Related ArticlesDecreased prevalence of Moraxella catarrhalis in addition to Streptococcus pneumoniae in children with upper respiratory tract infection after introduction of conjugated pneumococcal vaccine - A retrospective cohort study. Clin Microbiol Infect. 2020 Apr 30;: Authors: Littorin N, Rünow E, Ahl J, Resman F, Riesbeck K Abstract OBJECTIVES: To study effects of the introduction of pneumococcal conjugate vaccines (PCV) on the interspecies...
16:14
Related ArticlesClinical and Transmission Dynamics Characteristics of 406 Children with Coronavirus Disease 2019 in China: A Review. J Infect. 2020 Apr 28;: Authors: Zhen-Dong Y, Gao-Jun Z, Run-Ming J, Zhi-Sheng L, Zong-Qi D, Xiong X, Guo-Wei S Abstract OBJECTIVE: Chinese pediatricians are working on the front line to fight COVID-19. They have published a great amount of first-hand clinical data. Collecting their data and forming a large sample for...
16:14
Related ArticlesThe MEFV gene and its association with familial Mediterranean fever, severe atopy, and recurrent respiratory tract infections. Allergol Immunopathol (Madr). 2020 Apr 28;: Authors: Celiksoy MH, Dogan C, Erturk B, Keskin E, Ada BS Abstract BACKGROUND: Familial Mediterranean fever (FMF) is the most common auto-inflammatory disease and is characterized by self-limiting episodes of fever and polyserositis. The aim of this study was to...
16:14
Related ArticlesAetiology of Canine Infectious Respiratory Disease Complex and Prevalence of its Pathogens in Europe. J Comp Pathol. 2020 Apr;176:86-108 Authors: Day MJ, Carey S, Clercx C, Kohn B, MarsilIo F, Thiry E, Freyburger L, Schulz B, Walker DJ Abstract The canine infectious respiratory disease complex (CIRDC) is an endemic worldwide syndrome involving multiple viral and bacterial pathogens. Traditionally, Bordetella bronchiseptica (Bb), canine...
16:14
TNF-related apoptosis-inducing ligand (TRAIL) and an agonistic antibody against the death-inducing TRAIL receptor 5, DR5, are thought to selectively induce tumor cell death and therefore, have gained attention as potential therapeutics currently under investigation in several clinical trials. However, some tumor cells are resistant to TRAIL/DR5–induced cell death, even though they express DR5. Previously, we reported that DR5 is transported into the nucleus by importin β1, and knockdown of importin...
15:39
Overexpression of transcription factor 3 in alveolar soft part sarcoma(ASPS) results in upregulation of cell proliferation pathways. No standard treatment algorithm exists for ASPS; multikinase inhibitors[tyrosine kinase inhibitor (TKI)] and immune checkpoint inhibitors (ICI) have shown clinical benefit. To date, no studies have reported on management strategies or sequencing of therapy. We evaluated ASPS treatment patterns and responses in an experimental therapeutics clinic. Genomic and morphoproteomic...
15:39
The development of efficacious therapies targeting metastatic spread of breast cancer to the brain represents an unmet clinical need. Accordingly, an improved understanding of the molecular underpinnings of central nervous system spread and progression of breast cancer brain metastases (BCBM) is required. In this study, the clinical burden of disease in BCBM was investigated, as well as the role of aldehyde dehydrogenase 1A3 (ALDH1A3) in the metastatic cascade leading to BCBM development. Initial...
15:39
There is a need to develop novel approaches to improve the balance between efficacy and toxicity for transcription factor–targeted therapies. In this study, we exploit context-dependent differences in RNA polymerase II processivity as an approach to improve the activity and limit the toxicity of the EWS-FLI1–targeted small molecule, mithramycin, for Ewing sarcoma. The clinical activity of mithramycin for Ewing sarcoma is limited by off-target liver toxicity that restricts the serum concentration...
15:39
KRAS mutation is a negative predictive biomarker of anti-EGFR agents in patients with metastatic colorectal cancer (mCRC), and remains an elusive target. Pelareorep, a double-stranded RNA virus selectively replicates in KRAS-mutated cells, and is synergistic with irinotecan. A dose escalation trial of FOLFIRI/bevacizumab [irinotecan (150–180 mg/m2) and pelareorep (1 x 1010 TCID50–3 x 1010 TCID50)] was implemented in adult patients with oxaliplatin refractory/intolerant, KRAS-mutant mCRC. Pelareorep...
15:39
This first-in-human phase I study evaluated the pharmacokinetics, safety, and preliminary efficacy of telisotuzumab, formerly called ABT-700, an antagonistic antibody directed against c-Met. For dose escalation (3+3 design), 3 to 6 patients with advanced solid tumors were enrolled into four dose cohorts (5–25 mg/kg). In the dose-expansion phase, a subset of patients was prospectively selected for MET amplification (FISH screening). Patients received telisotuzumab intravenously on day 1 every 21 days....
15:39
Summary Scleroderma is a heterogeneous group of fibrosing connective tissue disorders of unknown etiology. Morphea is a localized form of scleroderma that occasionally leads to chronic erosions and ulcerations of the skin. Fibrosis, inflammation and chronic ulcerations may eventually promote skin neoplasms; morphea is therefore a rare but established risk factor for cutaneous squamous cell carcinoma (cSCC). We present a review of 16 scleroderma patients: 15 case reports from the literature (identified...
15:39
Related ArticlesUSP48 Sustains Chemoresistance and Metastasis in Ovarian Cancer. Curr Cancer Drug Targets. 2020 May 02;: Authors: Lei X, Li X, Chen H, Liu Z Abstract Ubiquitin specific protease 48 (USP48) is a member of the deubiquitinating enzymes (DUBs) family. However, the function of USP48 in ovarian cancer remains unclear. The present study reveals that USP48 knockdown could significantly inhibit cell migration and invasion in ES2, 3AO and A2780...
15:55
Related ArticlesTelephonic triage before surgical ward admission and telemedicine during COVID-19 outbreak in Italy. Effective and easy procedures to reduce in-hospital positivity. Int J Surg. 2020 Apr 30;: Authors: Tolone S, Gambardella C, Brusciano L, Genio GD, Lucido FS, Docimo L PMID: 32360932 [PubMed - as supplied by publisher]
15:55
Related ArticlesAn invited Commentary on "Neo-nervegenesis in 3D dynamic responsive implant for inguinal hernia repair. Qualitative study. Int J Surg 2020;76:114-119". Int J Surg. 2020 Apr 29;: Authors: Srivastava V, Basu S PMID: 32360504 [PubMed - as supplied by publisher]
15:55
Related ArticlesInvited Commentary on "Radical excision versus local resection for primary rectal gastrointestinal stromal tumors. A cohort study" (Int J Surg 2020; 77:190-197). Int J Surg. 2020 Apr 29;: Authors: Lussiez A, Suwanabol PA PMID: 32360503 [PubMed - as supplied by publisher]
15:55
Related ArticlesAn Invited Commentary on "Long-term oncological outcomes in robotic versus laparoscopic approach for rectal cancers: a systematic review and meta-analysis" (Int J Surg 2020; Epub ahead of print). Int J Surg. 2020 Apr 29;: Authors: Parasnis A, Khaladkar B PMID: 32360502 [PubMed - as supplied by publisher]
15:55
Related ArticlesAn Invited Commentary on "The Socio-Economic Implications of the Coronavirus and COVID-19 Pandemic: A Review". Int J Surg. 2020 Apr 29;: Authors: Atar S, Atar I PMID: 32360501 [PubMed - as supplied by publisher]
15:55
Related ArticlesUnusual enhancement patterns from inadvertent arterial contrast injection during CT angiography. J Clin Neurosci. 2020 Apr 29;: Authors: Wong M, Brennan D, Gaillard F Abstract Investigation of cerebrovascular incidents typically involve non-contrast intracranial computed tomography (CT) and CT angiography (CTA) of the arch of aorta to vertex with or without CT perfusion. Though rare, inadvertent direct arterial contrast injection is a...
15:54
Related ArticlesHow common is repeat surgery and multi-level treatment in Degenerative Cervical Myelopathy? Findings from a patient perspective survey. J Clin Neurosci. 2020 Apr 30;: Authors: Gharooni AA, Grodzinski B, Davies BM, Kotter MRN Abstract Degenerative Cervical Myelopathy (DCM) is a common condition which causes significant disability and reduces health-related quality of life. The only evidence-based treatment and current management guidance...
15:54
Related ArticlesVolume estimation of brain ventricles using Cavalieri's principle and Atlas-based methods in Alzheimer disease: Consistency between methods. J Clin Neurosci. 2020 Apr 29;: Authors: Karaca O, Buyukmert A, Tepe N, Ozcan E, Kus I Abstract Automatic estimations of brain ventricles are needed to assess disease progression in neurodegenerative disorders such as Alzheimer Disease (AD). The objectives of this study are to evaluate the diagnostic...
