Abstract Introduction EGFR mutations occur most frequently in patients with lung adenocarcinoma in East Asia. However, the prognostic and therapeutic impact of co-mutational status of EGFR and tumor suppressor genes is not fully understood. This study aims to provide a deeper understanding of lung adenocarcinoma patients with co-mutation of EGFR and tumor suppressor genes. ...
Sat May 02, 2020 03:00
Abstract Purpose Some metastatic colorectal cancer (mCRC) patients receive conversion surgery (CS), including metastasectomy after palliative chemotherapy. Although targeted agents significantly improved the outcomes, the clinical outcome of CS in the targeted agent era has not yet been thoroughly investigated. Methods We analyzed the clinical data...
Fri May 01, 2020 03:00
Objectives Contemporary clinical assessment of vocal fold adduction and abduction is qualitative and subjective. Herein is described a novel computer vision tool for automated quantitative tracking of vocal fold motion from videolaryngoscopy. The potential of this software as a diagnostic aid in unilateral vocal fold paralysis is demonstrated. Study Design Case‐control. Methods A deep‐learning algorithm was trained for vocal fold localization from videoendoscopy for automated...
Fri May 01, 2020 16:28
Fri May 01, 2020 16:04
Fri May 01, 2020 15:59
Thu Apr 30, 2020 14:34
Objectives/Hypothesis To investigate olfactory and gustatory function in patients with maxillofacial trauma and associated fractures. Study Design Retrospective cohort study. Methods Olfactory and gustatory function was assessed psychophysically in 124 patients who had sustained maxillofacial trauma with an associated fracture. Five groups were defined based on the fracture type: Le Fort, mandibular, nasal, orbital, and zygomatic. Olfaction was measured with Sniffin' Sticks...
Thu Apr 30, 2020 14:33
Objective To evaluate the utility of lymph node ratio (LNR) as a prognostic factor for survival and recurrence in surgically treated patients with human papillomavirus (HPV)‐related oropharyngeal squamous cell carcinoma (OPSCC). Study Design Retrospective cohort study. Methods In this retrospective cohort study of a tertiary healthcare system in a major metropolitan area, we reviewed 169 consecutive patients with HPV‐related OPSCC treated using transoral robotic surgery. Univariable...
Wed Apr 29, 2020 19:21
Wed Apr 29, 2020 19:08
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Objective:Colorectal cancer is one of the most important malignant cancer in the world with high incidence and mortality. Some studies have found that the expression of low serum L1 cell adhesion molecule is associated with poor prognosis in some malignancies. It is suggested that L1 cell adhesion molecule is a candidate serum marker for certain tumors. However, the relationship between serum L1 cell adhesion...
Fri May 01, 2020 13:04
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Background:In recent studies, microRNAs have been demonstrated as stable detectable biomarkers in blood for cancer. In addition, computer-aided biomarker discovery has now become an attractive paradigm for precision diagnosis.Methods:In this study, we identified and evaluated miR-139-3p as a biomarker for screening of esophageal squamous cell carcinoma using the Cancer Genome Atlas and Gene Expression Omnibus...
Fri May 01, 2020 13:00
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Objective:This study aimed to investigate the diagnostic values of microRNA-21, microRNA-124, and macrophage colony-stimulating factor in patients with cervical cancer.Methods:A total of 68 patients with cervical cancer admitted in our hospital (cervical cancer group) and 57 healthy individuals undergoing physical examinations (healthy group, also control group) were enrolled in this study. The expression of serum...
Fri May 01, 2020 12:56
As the coronavirus disease 2019 (Covid-19) pandemic has spread around the globe, there has been growing recognition that persons with underlying increased cardiovascular risk may be disproportionately affected. Several studies of case series have noted cardiac arrhythmias, cardiomyopathy, and…
Fri May 01, 2020 03:00
To the Editor: On February 20, 2020, the incidence of Covid-19 began to rapidly escalate in Italy. By March 25, Italy had the second highest number of Covid-19 infections worldwide and the greatest number of deaths. Children younger than 18 years of age who had Covid-19 composed only 1% of the…
Fri May 01, 2020 03:00
Studies in animals have shown that angiotensin-converting enzyme 2 (ACE2), a membrane-bound aminopeptidase that is abundantly expressed in the lungs, the heart, and other tissues, is used by coronaviruses as a functional receptor for their entrance into the cells. Angiotensin-receptor blockers…
Fri May 01, 2020 03:00
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (Covid-19), can infect host cells by means of interaction with membrane-bound angiotensin-converting enzyme 2 (ACE2) on respiratory epithelium. ACE2 is part of the…
Fri May 01, 2020 03:00
To the Editor: Traditional approaches to respiratory virus surveillance may not identify novel pathogens in time to implement crucial public health interventions. The Seattle Flu Study is a multi-institutional, community-wide pandemic surveillance platform that was established in November 2018.…
Fri May 01, 2020 03:00
SARS-CoV-2, the coronavirus that causes Covid-19, enters human cells by binding of its viral spike protein to the membrane-bound form of the aminopeptidase angiotensin-converting enzyme 2 (ACE2). From the viewpoint of human physiology, ACE2 plays an important regulatory role in the…
Fri May 01, 2020 03:00
Abstract Background Proximal femoral physeal fractures are rare in abused children. Recognition may be hampered due to their rarity and lack of an ossified femoral head. Prompt diagnosis and treatment are essential to preventing coxa vara. Objective To demonstrate the radiographic features of proximal femoral physeal fractures both with unossified...
Sat May 02, 2020 03:00
Sat May 02, 2020 03:00
Abstract Background The current staging system of twin–twin transfusion syndrome (TTTS) is based on the ultrasound criteria and does not consider the cerebral injury. Objective To assess the incidence of cerebral damage on fetal MRI and correlate abnormal cerebral diffusion-weighted imaging (DWI) findings with survival outcome and the ultrasound staging...
Sat May 02, 2020 03:00
Journal of International Medical Research, Volume 48, Issue 5, May 2020. ObjectiveThis study aimed to present our experience of concomitant management of renal calculi and recurrent ureteropelvic junction obstruction (UPJO) with percutaneous nephrolithotomy (PCNL) and antegrade balloon dilation.MethodsWe retrospectively reviewed 31 patients who underwent PCNL and antegrade balloon dilation for treatment of renal calculi and recurrent UPJO. The inclusion criterion was the presence of UPJO after failed...
Fri May 01, 2020 15:58
Journal of International Medical Research, Volume 48, Issue 5, May 2020. ObjectiveTo investigate the postoperative analgesic effect of ultrasound-guided quadratus lumborum block (QLB) in patients undergoing arthroscopic hip surgery.MethodsPatients who were scheduled to undergo elective arthroscopic hip surgery were randomly assigned to the QLB (Q) or control (C) group (n = 40 each). After general anesthesia induction, unilateral QLB was performed under ultrasound guidance in the Q group. The amount...
Fri May 01, 2020 14:18
Journal of International Medical Research, Volume 48, Issue 5, May 2020. This report describes a clinically rare and atypical case of 46,X,idic(X)(q21.32)/45,X-type Turner syndrome with rapidly progressive puberty development. After 11 months of treatment with recombinant human growth hormone (rhGH), the child’s height increased. After 18 months of treatment with rhGH, the child showed secondary sex characteristics. The child was followed up for 1 year after the appearance of the secondary sex characteristics,...
Fri May 01, 2020 08:09
Journal of International Medical Research, Volume 48, Issue 5, May 2020. ObjectiveCerebral infarction has a poor prognosis and causes a serious burden on families and society. Recombinant tissue plasminogen activator (rt-PA) and urokinase (UK) are commonly used thrombolytic agents in the clinic. However, direct and powerful clinical trial evidence to determine the therapeutic effect of rt-PA and UK on intravenous thrombolysis is lacking.MethodsIn this study, 180 patients with acute cerebral infarction...
Fri May 01, 2020 08:03
Journal of International Medical Research, Volume 48, Issue 5, May 2020. A coronary artery fistula (CAF) is an abnormal connection between a coronary artery and any of the four cardiac chambers, the large vessels, or other vascular structures. Wellens syndrome is an ST-segment elevation myocardial infarction equivalent. Although both Wellens syndrome and CAFs have been reported in the literature, they have rarely been reported in the same patient. We herein report a case clinically diagnosed as Wellens...
Fri May 01, 2020 08:01
Journal of International Medical Research, Volume 48, Issue 5, May 2020. ObjectiveTo investigate the use of the aortic balloon occlusion technique to assist total aortic arch replacement (TAR) with frozen elephant trunk (FET) to shorten the lower body circulatory arrest (CA) time and raise the nadir temperature during cardiopulmonary bypass.MethodsThis retrospective study reviewed consecutive patients that underwent aortic balloon occlusion to assist TAR with FET and patients that received conventional...
Fri May 01, 2020 07:57
Journal of International Medical Research, Volume 48, Issue 5, May 2020. Progressive hemifacial atrophy (PHA) is mainly characterized by asymmetrical atrophy of craniofacial tissue; however, 10% to 30% of patients with PHA exhibit ocular manifestations. Here, we describe abnormal ocular findings in a Chinese patient with PHA. The patient was a 29-year-old Chinese man. Characteristic ocular findings in his affected eye included keratic precipitate, corneal endothelial degeneration, fundus tessellation,...
Thu Apr 30, 2020 13:43
Journal of International Medical Research, Volume 48, Issue 4, April 2020. ObjectiveWe aimed to investigate practices of nasogastric tube (NGT) intubation and feeding for adults by clinical nurses in China.MethodsA self-designed and validated questionnaire comprising 30 questions was distributed to 560 clinical nurses in three comprehensive hospitals of Xiamen, China. The questionnaire covered participants’ demographic characteristics, NGT placement, administration of enteral nutrition (EN), and...
Thu Apr 30, 2020 08:02
Journal of International Medical Research, Volume 48, Issue 4, April 2020. ObjectiveTo evaluate the correlation between interleukin 10 (IL-10) −1082A/G polymorphism (rs1800896) and breast cancers by performing a meta-analysis.MethodsThe Embase and Medline databases were searched through 1 September 2018 to identify qualified articles. Odds ratios (OR) and corresponding 95% confidence intervals (CIs) were applied to evaluate associations.ResultsIn total, 14 case-control studies, including 5320 cases...
Thu Apr 30, 2020 07:55
Pediatric Allergy, Immunology, and Pulmonology, Ahead of Print.
Thu Apr 30, 2020 10:00
Although costal cartilage autograft has versatile usage, harvesting the graft is an invasive procedure with potential risks for complications. Therefore, it is important to make every effort to minimize these risks. Moreover, sculpting costal cartilage to the desired shape is challenging and time-consuming because of the natural rigidity. This study aimed to evaluate cases of costal cartilage harvest in terms of the most important donor site complications and to present a novel, practical and inexpensive...
Fri May 01, 2020 03:00
Inappropriate fusion of the cranial sutures leads to craniosynostosis and the subsequent skull rigidity can cause many developmental and structural problems. Cephalohematoma is a subperiosteal collection of blood commonly associated with birth trauma or instrument-assisted delivery and is one of the most frequently reported fetal injuries in Caesarian section procedures. There have been very few cases reported of patients with both scaphocephaly due to sagittal craniosynostosis and cephalohematoma...
Fri May 01, 2020 03:00
No abstract available
Fri May 01, 2020 03:00
Zygomatic-coronoid ankylosis is a rare complication in maxillofacial trauma. Currently, less of 30 cases reported in the literature. The aim of this study was to report a case of zygomatic-coronoid ankylosis after trauma. A 26-year-old male, with zygomatic-coronoid ankylosis after 7 years of facial trauma, was treated by intraoral bilateral coronoidectomy. However, the literature continues to discuss the best approach, intraorally or extraorally. This study observed that the intraoral approach was...
Fri May 01, 2020 03:00
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