Related ArticlesNedd8-activating enzyme inhibitor MLN4924 (Pevonedistat), inhibits miR-1303 to suppress human breast cancer cell proliferation via targeting p27Kip1. Exp Cell Res. 2020 Apr 30;:112038 Authors: Chen Y, Du M, Yusuying S, Liu W, Tan Y, Xie P Abstract MLN4924/Pevonedistat, a Nedd8-activating enzyme (NAE, E1) inhibitor, has shown notable anti-cancer effect in pre-clinical trials, but it still faces tolerance resistance risk. Combination...
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Related ArticlesBiosurfactants: Potential applications as immunomodulator drugs. Immunol Lett. 2020 Apr 30;: Authors: Sajid M, Ahmad Khan MS, Singh Cameotra S, Safar Al-Thubiani A Abstract Biosurfactants (BSs) molecules are classically branded as emulsifiers of hydrocarbon compounds and are extensively applied in several fields including pharmaceutics, food processing, biodegradation, bioremediation, cosmetics, and pest control management. Due to...
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Related ArticlesSilencing Sirtuin 6 induces cell cycle arrest and apoptosis in non-small cell lung cancer cell lines. Genomics. 2020 Apr 29;: Authors: Krishnamoorthy V, Vilwanathan R Abstract Sirtuins (SIRT1-7), are NAD-dependent deacetylases and ADP-ribosyl transferases, plays a major part in carcinogenesis. The previous report suggests that in cancer sirtuins gained tremendous interest and critical regulators of the unusual processes. In carcinogenesis,...
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Related ArticlesCrosstalk between aldehyde dehydrogenase-1 and chemoresistance in breast cancer: Insights into the role of vitamin D3. Life Sci. 2020 Apr 28;:117733 Authors: Attia YM, Hammam OA, Ammar RA, Mansour MT, Elmazar MM Abstract AIMS: Aldehyde dehydrogenase-1 (ALDH-1) is considered a signature of breast cancer stem cells and is linked to poor outcomes in breast cancer patients. This study aimed at investigating the effect of vitamin D3 on...
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Related ArticlesIdentification of a Structural Determinant for Selective Targeting of HDMX. Structure. 2020 Apr 29;: Authors: Ben-Nun Y, Seo HS, Harvey EP, Hauseman ZJ, Wales TE, Newman CE, Cathcart AM, Engen JR, Dhe-Paganon S, Walensky LD Abstract p53 is a critical tumor-suppressor protein that guards the human genome against mutations by inducing cell-cycle arrest or apoptosis. Cancer cells subvert p53 by deletion, mutation, or overexpression of...
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Related ArticlesRegular Coffee Consumption Is Associated with Lower Regional Adiposity Measured by DXA among US Women. J Nutr. 2020 May 03;: Authors: Cao C, Liu Q, Abufaraj M, Han Y, Xu T, Waldhoer T, Shariat SF, Li S, Yang L, Smith L Abstract BACKGROUND: Coffee is among the most popular daily beverages in the United States. Importantly, coffee consumption has been associated with a lower risk of multiple health outcomes including a reduction in adiposity....
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It is well established that African Americans exhibit higher incidence, higher mortality, and more aggressive forms of some cancers, including those of breast, prostate, colon, stomach, and cervix. Here we examine the ancestral haplotype of the TRPV6 calcium channel as a putative genomic factor in this racial divide. The minor (ancestral) allele frequency is 60% in people of African ancestry, but between 1% and 11% in all other populations. Research on TRPV6 structure/function, its association with...
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Ovarian cancer imposes a substantial health and economic burden. We systematically reviewed current health-economic evidence for ovarian cancer early detection or prevention strategies. Accordingly, we searched relevant databases for cost-effectiveness studies evaluating ovarian cancer early detection or prevention strategies. Study characteristics and results including quality-adjusted life years (QALY), and incremental cost-effectiveness ratios (ICER) were summarized in standardized evidence tables....
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Mammographic breast density is a strong risk factor for breast cancer. We comprehensively investigated the associations of body mass index (BMI) change from ages 10, 18, and 30 to age at mammogram with mammographic breast density in postmenopausal women. We used multivariable linear regression models, adjusted for confounders, to investigate the associations of BMI change with volumetric percent density, dense volume, and nondense volume, assessed using Volpara in 367 women. At the time of mammogram,...
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Colorectal cancer is a growing burden in adults less than 50 years old. In 2018, the American Cancer Society published a guideline update recommending a reduction in the colorectal cancer screening start age for average-risk individuals from 50 to 45. Implementing these recommendations would have important implications for public health. However, the approximate number of people impacted by this change, the average-risk population ages 45–49, is not well-described in the literature. Here, we provide...
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While smoking is inextricably linked to oral/head and neck cancer (HNSCC), only a small fraction of smokers develop HNSCC. Thus, we have sought to identify other factors, which may influence the development of HNSCC in smokers including microbiology. To determine microbial associations with HNSCC among tobacco users, we characterized oral microbiome composition in smokers with and without HNSCC. 16S rRNA MiSeq sequencing was used to examine the oral mucosa microbiome of 27 smokers with (cases) and...
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Cruciferous vegetables have been of special interest due to the rich presence of bioactive compounds such as sulforaphane which show promising potential on cancer prevention and therapy as an epigenetic dietary strategy. Abnormal epigenetic alteration as one of the primary contributors to tumor development is closely related to breast cancer initiation and progression. In the present study, we investigated the effect of dietary broccoli sprouts (BSp), a common cruciferous vegetable, on prevention...
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Tobacco smoking is the primary risk factor for lung cancer, driven by the addictive nature of nicotine and the indisputable carcinogenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) as well as other compounds. The integration of lung cancer chemoprevention with smoking cessation is one potential approach to reduce this risk and mitigate lung cancer mortality. Experimental data from our group suggest that kava, commonly consumed in the South Pacific Islands as a beverage to promote relaxation,...
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Publication date: Available online 4 May 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Claude Charles LeRose, Judith Boura, Carlos Antonio Ramirez
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Related Articles[Features of autonomic regulation of the cardiovascular system in human late ontogenesis.] Adv Gerontol. 2020;33(1):74-81 Authors: Nesterov VP, Burdygin AI, Ivanov KB, Korotkov SM, Shemarova IV, Nesterov SV Abstract Using the method of arterial piezopulsometry, statistical and spectral analyzes of variable parameters (VmaxPP and TNN) of pulse waves of blood pressure in patients aged 18 to 85 years were performed. The individual characteristics...
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Related Articles[Natural age-related cognitive impairments: overview of recent investigations in non-human primates.] Adv Gerontol. 2020;33(1):23-33 Authors: Semenov DG, Belyakov AV Abstract Human aging is followed by the weakening of cognitive functions of the brain. The relevance of the study of this process as well as the search for ways of its medical correction increases due to the rise of the middle life span in developed countries. Non-human primates...
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Related ArticlesSkeletal muscle ClC-1 chloride channels in health and diseases. Pflugers Arch. 2020 May 02;: Authors: Altamura C, Desaphy JF, Conte D, De Luca A, Imbrici P Abstract In 1970, the study of the pathomechanisms underlying myotonia in muscle fibers isolated from myotonic goats highlighted the importance of chloride conductance for skeletal muscle function; 20 years later, the human ClC-1 chloride channel has been cloned; last year, the crystal...
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Related ArticlesDifferential Expression of the Angiotensin-(1-12)/Chymase Axis in Human Atrial Tissue. J Surg Res. 2020 Apr 30;253:173-184 Authors: Wang H, Varagic J, Nagata S, Kon ND, Ahmad S, VonCannon JL, Wright KN, Sun X, Deal D, Groban L, Ferrario CM Abstract BACKGROUND: Heart chymase rather than angiotensin (Ang)-converting enzyme has higher specificity for Ang I conversion into Ang II in humans. A new pathway for direct cardiac Ang II generation...
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Related ArticlesHigh and low anxiety phenotypes in a rat model of complex post-traumatic stress disorder are associated with different alterations in regional brain monoamine neurotransmission. Psychoneuroendocrinology. 2020 Apr 23;117:104691 Authors: Tseilikman V, Komelkova M, Lapshin M, Alliluev A, Tseilikman O, Karpenko M, Pestereva N, Manukhina E, Downey HF, Kondashevskaya M, Sarapultsev A, Dremencov E Abstract BACKGROUND: Repeated exposure to predator...
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Related ArticlesWater extract from Euglena gracilis prevents lung carcinoma growth in mice by attenuation of the myeloid-derived cell population. Biomed Pharmacother. 2020 Apr 28;127:110166 Authors: Ishiguro S, Upreti D, Robben N, Burghart R, Loyd M, Ogun D, Le T, Delzeit J, Nakashima A, Thakkar R, Nakashima A, Suzuki K, Comer J, Tamura M Abstract The partially purified water extract from Euglena gracilis (EWE) was evaluated for its antitumor and immunomodulatory...
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Related ArticlesSingle-cell RNA-seq analysis of the brainstem of mutant SOD1 mice reveals perturbed cell types and pathways of amyotrophic lateral sclerosis. Neurobiol Dis. 2020 Apr 29;:104877 Authors: Liu W, Venugopal S, Majid S, Ahn IS, Diamante G, Hong J, Yang X, Chandler SH Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease in which motor neurons throughout the brain and spinal cord progressively degenerate resulting in muscle...
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Related ArticlesGlyphosate induces epithelial mesenchymal transition-related changes in human endometrial Ishikawa cells via estrogen receptor pathway. Mol Cell Endocrinol. 2020 Apr 28;:110841 Authors: Gastiazoro MP, Durando M, Milesi MM, Lorenz V, Vollmer G, Varayoud J, Zierau O Abstract Glyphosate based herbicides are the most commonly used herbicide in the world. We aimed to determine whether glyphosate (Gly) induces epithelial mesenchymal transition...
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Related ArticlesPoloxamer micellar system for intra-articular injection of 15-deoxy-Δ12,14-prostaglandin J2 with improved bioavailability and anti-inflammatory properties in the temporomandibular joint of rats. Int J Pharm. 2020 Apr 28;:119383 Authors: Abdalla HB, Napimoga MH, Macedo CG, Bonfante R, De Araujo DR, F S de Mello N, Carvalho LB, Fraceto LF, Clemente-Napimoga JT Abstract Painful conditions of the temporomandibular joint (TMJ) are challenging...
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Related ArticlesThe impact of housing environment color on zebrafish anxiety-like behavioral and physiological (cortisol) responses. Gen Comp Endocrinol. 2020 Apr 29;:113499 Authors: de Abreu MS, C V V Giacomini A, Genario R, Dos Santos BE, Marcon L, Demin KA, Kalueff AV Abstract Color of the environment is an important factor modulating human and animal behavior and physiology. Animal models are a valuable tool to understand how colors affect social,...
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Related ArticlesInhibition of cardiac Kv4.3 (Ito) channel isoforms by class I antiarrhythmic drugs lidocaine and mexiletine. Eur J Pharmacol. 2020 Apr 29;:173159 Authors: Rahm AK, Müller ME, Gramlich D, Lugenbiel P, Uludag E, Rivinius R, Ullrich ND, Schmack B, Ruhparwar A, Heimberger T, Weis T, Karck M, Katus HA, Thomas D Abstract Transient outward K+ current, Ito, contributes to cardiac action potential generation and is primarily carried by Kv4.3 (KCND3)...
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Related ArticlesTranslatable circRNAs and lncRNAs: Driving mechanisms and functions of their translation products. Cancer Lett. 2020 Apr 28;: Authors: Kong S, Tao M, Shen X, Ju S Abstract Long non-coding RNA (lncRNAs) are functional RNA segments longer than 200 nucleotides, which are considered a redundant transcriptional product. Recently, lncRNAs have been shown to harbor open reading frame (ORF) sequences and encode proteins/peptides. Circular RNAs...
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Related ArticlesCritical Review of Large Animal Models for Central Deep Venous Thrombosis. Eur J Vasc Endovasc Surg. 2020 Apr 29;: Authors: Schwein A, Magnus L, Chakfé N, Bismuth J Abstract OBJECTIVE: To review the existing literature on large animal models of central venous thrombosis (CVT) and to evaluate its relevance in regard to the development and testing of dedicated therapeutics applicable to humans. METHODS: A literature search was...
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Related ArticlesLRRK2 Is Recruited to Phagosomes and Co-recruits RAB8 and RAB10 in Human Pluripotent Stem Cell-Derived Macrophages. Stem Cell Reports. 2020 Apr 15;: Authors: Lee H, Flynn R, Sharma I, Haberman E, Carling PJ, Nicholls FJ, Stegmann M, Vowles J, Haenseler W, Wade-Martins R, James WS, Cowley SA Abstract The Parkinson's disease-associated gene, LRRK2, is also associated with immune disorders and infectious disease and is expressed in immune...
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Related ArticlesMyt Transcription Factors Prevent Stress-Response Gene Overactivation to Enable Postnatal Pancreatic β Cell Proliferation, Function, and Survival. Dev Cell. 2020 Apr 26;: Authors: Hu R, Walker E, Huang C, Xu Y, Weng C, Erickson GE, Coldren A, Yang X, Brissova M, Kaverina I, Appakalai BN, Wright CVE, Li Y, Stein R, Gu G Abstract Although cellular stress response is important for maintaining function and survival, overactivation of late-stage...
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Correction to: Comprehensive functional annotation of susceptibility variants associated with asthma
In the original article published, the “p” value in the Fig. 5 legend is incorrectly presented as *p < 0.50. The correct p value is *p < 0.050.
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Related ArticlesPrevalence, clinical characteristics, and health-related quality of life of rosacea in Chinese adolescents: a population-based study. J Eur Acad Dermatol Venereol. 2020 May 03;: Authors: Chen Q, Tang Y, Shi X, Yang X, Shan S, Wang X, Xiao Y, Chen X, Shen M, Li J Abstract Rosacea is a chronic inflammatory dermatosis that may manifest with flushing, erythema, telangiectasia, papules and pustules, or phymatous changes, occasionally with...
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Related ArticlesVEGF inhibition in urothelial cancer: the past, present and future. World J Urol. 2020 May 02;: Authors: Ghafouri S, Burkenroad A, Pantuck M, Almomani B, Stefanoudakis D, Shen J, Drakaki A Abstract PURPOSE: To describe the role of anti-angiogenic agents that have been used as a treatment approach for locally advanced or metastatic urothelial cancers and to propose future directions. METHODS: PubMed/MEDLINE was searched for...
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Related ArticlesApplication of artificial intelligence in cardiac CT: From basics to clinical practice. Eur J Radiol. 2020 Apr 08;128:108969 Authors: van den Oever LB, Vonder M, van Assen M, van Ooijen PMA, de Bock GH, Xie XQ, Vliegenthart R Abstract Research into the possibilities of AI in cardiac CT has been growing rapidly in the last decade. With the rise of publicly available databases and AI algorithms, many researchers and clinicians have...
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Related ArticlesThe chimeric antigen receptor-intensive care unit (CAR-ICU) initiative: Surveying intensive care unit practices in the management of CAR T-cell associated toxicities. J Crit Care. 2020 Apr 15;58:58-64 Authors: Gutierrez C, Brown ART, Herr MM, Kadri SS, Hill B, Rajendram P, Duggal A, Turtle CJ, Patel K, Lin Y, May HP, Gallo de Moraes A, Maus MV, Frigault MJ, Brudno JN, Athale J, Shah NN, Kochenderfer JN, Dharshan A, Beitinjaneh A, Arias AS, McEvoy C,...
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Related ArticlesThe rapid adoption of opportunistic salpingectomy at the time of hysterectomy for benign gynecological disease in the United States. Am J Obstet Gynecol. 2020 Apr 30;: Authors: Mandelbaum RS, Adams CL, Yoshihara K, Nusbaum DJ, Matsuzaki S, Matsushima K, Klar M, Paulson RJ, Roman LD, Wright JD, Matsuo K Abstract BACKGROUND: Mounting evidence for the role of the distal fallopian tubes in the pathogenesis of epithelial ovarian cancer...
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Related ArticlesThoracic radiation oncology clinical trial accrual and reasons for non-enrollment: results of a large, prospective, multi-year analysis. Int J Radiat Oncol Biol Phys. 2020 Apr 29;: Authors: Mesko S, Ning MS, Lakomy D, Verma V, Chang JY, O'Reilly M, Jeter MD, Gandhi SJ, Lin SH, Nguyen QN, Liao Z, Welsh J, Chen AB, Hahn S, Gomez DR Abstract BACKGROUND: Clinical trials are considered the "gold-standard" in evidence-based medicine, yet...
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Related ArticlesNovel use for old drugs: The emerging role of artemisinin and its derivatives in fibrosis. Pharmacol Res. 2020 Apr 29;:104829 Authors: Wang Y, Wang Y, You F, Xue J Abstract Artemisinin and its derivatives are a family of anti-malarial drugs with known clinical safety and efficacy. Apart from its anti-malarial effect, artemisinin has also been reported to show anti-cancer, anti-viral, anti-parasitosis, anti-inflammatory properties...
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Related ArticlesCandidate drugs against SARS-CoV-2 and COVID-19. Pharmacol Res. 2020 Apr 29;:104859 Authors: McKee DL, Sternberg A, Stange U, Laufer S, Naujokat C Abstract Outbreak and pandemic of coronavirus SARS-CoV-2 in 2019/2020 will challenge global health for the future. Because a vaccine against the virus will not be available in the near future, we herein try to offer a pharmacological strategy to combat the virus. There exists a number of...
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Related ArticlesSulfated glycolipid PG545 induces endoplasmic reticulum stress and augments autophagic flux by enhancing anticancer chemotherapy efficacy in endometrial cancer. Biochem Pharmacol. 2020 Apr 28;:114003 Authors: Hoffmann R, Sarkar Bhattacharya S, Roy D, Winterhoff B, Schmidmaier R, Dredge K, Hammond E, Shridhar V Abstract The sulfated glycolipid PG545 shows promising antitumor activity in various cancers. This study was conducted to...
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