15:54
Related ArticlesSexual dysfunction in Neuro-Behcet's disease. J Clin Neurosci. 2020 Apr 29;: Authors: Hayriye Sorgun M, Kuzu M, Erdoğan S, Yucesan C Abstract The aim of the study was evaluation of sexual dysfunction in neuro-Behcet's disease (NBD). A total of 25 patients with NBD, 22 patients with Behçet's disease (BD) without neurologic involvement (BDWONI) and 19 persons in control group were prospectively included in the study. We collected all demographic...
15:54
Related ArticlesVision loss, gaze palsy, and nystagmus in a patient with leukemia. J Clin Neurosci. 2020 Apr 29;: Authors: Jung EE, Greer C, Patel VR Abstract A 22-year old male with a history of B-cell acute lymphoblastic leukemia with recent bone marrow transplantation and on immunosuppressive therapy presented with painless, subacute vision loss of two weeks duration. He exhibited a horizontal gaze palsy, nystagmus, and mildly swollen and hyperemic...
15:54
Related ArticlesReadmission in elective spine surgery: Will short stays be beneficial to patients. J Clin Neurosci. 2020 Apr 29;: Authors: Brown AE, Saleh H, Naessig S, Pierce KE, Ahmad W, Bortz CA, Alas H, Chern I, Vasquez-Montes D, Ihejirika RC, Segreto FA, Haskel J, James Kaplan D, Diebo BG, Gerling MC, Paulino CB, Theologis A, Lafage V, Janjua MB, Passias PG Abstract There has been limited discussion as to whether spine surgery patients are benefiting...
15:54
Related ArticlesEffects of p38 MAPK signaling pathway on cognitive function and recovery of neuronal function after hypoxic-ischemic brain injury in newborn rats. J Clin Neurosci. 2020 Apr 30;: Authors: Zhu Z, Ge M, Li C, Yu L, Gu Y, Hu Y, Cao Z Abstract To explore the effects of p38 MAPK signaling pathway on cognitive function and recovery of neuronal function after hypoxic-ischemic brain injury (HIBI) in newborn rats. Seventy-two healthy SPF grade...
15:54
Related ArticlesLow recurrence after Simpson grade II resection of spinal benign meningiomas in a single-institute 10-year retrospective study. J Clin Neurosci. 2020 Apr 29;: Authors: Naito K, Yamagata T, Arima H, Takami T Abstract The objective of this study was to more fully understand the optimal neurosurgical strategy for spinal benign meningiomas from a medium to long-term perspective. This retrospective study included a cohort of 35 patients with...
15:54
Related ArticlesPredicting prolonged length of stay after endoscopic transsphenoidal surgery for pituitary adenoma. Int Forum Allergy Rhinol. 2020 May 03;: Authors: Vimawala S, Chitguppi C, Reilly E, Fastenberg JH, Garzon-Muvdi T, Farrell C, Rabinowitz MR, Rosen MR, Evans J, Nyquist GG Abstract BACKGROUND: Endoscopic transsphenoidal surgery (ETS) for the resection of pituitary adenoma has become more common throughout the past decade. Although most patients...
15:53
Related ArticlesThe role of ferroptosis in chronic intermittent hypoxia-induced liver injury in rats. Sleep Breath. 2020 May 03;: Authors: Chen LD, Wu RH, Huang YZ, Chen MX, Zeng AM, Zhuo GF, Xu FS, Liao R, Lin QC Abstract PURPOSE: Obstructive sleep apnea (OSA) has been related to an increased risk of liver injury. Ferroptosis is a form of programmed cell death implicated in multiple physiological and pathological processes. This study aimed to explore...
15:53
Related ArticlesSleep endoscopy findings in children in supine versus left lateral position. Int J Pediatr Otorhinolaryngol. 2020 Apr 21;134:110056 Authors: Carr M, Phillips D Abstract OBJECTIVE: To describe how drug-induced sleep endoscopy (DISE) findings in children with obstructive sleep apnea (OSA) change with lateral positioning. METHODS: Children undergoing DISE for OSA in 2018-19 at a tertiary care children's hospital were positioned...
15:53
Related ArticlesAtypical lymphoid hyperplasia in a patient undergoing tonsillectomy for severe obstructive sleep apnea. Int J Pediatr Otorhinolaryngol. 2020 Apr 24;134:110066 Authors: Kinealy BP, Harding BC, Vazmitsel MA, Laziuk K, Gov-Ari E Abstract Tonsillectomy is a common procedure in the pediatric population, with subsequent microscopic examination of the specimen for cancer and other rare diagnoses occurring routinely. A 17 year-old female with...
15:53
Related ArticlesAssociation of Systemic Hypertension with Primary Open-Angle Glaucoma: A Population-Based Case-control Study. Am J Ophthalmol. 2020 Apr 28;: Authors: Kuang TM, Xirasagar S, Kao YW, Shia BC, Lin HC Abstract PURPOSE: To examine the association between systemic hypertension (HTN) and primary open angle glaucoma (POAG) using Taiwan's nationwide health insurance claims data. DESIGN: A case-control study METHODS: Data for this case-control...
15:53
Publication date: October 2020Source: Current Opinion in Neurobiology, Volume 64Author(s): George Dragoi
15:53
Publication date: Available online 4 May 2020Source: Clinical TherapeuticsAuthor(s): Seung-Jun Lee, Jaewon Oh, Sung-Jin Hong, In-Jeong Cho, Su Rae Kim, Jae-Sun Uhm, Chi Young Shim, Hyuk-Jae Chang, Chul-Min Ahn, Jung-Sun Kim, Byeong-Keuk Kim, Sungha Park, Sang-Hak Lee, Geu Ru Hong, Young-Guk Ko, Donghoon Choi
15:53
Related ArticlesX irradiation induced colonic mucosal injury and the detection of apoptosis through PARP-1/p53 regulatory pathway. Biomed Pharmacother. 2020 Apr 30;127:110134 Authors: Akpolat M, Oz ZS, Gulle K, Hamamcioglu AC, Bakkal BH, Kececi M Abstract This study aimed to explore whether PARP-1 regulatory pathway mediated X irradiation induced cell cycle arrest and apoptosis or not. In this regard, colonic mucosal injury caused by whole-body X-irradiation...
15:50
Related ArticlesRequirement of PP2A-B56Par1 for the Stabilization of the CDK Inhibitor Rum1 and Activation of APC/CSte9 during Pre-Start G1 in S. pombe. iScience. 2020 Apr 16;23(5):101063 Authors: Stonyte V, Martín R, Segura-Peña D, Sekulić N, Lopez-Aviles S Abstract Exit from the cell cycle during the establishment of quiescence and upon cell differentiation requires the sustained inactivation of CDK complexes. Fission yeast cells deprived of nitrogen...
15:50
Related ArticlesDevelopment of small-molecule BRD4 degraders based on pyrrolopyridone derivative. Bioorg Chem. 2020 Apr 09;99:103817 Authors: Zhang J, Chen P, Zhu P, Zheng P, Wang T, Wang L, Xu C, Zhou J, Zhang H Abstract Bromodomain-containing protein 4 (BRD4) plays a crucial role in the epigenetic regulation of gene transcription and some BRD4 inhibitors have been advanced to clinical trials. Nevertheless, the clinical application of BRD4 inhibitors...
15:50
Related ArticlesFlavokawain A inhibits prostate cancer cells by inducing cell cycle arrest and cell apoptosis and regulating the glutamine metabolism pathway. J Pharm Biomed Anal. 2020 Apr 04;186:113288 Authors: Wang K, Zhang W, Wang Z, Gao M, Wang X, Han W, Zhang N, Xu X Abstract Flavokawain A (FKA), a major chalcone in kava extracts, has exhibited anti-proliferative and apoptotic effects in the prostate cancer. However, the molecular mechanism...
15:50
Related ArticlesNedd8-activating enzyme inhibitor MLN4924 (Pevonedistat), inhibits miR-1303 to suppress human breast cancer cell proliferation via targeting p27Kip1. Exp Cell Res. 2020 Apr 30;:112038 Authors: Chen Y, Du M, Yusuying S, Liu W, Tan Y, Xie P Abstract MLN4924/Pevonedistat, a Nedd8-activating enzyme (NAE, E1) inhibitor, has shown notable anti-cancer effect in pre-clinical trials, but it still faces tolerance resistance risk. Combination...
15:50
Related ArticlesBiosurfactants: Potential applications as immunomodulator drugs. Immunol Lett. 2020 Apr 30;: Authors: Sajid M, Ahmad Khan MS, Singh Cameotra S, Safar Al-Thubiani A Abstract Biosurfactants (BSs) molecules are classically branded as emulsifiers of hydrocarbon compounds and are extensively applied in several fields including pharmaceutics, food processing, biodegradation, bioremediation, cosmetics, and pest control management. Due to...
15:50
Related ArticlesSilencing Sirtuin 6 induces cell cycle arrest and apoptosis in non-small cell lung cancer cell lines. Genomics. 2020 Apr 29;: Authors: Krishnamoorthy V, Vilwanathan R Abstract Sirtuins (SIRT1-7), are NAD-dependent deacetylases and ADP-ribosyl transferases, plays a major part in carcinogenesis. The previous report suggests that in cancer sirtuins gained tremendous interest and critical regulators of the unusual processes. In carcinogenesis,...
15:50
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου