Related Articles Overview of risk assessment models for venous thromboembolism in ambulatory patients with cancer. Thromb Res. 2020 Jul;191 Suppl 1:S50-S57 Authors: Gerotziafas GT, Mahé I, Lefkou E, AboElnazar E, Abdel-Razeq H, Taher A, Antic D, Elalamy I, Syrigos K, Van Dreden P Abstract A B S T R A C T Important progress has been made in the development of risk assessment models (RAM) for the identification of outpatients on anticancer treatment...
Sun Aug 02, 2020 13:26
Related Articles ATM mutations improve radio-sensitivity in wild-type isocitrate dehydrogenase-associated high-grade glioma: retrospective analysis using next-generation sequencing data. Radiat Oncol. 2020 Jul 31;15(1):184 Authors: Kim N, Kim SH, Kang SG, Moon JH, Cho J, Suh CO, In Yoon H, Chang JH Abstract BACKGROUND: To identify the association between somatic ataxia-telangiectasia mutated (ATM) mutations and improved radio-sensitivity, we...
Sun Aug 02, 2020 13:26
Related Articles Evaluating different adoption scenarios for TIL-therapy and the influence on its (early) cost-effectiveness. BMC Cancer. 2020 Jul 31;20(1):712 Authors: Lindenberg M, Retèl V, Rohaan M, van den Berg J, Haanen J, van Harten W Abstract BACKGROUND: Treatment with tumor-Infiltrating Lymphocytes (TIL) is an innovative therapy for advanced melanoma with promising clinical phase I/II study results and likely beneficial cost-effectiveness....
Sun Aug 02, 2020 13:26
Related Articles Evaluating entrectinib as a treatment option for non-small cell lung cancer. Expert Opin Pharmacother. 2020 Jul 31;:1-8 Authors: Lee J, Park S, Jung HA, Sun JM, Lee SH, Ahn JS, Park K, Ahn MJ Abstract INTRODUCTION: Entrectinib, an oral pan-TRK, ALK, and ROS1 inhibitor is approved as a first-line treatment for NTRK-rearranged solid tumors and ROS1-rearranged non-small cell lung cancer (NSCLC). It has demonstrated clinical efficacy...
Sun Aug 02, 2020 13:26
Prognostic impact of CD8-positive tumour-infiltrating lymphocytes and PD-L1 expression in salivary gland cancer. Oral Oncol. 2020 Jul 28;111:104931 Authors: Kesar N, Winkelmann R, Oppermann J, Ghanaati S, Martin D, Neumayer T, Balster S, Rödel C, Rödel F, von der Grün J, Balermpas P Abstract OBJECTIVES: Aim of the study was to evaluate the prognostic impact of CD8-positive (CD8+) tumour-infiltrating lymphocytes (TILs) and PD-L1 expression on...
Sat Aug 01, 2020 14:35
Diagnostic Spectro-cytology revealing differential recognition of cervical Cancer lesions by label-free surface enhanced Raman fingerprints and Chemomssetrics. Nanomedicine. 2020 Jul 28;:102276 Authors: Karunakaran V, Saritha VN, Joseph MM, Nair JB, Saranya G, Raghu KG, Sujathan K, Kumar KS, Maiti KK Abstract Herein we have stepped-up on a strategic spectroscopic modality by utilizing label free ultrasensitive surface enhanced Raman scattering...
Sat Aug 01, 2020 14:35
Classification of extrachromosomal circular DNA with a focus on the role of extrachromosomal DNA (ecDNA) in tumor heterogeneity and progression. Biochim Biophys Acta Rev Cancer. 2020 Jul 28;:188392 Authors: Liao Z, Jiang W, Ye L, Li T, Yu X, Liu L Abstract Although the eukaryotic genome is mainly comprised of linear chromosomal DNA, genes can also be found outside of chromosomes. The unconventional presence of extrachromosomal genes is usually...
Sat Aug 01, 2020 14:35
Artificial Intelligence in Lung Cancer: Bridging the Gap Between Computational Power and Clinical Decision-Making. Can Assoc Radiol J. 2020 Jul 31;:846537120941434 Authors: Christie JR, Lang P, Zelko LM, Palma DA, Abdelrazek M, Mattonen SA Abstract Lung cancer remains the most common cause of cancer death worldwide. Recent advances in lung cancer screening, radiotherapy, surgical techniques, and systemic therapy have led to increasing complexity...
Sat Aug 01, 2020 14:35
Overview of Delivery of Cancer Care in Nepal: Current Status and Future Priorities. JCO Glob Oncol. 2020 Jul;6:1211-1217 Authors: Gyawali B, Sharma S, Shilpakar R, Dulal S, Pariyar J, Booth CM, Sharma Poudyal B Abstract Nepal is a small, low-income country between India and China with a unique health care delivery system. Cancer is becoming an important public health problem in the country, but a systematic plan to cancer control is lacking....
Sat Aug 01, 2020 14:35
Related Articles Understanding American Indian Perceptions Toward Radiation Therapy. Cancer Control. 2020 Jul-Aug;27(3):1073274820945991 Authors: Patel SH, Ebrahimi S, Northfelt DW, Mathews TE, Omar FM, Martinez ED, DeWees TA, Okamoto JM Abstract Many American Indian (AI) and Alaska native (AN) patients do not complete guideline-concordant cancer care for the 4 most common cancers. Our aim was to better understand AI/AN attitudes toward radiation...
Sat Aug 01, 2020 14:35
Related Articles Trastuzumab emtansine: a game changer in HER2-positive early breast cancer. Future Oncol. 2020 Jul 31;: Authors: S Mano M Abstract Trastuzumab emtansine (T-DM1), given postoperatively for 14 cycles to patients with human epidermal growth factor receptor 2-positive (HER2-positive) early breast cancer (EBC) who failed to achieve a pathological complete response after standard chemotherapy and HER2 blockade, represents probably...
Sat Aug 01, 2020 14:35
Related Articles 18F-FDG PET and DCE kinetic modeling and their correlations in primary NSCLC: first voxel-wise correlative analysis of human simultaneous [18F]FDG PET-MRI data. EJNMMI Res. 2020 Jul 30;10(1):88 Authors: Besson FL, Fernandez B, Faure S, Mercier O, Seferian A, Mignard X, Mussot S, le Pechoux C, Caramella C, Botticella A, Levy A, Parent F, Bulifon S, Montani D, Mitilian D, Fadel E, Planchard D, Besse B, Ghigna-Bellinzoni MR, Comtat C, Lebon V, Durand...
Sat Aug 01, 2020 14:35
Related Articles Prostate-specific membrane antigen targeted PET imaging for prostate cancer recurrence. Curr Opin Urol. 2020 Jul 23;: Authors: Ferdinandus J, Fendler WP, Hadaschik B, Herrmann K Abstract PURPOSE OF REVIEW: Prostate-specific membrane antigen targeted PET imaging (PSMA PET) of biochemically recurrent prostate cancer (BCR) is implemented in routine management in many countries and recommended in European Association of Urology...
Sat Aug 01, 2020 14:35
Related Articles Impact of nonspecific death on overall survival in early-stage epithelial ovarian cancer patients. Curr Probl Cancer. 2020 Jul 18;:100621 Authors: Dai D, Deng T, Wang B, Chen S, Liu Z, Luo X, Wang F, Huang H, Liu J Abstract OBJECTIVE: To estimate the impacts of nonovarian cancer-specific death (non-OCSD) and ovarian cancer-specific death (OCSD) on early-stage patients, and to determine which statistical method yielded survival...
Sat Aug 01, 2020 14:35
Related Articles Impact of COVID-19 on early career scientists: an optimistic guide for the future. BMC Biol. 2020 Jul 30;18(1):95 Authors: Termini CM, Traver D PMID: 32731867 [PubMed - in process]
Sat Aug 01, 2020 14:35
Related Articles Inflammatory Biomarkers and Breast Cancer Risk: A Systematic Review of the Evidence and Future Potential for Intervention Research. Int J Environ Res Public Health. 2020 Jul 28;17(15): Authors: Kehm RD, McDonald JA, Fenton SE, Kavanaugh-Lynch M, Leung KA, McKenzie KE, Mandelblatt JS, Terry MB Abstract Measuring systemic chronic inflammatory markers in the blood may be one way of understanding the role of inflammation in breast...
Sat Aug 01, 2020 14:35
Related Articles Study of the Female Sex Survival Advantage in Melanoma-A Focus on X-Linked Epigenetic Regulators and Immune Responses in Two Cohorts. Cancers (Basel). 2020 Jul 28;12(8): Authors: Emran AA, Nsengimana J, Punnia-Moorthy G, Schmitz U, Gallagher SJ, Newton-Bishop J, Tiffen JC, Hersey P Abstract BACKGROUND: Survival from melanoma is strongly related to patient sex, with females having a survival rate almost twice that of males. Many...
Sat Aug 01, 2020 14:35
Future Perspectives in the Management of Tumors of the Anterior Skull Base. Adv Otorhinolaryngol. 2020;84:246-250 Authors: Nicolai P, Bradley PJ, Bossi P, Ferrari M Abstract In the coming years, further developments can be expected in the field of diagnosis and management of tumors involving the anterior skull base, and especially malignant tumors of the sinonasal tract, which account for the majority of lesions affecting this anatomic area....
Fri Jul 31, 2020 14:00
Rapid Processing and Drug Evaluation in Glioblastoma Patient-Derived Organoid Models with 4D Bioprinted Arrays. iScience. 2020 Jul 13;23(8):101365 Authors: Chadwick M, Yang C, Liu L, Gamboa CM, Jara K, Lee H, Sabaawy HE Abstract Glioblastoma is the most common and deadly primary brain malignancy. Despite advances in precision medicine oncology (PMO) allowing the identification of molecular vulnerabilities in glioblastoma, treatment options...
Fri Jul 31, 2020 14:00
Usage Patterns of a Web-Based Palliative Care Content Platform (PalliCOVID) during the COVID-19 Pandemic. J Pain Symptom Manage. 2020 Jul 27;: Authors: Lai L, Sato R, He S, Ouchi K, Leiter R, Thomas JD, Lawton A, Landman AB, Zhang HM Abstract BACKGROUND: The COVID-19 pandemic has highlighted the essential role of palliative care to support the delivery of compassionate, goal-concordant patient care. We created the web-based application, PalliCOVID...
Fri Jul 31, 2020 14:00
Precision Medicine in Non-Small Cell Lung Cancer: Current Applications and Future Directions. Semin Cancer Biol. 2020 Jul 27;: Authors: Yang SR, Schultheis AM, Yu H, Mandelker D, Ladanyi M, Büttner R Abstract Advances in biomarkers, targeted therapies, and immuno-oncology have transformed the clinical management of patients with advanced NSCLC. For oncogene-driven tumors, there are highly effective targeted therapies against EGFR, ALK, ROS1,...
Fri Jul 31, 2020 14:00
Adipose tissue density on CT as a prognostic factor in patients with cancer: a systematic review. Acta Oncol. 2020 Jul 30;:1-8 Authors: Kapoor ND, Twining PK, Groot OQ, Pielkenrood BJ, Bongers MER, Newman ET, Verlaan JJ, Schwab JH Abstract BACKGROUND: Predicting oncologic outcomes is essential for optimizing the treatment for patients with cancer. This review examines the feasibility of using Computed Tomography (CT) images of fat density as...
Fri Jul 31, 2020 14:00
Related Articles Tailgut cyst: from differential diagnosis to surgical resection-case report and literature review. J Surg Case Rep. 2020 Jul;2020(7):rjaa205 Authors: de Castro Gouveia G, Okada LY, Paes BP, Moura TM, da Conceição Júnior AH, Pinheiro RN Abstract Tailgut cyst is a rare tumor originating from the embryonic remnant located in the retrorectal space. The diagnosis is usually incidental duse to the absence of symptoms. When present,...
Fri Jul 31, 2020 14:00
Related Articles Automatic breast ultrasound: state of the art and future perspectives. Ecancermedicalscience. 2020;14:1062 Authors: Nicosia L, Ferrari F, Bozzini AC, Latronico A, Trentin C, Meneghetti L, Pesapane F, Pizzamiglio M, Balesetreri N, Cassano E Abstract The three-dimensional automated breast ultrasound system (3D ABUS) is a new device which represents a huge innovation in the breast ultrasound field, with several application scenarios...
Fri Jul 31, 2020 14:00
Related Articles RNA editing contributes to epitranscriptome diversity in chronic lymphocytic leukemia. Leukemia. 2020 Jul 30;: Authors: Gassner FJ, Zaborsky N, Buchumenski I, Levanon EY, Gatterbauer M, Schubert M, Rauscher S, Hebenstreit D, Nadeu F, Campo E, Egle A, Greil R, Geisberger R Abstract RNA editing-primarily conversion of adenosine to inosine (A > I)-is a widespread posttranscriptional mechanism, mediated by Adenosine Deaminases...
Fri Jul 31, 2020 14:00
Related Articles Evaluation of PARP and PDL-1 as potential therapeutic targets for women with high-grade neuroendocrine carcinomas of the cervix. Int J Gynecol Cancer. 2020 Jul 29;: Authors: Carroll MR, Ramalingam P, Salvo G, Fujimoto J, Solis Soto LM, Phoolcharoen N, Hillman RT, Cardnell R, Byers L, Frumovitz M Abstract OBJECTIVES: Women with recurrent high-grade neuroendocrine cervical cancer have few effective treatment options. The aim of...
Fri Jul 31, 2020 14:00
Related Articles Chimeric antigen receptor T-cell therapy beyond cancer: current practice and future prospects. Immunotherapy. 2020 Jul 30;: Authors: Zhang PF, Xie D, Li Q Abstract Adoptive cell therapy with chimeric antigen receptor T (CAR-T) cells has achieved remarkable efficacy in the treatment of hematological malignancies, which has inspired researchers to expand the application of CAR-T-cell therapy to other medical conditions. Here,...
Fri Jul 31, 2020 14:00
Related Articles [Chinese expert consensus on multiple primary cancers of hypopharynx and esophagus]. Zhonghua Wai Ke Za Zhi. 2020 Aug 01;58(8):589-595 Authors: Committee of Esophageal Cancer in China Anti-Cancer Association, Chinese Working Group on Cooperative Diagnosis and Treatment of Hypopharyngeal and Esophageal Cancer Abstract Hypopharyngeal cancer and esophageal cancer often occur synchronously or metachronously. Timely screening, diagnosis...
Fri Jul 31, 2020 14:00
Related Articles Triptolide-induced apoptosis in non-small cell lung cancer via a novel miR204-5p/Caveolin-1/Akt-mediated pathway. Oncotarget. 2020 Jul 14;11(28):2793-2806 Authors: Philips BJ, Kumar A, Burki S, Ryan JP, Noda K, D'Cunha J Abstract Lung cancer is one of the most prevalent malignancies world-wide with non-small cell lung cancer (NSCLC) comprising nearly 80% of all cases. Unfortunately, many lung cancer patients are diagnosed...
Sat Aug 01, 2020 14:15
Related Articles Working together for the family: determination of HER oncogene co-amplifications in breast cancer. Oncotarget. 2020 Jul 14;11(28):2774-2792 Authors: Sergio L, Teresita BM, Emanuel C, Sebastián R, Juan C, Guillermo U, Francisco G, Olga T, Telma G, Paola I, Lilit A, Suvi S, Maria R Abstract HER2 is a well-studied tyrosine kinase (TK) membrane receptor which functions as a therapeutic target in invasive ductal breast carcinomas...
Sat Aug 01, 2020 14:15
Related Articles Can Denosumab be used in combination with Doxorubicin in Osteosarcoma? Oncotarget. 2020 Jul 14;11(28):2763-2773 Authors: Punzo F, Tortora C, Argenziano M, Pinto DD, Pota E, Martino MD, Paola AD, Rossi F Abstract Osteosarcoma is an aggressive bone tumor of the pediatric age. It is therefore important to improve conventional therapies (chemotherapy and surgery). Anticancer drugs often cause osteoporosis due to a misbalance...
