Related ArticlesKetogenic low CHO, high fat diet: the future of elite endurance sport? J Physiol. 2020 May 02;: Authors: Burke LM Abstract KEY POINTS: A ketogenic low carbohydrate high fat (K-LCHF) diet can achieve a substantial (∼200%) increase in maximal rates of fat oxidation during exercise in endurance-trained athletes, up to ∼1.5 g min-1 at ∼70% of peak aerobic capacity. In high-level athletes, considerable individual variability is observed but...
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Related ArticlesInfiltration of intramuscular adipose tissue impairs skeletal muscle contraction. J Physiol. 2020 May 02;: Authors: Biltz NK, Collins KH, Shen KC, Schwartz K, Harris CA, Meyer GA Abstract KEY POINTS: Muscle infiltration with adipose tissue (IMAT) is common and associated with loss of skeletal muscle strength and physical function across a diverse set of pathologies. Whether the association between IMAT and muscle weakness is causative...
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Related ArticlesThyroid hormones as regulators of mammalian metamorphosis. J Physiol. 2020 May 02;: Authors: Thornburg KL, Chattergoon NN PMID: 32358795 [PubMed - as supplied by publisher]
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Related ArticlesCalcium and cell function. J Physiol. 2020 May;598(9):1647-1648 Authors: Prakriya M PMID: 32350889 [PubMed - in process]
Fri May 01, 2020 13:11
Related ArticlesSimulating the space station: a launch pad for new explorations in integrative physiology. J Physiol. 2020 Apr 29;: Authors: Leacy JK, O'Halloran KD, Day TA PMID: 32347549 [PubMed - as supplied by publisher]
Thu Apr 30, 2020 15:50
Related ArticlesNew insights into resting and exertional right ventricular performance in the healthy heart through real-time pressure-volume analysis. J Physiol. 2020 Apr 29;: Authors: Cornwell WK, Tran T, Cerbin L, Coe G, Muralidhar A, Hunter K, Altman N, Ambardekar AV, Tompkins C, Zipse M, Schulte M, O'Gean K, Ostertag M, Hoffman J, Pal JD, Lawley JS, Levine BD, Wolfel E, Kohrt WM, Buttrick P Abstract KEY POINTS: Despite growing interest in right...
Thu Apr 30, 2020 15:50
Related ArticlesHIITing the brain with exercise; mechanisms, consequences and practical recommendations. J Physiol. 2020 Apr 29;: Authors: Calverley TA, Ogoh S, Marley CJ, Steggall M, Marchi N, Brassard P, Lucas SJE, Cotter JD, Roig M, Ainslie PN, Wisløff U, Bailey DM Abstract The increasing number of older adults has seen a corresponding growth in those affected by neurovascular diseases, including stroke and dementia. Since cures are currently unavailable,...
Thu Apr 30, 2020 15:50
Related ArticlesIncreased skin wettedness independently augments cool-seeking behaviour during passive heat stress. J Physiol. 2020 Apr 29;: Authors: Vargas N, Chapman C, Ji W, Johnson B, Gathercole R, Schlader Z Abstract KEY POINTS: Skin wettedness occurring secondary to the buildup of sweat on the skin provokes thermal discomfort, the precursor to engaging in cool-seeking behaviour. Associative evidence indicates that skin wettedness stimulates cool-seeking...
Thu Apr 30, 2020 15:50
Related ArticlesNeuronal hypertrophy dampens neuronal intrinsic excitability and stress responsiveness during chronic stress. J Physiol. 2020 Apr 29;: Authors: Matovic S, Ichiyama A, Igarashi H, Salter EW, Sunstrum JK, Wang XF, Henry M, Kuebler ES, Vernoux N, Martinez-Trujillo J, Tremblay ME, Inoue W Abstract KEY POINTS: The hypothalamic-pituitary-adrenal (HPA) axis habituates to repeated stress exposure. We studied hypothalamic corticotropin-releasing...
Thu Apr 30, 2020 15:50
Related ArticlesThe effect of lifelong endurance exercise on cardiovascular structure and exercise function in women. J Physiol. 2020 Apr 29;: Authors: Carrick-Ranson G, Sloane NM, Howden EJ, Bhella PS, Sarma S, Shibata S, Fujimoto N, Hastings JL, Levine BD Abstract KEY POINTS: The beneficial effects of sustained or lifelong (>25 years) endurance exercise on cardiovascular structure and exercise function have been largely established in men. The current...
Thu Apr 30, 2020 15:50
Sat May 02, 2020 22:34
Abstract Background Acne cysts are a common dermatological problem that often leads to scarring and a significant negative impact on patients’ psyche. Objective To report the usefulness of intralesional foam sclerotherapy for the treatment of cystic acne. Material and methods Patients with cystic acne treated with intralesional foam sclerotherapy between June 2018 and May 2019 were identified. Treatment response and adverse effects were assessed during follow‐up. Results Twelve...
Sat May 02, 2020 19:34
Abstract Acne vulgaris is a common adolescents’ disorder. Nevertheless, there is lack of knowledge about acne among adolescents. To evaluate the adolescents’ knowledge and beliefs about acne, to investigate help‐seeking behavior and treatment preferences. A cross‐sectional study conducted in 10 public high schools in Tirana. A total of 2036 students enrolled. All participants were asked about socio‐demographic data, knowledge and beliefs about acne, treatment seeking behaviors and clinical preferences....
Sat May 02, 2020 19:14
Sat May 02, 2020 19:04
Abstract COVID‐19 is a pandemic disease caused by SARS‐CoV‐2 with high morbidity and mortality. There are very limited data on the interference of immunomodulating drugs on the risk of infection and on the course of the disease. In particular, there are no current clinical data about the interference exerted by dupilumab, a biologic drugs blocking IL‐4 and IL‐13, used for adult atopic dermatitis (AD). The pathogenesis of COVID‐19 is complex, characterized by an immune response mainly Th1/Th17. The...
Sat May 02, 2020 18:54
Sat May 02, 2020 18:18
Sat May 02, 2020 18:15
Abstract Background The clinical presentation of primary antiphospholipid syndrome (PAPS) can vary, often mimicking many other medical conditions. Therefore, it is difficult to diagnose at the first presentation because of the absence of classical symptoms. We described an unusual presentation of PAPS mimicking livedoid vasculopathy (LV), where the only diagnostic clue at the initial presentation was skin lesions in both lower legs. Methods A 75‐year‐old Han Chinese woman presented with...
Sat May 02, 2020 18:14
Abstract Background Tuberculin skin test (TST), which is used in the diagnosis of latent tuberculosis infection may cause Koebner's phenomenon and false positive results in psoriasis patients. Objective The purpose of this study is to compare TST with QuantiFERON‐TB Gold Plus (QFT‐plus) test in psoriasis patients, and to determine the effects of psoriasis on TST results. Methods Ninety‐two psoriasis patients and 30 control subjects were included in the study. QFT‐plus test, TST and...
Sat May 02, 2020 18:08
Abstract Mogamulizumab shows cytotoxicity against CCR4+ lymphoma cells by antibody‐dependent cell‐mediated cytotoxicity (ADCC) in advanced cutaneous T cell lymphoma (CTCL) patients. Although mogamulizumab is used as one of the anchor drugsfor the treatment of advanced CTCL, its efficacy is unsatisfactory, especially in mycosis fungoides (MF). Therefore, additional drugs to enhance the antitumor effects of mogamulizumab is needed to further optimize its use for the treatment of MF. In this report,two...
Sat May 02, 2020 16:23
Abstract Many patients with psoriasis fail to respond to biologic drugs either initially or lose response over time, the latter having predominantly been linked to low circulating drug levels. We examined how serum drug levels varied over three treatment cycles of stable maintenance therapy with either adalimumab or infliximab among a total of 28 patients with psoriasis (22 men, mean age 48.6 years, mean treatment time 6.2 years) and whether there was an association with various patient‐specific...
Sat May 02, 2020 15:19
Abstract COVID‐19 disease, is a highly contagious and a particularly popular problem in all countries. A variety of repurposed drugs and investigational drugs such as remdesivir, chloroquine, hydroxychloroquine, ritonavir, lopinavir, inteferon‐beta and the other potential drugs have been studied for COVID19 treatment. We reviewed the potential dermatological side‐effects of these drugs. This article is protected by copyright. All rights reserved.
Fri May 01, 2020 21:56
ABSTRACT The recent EAACI/GA2LEN/EDF/WAO guidelines recommend omalizumab (anti‐IgE) for the management of patients aged ≥12 years with chronic urticaria unresponsive to high‐doses second generation H1−antihistamines (antiH1). However, there is little published information on the success of omalizumab for such a treatment in children. We reported our experience of six patients with chronic spontaneous urticaria (CSU) treated with omalizumab. Mean age of our case series was 14.7 years (range 11‐16 years)...
Fri May 01, 2020 21:56
Fri May 01, 2020 21:55
Abstract Coronavirus disease 2019 (COVID‐19) is an infectious disease, caused by severe acute respiratory syndrome (SARS)‐CoV‐2, that broke out in December 2019. In just four months it has spread to almost every country in the world and up to April 182 020, the virus has infected more than 2 million people. Itch is the most common symptom in dermatology and a frequent one of systemic diseases. The association of itch and viral diseases has been widely documented; however, the actual prevalence of...
Fri May 01, 2020 21:54
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Fri May 01, 2020 14:59
ABSTRACT During COVID‐19 outbreak there are discordant opinion towards the impact on biologics in psoriatic patients. Thus we performed a single center case‐control study in Lombardia, the Italian region with the higher number of COVID‐19 confirmed cases. We enrolled 1193 PsO patients treated with biologics and small molecules and we used the entire Lombardia population as controls. Notably, 17 PsO patients COVID‐19 confirmed were quarantined at home and 5 hospitalized, no PsO patients were admitted...
Fri May 01, 2020 14:55
Abstract Palmoplantar psoriasis (PPP) is a chronic, inflammatory dermatosis of the palms and/or soles with significant morbidity. It is notoriously difficult to treat and unresponsive to traditional topical agents. To compare the effect of oral Methotrexate (MTX) monotherapy vs Methotrexate plus Narrowband UVB (NB‐UVB) in treatment of recalcitrant PPP. This was a comparative clinical trial involving 90 patients of PPP. Eligible patients were randomly assigned to one of the two treatment groups....
Fri May 01, 2020 14:54
Wed Apr 29, 2020 14:23
Abstract Coronavirus disease, first emerged in Wuhan, rapidly spread all over the World since December 2019. There are concerns about elective dermatology appointments and its results. Herein, we aimed to find out which type of dermatologic patients attended to dermatology outpatient clinic. The patients visiting the clinics for elective dermatologic diseases between 11 and March 18, 2020 were included in this study. Their age, sex, diagnosis of disease, requirement for emergent intervention, and...
Wed Apr 29, 2020 14:20
Abstract Background In the literature, there are reports about dermoscopic and size changes of nevi in patients undergoing biologic therapy and chemotherapeutics. There hasn't been any established data for melanoma and Rituximab therapy. Materials and Methods Sixteen patients, with 94 nevi were included in this study. Dermoscopic images of followup visits, which were performed at baseline, 3 months, 6 months, and 12 months after treatment, were evaluated. Suspicious lesions were excised....
Wed Apr 29, 2020 14:20
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