Fri Aug 14, 2020 03:00
Fri Aug 14, 2020 03:00
Nature Communications, Published online: 14 August 2020; doi:10.1038/s41467-020-17915-wHypercholesterolemia is associated with lipid peroxidation induced reactive dicarbonyl adducts. Here the authors show that the dicarbonyl scavenger, 2-hydroxybenzylamine(2-HOBA), decreases reactive dicarbonyl modifications of LDL and HDL, improves HDL function, reduces atherosclerosis and promotes features of stable plaques in a mouse model of hypercholestrolemia.
Fri Aug 14, 2020 03:00
Nature Communications, Published online: 14 August 2020; doi:10.1038/s41467-020-17917-8Neoplastic pancreatic cysts are associated with invasive pancreatic cancer, but their origins and evolutionary relationships are unclear. Here, the authors present the evolutionary analysis of neoplastic cysts and report them as precursors of invasive pancreatic cancer, and that SMAD4/TGFBR2 alterations are likely drivers of invasion in a subset of cases.
Fri Aug 14, 2020 03:00
Nature Communications, Published online: 14 August 2020; doi:10.1038/s41467-020-17905-yhnRNPA2 is involved in RNA metabolism and can form both functional amyloid-like fibrils in membraneless organelles, and pathogenic fibrils in neurodegenerative conditions. Here, the authors present the cryo-EM fibril structure of the wild-type hnRNPA2 low-complexity domain (LCD) and the crystal structure of a LCD segment with the disease causing D290V variant and discuss how mutations can transform fibril structure...
Fri Aug 14, 2020 03:00
Nature Communications, Published online: 14 August 2020; doi:10.1038/s41467-020-17853-7Rescue of ribosomes stalled on non-stop mRNA is essential for cell viability, and several rescue systems to resolve stalling exist in bacteria. Here, the authors use rapid kinetics and cryo-EM to reveal the pathway and selectivity mechanism of ArfB-mediated ribosome rescue.
Fri Aug 14, 2020 03:00
Nature Communications, Published online: 14 August 2020; doi:10.1038/s41467-020-17971-2Chest CT is emerging as a valuable diagnostic tool for clinical management of COVID-19 associated lung disease. Here, the authors present a multinational study on the application of deep learning algorithms for COVID-19 diagnosis against multiple lung conditions as controls.
Fri Aug 14, 2020 03:00
Nature Communications, Published online: 14 August 2020; doi:10.1038/s41467-020-17962-3Cells employ different repair pathways to repair DNA double strand breaks. Here, the authors develop a CRISPR/Cas9-dependent method to study choices in DNA repair called the Color Assay Tracing-Repair (CAT-R) which simultaneously measure outcomes of DSB repair via end-protection and end-resection pathways.
Fri Aug 14, 2020 03:00
Nature Communications, Published online: 14 August 2020; doi:10.1038/s41467-020-17940-9Staphylococcus aureus is thought to divide in three alternating orthogonal planes over three consecutive divisions. Here the authors dispel this idea, showing that one out of the multiple planes perpendicular to the septum can be used in daughter cells irrespective of its orientation in relation to the penultimate division plane.
Fri Aug 14, 2020 03:00
Nature Communications, Published online: 14 August 2020; doi:10.1038/s41467-020-17939-2Nitriles are key intermediates in production of pharmaceuticals, agrochemicals and organic materials. Here, the authors report a nickel-catalyzed reductive cyanation of organic chlorides with CO2/NH3 and urea as cyanation reagents to afford a broad range of organic nitriles.
Fri Aug 14, 2020 03:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου