Influence of FAZA PET hypoxia and HPV-status for the outcome of head and neck squamous cell carcinoma (HNSCC) treated with radiotherapy: Long-term results from the DAHANCA 24 trial (NCT01017224). Radiother Oncol. 2020 Aug 14;: Authors: Saksø M, Mortensen LS, Primdahl H, Johansen J, Kallehauge J, Hansen CR, Overgaard J Abstract PURPOSE: Hypoxic tumor volumes can be visualized with 18F-FAZA PET/CT. In head and neck squamous cell carcinoma (HNSCC),...
Tue Aug 18, 2020 16:22
Transoral Carbon Dioxide Microsurgery of the Larynx as a Day-Case Outpatient Procedure: An Observational, Retrospective, Single-Center Study. Ear Nose Throat J. 2020 Aug 17;:145561320951049 Authors: Chiesa-Estomba CM, Sistiaga Suarez JA, Ninchritz-Becerra E, Soriano-Reixach M, González-García JA, Larruscain E, Altuna X Abstract INTRODUCTION: Despite good results of transoral laser CO2 microsurgery (CO2TOLMS) of the larynx, a lack of data related...
Tue Aug 18, 2020 16:22
Related Articles Feasibility and efficacy of chemoradiotherapy with concurrent split-dose cisplatin after induction chemotherapy with docetaxel/cisplatin/5-fluorouracil for locally advanced head and neck cancer. Mol Clin Oncol. 2020 Oct;13(4):35 Authors: Yokota T, Shibata M, Hamauchi S, Shirasu H, Onozawa Y, Ogawa H, Onoe T, Kawakami T, Furuta M, Inoue H, Fushiki K, Onitsuka T Abstract Chemoradiotherapy (CRT) with concurrent high-dose cisplatin...
Tue Aug 18, 2020 16:22
Related Articles Real-time light-guided vocal fold injection as a simulation-based training tool. Auris Nasus Larynx. 2020 Aug 12;: Authors: Kim J, Seo HS, Na HS, Son HY, Lee DK, Jeong WJ, Cha W Abstract OBJECTIVE: Cricothyroid (CT) approach for vocal fold injection (VFI) has advantages of a low complication rate, suitability for in-office practice, and good patient compliance. However, it requires a high level of experience and a steep learning...
Tue Aug 18, 2020 16:22
Related Articles Congenital cholesteatoma assessment based on staging and classification criteria for middle ear cholesteatoma proposed by the Japan Otological Society. Auris Nasus Larynx. 2020 Aug 12;: Authors: Miura M, Yamamoto Y, Takahashi M, Komori M, Yamamoto K, Kojima H Abstract OBJECTIVE: We aimed to assess the clinical characteristics of extent patterns in congenital cholesteatoma, based on the Japan Otological Society (JOS) staging...
Tue Aug 18, 2020 16:22
Related Articles "Novel method for confirming appropriate nerve integrity monitor (NIM) endotracheal tube positioning". Am J Surg. 2020 Jul 28;: Authors: Engwall A, Behr I, Hess A, Haan P, McLeod MK Abstract Surgical injury to the recurrent laryngeal nerve (RLN) is a significant complication of head and neck surgery due to the potential for significant, permanent functional disability. Originally recommended by Lahey in 1938, intraoperative...
Tue Aug 18, 2020 16:22
Related Articles Anatomical classification of upper gastrointestinal organs under various image capture conditions using AlexNet. Comput Biol Med. 2020 Aug 07;124:103950 Authors: Igarashi S, Sasaki Y, Mikami T, Sakuraba H, Fukuda S Abstract BACKGROUND: Machine learning has led to several endoscopic studies about the automated localization of digestive lesions and prediction of cancer invasion depth. Training and validation dataset collection...
Tue Aug 18, 2020 16:22
Related Articles A novel approach in managing challenging tracheoesophageal fistulae. Int J Pediatr Otorhinolaryngol. 2020 Aug 05;138:110261 Authors: Quick ME, Giblett N, Uwiera TC, Herbert H, Vijayasekaran S Abstract OBJECTIVE: To analyze the outcomes of an open anterior cervical approach and tospecifically describe a novel extended tracheotomy incision ("Key-hole technique") torepair H-type and other challenging tracheoesophageal fistulae...
Tue Aug 18, 2020 16:22
Related Articles Outcome of two variations of a surgical technique performed for canine unilateral arytenoid lateralisation. Vet Rec. 2019 09 07;185(9):268 Authors: Perez Lopez P, Barnes DC, Nelissen P, Demetriou J Abstract Background The purpose of this study is to compare the rate of aspiration pneumonia and survival time of dogs undergoing two unilateral arytenoid lateralisation (UAL) techniques.Methods Eighty dogs diagnosed with laryngeal...
Tue Aug 18, 2020 16:22
Treatment and outcomes of iatrogenic cerebrospinal fluid leak caused by different surgical procedures. World Neurosurg. 2020 Aug 14;: Authors: Tang R, Mao S, Li D, Ye H, Zhang W Abstract BACKGROUND: Iatrogenic cerebrospinal fluid (CSF) leaks are associated with serious sequelae. We analyzed the causes, complications, treatments, and outcomes of iatrogenic CSF leaks. Furthermore, the comorbidities and outcomes between timely and delayed repairs...
Tue Aug 18, 2020 16:03
Related Articles Modified Ipsilateral Endonasal Endoscopic Trans-Sphenoidal Approach to Sphenoid Sinus Lateral Recess Cerebrospinal Fluid Leak Management in Two Cases: A Technical Note. J Neurosci Rural Pract. 2020 Jul;11(3):459-462 Authors: Rai SKR, Dandpat SK Abstract Background Cerebrospinal fluid (CSF) leak from the sphenoid sinus lateral recess (SSLR) is very rare. Majority prefer transpterygoid approach which is extensive and time consuming....
Tue Aug 18, 2020 16:03
Related Articles Prevalence of leukoencephalopathy and its potential cognitive sequelae in cancer patients. J Chemother. 2020 Aug 17;:1-17 Authors: Schroyen G, Meylaers M, Deprez S, Blommaert J, Smeets A, Jacobs S, Sunaert S, Sleurs C, Uyttebroeck A Abstract Due to the rising use of chemotherapy treatment in cancer patients and growing survival rates, therapy-induced neurotoxic side effects are increasingly reported. Given the ambiguity about...
Tue Aug 18, 2020 20:53
Prospective Phase II Trial of Levonorgestrel Intrauterine Device: Non-Surgical Approach for Complex Atypical Hyperplasia and Early Endometrial Cancer. Am J Obstet Gynecol. 2020 Aug 14;: Authors: Westin SN, Fellman B, Sun CC, Broaddus RR, Woodall ML, Pal N, Urbauer DL, Ramondetta LM, Schmeler KM, Soliman PT, Fleming ND, Burzawa JK, Nick AM, Milbourne AM, Yuan Y, Lu KH, Bodurka DC, Coleman RL, Yates MS Abstract BACKGROUND: The incidence of complex...
Tue Aug 18, 2020 14:10
Factor Xa inhibitors in the prevention of cancer-related venous thromboembolism: lessons learned by clinical trials. Future Oncol. 2020 Aug 17;: Authors: Lavalle C, V Mariani M, Fedele F PMID: 32805155 [PubMed - as supplied by publisher]
Tue Aug 18, 2020 14:10
Future perspectives and challenges with CDK4/6 inhibitors in hormone receptor-positive metastatic breast cancer. Future Oncol. 2020 Aug 17;: Authors: Bayraktar S, Batoo S, Al-Hattab E, Basu S, Okuno S, Glück S Abstract There are three US FDA-approved CDK4/6 inhibitors: palbociclib, ribociclib and abemaciclib for patients with HR-positive, HER2-negative (HR+/HER2-) metastatic breast cancer (MBC). They are all equally effective, so the question...
Tue Aug 18, 2020 14:10
Targeting HER2 in the management of potentially resectable gastric adenocarcinoma: what are oncologists waiting for? Future Oncol. 2020 Aug 17;: Authors: Gharib KE, R Kourie H PMID: 32805125 [PubMed - as supplied by publisher]
Tue Aug 18, 2020 14:10
Selective targeting of cancer signaling pathways with nanomedicines: challenges and progress. Future Oncol. 2020 Aug 17;: Authors: Barkat HA, Das SS, Barkat MA, Beg S, Hadi HA Abstract Cancer is one of the leading causes of death worldwide. Regardless of advances in understanding the molecular mechanics of cancer, its treatment is still lacking and the death rates for many forms of the disease remain the same as six decades ago. Although a...
Tue Aug 18, 2020 14:10
Prognostic value of POD24 validation in follicular lymphoma patients initially treated with chemotherapy-free regimens in a pooled analysis of three randomized trials of the Swiss Group for Clinical Cancer Research (SAKK). Br J Haematol. 2020 Aug 17;: Authors: Moccia AA, Schär S, Hayoz S, Pirosa MC, Taverna C, Novak U, Kimby E, Ghielmini M, Zucca E Abstract The relapse of follicular lymphoma (FL) within 24 months (POD24) of chemoimmunotherapy...
Tue Aug 18, 2020 14:10
Comparison of Health Care Utilization at the End of Life Among Patients With Cancer in Alberta, Canada, Versus Washington State. JCO Oncol Pract. 2020 Aug 17;:OP2000217 Authors: Khaki AR, Xu Y, Cheung WY, Li L, Fedorenko C, Grivas P, Ramsey S, Shankaran V Abstract PURPOSE: Aggressive care at the end of life (EOL) can lead to unnecessary suffering and health care costs for patients with cancer. Despite geographic proximity and cultural similarities,...
Tue Aug 18, 2020 14:10
Cancer-associated fibroblasts induce epithelial-mesenchymal transition and cisplatin resistance in ovarian cancer via CXCL12/CXCR4 axis. Future Oncol. 2020 Aug 17;: Authors: Zhang F, Cui JY, Gao HF, Yu H, Gao FF, Chen JL, Chen L Abstract Aim: Cancer-associated fibroblasts (CAFs) are closely related to epithelial-mesenchymal transition (EMT) and chemoresistance in various cancers. Patients & methods: Experiments in vivo and retrospective...
Tue Aug 18, 2020 14:10
Related Articles NMR in integrated biophysical drug discovery for RAS: past, present, and future. J Biomol NMR. 2020 Aug 17;: Authors: Marshall CB, KleinJan F, Gebregiworgis T, Lee KY, Fang Z, Eves BJ, Liu NF, Gasmi-Seabrook GMC, Enomoto M, Ikura M Abstract Mutations in RAS oncogenes occur in ~ 30% of human cancers, with KRAS being the most frequently altered isoform. RAS proteins comprise a conserved GTPase domain and a C-terminal lipid-modified...
Tue Aug 18, 2020 15:47
Related Articles 177Lu radiolabeling and preclinical theranostic study of 1C1m-Fc: an anti-TEM-1 scFv-Fc fusion protein in soft tissue sarcoma. EJNMMI Res. 2020 Aug 17;10(1):98 Authors: Delage JA, Faivre-Chauvet A, Fierle JK, Gnesin S, Schaefer N, Coukos G, Dunn SM, Viertl D, Prior JO Abstract PURPOSE: TEM-1 (tumor endothelial marker-1) is a single-pass transmembrane cell surface glycoprotein expressed at high levels by tumor vasculature and...
Tue Aug 18, 2020 15:47
Related Articles A walk with Lu-177 PSMA: How close we have reached from bench to bedside? Cancer Invest. 2020 Aug 17;:1-19 Authors: Gupta M, Karthikeyan G, Choudhury PS, Babu VP, Sharma M, Jain P, Talwar I, Singh A, Rawal S Abstract Metastatic castration-resistant prostate cancer (mCRPC) is a natural sequela in advanced prostate cancer following resistance to standard treatment regimes. Where patients develop with rising PSA, bone pains, and...
Tue Aug 18, 2020 15:47
Related Articles Triple-negative breast cancer: new treatment strategies in the era of precision medicine. Sci China Life Sci. 2020 Aug 11;: Authors: Wu SY, Wang H, Shao ZM, Jiang YZ Abstract Triple-negative breast cancer (TNBC) remains the most aggressive cluster of all breast cancers, which is due to its rapid progression, high probabilities of early recurrence, and distant metastasis resistant to standard treatment. Following the advances...
Tue Aug 18, 2020 15:47
Related Articles Phase Ib clinical trial of the anti-frizzled antibody vantictumab (OMP-18R5) plus paclitaxel in patients with locally advanced or metastatic HER2-negative breast cancer. Breast Cancer Res Treat. 2020 Aug 14;: Authors: Diamond JR, Becerra C, Richards D, Mita A, Osborne C, O'Shaughnessy J, Zhang C, Henner R, Kapoun AM, Xu L, Stagg B, Uttamsingh S, Brachmann RK, Farooki A, Mita M Abstract PURPOSE: Vantictumab is a monoclonal antibody...
Tue Aug 18, 2020 15:47
Related Articles Striving toward Improved Outcomes for Surgically Resectable Non-Small Cell Lung Cancer: the Promise and Challenges of Neoadjuvant Immunotherapy. Curr Oncol Rep. 2020 Aug 15;22(11):109 Authors: Gentzler RD, Riley DO, Martin LW Abstract PURPOSE OF REVIEW: Immunotherapy has revolutionized the treatment of non-surgical stage III and stage IV non-small cell lung cancer (NSCLC). Here, we review emerging data on the safety, feasibility,...
Tue Aug 18, 2020 15:47
Related Articles Yttrium-90 Portal Vein Radioembolization in Sprague-Dawley Rats: Dose-Dependent Imaging and Pathological Changes in Normal Liver. Cardiovasc Intervent Radiol. 2020 Aug 16;: Authors: Gordon AC, White SB, Gates VL, Li W, Procissi D, Zhang Z, Harris KR, Kim DH, Mouli SK, Omary RA, Salem R, Larson AC, Lewandowski RJ Abstract PURPOSE: Portal vein embolization (PVE) is an established neoadjuvant method to induce future liver remnant...
Tue Aug 18, 2020 15:47
Related Articles The Impact of Mammography Screening Guideline Changes Among Women Serving in the U.S. Military. Mil Med. 2020 Aug 17;: Authors: Bytnar JA, Byrne C, Olsen C, Witkop CT, Martin MB, Banaag A, Koehlmoos T Abstract INTRODUCTION: The U.S. Preventive Services Task Force (USPSTF) modified their screening guidelines for breast cancer in November 2009. Previous studies evaluated the impact of these guideline changes among privately and...
Tue Aug 18, 2020 15:47
Related Articles Predicting Postoperative Outcomes in Brain Tumor Patients With a 5-Factor Modified Frailty Index. Neurosurgery. 2020 Aug 17;: Authors: Huq S, Khalafallah AM, Jimenez AE, Gami A, Lam S, Ruiz-Cardozo MA, Oliveira LAP, Mukherjee D Abstract BACKGROUND: Frailty indices may represent useful decision support tools to optimize modifiable drivers of quality and cost in neurosurgical care. However, classic indices are cumbersome to calculate...
Tue Aug 18, 2020 15:47
Related Articles Vaginal microbiota, genital inflammation, and neoplasia impact immune checkpoint protein profiles in the cervicovaginal microenvironment. NPJ Precis Oncol. 2020;4:22 Authors: Łaniewski P, Cui H, Roe DJ, Chase DM, Herbst-Kralovetz MM Abstract Emerging evidence suggests that the vaginal microbiota play a role in HPV persistence and cervical neoplasia development and progression. Here we examine a broad range of immune checkpoint...
Tue Aug 18, 2020 15:47
Related Articles High CXCR3 on Leukemic Cells Distinguishes IgHV mut from IgHV unmut in Chronic Lymphocytic Leukemia: Evidence from CD5high and CD5low Clones. J Immunol Res. 2020;2020:7084268 Authors: Manukyan G, Papajik T, Mikulkova Z, Urbanova R, Kraiczova VS, Savara J, Kudelka M, Turcsanyi P, Kriegova E Abstract Despite the shared pattern of surface antigens, neoplastic cells in chronic lymphocytic leukemia (CLL) are highly heterogeneous...
