNPs) in monogenean parasites of the genus Cichlidogyrus...
Sun Aug 16, 2020 03:00
IJMS, Vol. 21, Pages 5887: Role of Leptin in Inflammation and Vice Versa International Journal of Molecular Sciences doi: 10.3390/ijms21165887 Authors: Antonio Pérez-Pérez Flora Sánchez-Jiménez Teresa Vilariño-García Víctor Sánchez-Margalet Inflammation is an essential immune response for the maintenance of tissue homeostasis. In a general sense, acute and chronic inflammation are different types of adaptive response that are called into action when other homeostatic mechanisms...
Sun Aug 16, 2020 03:00
IJMS, Vol. 21, Pages 5886: An Exo-Polygalacturonase Pgc4 Regulates Aerial Hyphal Growth and Virulence in Fusarium oxysporum f. sp. cubense race 4 International Journal of Molecular Sciences doi: 10.3390/ijms21165886 Authors: Zhangyong Dong Mei Luo Zhenzhong Wang Fusarium oxysporum f. sp. cubense race 4 (Foc4) causes Fusarium wilt that affects banana plants, and hence, the molecular mechanisms of its virulence need to be investigated. We purified an exo-polygalacturonase (exo-PG),...
Sun Aug 16, 2020 03:00
IJMS, Vol. 21, Pages 5885: Sweet Immunity: The Effect of Exogenous Fructans on the Susceptibility of Apple (Malus × domestica Borkh.) to Venturia inaequalis International Journal of Molecular Sciences doi: 10.3390/ijms21165885 Authors: Anze Svara Łukasz Paweł Tarkowski Henry Christopher Janse van Rensburg Evelien Deleye Jarl Vaerten Nico De Storme Wannes Keulemans Wim Van den Ende There is an urgent need for novel, efficient and environmentally friendly strategies...
Sun Aug 16, 2020 03:00
IJMS, Vol. 21, Pages 5883: Association of Electronegative LDL with Macrophage Foam Cell Formation and CD11c Expression in Rheumatoid Arthritis Patients International Journal of Molecular Sciences doi: 10.3390/ijms21165883 Authors: Ching-Kun Chang Po-Ku Chen Joung-Liang Lan Shih-Hsin Chang Tsu-Yi Hsieh Pei-Jyuan Liao Chu-Huang Chen Der-Yuan Chen L5, the most negatively charged subfraction of low-density lipoprotein (LDL), is implicated in atherogenesis, but the pathogenic...
Sun Aug 16, 2020 03:00
IJMS, Vol. 21, Pages 5882: From Ivacaftor to Triple Combination: A Systematic Review of Efficacy and Safety of CFTR Modulators in People with Cystic Fibrosis International Journal of Molecular Sciences doi: 10.3390/ijms21165882 Authors: Andrea Gramegna Martina Contarini Stefano Aliberti Rosaria Casciaro Francesco Blasi Carlo Castellani Over the last years CFTR (cystic fibrosis transmembrane conductance regulator) modulators have shown the ability to improve relevant clinical...
Sun Aug 16, 2020 03:00
IJMS, Vol. 21, Pages 5884: Genistein Induces Adipogenic and Autophagic Effects in Rainbow Trout (Oncorhynchus mykiss) Adipose Tissue: In Vitro and In Vivo Models International Journal of Molecular Sciences doi: 10.3390/ijms21165884 Authors: Sara Balbuena-Pecino Esmail Lutfi Natàlia Riera-Heredia Esther Gasch-Navalón Emilio J. Vélez Joaquim Gutiérrez Encarnación Capilla Isabel Navarro Soybeans are one of the most used alternative dietary ingredients in aquafeeds....
Sun Aug 16, 2020 03:00
IJMS, Vol. 21, Pages 5881: Preparation and Characterization of Poly(ethylene-co-vinyl alcohol)/poly(ε-caprolactone) Blend for Bioscaffolding Applications International Journal of Molecular Sciences doi: 10.3390/ijms21165881 Authors: Abdulaziz Ali Alghamdi Hussain Alattas Waseem Sharaf Saeed Abdel-Basit Al-Odayni Ali Alrahlah Taieb Aouak In order to improve the cell adhesion on poly(ε-caprolactone) (PCL) scaffolds, poly(ethylene-co-vinyl alcohol) (E-VAL) which...
Sun Aug 16, 2020 03:00
IJMS, Vol. 21, Pages 5880: Mitochondrial Genetic Drift after Nuclear Transfer in Oocytes International Journal of Molecular Sciences doi: 10.3390/ijms21165880 Authors: Mitsutoshi Yamada Kazuhiro Akashi Reina Ooka Kenji Miyado Hidenori Akutsu Mitochondria are energy-producing intracellular organelles containing their own genetic material in the form of mitochondrial DNA (mtDNA), which codes for proteins and RNAs essential for mitochondrial function. Some mtDNA mutations can...
Sun Aug 16, 2020 03:00
IJMS, Vol. 21, Pages 5879: Zooming into the Dark Side of Human Annexin-S100 Complexes: Dynamic Alliance of Flexible Partners International Journal of Molecular Sciences doi: 10.3390/ijms21165879 Authors: Judith Weisz Vladimir N. Uversky Annexins and S100 proteins form two large families of Ca2+-binding proteins. They are quite different both structurally and functionally, with S100 proteins being small (10–12 kDa) acidic regulatory proteins from the EF-hand superfamily of...
Sun Aug 16, 2020 03:00
IJMS, Vol. 21, Pages 5875: The New Model of Snail Expression Regulation: The Role of MRTFs in Fast and Slow Endothelial–Mesenchymal Transition International Journal of Molecular Sciences doi: 10.3390/ijms21165875 Authors: Katarzyna Sobierajska Wojciech M. Ciszewski Ewa Macierzynska-Piotrowska Wanda Klopocka Patrycja Przygodzka Magdalena Karakula Karolina Pestka Marta E. Wawro Jolanta Niewiarowska Endothelial–mesenchymal transition (EndMT) is a crucial...
Sun Aug 16, 2020 03:00
IJMS, Vol. 21, Pages 5878: A Novel R2R3-MYB Transcription Factor PqMYB4 Inhibited Anthocyanin Biosynthesis in Paeonia qiui International Journal of Molecular Sciences doi: 10.3390/ijms21165878 Authors: Dan Huo Xiaokun Liu Yue Zhang Jingjing Duan Yanlong Zhang Jianrang Luo Paeonia qiui is a wild tree peony native to China. Its leaves show a clear purple-red color from the germination to the flowering stage, and it has high leaf-viewing value. A MYB transcription factor...
Sun Aug 16, 2020 03:00
IJMS, Vol. 21, Pages 5876: Anticancer Strategy Targeting Cell Death Regulators: Switching the Mechanism of Anticancer Floxuridine-Induced Cell Death from Necrosis to Apoptosis International Journal of Molecular Sciences doi: 10.3390/ijms21165876 Authors: Akira Sato Akiko Hiramoto Hye-Sook Kim Yusuke Wataya Cell death can be broadly characterized as either necrosis or apoptosis, depending on the morphological and biochemical features of the cell itself. We have previously reported...
Sun Aug 16, 2020 03:00
IJMS, Vol. 21, Pages 5877: A Two-Step Immunomagnetic Microbead-Based Method for the Isolation of Human Primary Skin Telocytes/CD34+ Stromal Cells International Journal of Molecular Sciences doi: 10.3390/ijms21165877 Authors: Eloisa Romano Irene Rosa Bianca Saveria Fioretto Elena Lucattelli Marco Innocenti Lidia Ibba-Manneschi Marco Matucci-Cerinic Mirko Manetti Telocytes (TCs), commonly referred to as TCs/CD34+ stromal cells, are a peculiar type of interstitial cells...
Sun Aug 16, 2020 03:00
IJMS, Vol. 21, Pages 5874: Morphological Changes and Cellular Uptake of Functionalized Graphene Oxide Loaded with Protocatechuic Acid and Folic Acid in Hepatocellular Carcinoma Cancer Cell International Journal of Molecular Sciences doi: 10.3390/ijms21165874 Authors: Kalaivani Buskaran Mohd Zobir Hussein Mohamad Aris Mohd Moklas Sharida Fakurazi The development of nanocomposites has swiftly changed the horizon of drug delivery systems in defining a new platform. Major understanding...
Sun Aug 16, 2020 03:00
IJMS, Vol. 21, Pages 5873: N-(2′-Hydroxyphenyl)-2-Propylpentanamide (HO-AAVPA) Inhibits HDAC1 and Increases the Translocation of HMGB1 Levels in Human Cervical Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21165873 Authors: Yudibeth Sixto-López Martha Cecilia Rosales-Hernández Arturo Contis-Montes de Oca Leticia Guadalupe Fragoso-Morales Jessica Elena Mendieta-Wejebe Ana María Correa-Basurto Edgar Abarca-Rojano José Correa-Basurto N-(2′-hydroxyphenyl)-2-propylpentanamide...
Sun Aug 16, 2020 03:00
IJMS, Vol. 21, Pages 5872: Lactobacillus Strains Alleviated Hyperlipidemia and Liver Steatosis in Aging Rats via Activation of AMPK International Journal of Molecular Sciences doi: 10.3390/ijms21165872 Authors: Lee-Ching Lew Yan-Yan Hor Mohamad-Hafis Jaafar Amy-Sie-Yik Lau Boon-Kiat Lee Li-Oon Chuah Kien-Pong Yap Azali Azlan Ghows Azzam Sy-Bing Choi Min-Tze Liong In this study, we hypothesized that different strains of Lactobacillus can alleviate hyperlipidemia...
Sun Aug 16, 2020 03:00
IJMS, Vol. 21, Pages 5871: Knowing When to Silence: Roles of Polycomb-Group Proteins in SAM Maintenance, Root Development, and Developmental Phase Transition International Journal of Molecular Sciences doi: 10.3390/ijms21165871 Authors: Bowen Yan Yanpeng Lv Chunyu Zhao Xiaoxue Wang Polycomb repressive complex 1 (PRC1) and PRC2 are the major complexes composed of polycomb-group (PcG) proteins in plants. PRC2 catalyzes trimethylation of lysine 27 on histone 3 to silence target...
Sat Aug 15, 2020 03:00
IJMS, Vol. 21, Pages 5870: p-Cymene and Rosmarinic Acid Ameliorate TNBS-Induced Intestinal Inflammation Upkeeping ZO-1 and MUC-2: Role of Antioxidant System and Immunomodulation International Journal of Molecular Sciences doi: 10.3390/ijms21165870 Authors: Rodrigo de Oliveira Formiga Edvaldo Balbino Alves Júnior Roseane Carvalho Vasconcelos Gerlane Coelho Bernardo Guerra Aurigena Antunes de Araújo Thaís Gomes de Carvalho Vinícius Barreto Garcia Raimundo Fernandes de Araújo...
Sat Aug 15, 2020 03:00
IJMS, Vol. 21, Pages 5868: Oxidative Photocyclization of Aromatic Schiff Bases in Synthesis of Phenanthridines and Other Aza-PAHs International Journal of Molecular Sciences doi: 10.3390/ijms21165868 Authors: Martin Kos Jaroslav Žádný Jan Storch Vladimír Církva Petra Cuřínová Jan Sýkora Ivana Císařová Febin Kuriakose Igor. V. Alabugin The oxidative photocyclization of aromatic Schiff bases was investigated as a potential method for synthesis of phenanthridine...
Sat Aug 15, 2020 03:00
IJMS, Vol. 21, Pages 5869: Parkin Coordinates Platelet Stress Response in Diabetes Mellitus: A Big Role in a Small Cell International Journal of Molecular Sciences doi: 10.3390/ijms21165869 Authors: Seung Hee Lee Jing Du John Hwa Won-Ho Kim Increased platelet activation and apoptosis are characteristic of diabetic (DM) platelets, where a Parkin-dependent mitophagy serves a major endogenous protective role. We now demonstrate that Parkin is highly expressed in both healthy platelets...
