Biomolecules, Vol. 10, Pages 1133: Arachidonic Acid as an Early Indicator of Inflammation during Non-Alcoholic Fatty Liver Disease Development Biomolecules doi: 10.3390/biom10081133 Authors: Klaudia Sztolsztener Adrian Chabowski Ewa Harasim-Symbor Patrycja Bielawiec Karolina Konstantynowicz-Nowicka Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease characterized by excessive lipid deposition. Lipid metabolism disturbances are possibly associated with hepatocyte...
Fri Jul 31, 2020 03:00
Biomolecules, Vol. 10, Pages 1132: Immune Regulation, but Not Antibacterial Activity, Is a Crucial Function of Hepcidins in Resistance against Pathogenic Bacteria in Nile Tilapia (Oreochromis niloticus Linn.) Biomolecules doi: 10.3390/biom10081132 Authors: Pagaporn Phan-Aram Gunanti Mahasri Pattanapon Kayansamruaj Piti Amparyup Prapansak Srisapoome In this study, the functions of a recombinant propeptide (rProOn-Hep1) and the synthetic FITC-labelled mature peptides sMatOn-Hep1...
Fri Jul 31, 2020 03:00
Biomolecules, Vol. 10, Pages 1130: Structural Characterization of an S-enantioselective Imine Reductase from Mycobacterium Smegmatis Biomolecules doi: 10.3390/biom10081130 Authors: Timo Meyer Nadine Zumbrägel Christina Geerds Harald Gröger Hartmut H. Niemann NADPH-dependent imine reductases (IREDs) are enzymes capable of enantioselectively reducing imines to chiral secondary amines, which represent important building blocks in the chemical and pharmaceutical industry. Since...
Fri Jul 31, 2020 03:00
Biomolecules, Vol. 10, Pages 1131: Structural Features Defining NF-κB Inhibition by Lignan-Inspired Benzofurans and Benzothiophenes Biomolecules doi: 10.3390/biom10081131 Authors: Toan Dao-Huy Simone Latkolik Julia Bräuer Andreas Pfeil Hermann Stuppner Michael Schnürch Verena M. Dirsch Marko D. Mihovilovic A series of 2-arylbenzofurans and 2-arylbenzothiophenes was synthesized carrying three different side chains in position five. The synthesized compounds were tested...
Fri Jul 31, 2020 03:00
Biomolecules, Vol. 10, Pages 1129: Physical, Thermal, and Antibacterial Effects of Active Essential Oils with Potential for Biomedical Applications Loaded onto Cellulose Acetate/Polycaprolactone Wet-Spun Microfibers Biomolecules doi: 10.3390/biom10081129 Authors: Helena P. Felgueiras Natália C. Homem Marta A. Teixeira Ana R. M. Ribeiro Joana C. Antunes Maria Teresa P. Amorim New approaches to deal with the growing concern associated with antibiotic-resistant bacteria are...
Fri Jul 31, 2020 03:00
Biosensors, Vol. 10, Pages 87: Instrumentation-Free Semiquantitative Immunoanalysis Using a Specially Patterned Lateral Flow Assay Device Biosensors doi: 10.3390/bios10080087 Authors: Kyung Won Lee Ye Chan Yu Hyeong Jin Chun Yo Han Jang Yong Duk Han Hyun C. Yoon In traditional colorimetric lateral flow immunoassay (LFI) using gold nanoparticles (AuNPs) as a probe, additional optical transducers are required to quantify the signal intensity of the test line because it presents...
Fri Jul 31, 2020 03:00
Brain Sciences, Vol. 10, Pages 511: Sleep, Little Baby: The Calming Effects of Prenatal Speech Exposure on Newborns’ Sleep and Heartrate Brain Sciences doi: 10.3390/brainsci10080511 Authors: Adelheid Lang Renata del Giudice Manuel Schabus In a pilot study, 34 fetuses were stimulated daily with a maternal spoken nursery rhyme from week 34 of gestation onward and re-exposed two and five weeks after birth to this familiar, as well as to an unfamiliar rhyme, both spoken with the maternal...
Sun Aug 02, 2020 03:00
Brain Sciences, Vol. 10, Pages 512: Functional Electrical Stimulation Controlled by Motor Imagery Brain-Computer Interface for Rehabilitation Brain Sciences doi: 10.3390/brainsci10080512 Authors: Inchul Choi Gyu Hyun Kwon Sangwon Lee Chang S. Nam Sensorimotor rhythm (SMR)-based brain–computer interface (BCI) controlled Functional Electrical Stimulation (FES) has gained importance in recent years for the rehabilitation of motor deficits. However, there still remain...
Sun Aug 02, 2020 03:00
Brain Sciences, Vol. 10, Pages 510: Grammatical Comprehension in Italian Children with Autism Spectrum Disorder Brain Sciences doi: 10.3390/brainsci10080510 Authors: Jessica Barsotti Gloria Mangani Roberta Nencioli Lucia Pfanner Raffaella Tancredi Angela Cosenza Gianluca Sesso Antonio Narzisi Filippo Muratori Paola Cipriani Anna Maria Chilosi Language deficits represent one of the most relevant factors that determine the clinical phenotype of children with...
Sun Aug 02, 2020 03:00
Brain Sciences, Vol. 10, Pages 509: Advances in the Neurocognition of Music and Language Brain Sciences doi: 10.3390/brainsci10080509 Authors: Daniela Sammler Stefan Elmer Neurocomparative music and language research has seen major advances over the past two decades. The goal of this Special Issue “Advances in the Neurocognition of Music and Language” was to showcase the multiple neural analogies between musical and linguistic information processing, their entwined...
Sun Aug 02, 2020 03:00
Brain Sciences, Vol. 10, Pages 507: Autistic-Like Features in Visually Impaired Children: A Review of Literature and Directions for Future Research Brain Sciences doi: 10.3390/brainsci10080507 Authors: Anna Molinaro Serena Micheletti Andrea Rossi Filippo Gitti Jessica Galli Lotfi B. Merabet Elisa Maria Fazzi There remains great interest in understanding the relationship between visual impairment (VI) and autism spectrum disorder (ASD) due to the extraordinarily high...
Sat Aug 01, 2020 03:00
Brain Sciences, Vol. 10, Pages 508: Effects of Depressive Symptoms, Feelings, and Interoception on Reward-Based Decision-Making: Investigation Using Reinforcement Learning Model Brain Sciences doi: 10.3390/brainsci10080508 Authors: Hiroyoshi Ogishima Shunta Maeda Yuki Tanaka Hironori Shimada Background: In this study, we examined the relationships between reward-based decision-making in terms of learning rate, memory rate, exploration rate, and depression-related subjective...
Sat Aug 01, 2020 03:00
Brain Sciences, Vol. 10, Pages 505: End-of-Life in Oncologic Patients’ Dream Content Brain Sciences doi: 10.3390/brainsci10080505 Authors: Alessandro Cicolin Michele Boffano Guglielmo Beccuti Raimondo Piana Alessandra Giordano Both non-rapid eye movements and rapid eye movements sleep facilitate the strengthening of newly encoded memory traces, and dream content reflects this process. Numerous studies evaluated the impact of diseases on dream content, with particular reference...
Sat Aug 01, 2020 03:00
Brain Sciences, Vol. 10, Pages 506: Diagnosis and Management of Type 1 Sialidosis: Clinical Insights from Long-Term Care of Four Unrelated Patients Brain Sciences doi: 10.3390/brainsci10080506 Authors: Antonietta Coppola Marta Ianniciello Ebru N. Vanli-Yavuz Settimio Rossi Francesca Simonelli Barbara Castellotti Marcello Esposito Stefano Tozza Serena Troisi Marta Bellofatto Lorenzo Ugga Salvatore Striano Alessandra D’Amico Betul Baykan Pasquale Striano...
Sat Aug 01, 2020 03:00
Brain Sciences, Vol. 10, Pages 503: The Increased Densities, But Different Distributions, of Both C3 and S100A10 Immunopositive Astrocyte-Like Cells in Alzheimer’s Disease Brains Suggest Possible Roles for Both A1 and A2 Astrocytes in the Disease Pathogenesis Brain Sciences doi: 10.3390/brainsci10080503 Authors: Andrew King Boglarka Szekely Eda Calapkulu Hanan Ali Francesca Rios Shalmai Jones Claire Troakes There is increasing evidence of astrocyte dysfunction in the...
Fri Jul 31, 2020 03:00
Brain Sciences, Vol. 10, Pages 504: Distinguishing and Biochemical Phenotype Analysis of Epilepsy Patients Using a Novel Serum Profiling Platform Brain Sciences doi: 10.3390/brainsci10080504 Authors: Jay S. Hanas James R. S. Hocker Christian Vannarath Betcy Evangeline Vasudevan Prabhakaran Anna Oommen James Couch Michael Anderson Vedantam Rajshekhar Hélène Carabin Douglas Drevets Diagnosis of non-symptomatic epilepsy includes a history of two or more seizures...
Fri Jul 31, 2020 03:00
Brain Sciences, Vol. 10, Pages 501: Current Treatment of Anterior Communicating Artery Aneurysms: Single Center Study Brain Sciences doi: 10.3390/brainsci10080501 Authors: Ondřej Navrátil Kamil Ďuriš Vilém Juráň Karel Svoboda Jakub Hustý Evžen Hovorka Eduard Neuman Andrej Mrlian Martin Smrčka Introduction: Anterior communicating artery aneurysms (ACoAAs) are the most frequent intracranial aneurysms treated at neurosurgical departments with a vascular program....
Fri Jul 31, 2020 03:00
Brain Sciences, Vol. 10, Pages 502: Amygdala: Neuroanatomical and Morphophysiological Features in Terms of Neurological and Neurodegenerative Diseases Brain Sciences doi: 10.3390/brainsci10080502 Authors: Vladimir N. Nikolenko Marine V. Oganesyan Negoriya A. Rizaeva Valentina A. Kudryashova Arina T. Nikitina Maria P. Pavliv Marina A. Shchedrina Dmitry B. Giller Kirill V. Buligin Mikhail Y. Sinelnikov The amygdala is one of the most discussed structures of the...
Fri Jul 31, 2020 03:00
Brain Sciences, Vol. 10, Pages 500: Vividness, Consciousness and Mental Imagery: A Start on Connecting the Dots Brain Sciences doi: 10.3390/brainsci10080500 Authors: Amedeo D’Angiulli Over twenty years ago, Baars [...]
Fri Jul 31, 2020 03:00
Cancers, Vol. 12, Pages 2142: Lytic Induction Therapy against Epstein–Barr Virus-Associated Malignancies: Past, Present, and Future Cancers doi: 10.3390/cancers12082142 Authors: Stephanie Pei Tung Yiu Mike Dorothea Kwai Fung Hui Alan Kwok Shing Chiang Epstein–Barr virus (EBV) lytic induction therapy is an emerging virus-targeted therapeutic approach that exploits the presence of EBV in tumor cells to confer specific killing effects against EBV-associated malignancies....
Sun Aug 02, 2020 03:00
Cancers, Vol. 12, Pages 2143: Metformin and Everolimus: A Promising Combination for Neuroendocrine Tumors Treatment Cancers doi: 10.3390/cancers12082143 Authors: Eleonora Vitali Ilena Boemi Giulia Tarantola Sara Piccini Alessandro Zerbi Giulia Veronesi Roberto Baldelli Gherardo Mazziotti Valeria Smiroldo Elisabetta Lavezzi Anna Spada Giovanna Mantovani Andrea G. Lania Introduction: Treatment options for neuroendocrine tumors (NETs) are rarely curative,...
Sun Aug 02, 2020 03:00
Cancers, Vol. 12, Pages 2141: Quercetin–Resveratrol Combination for Prostate Cancer Management in TRAMP Mice Cancers doi: 10.3390/cancers12082141 Authors: Chandra K. Singh Gagan Chhabra Mary A. Ndiaye Imtiaz A. Siddiqui Jennifer E. Panackal Charlotte A. Mintie Nihal Ahmad Prostate Cancer (PCa) is a leading cause of cancer-related morbidity and mortality in men. Therefore, novel mechanistically-driven approaches are needed for PCa management. Here, we determined the...
Sun Aug 02, 2020 03:00
Cancers, Vol. 12, Pages 2140: Cisplatin Decreases ENaC Activity Contributing to Renal Salt Wasting Syndrome Cancers doi: 10.3390/cancers12082140 Authors: Antonio G. Soares Elena Mironova Crystal R. Archer Jorge Contreras James D. Stockand Tarek Mohamed Abd El-Aziz Cisplatin (CDDP) is an important anticancer drug. A common side effect of CDDP is renal salt and water-wasting syndrome (RSWS). The origin of RSWS is obscure. Emerging evidence, though, suggests that broad inhibition...
Sat Aug 01, 2020 03:00
Cancers, Vol. 12, Pages 2139: Multiplex Digital PCR to Detect Amplifications of Specific Androgen Receptor Loci in Cell-Free DNA for Prognosis of Metastatic Castration-Resistant Prostate Cancer Cancers doi: 10.3390/cancers12082139 Authors: Meijun Du Chiang-Ching Huang Winston Tan Manish Kohli Liang Wang Amplification of androgen receptor (AR) is a common genomic event in metastatic castration-resistant prostate cancer (mCRPC). To evaluate the prognostic value of the amplifications...
Sat Aug 01, 2020 03:00
Cancers, Vol. 12, Pages 2138: Extracellular Vesicle Transfer from Endothelial Cells Drives VE-Cadherin Expression in Breast Cancer Cells, Thereby Causing Heterotypic Cell Contacts Cancers doi: 10.3390/cancers12082138 Authors: Maryam Rezaei Ana C. Martins Cavaco Martin Stehling Astrid Nottebaum Katrin Brockhaus Michele F. Caliandro Sonja Schelhaas Felix Schmalbein Dietmar Vestweber Johannes A. Eble Cadherins mediate cohesive contacts between isotypic cells by...
Sat Aug 01, 2020 03:00
Cancers, Vol. 12, Pages 2137: Epigenetic Targeting of Mcl-1 Is Synthetically Lethal with Bcl-xL/Bcl-2 Inhibition in Model Systems of Glioblastoma Cancers doi: 10.3390/cancers12082137 Authors: Enyuan Shang Trang T. T. Nguyen Chang Shu Mike-Andrew Westhoff Georg Karpel-Massler Markus D. Siegelin Apoptotic resistance remains a hallmark of glioblastoma (GBM), the most common primary brain tumor in adults, and a better understanding of this process may result in more efficient...
Sat Aug 01, 2020 03:00
Cancers, Vol. 12, Pages 2135: Recent Advances in Desmoid Tumor Therapy Cancers doi: 10.3390/cancers12082135 Authors: Andrea Napolitano Alessandro Mazzocca Mariella Spalato Ceruso Alessandro Minelli Francesca Baldo Giuseppe Badalamenti Marianna Silletta Daniele Santini Giuseppe Tonini Lorena Incorvaia Bruno Vincenzi The desmoid tumor is a locally aggressive proliferative disease within the family of soft-tissue sarcomas. Despite its relatively good prognosis,...
Sat Aug 01, 2020 03:00
Cancers, Vol. 12, Pages 2136: Optimization of a Luciferase-Expressing Non-Invasive Intrapleural Model of Malignant Mesothelioma in Immunocompetent Mice Cancers doi: 10.3390/cancers12082136 Authors: Elisabeth Digifico Marco Erreni Federico Simone Colombo Camilla Recordati Roberta Migliore Roberta Frapolli Maurizio D’Incalci Cristina Belgiovine Paola Allavena Malignant Pleural Mesothelioma (MPM) is an aggressive tumor of the pleural lining that is usually identified...
Sat Aug 01, 2020 03:00
Cancers, Vol. 12, Pages 2133: PLEKHS1 Over-Expression Is Associated with Metastases and Poor Outcomes in Papillary Thyroid Carcinoma Cancers doi: 10.3390/cancers12082133 Authors: Xiangling Xing Ninni Mu Xiaotian Yuan Na Wang C. Christofer Juhlin Klas Strååt Catharina Larsson Dawei Xu Pleckstrin homology domain containing S1 (PLEKHS1) is a poorly characterized factor, although its promoter mutations were identified in human malignancies including thyroid carcinoma...
Fri Jul 31, 2020 03:00
Cancers, Vol. 12, Pages 2134: Senescence and Cancer: A Review of Clinical Implications of Senescence and Senotherapies Cancers doi: 10.3390/cancers12082134 Authors: Lynda Wyld Ilaria Bellantuono Tamara Tchkonia Jenna Morgan Olivia Turner Fiona Foss Jayan George Sarah Danson James L. Kirkland Cellular senescence is a key component of human aging that can be induced by a range of stimuli, including DNA damage, cellular stress, telomere shortening, and the activation...
Fri Jul 31, 2020 03:00
Cancers, Vol. 12, Pages 2132: Optimizing Sequential Systemic Therapies for Advanced Hepatocellular Carcinoma: A Decision Analysis Cancers doi: 10.3390/cancers12082132 Authors: Giuseppe Cabibbo Ciro Celsa Marco Enea Salvatore Battaglia Giacomo Emanuele Maria Rizzo Stefania Grimaudo Domenica Matranga Massimo Attanasio Paolo Bruzzi Antonio Craxì Calogero Cammà Background: An optimal sequential systemic therapy for advanced hepatocellular carcinoma (HCC) has...
