Publication date: Available online 4 May 2020Source: The Journal of Prosthetic DentistryAuthor(s): Soner Sismanoglu, Zuhal Yildirim-Bilmez, Aysegul Erten-Taysi, Pınar Ercal
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Publication date: Available online 4 May 2020Source: The Journal of Prosthetic DentistryAuthor(s): Junying Li, Celia Sommer, Hom-Lay Wang, Luca Lepidi, Tim Joda, Gustavo Mendonca
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Publication date: Available online 4 May 2020Source: The Journal of Prosthetic DentistryAuthor(s): Marta Revilla-León, Joshua Fountain, Wenceslao Piedra-Cascón, Mutlu Özcan, Amirali Zandinejad
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Publication date: Available online 4 May 2020Source: The Journal of Prosthetic DentistryAuthor(s): Ju-Hyoung Lee
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Related ArticlesThree-dimensional morphological analysis and clinical application of ankle joint in Chinese population based on CT reconstruction. Surg Radiol Anat. 2020 May 02;: Authors: Hongyu C, Haowen X, Xiepeng Z, Kehui W, Kailiang C, Yanyan Y, Qing H, Youqiong L, Jincheng W Abstract PURPOSE: To study the anatomical features of the ankle joint in Chinese northeast healthy adults and provide accurate data for the design of the total ankle arthroplasty...
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Related ArticlesShort and medium-chain chlorinated paraffins in serum from residents aged from 50 to 84 in Jinan, China: Occurrence, composition and association with hematologic parameters. Sci Total Environ. 2020 Apr 19;728:137998 Authors: Ding L, Luo N, Liu Y, Fang X, Zhang S, Li S, Jiang W, Zhao N Abstract Human exposure to chlorinated paraffins (CPs) has been expected and assessed by external pathways considering their pervasive environmental occurrence....
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Related ArticlesVitamin D (VD3) antioxidative and anti-inflammatory activities: Peripheral and central effects. Eur J Pharmacol. 2020 Apr 28;:173099 Authors: Almeida Moreira Leal LK, Lima LA, Alexandre de Aquino PE, Costa de Sousa JA, Jataí Gadelha CV, Felício Calou IB, Pereira Lopes MJ, Viana Lima FA, Tavares Neves KR, Matos de Andrade G, Socorro de Barros Viana G Abstract Vitamin D (VD3, cholecalciferol), besides its role on bone calcium homeostasis,...
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Related ArticlesThe potential of lipid mediator networks as ocular surface therapeutics and biomarkers. Ocul Surf. 2020 Apr 28;: Authors: Flitter BA, Fang X, Matthay MA, Gronert K Abstract In the last twenty years an impressive body of evidence in diverse inflammatory animal disease models and human tissues, has established polyunsaturated fatty acids (PUFA) derived specialized-pro-resolving mediators (SPM), as essential mediators for controlling acute...
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Related ArticlesProteomic profiling unveils citral modulating expression of IsaA, CodY and SaeS to inhibit biofilm and virulence in methicillin-resistant Staphylococcus aureus. Int J Biol Macromol. 2020 Apr 29;: Authors: Valliammai A, Sethupathy S, Ananthi S, Priya A, Selvaraj A, Nivetha V, Aravindraja C, Mahalingam S, Pandian SK Abstract Methicillin-resistant Staphylococcus aureus (MRSA) is one of the dangerous human pathogens and it is categorized...
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Related ArticlesHigh-yield production in E. coli and characterization of full-length functional p13II protein from human T-cell leukemia virus type 1. Protein Expr Purif. 2020 Apr 29;:105659 Authors: Georgieva ER, Borbat PP, Fanouraki C, Freed JH Abstract Human T-cell leukemia virus type 1 is an oncovirus that causes aggressive adult T-cell leukemia but is also responsible for severe neurodegenerative and endocrine disorders. Combatting HTLV-1 infections...