Tue Aug 18, 2020 15:47
Related Articles Difference of environment behind research and clinical practice between USA and Japan. J Thorac Dis. 2020 Jul;12(7):3804-3808 Authors: Komiya T, Chaaya G, Deshotels L, Wang A Abstract Recent studies have demonstrated that there are differences among races in efficacy, tolerance and other outcomes in oncologic care. Some of these differences may be explained by different pharmacogenetics; however, social and environmental factors...
Tue Aug 18, 2020 15:47
Related Articles A new standardized data collection system for brain stereotactic external radiotherapy: the PRE.M.I.S.E project. Future Sci OA. 2020 May 27;6(7):FSO596 Authors: Chiesa S, Tolu B, Longo S, Nardiello B, Capocchiano ND, Rea F, Capone L, Stimato G, Gatta R, Pacchiarotti A, Massaccesi M, Minniti G, Cellini F, Damiani A, Balducci M, Gentile P, Valentini V, Bianciardi F Abstract Background: In recent years, novel radiation therapy...
Tue Aug 18, 2020 15:47
Related Articles ITGA4 gene methylation status in chronic lymphocytic leukemia. Future Sci OA. 2020 Jun 26;6(7):FSO583 Authors: Attia HR, Ibrahim MH, El-Aziz SHA, Hassan NM, Osman RA, Hagag HA, Yassa ME, Abdelrahman AH, Salama II, Sobeih ME Abstract Background: We aimed to investigate ITGA4 gene expression pattern and to explore its methylation heterogeneity in chronic lymphocytic leukemia (CLL). Patients & methods: Eighty one CLL...
Tue Aug 18, 2020 15:47
Related Articles Centrosomal protein72 rs924607 and vincristine-induced neuropathy in pediatric acute lymphocytic leukemia: meta-analysis. Future Sci OA. 2020 May 27;6(7):FSO582 Authors: Zečkanović A, Jazbec J, Kavčič M Abstract Aim: We examined the utility of the rs924607 TT genotype of the centrosomal protein 72 (CEP72) as a potential biomarker for predilection toward vincristine-induced peripheral neuropathy in children treated for acute...
Tue Aug 18, 2020 15:47
Related Articles Development of thrombocytopenia is associated with improved survival in patients treated with immunotherapy. Future Sci OA. 2020 Jun 25;6(7):FSO581 Authors: Assi HA, Asch AS, Machiorlatti M, Vesely SK, Ibrahimi S Abstract Background: Immune-related adverse events are associated with efficacy of immune checkpoint inhibitors (ICIs). We hypothesize that immune-mediated thrombocytopenia could be a biomarker for response to ICIs....
Tue Aug 18, 2020 15:47
Related Articles Research Progress and Existing Problems for Abscopal Effect. Cancer Manag Res. 2020;12:6695-6706 Authors: Wang D, Zhang X, Gao Y, Cui X, Yang Y, Mao W, Li M, Zhang B, Yu J Abstract Radiation therapy plays a vital role in the treatment of tumours. In particular, the occurrence of the "abscopal effect" brings about a favourable turn for the treatment of patients with advanced metastatic malignant tumours. Because of the abscopal...
Tue Aug 18, 2020 15:47
Related Articles FKBP10 Acts as a New Biomarker for Prognosis and Lymph Node Metastasis of Gastric Cancer by Bioinformatics Analysis and in Vitro Experiments. Onco Targets Ther. 2020;13:7399-7409 Authors: Gong LB, Zhang C, Yu RX, Li C, Fan YB, Liu YP, Qu XJ Abstract Purpose: To explore the role of FKBP prolyl isomerase 10 (FKBP10) protein in the progression of gastric cancer. Methods: Four independent gastric cancer databases (GSE27342,...
Tue Aug 18, 2020 15:47
Related Articles Novel Albumin Nanoparticle Enhanced the Anti-Insulin-Resistant-Hepatoma Activity of Metformin. Int J Nanomedicine. 2020;15:5203-5215 Authors: Lu Z, Qi L, Lin YR, Sun L, Zhang L, Wang GC, Li JQ, Yu JM Abstract Introduction: Metformin is an ideal candidate to treat the liver tumor with insulin resistance because of its good performance in the treatment of type 2 diabetes and the advantage in cancer therapy. We aim to develop a...
Tue Aug 18, 2020 15:47
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