Fri Jul 31, 2020 03:00
Cancers, Vol. 12, Pages 2130: Molecular Biology of Osteosarcoma Cancers doi: 10.3390/cancers12082130 Authors: Anna M. Czarnecka Kamil Synoradzki Wiktoria Firlej Ewa Bartnik Pawel Sobczuk Michal Fiedorowicz Pawel Grieb Piotr Rutkowski Osteosarcoma (OS) is the most frequent primary bone cancer in children and adolescents and the third most frequent in adults. Many inherited germline mutations are responsible for syndromes that predispose to osteosarcomas including...
Fri Jul 31, 2020 03:00
Cancers, Vol. 12, Pages 2131: Natural Born Killers: NK Cells in Cancer Therapy Cancers doi: 10.3390/cancers12082131 Authors: S. Elizabeth Franks Benjamin Wolfson James W. Hodge Cellular therapy has emerged as an attractive option for the treatment of cancer, and adoptive transfer of chimeric antigen receptor (CAR) expressing T cells has gained FDA approval in hematologic malignancy. However, limited efficacy was observed using CAR-T therapy in solid tumors. Natural killer (NK)...
Fri Jul 31, 2020 03:00
Cancers, Vol. 12, Pages 2125: Oncologic Benefit of Adjuvant Chemoradiation after D2 Gastrectomy: A Stepwise Hierarchical Pooled Analysis and Systematic Review Cancers doi: 10.3390/cancers12082125 Authors: Chai Hong Rim In-Soo Shin Hye Yoon Lee Won Sup Yoon Sunmin Park Our study aimed to evaluate the benefits of chemoradiotherapy (CRT) after D2 gastrectomy, as compared to adjuvant chemotherapy, alone. PubMed, MEDLINE, Embase, and the Cochrane Library were systematically searched....
Fri Jul 31, 2020 03:00
Cancers, Vol. 12, Pages 2127: Cancer Nanomedicine Cancers doi: 10.3390/cancers12082127 Authors: Clare Hoskins This Special Issue on Cancer Nanomedicine within Cancers brings together 46 cutting-edge papers covering research within the field along with insightful reviews and opinions reflecting our community [...]
Fri Jul 31, 2020 03:00
Cancers, Vol. 12, Pages 2128: The Clinicopathological and Prognostic Significance of Nrf2 and Keap1 Expression in Hepatocellular Carcinoma Cancers doi: 10.3390/cancers12082128 Authors: Kiryang Lee Seunghye Kim Yangkyu Lee Hyejung Lee Youngeun Lee Hyunjin Park Ji Hae Nahm Soomin Ahn Su Jong Yu Kyoungbun Lee Haeryoung Kim Nuclear factor E2-related factor2 (Nrf2) activation is associated with both cytoprotective effects and malignant behavior of cancer cells....
Fri Jul 31, 2020 03:00
Cancers, Vol. 12, Pages 2123: DNA Methyltransferases in Cancer: Biology, Paradox, Aberrations, and Targeted Therapy Cancers doi: 10.3390/cancers12082123 Authors: Jiayu Zhang Cheng Yang Chunfu Wu Wei Cui Lihui Wang DNA methyltransferases are an essential class of modifiers in epigenetics. In mammals, DNMT1, DNMT3A and DNMT3B participate in DNA methylation to regulate normal biological functions, such as embryo development, cell differentiation and gene transcription. Aberrant...
Fri Jul 31, 2020 03:00
Cancers, Vol. 12, Pages 2126: Genomic Database Analysis of Uterine Leiomyosarcoma Mutational Profile
Cancers, Vol. 12, Pages 2126: Genomic Database Analysis of Uterine Leiomyosarcoma Mutational Profile Cancers doi: 10.3390/cancers12082126 Authors: Annalisa Astolfi Margherita Nannini Valentina Indio Angela Schipani Alessandro Rizzo Anna Myriam Perrone Pierandrea De Iaco Maria Giulia Pirini Antonio De Leo Milena Urbini Paola Secchiero Maria Abbondanza Pantaleo Uterine Leiomyosarcoma (uLMS) is by far the most common type of uterine sarcoma, characterized...
Fri Jul 31, 2020 03:00
Cancers, Vol. 12, Pages 2124: Relation of Neutrophil Gelatinase-Associated Lipocalin Overexpression to the Resistance to Apoptosis of Tumor B Cells in Chronic Lymphocytic Leukemia Cancers doi: 10.3390/cancers12082124 Authors: Brigitte Bauvois Elodie Pramil Ludovic Jondreville Elise Chapiro Claire Quiney Karim Maloum Santos A. Susin Florence Nguyen-Khac The resistance to apoptosis of chronic lymphocytic leukemia (CLL) cells partly results from the deregulated production...
Fri Jul 31, 2020 03:00
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