Related Articles Triptolide Inhibits the Proliferation of HaCaT Cells Induced by IL22 via Upregulating miR-181b-5p. Drug Des Devel Ther. 2020;14:2927-2935 Authors: He Q, Zhang B, Hu F, Long J, Shi Q, Pi X, Chen H, Li J Abstract Background: Evidence has been shown that triptolide was effective in the treatment of psoriasis; however, the mechanisms remain poorly understood. Thus, this study aimed to investigate the role of triptolide on the...
Tue Aug 18, 2020 15:11
Related Articles Diffuse intrinsic pontine glioma cells are vulnerable to mitotic abnormalities associated with BMI-1 modulation. Mol Cancer Res. 2020 Aug 14;: Authors: Senthil Kumar S, Sengupta S, Zhu X, Mishra DK, Phoenix T, Dyer L, Fuller C, Stevenson CB, DeWire M, Fouladi M, Drissi R Abstract Diffuse intrinsic pontine glioma (DIPG) is a poor-prognosis pediatric brain tumor with a median survival of less than one year. No effective therapy...
Tue Aug 18, 2020 15:11
Related Articles A Senescence-Centric View of Aging: Implications for Longevity and Disease. Trends Cell Biol. 2020 Aug 13;: Authors: Borghesan M, Hoogaars WMH, Varela-Eirin M, Talma N, Demaria M Abstract Cellular senescence is a state of stable cell cycle arrest associated with macromolecular alterations and secretion of proinflammatory cytokines and molecules. From their initial discovery in the 1960s, senescent cells have been hypothesized...
Tue Aug 18, 2020 15:11
Related Articles Effects of melatonin to arecoline-induced reactive oxygen species production and DNA damage in oral squamous cell carcinoma. J Formos Med Assoc. 2020 Aug 13;: Authors: Shih YH, Chiu KC, Wang TH, Lan WC, Tsai BH, Wu LJ, Hsia SM, Shieh TM Abstract BACKGROUND/PURPOSE: Arecoline, the major alkaloid of areca nut, is known to induce reactive oxygen species (ROS) and DNA damage during oral cancer progression. This study aim to...
Tue Aug 18, 2020 15:11
Related Articles Low-concentration staurosporine improves recombinant antibody productivity in Chinese hamster ovary cells without inducing cell death. J Biosci Bioeng. 2020 Aug 12;: Authors: Kido M, Idogaki H, Nishikawa K, Omasa T Abstract Chinese hamster ovary (CHO) cells are used as host cells for biopharmaceutical production, including monoclonal antibodies (mAbs). Arresting the cell cycle with chemical compounds is an effective approach...
Tue Aug 18, 2020 15:11
Related Articles Gephyromycin C, a novel small-molecule inhibitor of heat shock protein Hsp90, induces G2/M cell cycle arrest and apoptosis in PC3 cells in vitro. Biochem Biophys Res Commun. 2020 Aug 12;: Authors: Ding WJ, Ji YY, Jiang YJ, Ying WJ, Fang ZY, Gao TT Abstract Gephyromycin C (GC), a natural compound isolated from a marine-derived actinomycete Streptomyces sp. SS13I, which exerts anti-proliferative effect on PC3 cells. However,...
Tue Aug 18, 2020 15:11
Related Articles Kinesin-7 CENP-E regulates cell division, gastrulation and organogenesis in development. Eur J Cell Biol. 2020 Aug;99(6):151107 Authors: Yu KW, She ZY, Wei YL, Zhong N Abstract Kinesin-7 CENP-E motor protein is essential for chromosome alignment and kinetochore-microtubule attachment in cell division. Human CENP-E has recently identified to be linked with the microcephalic primordial dwarfism syndromes associated with a...
Tue Aug 18, 2020 15:11
Related Articles Aging of the cells: Insight into cellular senescence and detection Methods. Eur J Cell Biol. 2020 Aug;99(6):151108 Authors: Mohamad Kamal NS, Safuan S, Shamsuddin S, Foroozandeh P Abstract Cellular theory of aging states that human aging is the result of cellular aging, in which an increasing proportion of cells reach senescence. Senescence, from the Latin word senex, means "growing old," is an irreversible growth arrest...