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Related ArticlesSex- and age-dependent effects of maternal organophosphate flame-retardant exposure on neonatal hypothalamic and hepatic gene expression. Reprod Toxicol. 2020 Apr 29;: Authors: Adams S, Wiersielis K, Yasrebi A, Conde K, Armstrong L, Guo GL, Roepke TA Abstract After the phase-out of polybrominated diphenyl ethers, their replacement compounds, organophosphate flame retardants (OPFRs) became ubiquitous in home and work environments. OPFRs,...
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Related ArticlesAtractylenolide II prevents radiation damage via MAPKp38/Nrf2 signaling pathway. Biochem Pharmacol. 2020 Apr 29;:114007 Authors: Xiao C, Xu C, He N, Liu Y, Wang Y, Zhang M, Ji K, Du L, Wang Data Processing J, Wang Q, Liu Q Abstract Ionizing radiation (IR) can act as a negative factor for human homeostasis, by causing and even aggravating a series of pathological conditions. To protect the intactness of normal tissues, effective anti-radiation...
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Related ArticlesSqualene monooxygenase: a journey to the heart of cholesterol synthesis. Prog Lipid Res. 2020 Apr 28;:101033 Authors: Chua NK, Coates HW, Brown AJ Abstract Squalene monooxygenase (SM) is a vital sterol synthesis enzyme across eukaryotic life. In yeast, it is a therapeutic target for treating certain fungal infections, and in mammals it is a rate-limiting enzyme that represents a key control point in the cholesterol synthesis pathway....
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Related ArticlesAnalysis of U8 snoRNA Variants in Zebrafish Reveals How Bi-allelic Variants Cause Leukoencephalopathy with Calcifications and Cysts. Am J Hum Genet. 2020 Apr 28;: Authors: Badrock AP, Uggenti C, Wacheul L, Crilly S, Jenkinson EM, Rice GI, Kasher PR, Lafontaine DLJ, Crow YJ, O'Keefe RT Abstract How mutations in the non-coding U8 snoRNA cause the neurological disorder leukoencephalopathy with calcifications and cysts (LCC) is poorly understood....
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Publication date: Available online 4 May 2020Source: CortexAuthor(s): Adam Zeman, Fraser Milton, Sergio Della Sala, Michaela Dewar, Timothy Frayling, James Gaddum, Andrew Hattersley, Brittany Heuerman-Williamson, Kealan Jones, Matthew MacKisack, Crawford Winlove
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Publication date: Available online 4 May 2020Source: Auris Nasus LarynxAuthor(s): Yoshihiro Yokota, Akinori Yamashita, Shinji Koyama, Koichi Kitano, Shintaro Otsuka, Tadashi Kitahara
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Publication date: Available online 4 May 2020Source: Auris Nasus LarynxAuthor(s): Taichi Kan, Hiromi Ueda, Mayuko Kishimoto, Yoshimasa Tsuchiya, Tetsuya Ogawa, Yasue Uchida
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Publication date: Available online 4 May 2020Source: Auris Nasus LarynxAuthor(s): Koh Miwa, Masahiro Tsutsumi, Keiko Fukino, Kohtaro Eguchi, Ryuhei Okada, Keiichi Akita
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Abstract Following a request from the European Commission, the EFSA Panel on Additives and products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of Sorbiflore® ADVANCE when used as a zootechnical feed additive for chickens for fattening. Sorbiflore® ADVANCE is an additive resulting from the fermentation of milk‐based broth with Lactobacillus rhamnosus CNCM I‐3698 and Lactobacillus farciminis CNCM I‐3699. Sorbiflore® ADVANCE is intended...
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Abstract Following a request from the European Commission, the EFSA Panel on Additives and products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of Sorbiflore® ADVANCE when used as a zootechnical feed additive for weaned piglets. Sorbiflore® ADVANCE results from the fermentation of milk based‐broth with Lactobacillus rhamnosus CNCM I‐3698 and Lactobacillus farciminis CNCM I‐3699. The additive is intended for use in feed for weaned...
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Abstract Functional endoscopic sinus surgery (FESS) has become one of the most common surgical techniques performed by otolaryngologists with significant data demonstrating its efficacy in managing patients with chronic rhinosinusitis (CRS). However, despite this initial success, patients may continue to present with recurrent symptoms and approximately 10–15% of them will require revision surgery. Failure of FESS may have many different causes which include inappropriate patient...
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Related ArticlesCardiac monitoring in HER2-positive patients on trastuzumab treatment: A review and implications for clinical practice. Breast. 2020 Apr 16;52:33-44 Authors: Bouwer NI, Jager A, Liesting C, Kofflard MJM, Brugts JJ, Kitzen JJEM, Boersma E, Levin MD Abstract Trastuzumab prolongs progression-free and overall survival in patients with human epidermal growth factor receptor 2 (HER2) positive breast cancer. However, trastuzumab treatment is...
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Related ArticlesShould hearing targeted screening for congenital cytomegalovirus infection Be implemented? Int J Pediatr Otorhinolaryngol. 2020 Apr 23;134:110055 Authors: Haller T, Shoup A, Park AH Abstract Since 2013, after Utah became the first state to implement hearing targeted early CMV screening, a national debate has been percolating about whether this approach should be introduced nationally. Currently Utah, Iowa, Connecticut, and New York have...
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Related ArticlesSpeech and language development of children born following assisted reproductive technologies. Int J Pediatr Otorhinolaryngol. 2020 Apr 21;134:110060 Authors: Dehghan M, Kuhi M, Rezvani S, Esmaeilzadeh S, Samadinezhad H, Basirat Z, Mir FN, Khafri S, Ahmadi A Abstract OBJECTIVES: Studies which targeted communication skills of children born following assisted reproductive technologies have reported contradictory results. Concerning the...
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Related ArticlesSleep endoscopy findings in children in supine versus left lateral position. Int J Pediatr Otorhinolaryngol. 2020 Apr 21;134:110056 Authors: Carr M, Phillips D Abstract OBJECTIVE: To describe how drug-induced sleep endoscopy (DISE) findings in children with obstructive sleep apnea (OSA) change with lateral positioning. METHODS: Children undergoing DISE for OSA in 2018-19 at a tertiary care children's hospital were positioned...
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Related ArticlesA cleft care workshop for speech and language pathologists in resource-limited countries: The participants' experiences about cleft care in Uganda and satisfaction with the training effect. Int J Pediatr Otorhinolaryngol. 2020 Apr 21;134:110052 Authors: Alighieri C, Kissel I, D'haeseleer E, Bruneel L, Bettens K, Sseremba D, Pype P, Van Lierde K Abstract OBJECTIVES: workshops and specialized training programs are often inaccessible for...
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Related ArticlesAtypical lymphoid hyperplasia in a patient undergoing tonsillectomy for severe obstructive sleep apnea. Int J Pediatr Otorhinolaryngol. 2020 Apr 24;134:110066 Authors: Kinealy BP, Harding BC, Vazmitsel MA, Laziuk K, Gov-Ari E Abstract Tonsillectomy is a common procedure in the pediatric population, with subsequent microscopic examination of the specimen for cancer and other rare diagnoses occurring routinely. A 17 year-old female with...
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Related ArticlesEnlarged vestibular aqueduct: Intraoperative electrocochleography findings during cochlear implantation. Int J Pediatr Otorhinolaryngol. 2020 Apr 24;134:110065 Authors: Riggs WJ, Hiss MM, Varadarajan VV, Mattingly JK, Adunka OF Abstract Enlarged vestibular aqueduct (EVA) is the most frequent inner ear abnormality found on computed tomography in children with sensorineural hearing loss. The effects EVA abnormalities have on electrocochleography...
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Related ArticlesAcquisition limitations of bone conduction hearing devices in children with unilateral microtia and atresia. Int J Pediatr Otorhinolaryngol. 2020 Apr 06;134:110040 Authors: Alexander NL, Silva RC, Barton G, Liu YC Abstract OBJECTIVE: To characterize the use of bone conduction hearing devices (BCHD) for hearing management in children with unilateral congenital aural atresia (CAA) at a tertiary pediatric center's microtia clinic while assessing...
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Related ArticlesPrevention methods for Treacher Collins syndrome: A systematic review. Int J Pediatr Otorhinolaryngol. 2020 Apr 21;134:110062 Authors: Guo P, Pan B, Jiang H, Yang Q, He L, Lin L Abstract OBJECTIVES: Treacher Collins syndrome (TCS) is a severe congenital mandibulofacial dysostosis that occurs one in every 50,000 births. The main clinical treatment of this rare disorder is reconstruction surgery. However, the high invasion, low security...
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Expression of the DNA/RNA helicase schlafen family member 11 (SLFN11) has been identified as a sensitizer of tumor cells to DNA-damaging agents including platinum chemotherapy. We assessed the impact of SLFN11 expression on response to platinum chemotherapy and outcomes in patients with metastatic castration-resistant prostate cancer (CRPC). Tumor expression of SLFN11 was assessed in 41 patients with CRPC treated with platinum chemotherapy by RNA sequencing (RNA-seq) of metastatic biopsy tissue (n...
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Physical and chemical DNA-damaging agents are used widely in the treatment of cancer. Double-strand break (DSB) lesions in DNA are the most deleterious form of damage and, if left unrepaired, can effectively kill cancer cells. DNA-dependent protein kinase (DNA-PK) is a critical component of nonhomologous end joining (NHEJ), one of the two major pathways for DSB repair. Although DNA-PK has been considered an attractive target for cancer therapy, the development of pharmacologic DNA-PK inhibitors for...
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Long noncoding RNAs (lncRNA) have been found to play critical roles in tumorigenesis and the development of various cancers, including hepatocellular carcinoma (HCC). Metastasis associated with lung adenocarcinoma transcript-1 (MALAT1) has been identified as an oncogene and prognostic biomarker in HCC. Here, we demonstrated that MALAT1 expression was obviously high in sorafenib-resistant HCC cells. Furthermore, knockdown of MALAT1 increased sorafenib sensitivity in nonresponsive HCC cells, whereas...
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2-fluorofucose (2FF) inhibits protein and cellular fucosylation. Afucosylation of IgG antibodies enhances antibody-dependent cell-mediated cytotoxicity by modulating antibody affinity for FcRIIIa, which can impact secondary T-cell activation. Immune responses toward most common solid tumors are dominated by a humoral immune response rather than the presence of tumor-infiltrating cytotoxic T cells. IgG antibodies directed against numerous tumor-associated proteins are found in the sera of both patients...
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Gastrointestinal stromal tumor (GIST), the most common sarcoma, is characterized by KIT protein overexpression, and tumors are frequently driven by oncogenic KIT mutations. Targeted inhibition of KIT revolutionized GIST therapy and ushered in the era of precision medicine for the treatment of solid malignancies. Here, we present the first use of a KIT-specific DNA aptamer for targeted labeling of GIST. We found that an anti-KIT DNA aptamer bound cells in a KIT-dependent manner and was highly specific...
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Dysregulation of DNA methylation is an established feature of breast cancers. DNA demethylating therapies like decitabine are proposed for the treatment of triple-negative breast cancers (TNBC) and indicators of response need to be identified. For this purpose, we characterized the effects of decitabine in a panel of 10 breast cancer cell lines and observed a range of sensitivity to decitabine that was not subtype specific. Knockdown of potential key effectors demonstrated the requirement of deoxycytidine...
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