Related ArticlesNews Feature: To counter the pandemic, clinicians bank on repurposed drugs. Proc Natl Acad Sci U S A. 2020 Apr 29;: Authors: Madhusoodanan J PMID: 32350142 [PubMed - as supplied by publisher]
Fri May 01, 2020 14:01
Related ArticlesNOD2 modulates immune tolerance via the GM-CSF-dependent generation of CD103+ dendritic cells. Proc Natl Acad Sci U S A. 2020 Apr 29;: Authors: Prescott D, Maisonneuve C, Yadav J, Rubino SJ, Girardin SE, Philpott DJ Abstract Four decades ago, it was identified that muramyl dipeptide (MDP), a peptidoglycan-derived bacterial cell wall component, could display immunosuppressive functions in animals through mechanisms that remain unexplored....
Fri May 01, 2020 14:01
Related ArticlesLoss of Arc attenuates the behavioral and molecular responses for sleep homeostasis in mice. Proc Natl Acad Sci U S A. 2020 Apr 29;: Authors: Suzuki A, Yanagisawa M, Greene RW Abstract The activity-regulated cytoskeleton-associated protein (Arc) gene is a neural immediate early gene that is involved in synaptic downscaling and is robustly induced by prolonged wakefulness in rodent brains. Converging evidence has led to the hypothesis...
Fri May 01, 2020 14:01
Related ArticlesAll-electrical monitoring of bacterial antibiotic susceptibility in a microfluidic device. Proc Natl Acad Sci U S A. 2020 Apr 29;: Authors: Yang Y, Gupta K, Ekinci KL Abstract The lack of rapid antibiotic susceptibility tests adversely affects the treatment of bacterial infections and contributes to increased prevalence of multidrug-resistant bacteria. Here, we describe an all-electrical approach that allows for ultrasensitive measurement...
Fri May 01, 2020 14:01
Related ArticlesCharacterization of the coformycin biosynthetic gene cluster in Streptomyces kaniharaensis. Proc Natl Acad Sci U S A. 2020 Apr 29;: Authors: Ren D, Ruszczycky MW, Ko Y, Wang SA, Ogasawara Y, Kim M, Liu HW Abstract Coformycin and pentostatin are structurally related N-nucleoside inhibitors of adenosine deaminase characterized by an unusual 1,3-diazepine nucleobase. Herein, the cof gene cluster responsible for coformycin biosynthesis is...
Fri May 01, 2020 14:01
Related ArticlesGeometric charges and nonlinear elasticity of two-dimensional elastic metamaterials. Proc Natl Acad Sci U S A. 2020 Apr 29;: Authors: Bar-Sinai Y, Librandi G, Bertoldi K, Moshe M Abstract Problems of flexible mechanical metamaterials, and highly deformable porous solids in general, are rich and complex due to their nonlinear mechanics and the presence of nontrivial geometrical effects. While numeric approaches are successful, analytic...
Fri May 01, 2020 14:01
Related ArticlesStressed DNA replication generates stressed DNA. Proc Natl Acad Sci U S A. 2020 Apr 29;: Authors: Klein HL PMID: 32350136 [PubMed - as supplied by publisher]
Fri May 01, 2020 14:01
Related ArticlesMathematical modeling of human oocyte aneuploidy. Proc Natl Acad Sci U S A. 2020 Apr 29;: Authors: Tyc KM, McCoy RC, Schindler K, Xing J Abstract Aneuploidy is the leading contributor to pregnancy loss, congenital anomalies, and in vitro fertilization (IVF) failure in humans. Although most aneuploid conceptions are thought to originate from meiotic division errors in the female germline, quantitative studies that link the observed phenotypes...
Fri May 01, 2020 14:01
Related ArticlesEffective treatment of severe COVID-19 patients with tocilizumab. Proc Natl Acad Sci U S A. 2020 Apr 29;: Authors: Xu X, Han M, Li T, Sun W, Wang D, Fu B, Zhou Y, Zheng X, Yang Y, Li X, Zhang X, Pan A, Wei H Abstract After analyzing the immune characteristics of patients with severe coronavirus disease 2019 (COVID-19), we have identified that pathogenic T cells and inflammatory monocytes with large amount of interleukin 6 secreting may...
Fri May 01, 2020 14:01
Related ArticlesReply to Zhang et al.: The differential role of LRRK2 variants in nested leprosy phenotypes. Proc Natl Acad Sci U S A. 2020 Apr 28;: Authors: Fava VM, Cobat A, Gzara C, Alcaïs A, Abel L, Schurr E PMID: 32345724 [PubMed - as supplied by publisher]
Thu Apr 30, 2020 14:46
Related ArticlesAmyloid assembly is dominated by misregistered kinetic traps on an unbiased energy landscape. Proc Natl Acad Sci U S A. 2020 Apr 28;: Authors: Jia Z, Schmit JD, Chen J Abstract Atomistic description of protein fibril formation has been elusive due to the complexity and long time scales of the conformational search. Here, we develop a multiscale approach combining numerous atomistic simulations in explicit solvent to construct Markov State...
Thu Apr 30, 2020 14:46
Related ArticlesBringing light to ER contacts and a new phase in organelle communication. Proc Natl Acad Sci U S A. 2020 Apr 28;: Authors: Bag N, Ramezani M, Holowka DA, Baird BA PMID: 32345722 [PubMed - as supplied by publisher]
Thu Apr 30, 2020 14:46
Related ArticlesInhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant wobbler mice, a model of motor neuron degeneration. Proc Natl Acad Sci U S A. 2020 Apr 28;: Authors: Petit CS, Lee JJ, Boland S, Swarup S, Christiano R, Lai ZW, Mejhert N, Elliott SD, McFall D, Haque S, Huang EJ, Bronson RT, Harper JW, Farese RV, Walther TC Abstract Numerous mutations that impair retrograde membrane trafficking between endosomes and the...
Thu Apr 30, 2020 14:46
Related ArticlesDrosophila as a model for studying cystic fibrosis pathophysiology of the gastrointestinal system. Proc Natl Acad Sci U S A. 2020 Apr 28;: Authors: Kim K, Lane EA, Saftien A, Wang H, Xu Y, Wirtz-Peitz F, Perrimon N Abstract Cystic fibrosis (CF) is a recessive disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. The most common symptoms include progressive lung disease and chronic digestive conditions....
Thu Apr 30, 2020 14:46
Related ArticlesA widespread toxin-antitoxin system exploiting growth control via alarmone signaling. Proc Natl Acad Sci U S A. 2020 Apr 28;: Authors: Jimmy S, Saha CK, Kurata T, Stavropoulos C, Oliveira SRA, Koh A, Cepauskas A, Takada H, Rejman D, Tenson T, Strahl H, Garcia-Pino A, Hauryliuk V, Atkinson GC Abstract Under stressful conditions, bacterial RelA-SpoT Homolog (RSH) enzymes synthesize the alarmone (p)ppGpp, a nucleotide second messenger. (p)ppGpp...
Thu Apr 30, 2020 14:46
Related ArticlesThe evolutionary scaling of cellular traits imposed by the drift barrier. Proc Natl Acad Sci U S A. 2020 Apr 28;: Authors: Lynch M Abstract Owing to internal homeostatic mechanisms, cellular traits may experience long periods of stable selective pressures, during which the stochastic forces of drift and mutation conspire to generate variation. However, even in the face of invariant selection, the drift barrier defined by the genetic effective...
Thu Apr 30, 2020 14:46
Related ArticlesDevelopment of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy. Proc Natl Acad Sci U S A. 2020 Apr 28;: Authors: Tom I, Pham VC, Katschke KJ, Li W, Liang WC, Gutierrez J, Ah Young A, Figueroa I, Eshghi ST, Lee CV, Kanodia J, Snipas SJ, Salvesen GS, Lai P, Honigberg L, van Lookeren Campagne M, Kirchhofer D, Baruch A, Lill JR Abstract Genetic polymorphisms in the region...
Thu Apr 30, 2020 14:46
Related ArticlesAseismic transient slip on the Gofar transform fault, East Pacific Rise. Proc Natl Acad Sci U S A. 2020 Apr 28;: Authors: Liu Y, McGuire JJ, Behn MD Abstract Oceanic transform faults display a unique combination of seismic and aseismic slip behavior, including a large globally averaged seismic deficit, and the local occurrence of repeating magnitude (M) [Formula: see text] earthquakes with abundant foreshocks and seismic swarms, as on...
Thu Apr 30, 2020 14:46
Related ArticlesReexamining research on motivations and perspectives of scientists relating to public engagement. Proc Natl Acad Sci U S A. 2020 Apr 28;: Authors: Jensen EA PMID: 32345715 [PubMed - as supplied by publisher]
Thu Apr 30, 2020 14:46
Related ArticlesTurning up the heat in turbulent thermal convection. Proc Natl Acad Sci U S A. 2020 Apr 28;: Authors: Doering CR PMID: 32345714 [PubMed - as supplied by publisher]
Thu Apr 30, 2020 14:46
Related ArticlesIs there an antagonistic pleiotropic effect of a LRRK2 mutation on leprosy and Parkinson's disease? Proc Natl Acad Sci U S A. 2020 Apr 28;: Authors: Zhang DF, Wang D, Li YY, Yao YG PMID: 32345713 [PubMed - as supplied by publisher]
Thu Apr 30, 2020 14:46
Incidence of Dysphagia and Its Association With Functional Recovery and 1-Year Mortality in Hospitalized Older Patients With Heart Failure: A Prospective Cohort Study. JPEN J Parenter Enteral Nutr. 2020 May 02;: Authors: Matsuo H, Yoshimura Y, Fujita S, Maeno Y Abstract PURPOSE: Dysphagia following heart failure (HF) has gained little attention. This study aimed to evaluate the incidence of dysphagia and its associations with the clinical outcomes in...
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Related ArticlesThe Dysphagia in Multiple Sclerosis Questionnaire Correlates with Fiber-Optic Endoscopic Examination for Detecting Swallowing Deficits in MS. Dysphagia. 2020 Apr 30;: Authors: Grasso MG, Gamberini G, Patti F, D'Amico E, Bergamaschi R, Berra E, Giusti A, Cuccaro A, Messmer Uccelli M, Solaro C Abstract Multiple sclerosis (MS) refers to chronic inflammation of the central nervous system including the brain and spinal cord. Assessing for...
Sat May 02, 2020 14:41
Related ArticlesTherapy of Dysphagia by Prolonged Pharyngeal Electrical Stimulation (Phagenyx) in a Patient with Brainstem Infarction. Brain Sci. 2020 Apr 28;10(5): Authors: Florea C, Bräumann C, Mussger C, Leis S, Hauer L, Sellner J, Golaszewski SM Abstract Dysphagia after stroke impacts quality of life and is a risk factor for respiratory infections. Patients frequently require prophylactic measures including nasogastric tube or percutaneous endoscopic...
Sat May 02, 2020 14:41
The effect of tongue-strengthening exercises on tongue strength and swallowing-related parameters in chronic radiation-associated dysphagia. Head Neck. 2020 Apr 30;: Authors: Van den Steen L, Baudelet M, Tomassen P, Bonte K, De Bodt M, Van Nuffelen G Abstract BACKGROUND: Radiation-associated dysphagia (RAD) is highly prevalent in head and neck cancer (HNC) patients, with insufficient tongue strength (TS) as a characteristic of this disabling complication....
Fri May 01, 2020 13:33
Related ArticlesSIP SMART: a parallel group randomised feasibility trial of a tailored pre-treatment swallowing intervention package compared with usual care for patients with head and neck cancer. BMC Cancer. 2020 Apr 29;20(1):360 Authors: Govender R, Smith CH, Barratt H, Gardner B, Taylor SA Abstract BACKGROUND: Dysphagia or difficulty in swallowing affects quality of life for most patients with head and neck cancer. SIP SMART - [Swallowing Intervention...
Fri May 01, 2020 13:33
Related ArticlesCorrelation of Temporal Parameters of Laryngeal Excursion by Using Force-Sensing Resistor Sensors with Hyoid Motion in Videofluoroscopic Swallowing Study. Dysphagia. 2020 Apr 28;: Authors: Wang CM, Wang CJ, Shieh WY, Chen YC, Cheng WJ, Chang WH Abstract Small flexible force-sensing resistor (FSR) sensors can detect laryngeal excursion during swallowing, but the detected laryngeal excursion has not been correlated with videofluoroscopic...
Thu Apr 30, 2020 14:22
Related ArticlesBiomechanical Biomarkers of Tongue Impairment During Swallowing in Persons Diagnosed with Amyotrophic Lateral Sclerosis. Dysphagia. 2020 Apr 28;: Authors: Perry BJ, Stipancic KL, Martino R, Plowman EK, Green JR Abstract BACKGROUND: The impact of tongue dysfunction on deglutition in persons diagnosed with amyotrophic lateral sclerosis (ALS) is not well understood. This information is needed to improve our understanding of the mechanisms...
Thu Apr 30, 2020 14:22
Related ArticlesVisiting Sub-Interships in Wake of the Covid-19 Crisis: An Opportunity for Improvement. Ann Plast Surg. 2020 Apr 30;: Authors: Patel V, Nolan IT, Morrison SD, Fosnot J PMID: 32358231 [PubMed - as supplied by publisher]
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Related ArticlesPLASTIC SURGERY AND THE COVID-19 PANDEMIC: A REVIEW OF CLINICAL GUIDELINES. Ann Plast Surg. 2020 May 01;: Authors: Ozturk CN, Kuruoglu D, Ozturk C, Rampazzo A, Gurunian Gurunluoglu R Abstract BACKGROUND: A novel coronavirus disease (COVID-19) was first reported in December 2019 in China and was soon declared a pandemic by World Health Organization. Many elective and non-essential surgeries were postponed worldwide in an effort to minimize...
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Related ArticlesThe Use of Ultrasound Guidance for the Treatment of Raynaud Disease of the Hand With Botulinum Toxin. Ann Plast Surg. 2020 Feb 20;: Authors: Lobb DC, Pierce J, Perry M, DeGeorge B Abstract BACKGROUND: This study sought to examine the feasibility and effectiveness of the use of ultrasound (US) as a clinical adjunct in the delivery of botulinum toxin for the treatment of Raynaud disease of the hand. METHODS: One cadaver hand was...
Sat May 02, 2020 14:45
Related ArticlesScreening and Intervention for Skin Cancer in the Galapagos. Ann Plast Surg. 2020 Apr 28;: Authors: Ayasse MT, Marquez JE, Lozeau DF, Slutsky JB, Kaufmann TL, Lee Y, Scriven RJ, Dagum AB Abstract OBJECTIVE: This study aimed to assess the general dermatological needs and correlation of tentative skin cancer screening diagnoses with histopathological confirmation in the highly sun-exposed locals of the Galapagos Islands. METHODS:...
Sat May 02, 2020 14:45
Catheter-Based Computer Tomography Angiography in Double-Skin Paddle Anterolateral Thigh Perforator.
Related ArticlesCatheter-Based Computer Tomography Angiography in Double-Skin Paddle Anterolateral Thigh Perforator. Ann Plast Surg. 2020 Apr 27;: Authors: Pang X, Qing L, Wu P, Tang JY PMID: 32349085 [PubMed - as supplied by publisher]
Thu Apr 30, 2020 15:05
Related ArticlesA Simplified Approach to Myelomeningocele Defect Repair. Ann Plast Surg. 2020 Apr 27;: Authors: Brown OH, Makar KG, Ulma RM, Buchman SR, Kasten SJ, Muraszko KM, Vercler CJ Abstract BACKGROUND: Repair of the soft tissue defect in myelomeningoceles remains challenging. The literature currently lacks a systematic approach, reporting high rates of complications. We present outcomes from the largest series to date and describe a simplified...
Thu Apr 30, 2020 15:05
Related ArticlesThe Impact of Social Media on Plastic Surgery Residency Applicants. Ann Plast Surg. 2020 Apr 27;: Authors: Irwin TJ, Riesel JN, Ortiz R, Helliwell LA, Lin SJ, Eberlin KR Abstract BACKGROUND: Plastic surgeons have been early adopters of social media, and the efficacy and ethics of this practice have been studied. In addition, plastic and reconstructive surgery (PRS) training programs have begun using social media to connect with the public,...
Thu Apr 30, 2020 15:05
Related ArticlesPatient- and Physician-Reported Outcome of Combined Fractional CO2 and Pulse Dye Laser Treatment for Hypertrophic Scars in Children. Ann Plast Surg. 2020 Apr 27;: Authors: Elrod J, Schiestl C, Neuhaus D, Mohr C, Neuhaus K Abstract BACKGROUND: Hypertrophic scars are commonly seen in children and associated with pruritus, pain, functional impairment, and aesthetic disfigurement. Ablative fractional CO2 and pulse dye laser are emerging techniques...
Thu Apr 30, 2020 15:05
Related ArticlesOutlook for Independent Plastic Surgery Training: A Survey of Plastic Surgery Program Directors. Ann Plast Surg. 2020 Apr 27;: Authors: Ovadia SA, Thaller SR Abstract INTRODUCTION: Traditionally, plastic surgery training occurs through the independent model after completion of another surgical residency. Training is a minimum of 3 years in duration. Integrated training in contrast commences upon completion of medical school and is a minimum...
Thu Apr 30, 2020 15:05
Related ArticlesA Human-Derived, Collagen-Rich Hydrogel Augments Wound Healing in a Diabetic Animal Model. Ann Plast Surg. 2020 Apr 27;: Authors: Williams T, Sotelo Leon D, Kaizawa Y, Wang Z, Leyden J, Chang J, Fox PM Abstract BACKGROUND: Application of collagen products to wounds has been shown to improve wound healing. Using a collagen-based hydrogel (cHG) capable of cellular support previously developed by our laboratory, we hypothesize that our hydrogel...
Thu Apr 30, 2020 15:05
Related ArticlesMedial Sural Artery Perforator Flap for Leg and Knee Coverage: Extended Skin Paddle With 2 Perforators. Ann Plast Surg. 2020 Apr 27;: Authors: Luca-Pozner V, Delgove A, Kerfant N, Karra A, Herlin C, Chaput B Abstract BACKGROUND: For soft-tissue defect coverage in the lower leg and around the knee joint, the gastrocnemius muscle flap is the most commonly used. Having constant anatomy, a long pedicle, and decreased donor site morbidity,...
Thu Apr 30, 2020 15:05
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