Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Tue Aug 04, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Tue Aug 04, 2020 10:00
Abstract Introduction A hypersensitivity response akin to immune reconstitution inflammatory syndrome (IRIS) has been proposed as a mechanism responsible for anti-PD-1 therapy-induced tuberculosis. IRIS is associated with enhanced activation of IL-17A-expressing CD4 + T cells (Th17). Gut microbiota is thought to be linked to pulmonary inflammation through the gut-lung axis. ...
Thu Aug 06, 2020 03:00
Abstract Recent studies suggested that the immune microenvironment and mutational landscape are associated with the response to immune-based therapy in several types of cancer. The roles of those factors in Chinese HCC remain largely unknown. In this study, we obtained 182 FFPE samples of HCC cohort that were previously subjected to NGS (49 WGS, 18 WES, and 115 targeted sequencing). We performed immunohistochemistry to detect CD3, CD4, CD8, CD57, Foxp3, CD68, CD66b, and PD-L1...
Thu Aug 06, 2020 03:00
Abstract CD47, an immune checkpoint receptor frequently unregulated in various blood and solid tumors, interacts with ligand SIPRα on innate immune cells, and conveys a “do not eat me” signal to inhibit macrophage-mediated tumor phagocytosis. This makes CD47 a valuable target for cancer immunotherapy. However, the therapeutic utility of CD47-SIRPα blockade monoclonal antibodies is largely compromised due to significant red blood cell (RBCs) toxicities and fast target-mediated...
Thu Aug 06, 2020 03:00
Abstract C57BL/6 mice implanted in the flank with murine Lewis lung carcinoma cells were randomized into control, anti-angiogenic, anti-PD-L1, radiotherapy (RT), RT + anti-angiogenic, RT + anti-PD-L1, and RT + anti-PD-L1 + anti-angiogenic therapy groups. Immune response and immunophenotyping were determined by flow cytometry. Vasculature analysis after RT and anti-angiogenic therapy was assessed by quantified power Doppler sonography. Antitumor response, survival, and rechallenged...
Thu Aug 06, 2020 03:00
Publication date: Available online 6 August 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): Wei Guo, Xingtong Wang, Yan Li, Ou Bai
Thu Aug 06, 2020 17:43
Publication date: Available online 5 August 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): Héctor G. van den Boorn, Charlotte I. Stroes, Aeilko H. Zwinderman, Wietse J. Eshuis, Maarten C.C.M. Hulshof, Faridi S. van Etten-Jamaludin, Mirjam A.G. Sprangers, Hanneke W.M. van Laarhoven
Thu Aug 06, 2020 17:43
Publication date: Available online 5 August 2020Source: European Journal of Surgical OncologyAuthor(s): Helgi Birgisson, Malin Enblad, Sara Artursson, Lana Ghanipour, Peter Cashin, Wilhelm Graf
Thu Aug 06, 2020 17:51
Background Prescribing of systemic antibiotics in general and of cephalosporins in particular in German paediatric outpatients has previously been reported to be higher than in other European countries. Aim Our objective was to assess recent trends in antibiotic prescribing in German children. Methods This study was conducted as consecutive annual cross-sectional analyses and included all children aged 0–14 years (n = 9,389,183 in 2018) covered by statutory health insurance...
Thu Aug 06, 2020 03:00
A serosurvey of IgG antibodies against severe acute respiratory coronavirus 2 (SARS-CoV-2) was performed during March and April 2020. Among 6,586 leftover sera, 24 (0.36%) were positive, with higher prevalence in females, older individuals and residents of large urban areas. Seroprevalence was estimated at 0.02% and 0.25%, respectively, in March and April, infection fatality rate at 2.66% and 0.54%. Our findings confirm low COVID-19 incidence in Greece and possibly the effectiveness of early measures.
Thu Aug 06, 2020 03:00
We analysed 5,484 close contacts of coronavirus disease (COVID-19) cases in Italy, all tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Infection fatality ratio was 0.43% (95% confidence interval (CI): 0.21–0.79) for individuals younger than 70 years and 10.5% (95% CI: 8.0–13.6) for older individuals. Risk of death after infection was 62% lower (95% CI: 31–80) in clusters identified after 16 March 2020 and 1.8-fold higher for males (95% CI: 1.03–3.16).
Thu Aug 06, 2020 03:00
The number of measles cases declined in European Union/European Economic Area countries and the United Kingdom in 2020. Reported cases to The European Centre for Disease Prevention and Control decreased from 710 to 54 between January and May. Epidemic intelligence screening observed a similar trend. Under-diagnoses and under-reporting during the coronavirus disease (COVID-19) pandemic should be ruled out before concluding reduced measles circulation is because of social distancing and any community...
Thu Aug 06, 2020 03:00
Future Oncology, Volume 16, Issue 22, Page 1585-1595, August 2020.
Thu Aug 06, 2020 06:15
Journal of Adolescent and Young Adult Oncology, Ahead of Print.
Tue Aug 04, 2020 10:00
Journal of Adolescent and Young Adult Oncology, Ahead of Print.
Thu Jul 30, 2020 10:00
Abstract Oral complications associated with cancer therapy lead to a significant deterioration of oral health and overall quality of life. The primary aim of this study was to assess dental practice patterns followed by dentists for oral care of medical oncology patients and to identify potential barriers to recommended care. A questionnaire-based survey was developed using the Qualtrics online platform. It was electronically distributed to all dentists within the Massachusetts...
Thu Aug 06, 2020 03:00
Abstract The transcription factor forkhead box Q1 (FoxQ1) is overexpressed in different solid tumors including breast cancer, but the mechanism underlying its oncogenic function is still not fully understood. In this study, we compared RNA‐seq data from FoxQ1 overexpressing SUM159 cells with that of empty vector‐transfected control cells to identify novel mechanistic targets of this transcription factor. Analysis of The Cancer Genome Atlas (TCGA) data set revealed significantly higher expression...
Wed Aug 05, 2020 22:35
In 2012, for the first time in its history, ESTRO published a vision statement for 2020 [1], in which ESTRO acknowledged that “whilst differences exist in the state of development of RO and clinical oncology in individual countries within Europe, ESTRO together with NS will create and prioritise innovative strategic partnerships in order to strengthen the clinical and scientific specialty in the respective countries and support an increased level of patient care and quality of treatment throughout...
Thu Aug 06, 2020 03:00
Adherence to chemotherapy and hormone therapy has proven to be a relevant problem in cancer patients undergoing different treatment regimens [1–3]. Adherence is defined as the degree to which the patient’s behaviour is consistent with the therapy prescribed by their doctor, and normally it is measured as the percentage of doses received relative to those indicated. The most typical cutoff to define adherence in these terms is 80% [4]. In patients with breast cancer, non-adherence is associated with...
Thu Aug 06, 2020 03:00
The deamination of adenosine to inosine at the wobble position of tRNA is an essential post-transcriptional RNA modification required for wobble decoding in bacteria and eukaryotes. In humans, the wobble inosine modification is catalyzed by the heterodimeric ADAT2/3 complex. Here, we describe novel pathogenic ADAT3 variants impairing adenosine deaminase activity through a distinct mechanism that can be corrected through expression of the heterodimeric ADAT2 subunit. The variants were identified in...
Thu Aug 06, 2020 20:09
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου