Related ArticlesDoes the addition of cannabidiol to conventional antiepileptic drug treatment reduce seizure frequency in dogs with epilepsy? Vet Rec. 2020 May 02;186(15):492-493 Authors: Morrow L, Belshaw Z PMID: 32358117 [PubMed - as supplied by publisher]
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Related ArticlesPharmacogenomics of Cognitive Dysfunction and Neuropsychiatric Disorders in Dementia. Int J Mol Sci. 2020 Apr 26;21(9): Authors: Cacabelos R Abstract Symptomatic interventions for patients with dementia involve anti-dementia drugs to improve cognition, psychotropic drugs for the treatment of behavioral disorders (BDs), and different categories of drugs for concomitant disorders. Demented patients may take >6-10 drugs/day with the consequent...
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Related Articles[Pilot Data from the Evaluation of an Integrative Body Psychotherapy Program for Patients with Psychogenic Non-Epileptic Seizures]. Psychother Psychosom Med Psychol. 2020 Apr 30;: Authors: Senf-Beckenbach P, Hinkelmann K, Hoheisel M, Devine J, Rose M Abstract Psychogenic non-epileptic seizures (PNES) occur in the context of various diseases. Therefore, PNES patients represent a heterogeneous group with different causative disorders. The...
Sat May 02, 2020 14:30
Related ArticlesTwo novel ECHS1 variants, affecting splicing and reducing enzyme activity, is associated with mitochondrial encephalopathy in infant: a case report. BMC Neurol. 2020 Apr 30;20(1):165 Authors: Wu M, Gao W, Deng Z, Liu Z, Ma J, Xiao H, Xu Y, Sun D Abstract BACKGROUND: Short-chain enoyl-CoA hydratase (ECHS1) is a multifunctional mitochondrial matrix enzyme involved in the second step of mitochondrial fatty acid β-oxidation. Mitochondrial...
Sat May 02, 2020 14:30
Related ArticlesChanges in Serum Valproate and Levetiracetam Levels Related to Sex Steroids in Adolescent Girls. Pediatr Neurol. 2019 07;96:76-78 Authors: Şahin S, Yılmaz SA, Cansu A, Kamaşak T, Arslan EA, Kaklıkkaya N PMID: 31023605 [PubMed - indexed for MEDLINE]
Sat May 02, 2020 14:30
Related ArticlesPhysical and Family History Variables Associated With Neurological and Cognitive Development in Sturge-Weber Syndrome. Pediatr Neurol. 2019 07;96:30-36 Authors: Day AM, McCulloch CE, Hammill AM, Juhász C, Lo WD, Pinto AL, Miles DK, Fisher BJ, Ball KL, Wilfong AA, Levin AV, Thau AJ, Comi AM, National Institute of Health Sponsor: Rare Disease Clinical Research Consortium (RDCRN) Brain and Vascular Malformation Consortium (BVMC) SWS Investigator Group, Koenig...
Sat May 02, 2020 14:30
Related ArticlesNeurologic disorders in 4858 survivors of central nervous system tumors in childhood-an Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study. Neuro Oncol. 2019 01 01;21(1):125-136 Authors: Kenborg L, Winther JF, Linnet KM, Krøyer A, Albieri V, Holmqvist AS, Tryggvadottir L, Madanat-Harjuoja LM, Stovall M, Hasle H, Olsen JH, ALiCCS study group Abstract Background: A comprehensive overview of neurologic complications among...
Sat May 02, 2020 14:30
RNAi-Based Gene Therapy Rescues Developmental and Epileptic Encephalopathy in a Genetic Mouse Model.
RNAi-Based Gene Therapy Rescues Developmental and Epileptic Encephalopathy in a Genetic Mouse Model. Mol Ther. 2020 Apr 16;: Authors: Aimiuwu OV, Fowler AM, Sah M, Teoh JJ, Kanber A, Pyne NK, Petri S, Rosenthal-Weiss C, Yang M, Harper SQ, Frankel WN Abstract Developmental and epileptic encephalopathy (DEE) associated with de novo variants in the gene encoding dynamin-1 (DNM1) is a severe debilitating disease with no pharmacological remedy. Like most...
Fri May 01, 2020 13:32
Seizure Freedom as an Outcome in Epilepsy Treatment Clinical Trials. Acta Neurol Scand. 2020 Apr 30;: Authors: Halford JJ, Edwards JC Abstract Seizure freedom is recognized as the goal of epilepsy treatment by patients, families, and in treatment guidelines, and is associated with notably improved quality of life. However, many studies of epilepsy treatments (including antiseizure medications/antiepileptic drugs, neurostimulation, and dietary therapies)...
Fri May 01, 2020 13:32
Transcutaneous Vagus Nerve Stimulation Does Not Affect Verbal Memory Performance in Healthy Volunteers. Front Psychol. 2020;11:551 Authors: Mertens A, Naert L, Miatton M, Poppa T, Carrette E, Gadeyne S, Raedt R, Boon P, Vonck K Abstract Introduction: Invasive vagus nerve stimulation (VNS) improves word recognition memory in patients with epilepsy. Recent studies with transcutaneous VNS (tVNS) have also shown positive effects on various subdomains of...
Fri May 01, 2020 13:32
Pregabalin as a Pain Therapeutic: Beyond Calcium Channels. Front Cell Neurosci. 2020;14:83 Authors: Alles SRA, Cain SM, Snutch TP Abstract Initially developed to generate new treatments for epilepsy, gabapentin, and pregabalin ("gabapentinoids") were engineered to mimic the action of GABA and to modulate GABA metabolism. Rather than their intended pharmacological action on GABA neurotransmission, instead, they exhibit a high affinity for the α2δ-1 and...
Fri May 01, 2020 13:32
Methimazole Inhibits the Expression of GFAP and the Migration of Astrocyte in Scratched Wound Model In Vitro. Mediators Inflamm. 2020;2020:4027470 Authors: Zhao L, Zhang X, Zhang C Abstract Astrocytes respond to central nervous system (CNS) insults with varieties of changes, such as cellular hypertrophy, migration, proliferation, scar formation, and upregulation of glial fibrillary acidic protein (GFAP) expression. While scar formation plays a very important...
Fri May 01, 2020 13:32
Related ArticlesA Phase II Randomized Trial to Explore the Potential for Pharmacokinetic Drug-Drug Interactions with Stiripentol or Valproate when Combined with Cannabidiol in Patients with Epilepsy. CNS Drugs. 2020 Apr 30;: Authors: Ben-Menachem E, Gunning B, Arenas Cabrera CM, VanLandingham K, Crockett J, Critchley D, Wray L, Tayo B, Morrison G, Toledo M Abstract BACKGROUND: In recent randomized, placebo-controlled, phase III trials, highly purified...
Fri May 01, 2020 13:32
Related ArticlesNew Treatment for Partial-Onset Seizures in Adults. Am J Nurs. 2020 03;120(3):24-25 Authors: Aschenbrenner DS PMID: 32079793 [PubMed - indexed for MEDLINE]
Fri May 01, 2020 13:32
Related ArticlesBathing and Hot Water Epilepsy. Pediatr Neurol. 2020 03;104:72 Authors: Panda PK, Sharawat IK PMID: 31911025 [PubMed - indexed for MEDLINE]
Fri May 01, 2020 13:32
Related ArticlesHypsarrhythmia and spasms resolution after Valproic acid discontinuation in an infantile spasm patient. Neurosciences (Riyadh). 2019 Oct;24(4):311-314 Authors: Alsallumi MS Abstract Several studies have reported a variable benefit of valproic acid for the treatment of infantile spasm. However, valproic acid can also worsen spasms, as occurred with this child who presented with post-traumatic seizure which evolved to spasms. The child...