Tue Aug 18, 2020 15:11
Related Articles The rRNA synthesis inhibitor CX-5461 may induce autophagy that inhibits anticancer drug-induced cell damage to leukemia cells. Biosci Biotechnol Biochem. 2020 Aug 15;:1-8 Authors: Okamoto S, Miyano K, Kajikawa M, Yamauchi A, Kuribayashi F Abstract Autophagy induced in cancer cells during chemotherapy is classified into two types, which differ depending on the kind of cells or anticancer drugs. The first type of autophagy...
Tue Aug 18, 2020 15:11
Related Articles The inhibitory effect of canine interferon gamma on the growth of canine tumors. Res Vet Sci. 2020 Aug 08;132:466-473 Authors: Hamamura Y, Nakagawa T, Okuda M, Noguchi S, Igase M, Mizuno T Abstract Recombinant canine interferon-γ (rc-IFNγ; InterdogⓇ) was exclusively approved as a therapeutic for canine atopic dermatitis. However, it has been used off-label for the treatment of canine cancer. We examined the inhibitory effect...
Tue Aug 18, 2020 13:10
Related Articles Evaluation of pyrrolizidine alkaloid-induced genotoxicity using metabolically competent TK6 cell lines. Food Chem Toxicol. 2020 Aug 13;:111662 Authors: Li X, He X, Chen S, Guo X, Bryant MS, Guo L, Manjanatha MG, Zhou T, Witt KL, Mei N Abstract Pyrrolizidine alkaloid (PA)-containing plants are among the most common poisonous plants affecting humans, livestock, and wildlife worldwide. A large number of PAs are known to induce...
Tue Aug 18, 2020 13:10
Related Articles [Effect of Sonic Hedgehog Signal Pathway Inhibitor Jervine on Myelodysplastic Syndromes MUTZ-1 Cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2020 Aug;28(4):1298-1302 Authors: Qin YT, Yao L, Yin Z, Wang H, Chen S, Nilupar T, Halida Y, Liu Y, Patiguli A, Jiang M, Hao JP Abstract OBJECTIVE: To study the effect of SMO inhibitor (Jervine) on proliferation, apoptosis and cell cycle of MDS cell line MUTZ-1, and its mechanism. ...
Tue Aug 18, 2020 13:10
Related Articles [Effect of Quercetin on Proliferation and Apoptosis of Multiple Myeloma Cells and Its Related Mechanism]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2020 Aug;28(4):1234-1239 Authors: Xu YW, Zou LF, Li F Abstract OBJECTIVE: To investigate the effect of quercetin (que) on proliferation and apoptosis of multiple myeloma cell line NCI-H929. METHODS: NCI-H929 cells were routinely cultured, and cells in logarithmic growth...
Tue Aug 18, 2020 13:10
Related Articles [Effect of CPEB4 on Migration and Cycle of Chronic Myeloid Leukemia Cell]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2020 Aug;28(4):1137-1143 Authors: Xu XY, Zhang LN, Wu HW Abstract OBJECTIVE: To investigate the effects of CPEB4 on the migration and cycle of K562 cells and the changes of protein molecules that may be involved in the regulatory mechanism. METHODS: Western blot was used to detect the expression of CPEB4...
Tue Aug 18, 2020 13:10
Related Articles [Inhibitory Effect of S1PR2 Antagonist JTE-013 on Proliferation of Chronic Myeloid Leukemia Cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2020 Aug;28(4):1081-1085 Authors: Pang M, Li F, Wang J, Jing HM Abstract OBJECTIVE: To investigate the effect of sphingosine-1-phosphate receptor 2 (S1PR2) specific antagonist JTE-013 on the proliferation of human chronic myeloid leukemia (CML) cell line K562. METHODS: K562 cells...
Tue Aug 18, 2020 13:10
Related Articles Mimicking Age-Associated Gadd45γ Dysregulation Results in Memory Impairments in Young Adult Mice. J Neurosci. 2020 02 05;40(6):1197-1210 Authors: Brito DVC, Kupke J, Gulmez Karaca K, Zeuch B, Oliveira AMM Abstract Age-related memory loss is observed across multiple mammalian species and preferentially affects hippocampus-dependent memory. Memory impairments are characterized by accelerated decay of spatial memories. Nevertheless,...