Sat Aug 15, 2020 03:00
IJMS, Vol. 21, Pages 5867: Signaling Molecules Regulating Pancreatic Endocrine Development from Pluripotent Stem Cell Differentiation International Journal of Molecular Sciences doi: 10.3390/ijms21165867 Authors: Hui Huang Taylor N. Bader Sha Jin Diabetes is one of the leading causes of death globally. Currently, the donor pancreas is the only source of human islets, placing extreme constraints on supply. Hence, it is imperative to develop renewable islets for diabetes research...
Sat Aug 15, 2020 03:00
IJMS, Vol. 21, Pages 5863: NanoBiT System and Hydrofurimazine for Optimized Detection of Viral Infection in Mice—A Novel in Vivo Imaging Platform International Journal of Molecular Sciences doi: 10.3390/ijms21165863 Authors: Natasa Gaspar Giorgia Zambito Iris J. C. Dautzenberg Steve J. Cramer Rob C. Hoeben Clemens Lowik Joel R. Walker Thomas A. Kirkland Thomas P. Smith Wytske M. van Weerden Jeroen de Vrij Laura Mezzanotte Reporter genes are used to visualize...
Sat Aug 15, 2020 03:00
IJMS, Vol. 21, Pages 5866: The Malignant Role of Exosomes as Nanocarriers of Rare RNA Species International Journal of Molecular Sciences doi: 10.3390/ijms21165866 Authors: Alina-Andreea Zimta Olafur Eysteinn Sigurjonsson Diana Gulei Ciprian Tomuleasa Nowadays, advancements in the oncology sector regarding diagnosis methods allow us to specifically detect an increased number of cancer patients, some of them in incipient stages. However, one of the main issues consists of the...
Sat Aug 15, 2020 03:00
IJMS, Vol. 21, Pages 5865: Current Understanding of the Role of Cytoskeletal Cross-Linkers in the Onset and Development of Cardiomyopathies International Journal of Molecular Sciences doi: 10.3390/ijms21165865 Authors: Ilaria Pecorari Luisa Mestroni Orfeo Sbaizero Cardiomyopathies affect individuals worldwide, without regard to age, sex and ethnicity and are associated with significant morbidity and mortality. Inherited cardiomyopathies account for a relevant part of these conditions....
Sat Aug 15, 2020 03:00
IJMS, Vol. 21, Pages 5864: Establishment of the Embryonic Shoot Meristem Involves Activation of Two Classes of Genes with Opposing Functions for Meristem Activities International Journal of Molecular Sciences doi: 10.3390/ijms21165864 Authors: Aida Tsubakimoto Shimizu Ogisu Kamiya Iwamoto Takeda Karim Mizutani Lenhard Tasaka The shoot meristem, a stem-cell-containing tissue initiated during plant embryogenesis, is responsible for continuous shoot...
Sat Aug 15, 2020 03:00
IJMS, Vol. 21, Pages 5861: Impact of Natural Occurring ERAP1 Single Nucleotide Polymorphisms within miRNA-Binding Sites on HCMV Infection International Journal of Molecular Sciences doi: 10.3390/ijms21165861 Authors: Ombretta Melaiu Silvia D’Amico Patrizia Tempora Valeria Lucarini Doriana Fruci Human cytomegalovirus (HCMV) is a β-herpesvirus that causes serious problems in people with a compromised immune system, whereas it coexists asymptomatically within the host...
Sat Aug 15, 2020 03:00
IJMS, Vol. 21, Pages 5862: Identification of a Novel Gene, Osbht, in Response to High Temperature Tolerance at Booting Stage in Rice International Journal of Molecular Sciences doi: 10.3390/ijms21165862 Authors: Jae-Ryoung Park Won-Tae Yang Doh-Hoon Kim Kyung-Min Kim Rice is one of the world’s leading food crops, and over 90% of the world’s rice production stems from Asia. In particular, an increase of 1 °C in the minimum temperature reduces the quantity...
Sat Aug 15, 2020 03:00
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