Fri May 01, 2020 13:32
Related ArticlesAntiepileptogenic effects of Ethosuximide and Levetiracetam in WAG/Rij rats are only temporary. Pharmacol Rep. 2019 Oct;71(5):833-838 Authors: Leo A, Caro C, Nesci V, Palma E, Tallarico M, Iannone M, Constanti A, Sarro G, Russo E, Citraro R Abstract BACKGROUND: WAG/Rij rats represent a validated genetic animal model of epileptogenesis, absence epilepsy and depressive-like comorbidity. Some treatments (e.g. ethosuximide), using specific...
Fri May 01, 2020 13:32
Related ArticlesAminoglycoside drugs induce efficient read-through of CDKL5 nonsense mutations, slightly restoring its kinase activity. RNA Biol. 2019 10;16(10):1414-1423 Authors: Fazzari M, Frasca A, Bifari F, Landsberger N Abstract The X-linked CDKL5 gene codes for a kinase whose mutations have been associated with a suite of neurodevelopmental disorders generally characterized by early-onset epileptic encephalopathy and severe intellectual disability....
Fri May 01, 2020 13:32
Related ArticlesSeizures in patients with a phaeochromocytoma/paraganglioma (PPGL): A review of clinical cases and postulated pathological mechanisms. Rev Neurol (Paris). 2019 Oct;175(9):495-505 Authors: Li Y, Zhang B Abstract The purpose of this work was to expound on the postulated pathological mechanisms through which pheochromocytoma/paraganglioma (PPGL) can cause seizures by conducting a comprehensive review of ten cases and several pathogenic...
Fri May 01, 2020 13:32
Related ArticlesAssessment of Interlaboratory Variation in the Interpretation of Genomic Test Results in Patients With Epilepsy. JAMA Netw Open. 2020 Apr 01;3(4):e203812 Authors: SoRelle JA, Pascual JM, Gotway G, Park JY Abstract Importance: Discordance in the interpretations of genetic test results has occurred with the increased number of laboratories that are performing testing. Differences in diagnostic interpretations may have implications for the...
Thu Apr 30, 2020 14:09
Related ArticlesStructure-based discovery of caspase-1 inhibitor with therapeutic potential for febrile seizures and later enhanced epileptogenic susceptibility. Br J Pharmacol. 2020 Apr 28;: Authors: Tang Y, Feng B, Wang Y, Sun H, You Y, Yu J, Chen B, Xu C, Ruan Y, Cui S, Hu G, Hou T, Chen Z Abstract BACKGROUND AND PURPOSE: Febrile seizures (FS), the most common seizures in childhood and often accompanied by later epileptogenesis, are not well controlled....
Thu Apr 30, 2020 14:09
Related ArticlesTuberous sclerosis complex associated intracranial lesion found by antenatal ultrasound. Radiol Case Rep. 2020 Jul;15(7):816-818 Authors: Hanes I, Muir K, Abdeen N, Sell E Abstract Tuberous sclerosis complex (TSC) is characterized by the growth of benign tumors in the skin, brain, kidneys, lung and heart [1]. Prognosis is mostly determined by the extent of brain involvement as tumors in the brain lead to seizures, cognitive impairment...
Thu Apr 30, 2020 14:09
Related ArticlesBilateral Femoral Neck Fracture Secondary to Seizure: Treatment with Total Hip Arthroplasty by the Direct Anterior approach. Rev Bras Ortop (Sao Paulo). 2020 Apr;55(2):254-257 Authors: Kimura OS, de Moraes RFP, Fernandes MBC, Freitas EHC, Seabra A, Lima GK Abstract Bilateral fracture of the femoral neck secondary to seizure is a rare event. The occurrence of these lesions is related to vigorous tonic-clonic muscular contractions and to...
Thu Apr 30, 2020 14:09
Related ArticlesExpansionHunter Denovo: a computational method for locating known and novel repeat expansions in short-read sequencing data. Genome Biol. 2020 Apr 28;21(1):102 Authors: Dolzhenko E, Bennett MF, Richmond PA, Trost B, Chen S, van Vugt JJFA, Nguyen C, Narzisi G, Gainullin VG, Gross AM, Lajoie BR, Taft RJ, Wasserman WW, Scherer SW, Veldink JH, Bentley DR, Yuen RKC, Bahlo M, Eberle MA Abstract Repeat expansions are responsible for over 40...
Thu Apr 30, 2020 14:09
Related ArticlesInterdisciplinary medication review to improve pharmacotherapy for patients with intellectual disabilities. Int J Clin Pharm. 2019 Dec;41(6):1516-1525 Authors: Granas AG, Halvorsen KH, Wendelbo J, Johannessen Landmark C Abstract Background Patients with intellectual disabilities is an underserved patient group that have poor abilities to express their health complaints. Objective The aim of this study was to improve pharmacotherapy in...
Thu Apr 30, 2020 14:09
Related ArticlesAnticonvulsive effect of anterior thalamic deep brain stimulation in super-refractory status epilepticus crucially depends on active stimulation zone-A single case observation. Seizure. 2019 10;71:286-288 Authors: Imbach LL, Baumann CR, Poryazova R, Geissler O, Brugger P, Sarnthein J, Mothersill I, Weller M, Oertel MF, Stieglitz LH PMID: 31493681 [PubMed - indexed for MEDLINE]
Thu Apr 30, 2020 14:09
Related ArticlesHyperperfusion can identify epileptic stroke mimics. Pract Neurol. 2019 Aug;19(4):352-353 Authors: Popkirov S, Grönheit W PMID: 31227576 [PubMed - indexed for MEDLINE]
Thu Apr 30, 2020 14:09
Related ArticlesOscillations in cortico-basal ganglia circuits: implications for Parkinson's disease and other neurologic and psychiatric conditions. J Neurophysiol. 2019 07 01;122(1):203-231 Authors: Halje P, Brys I, Mariman JJ, da Cunha C, Fuentes R, Petersson P Abstract Cortico-basal ganglia circuits are thought to play a crucial role in the selection and control of motor behaviors and have also been implicated in the processing of motivational content...
Thu Apr 30, 2020 14:09
Related ArticlesAnalysis for the Association Between Corpus Callosum Thickness and Corpus Callosotomy Outcomes for Patients With Epileptic Spasms or Tonic Spasms. Pediatr Neurol. 2019 06;95:79-83 Authors: Itamura S, Okanishi T, Nishimura M, Kanai S, Baba S, Masuda Y, Homma Y, Enoki H, Fujimoto A Abstract BACKGROUND: This retrospective study is designed to determine whether the thickness of the corpus callosum can predict corpus callosotomy outcome in...
Thu Apr 30, 2020 14:09
Related ArticlesThe effectiveness of music therapy for individuals with Rett syndrome and their families. J Formos Med Assoc. 2019 Dec;118(12):1633-1643 Authors: Chou MY, Chang NW, Chen C, Lee WT, Hsin YJ, Siu KK, Chen CJ, Wang LJ, Hung PL Abstract BACKGROUND: Patients with Rett syndrome (RTT) present characteristic regression in communication and hand skills, which eventually leads to intellectual and physical disability. Moreover, caregivers of patients...
Thu Apr 30, 2020 14:09
Related ArticlesLarge Thyroglossal Duct Cyst: A Case Report. Am J Case Rep. 2020 May 02;21:e919745 Authors: Mortaja S, Sebeih H, Alobida NW, Al-Qahtani K Abstract BACKGROUND Thyroglossal duct cysts are the most common congenital neck cysts. They typically present in childhood and early adulthood, and average a size of 2-4 cm, but can also present in later adult life. CASE REPORT We present a case of a 36-year-old female patient with a very large midline...
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Related ArticlesRuptured Arteriovenous Malformation Anterior to the Brainstem to a Child with Subsequent Spontaneous Thrombosis: Case Report and Literature Review. Am J Case Rep. 2020 May 01;21:e923289 Authors: Panagopoulos D, Markogiannakis G, Themistocleous M Abstract BACKGROUND Cerebral arteriovenous malformations (AVMs) are considered to be abnormalities of congenital origin, presumably arising due to a disorder in the process of embryogenesis, in...
Sat May 02, 2020 13:30
A Rare Case of Large Solid Pseudopapillary Tumor in a Child: A Care Report. Am J Case Rep. 2020 Apr 30;21:e923990 Authors: Minh Xuan N, Khanh Tuong TT, Quang Huy H Abstract BACKGROUND Solid pseudopapillary tumor (SPT) is a rare disease with low-grade malignancy potential of the pancreas. SPT accounts from 0.13% to 2.7% of all exocrine pancreatic tumors. We report an unusual case with a large solid pseudopapillary tumor that was diagnosed and treated...
Fri May 01, 2020 14:47
Related ArticlesMultiple Neural Tube Defects: A Case Report. Am J Case Rep. 2020 Apr 30;21:e922312 Authors: Jamous MA, Daoud SS, Abu-Aqoulah AM Abstract BACKGROUND Incomplete closure of the neural tube results in congenital anomalies called neural tube defects (NTD). These defects are rarely multiple, and are characterized by loss of central nervous system soft tissue and bony coverings, along with herniation of the involved part of the CNS through the...
Fri May 01, 2020 14:47
Related ArticlesAcute Intestinal Infarction Due to Diffuse Jejunoileal and Mesenteric Lipomatosis in a 39-Year-Old Woman. Am J Case Rep. 2020 Apr 29;21:e922830 Authors: Cojocari N, David L Abstract BACKGROUND Although lipomas are common benign tumors of adipose tissue, diffuse lipomas involving the small bowel, large bowel, and mesentery are rare. Multiple non-encapsulated lipomas characterize diffuse intestinal and mesenteric lipomatosis. Intestinal...
Thu Apr 30, 2020 16:04
Related ArticlesLeiomyosarcoma Tumor Embolism Masquerading as Thrombus in Transit. Am J Case Rep. 2020 Apr 29;21:e921124 Authors: Rosenfeld BL, Bashir R, Brisco-Bacik MA, Panidis IP, Vaidya A, Minakata K, Forfia PR Abstract BACKGROUND Tumor embolism is a rare neoplastic complication that occurs when there is intravenous invasion by a benign or malignant tumor. We present the case of an asymptomatic patient with an incidentally discovered leiomyosarcoma...
Thu Apr 30, 2020 14:01
Related ArticlesMultiple acid-base and electrolyte disturbances upregulate NBCn1, NBCn2, IRBIT and L-IRBIT in the mTAL. J Physiol. 2020 May 02;: Authors: Wang JL, Wang XY, Wang DK, Parker MD, Musa-Aziz R, Popple J, Guo YM, Min TX, Xia T, Tan M, Liu Y, Boron WF, Chen LM Abstract KEY POINTS: The roles of the Na+ /HCO3 - cotransporters NBCn1 and NBCn2 as well as their activators IRBIT and L-IRBIT in the regulation of the mTAL transport of NH4 + , HCO3 -...
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Related ArticlesMitochondrial lactate metabolism: history and implications for exercise and disease. J Physiol. 2020 May 02;: Authors: Glancy B, Kane DA, Kavazis AN, Goodwin ML, Willis WT, Gladden LB Abstract Mitochondrial structures were probably observed microscopically in the 1840s, but the idea of oxidative phosphorylation (OXPHOS) within mitochondria did not appear until the 1930s. The foundation for research into energetics arose from Meyerhof's...
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A 'fatigue threshold' during incremental exercise was identified (and then forgotten) 100 years ago.
Related ArticlesA 'fatigue threshold' during incremental exercise was identified (and then forgotten) 100 years ago. J Physiol. 2020 May 02;: Authors: Zoladz JA, Grassi B PMID: 32358814 [PubMed - as supplied by publisher]
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