Tue Aug 18, 2020 13:10
Related Articles Screening a fosmid library of Xenorhabdus stockiae HN_xs01 reveals SrfABC toxin that exhibits both cytotoxicity and injectable insecticidal activity. J Invertebr Pathol. 2019 10;167:107247 Authors: Yang X, Hou X, Sun Y, Zhang G, Hu X, Xie Y, Mo X, Ding X, Xia L, Hu S Abstract Xenorhabdus spp., entomopathogenic bacteria symbiotically associated with the nematodes of the Steinernematid family, are known to produce several toxic...
Tue Aug 18, 2020 13:10
Related Articles De novo lipogenesis at the mitotic exit is used for nuclear envelope reassembly/expansion. Implications for combined chemotherapy. Cell Cycle. 2019 07;18(14):1646-1659 Authors: Rodriguez Sawicki L, Garcia KA, Corsico B, Scaglia N Abstract Mitosis has been traditionally considered a metabolically inactive phase. We have previously shown, however, that extensive alterations in lipids occur as the cells traverse mitosis, including...
Tue Aug 18, 2020 13:10
Related Articles Methyl helicterate inhibits hepatic stellate cell activation through downregulating the ERK1/2 signaling pathway. J Cell Biochem. 2019 09;120(9):14936-14945 Authors: Wei Y, Zhang X, Wen S, Huang S, Huang Q, Lu S, Bai F, Nie J, Wei J, Lu Z, Lin X Abstract The present study was to investigate the inhibitory effect of methyl helicterate (MH) on hepatic stellate cells (HSC-T6), primarily elucidating the underlying mechanism of...
Tue Aug 18, 2020 13:10
Related Articles Biological activities of Ficus carica latex for potential therapeutics in Human Papillomavirus (HPV) related cervical cancers. Sci Rep. 2019 01 31;9(1):1013 Authors: Ghanbari A, Le Gresley A, Naughton D, Kuhnert N, Sirbu D, Ashrafi GH Abstract Infection caused by high-risk human papillomaviruses (HPVs) are implicated in the aetiology of cervical cancer. Although current methods of treatment for cervical cancer can ablate lesions,...
Tue Aug 18, 2020 13:10
Compassionate use of everolimus for refractory epilepsy in a patient with MTOR mosaic mutation. Eur J Med Genet. 2020 Aug 14;:104036 Authors: Hadouiri N, Darmency V, Guibaud L, Arzimanoglou A, Sorlin A, Carmignac V, Rivière JB, Huet F, Luu M, Bardou M, Thauvin-Robinet C, Vabres P, Faivre L Abstract The MTOR gene encodes the mechanistic target of rapamycin (mTOR), which is a core component of the PI3K-AKT-mTOR signaling pathway. Postzygotic...
Tue Aug 18, 2020 13:58
A comparison of the Avisoft (v.5.2) and MATLAB Mouse Song Analyzer (v.1.3) vocalization analysis systems in C57BL/6, Fmr1-FVB.129, NS-Pten-FVB, and 129 mice. J Neurosci Methods. 2020 Aug 14;:108913 Authors: Binder M, Nolan SO, Lugo JN Abstract BACKGROUND: Communicative behaviors play a vital role in mammals and are highly relevant to human neurodevelopmental conditions. Mice produce communicative vocalizations that occur in the ultrasonic range,...
Tue Aug 18, 2020 13:58
Optimised induction of on-demand focal hippocampal and neocortical seizures by electrical stimulation. J Neurosci Methods. 2020 Aug 14;:108911 Authors: Hannan S, Faulkner M, Aristovich K, Avery J, Walker MC, Holder DS Abstract BACKGROUND: Epilepsy is a common neurological disorder affecting over 60 million people globally, approximately a third of whom are refractory to pharmacotherapy. Surgical resection of the epileptogenic zone is frequently...
Tue Aug 18, 2020 13:58
Related Articles Neurexin-3alpha associated autoimmune encephalitis: Full recovery after rituximab therapy - A Case Report. Eur J Neurol. 2020 Aug 16;: Authors: Loehrer PA, Bien CI, Dusoi AE, Timmermann L, Simon OJ Abstract OBJECTIVE: To report the complete and sustained clinical remission of neurexin-3alpha associated autoimmune encephalitis after immunomodulatory and rituximab treatment. METHODS: Report of a case, review of the literature....
Tue Aug 18, 2020 17:09
Related Articles Antiepileptic effects of long-term intracerebroventricular infusion of angiotensin-(1-7) in an animal model of temporal lobe epilepsy. Clin Sci (Lond). 2020 Aug 17;: Authors: Gomes KP, Braga PPP, de Lima Junior CQ, Ghazale PP, Pedrino GR, Mendes EP, Pansani AP, Xavier CH, Henrique de Castro C, Colugnati DB Abstract Temporal lobe epilepsy (TLE) is the most frequent type of epilepsy and is often refractory to pharmacological treatment....
Tue Aug 18, 2020 17:09
Related Articles The Effects of G2013 (α-L-guluronic Acid) in a Pentylenetetrazole-induced Kindling Animal Model of Epilepsy. Innov Clin Neurosci. 2020 Apr 01;17(4-6):9-12 Authors: Tahmasebi S, Azizi G, Miladi H, Shafiei E, Kamali AN, Hamedifar H, Fayyaz F, Rasouli SE, Kalvandi M, Mohammadi H, Hassannia H, Eslami S, Hamid KM, Mirshafiey A Abstract Background: Recent studies have reported observing antioxidant, anti-inflammatory, and anti-aging...
Tue Aug 18, 2020 17:09
Related Articles Predicting functional effects of missense variants in voltage-gated sodium and calcium channels. Sci Transl Med. 2020 Aug 12;12(556): Authors: Heyne HO, Baez-Nieto D, Iqbal S, Palmer DS, Brunklaus A, May P, Epi25 Collaborative, Johannesen KM, Lauxmann S, Lemke JR, Møller RS, Pérez-Palma E, Scholl UI, Syrbe S, Lerche H, Lal D, Campbell AJ, Wang HR, Pan J, Daly MJ Abstract Malfunctions of voltage-gated sodium and calcium channels...
Tue Aug 18, 2020 17:09
Related Articles Associations between seizure severity change and patient characteristics, changes in seizure frequency, and health-related quality of life in patients with focal seizures treated with adjunctive eslicarbazepine acetate: Post hoc analyses of clinical trial results. Epilepsy Behav. 2020 Aug 12;112:107312 Authors: Cramer JA, Colman S, Anastassopoulos KP, Grinnell T, Mehta D, Williams GR Abstract The relationships between seizure...
Tue Aug 18, 2020 17:09
Related Articles Genome-wide microRNA profiling of plasma from three different animal models identifies biomarkers of temporal lobe epilepsy. Neurobiol Dis. 2020 Aug 12;:105048 Authors: Brennan GP, Bauer S, Engel T, Jimenez-Mateos EM, Del Gallo F, Hill TDM, Costard LS, Neubert V, Salvetti B, Sanz-Rodriguez A, Heiland M, Mamad O, Brindley E, Norwood B, Batool A, Raoof R, El-Naggar H, Connolly NMC, Reschke C, Delanty N, Prehn JHM, Fabene P, Mooney C, Rosenow F,...
Tue Aug 18, 2020 17:09
Related Articles Salidroside shows anticonvulsant and neuroprotective effects by activating the Nrf2-ARE pathway in a pentylenetetrazol-kindling epileptic model. Brain Res Bull. 2020 Aug 12;: Authors: Wu Y, Wang Y, Wu Y, Li T, Wang W Abstract Evidence points towards oxidative stress and neuroinflammation being major processes associated with brain dysfunction in epilepsy. Salidroside reportedly possesses anti-oxidative activity and neuroprotective...
Tue Aug 18, 2020 17:09
Related Articles Glycyrrhizic acid protects juvenile epileptic rats against hippocampal damage through activation of Sirtuin3: Running title: GA protects juvenile EP rats via activating Sirt3. Brain Res Bull. 2020 Aug 12;: Authors: Wu G, Liu J, Li S, Gao W, Qiu M, Yang C, Ma Y, Song X Abstract Glycyrrhizic acid (GA) and Sirtuin3 (Sirt3) were both found to be involved in epilepsy (EP), but their interaction was rarely studied. Herein, we aim...
Tue Aug 18, 2020 17:09
Related Articles Identification of microRNA-target genes in mice hippocampus at 1 week after pilocarpine-induced status epilepticus. Biochem Biophys Res Commun. 2020 Aug 13;: Authors: Xiao XL, Wu XL, Tong H, Tan J, Liu LF, Si KW, Peng-Bo-Yang, Ma YB, Zhou JS, Liu JX Abstract MicroRNAs (miRNA) are believed to play a crucial role in the cause and treatment of temporal lobe epilepsy (TLE) by controlling gene expression in different stages of the...
Tue Aug 18, 2020 17:09
Related Articles Therapeutic advances in Dravet syndrome: a targeted literature review. Expert Rev Neurother. 2020 Aug 16;:1-15 Authors: Strzelczyk A, Schubert-Bast S Abstract INTRODUCTION: Dravet syndrome (DS), a prototypic developmental and genetic epileptic encephalopathy (DEE), is characterized by an early onset of treatment-refractory seizures, together with impairments in motor control, behavior, and cognition. Even with multiple conventional...
Tue Aug 18, 2020 17:09
Related Articles Prevalence and factors of verbal learning and memory dysfunction in patients with epilepsy - A single centre study. J Clin Neurosci. 2020 Mar;73:31-36 Authors: Subramaniam SR, Khoo CS, Raymond AA, Che Din N, Syed Zakaria SZ, Tan HJ Abstract The objective of this study is to determine prevalence and factors leading to verbal learning and memory dysfunction among patients with epilepsy. A total of 211 subjects were recruited....
Tue Aug 18, 2020 13:58
Related Articles Epileptic Syndrome and Cranioplasty: Implication of Reconstructions in the Electroencephalogram. World Neurosurg. 2020 05;137:e517-e525 Authors: Pelegrini de Almeida L, Casarin MC, Mosser HL, Worm PV Abstract BACKGROUND: In the presence of a skull deformity after large decompressive craniectomy (DC), neurologic deterioration manifesting as epileptic syndrome (ES) may occur independently of the primary disease or spontaneous...
Tue Aug 18, 2020 13:58
Related Articles [Confusional migraine in a young adult female: Is it a subtype of migraine with aura?] Rinsho Shinkeigaku. 2020 Jan 30;60(1):46-50 Authors: Kano Y, Oguri T, Sugiyama H, Kikui S, Takeshima T, Yuasa H Abstract A 22-year-old female was admitted to our hospital due to acute onset of severe headache, confusion, and deterioration of consciousness. Results of initial examinations did not suggest cerebrovascular diseases, encephalitis,...
Tue Aug 18, 2020 13:58
Related Articles Eslicarbazepine acetate in epilepsy patients with psychiatric comorbidities and intellectual disability: Clinical practice findings from the Euro-Esli study. J Neurol Sci. 2019 Jul 15;402:88-99 Authors: Doherty CP, Rheims S, Assenza G, Boero G, Chaves J, McMurray R, Villanueva V Abstract Psychiatric and intellectual comorbidities are common in patients with epilepsy. However, data on the use of antiepileptic drugs in these...
Tue Aug 18, 2020 13:58
Related Articles Treatment of recurrent glioblastoma: state-of-the-art and future perspectives. Expert Rev Anticancer Ther. 2020 Aug 17;: Authors: Di Nunno V, Franceschi E, Tosoni A, Di Battista M, Gatto L, Lamperini C, Minichillo S, Mura A, Bartolini S, Brandes AA Abstract BACKGROUND: Almost all patients affected by glioblastoma experience recurrence of the disease. AREAS COVERED: Management of recurrent glioblastoma is a clinical...
Tue Aug 18, 2020 19:44
Related Articles Outcomes with anti-EGFR monoclonal antibodies in metastatic and recurrent anal squamous cell carcinoma. Expert Rev Anticancer Ther. 2020 Aug 15;: Authors: Rogers JE, Jácome AA, Ohinata A, Wolff R, Morris VK, Johnson B, Mehdizadeh A, Rothschild ND, Ahmed SU, Guerra JL, Eng C Abstract OBJECTIVES: Metastatic squamous cell carcinoma anal cancer (SCCA) is rare. Prospective data recommends front-line platinum doublet combinations...
Tue Aug 18, 2020 19:44
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