Sat Aug 01, 2020 14:15
Related Articles Novel role for the Golgi membrane protein TMEM165 in control of migration and invasion for breast carcinoma. Oncotarget. 2020 Jul 14;11(28):2747-2762 Authors: Murali P, Johnson BP, Lu Z, Climer L, Scott DA, Foulquier F, Oprea-Ilies G, Lupashin V, Drake RR, Abbott KL Abstract The TMEM165 gene encodes for a multiple pass membrane protein localized in the Golgi that has been linked to congenital disorders of glycosylation....
Sat Aug 01, 2020 14:15
Related Articles Rapid onset type 1 diabetes with anti-PD-1 directed therapy. Oncotarget. 2020 Jul 14;11(28):2740-2746 Authors: Yun K, Daniels G, Gold K, Mccowen K, Patel SP Abstract Type 1 diabetes is a rare immune-related adverse event (irAE) caused by checkpoint inhibitors with serious risk for diabetic ketoacidosis (DKA). Using our electronic medical record, we identified 1327 adult patients who received PD-(L)1 or CTLA-4 inhibitors...
Sat Aug 01, 2020 14:15
Related Articles Genetic analysis of the cooperative tumorigenic effects of targeted deletions of tumor suppressors Rb1, Trp53, Men1, and Pten in neuroendocrine tumors in mice. Oncotarget. 2020 Jul 14;11(28):2718-2739 Authors: Xu EY, Vosburgh E, Wong C, Tang LH, Notterman DA Abstract Genetic alterations of tumor suppressor genes (TSGs) are frequently observed to have cumulative or cooperative tumorigenic effects. We examined whether the...
Sat Aug 01, 2020 14:15
Related Articles Lipid and protein tumor markers for head and neck squamous cell carcinoma identified by imaging mass spectrometry. Oncotarget. 2020 Jul 14;11(28):2702-2717 Authors: Schmidt J, Kajtár B, Juhász K, Péter M, Járai T, Burián A, Kereskai L, Gerlinger I, Tornóczki T, Balogh G, Vígh L, Márk L, Balogi Z Abstract Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. To improve pre- and post-operative...
Sat Aug 01, 2020 14:15
Related Articles Development and comprehensive characterization of porcine hepatocellular carcinoma for translational liver cancer investigation. Oncotarget. 2020 Jul 14;11(28):2686-2701 Authors: Gaba RC, Elkhadragy L, Boas FE, Chaki S, Chen HH, El-Kebir M, Garcia KD, Giurini EF, Guzman G, LoBianco FV, Neto MF, Newson JL, Qazi A, Regan M, Rund LA, Schwind RM, Stewart MC, Thomas FM, Whiteley HE, Wu J, Schook LB, Schachtschneider KM Abstract ...
Sat Aug 01, 2020 14:15
Blue Liver: Case Report of Blue Liver. Am J Case Rep. 2020 Aug 01;21:e923553 Authors: Al-Qudah G, Ghanem M, Blebea J, Shaheen S Abstract BACKGROUND Although many cases of unusual liver discoloration exist, such as blue liver syndrome which is linked to oxaliplatin-based chemotherapy, our finding was seen in a patient who was not on chemotherapy. A 39-year-old male who presented with jaundice was found to have blue liver discoloration. CASE...
Sun Aug 02, 2020 16:43
Related Articles Ischemic Colitis in a Patient on Venovenous Extracorporeal Membrane Oxygenation (VV-ECMO) Treatment: An Emerging Complication? Am J Case Rep. 2020 Aug 01;21:e923374 Authors: Liaquat H, Zanders TB, Bratis LE, Stoll LM, Chaput KJ Abstract BACKGROUND There have been few reports of colonic ischemia in patients receiving venovenous extracorporeal membrane oxygenation (VV-ECMO) treatment, and all patients died during the same hospitalization....
Sun Aug 02, 2020 16:43
Related Articles Uncommon Presentation of Severe Empyema of the Gallbladder: Case Report and Literature Review. Am J Case Rep. 2020 Jul 31;21:e923040 Authors: Elkbuli A, Sanchez C, Kinslow K, McKenney M, Boneva D Abstract BACKGROUND Empyema of the gallbladder is a complication of cholecystitis that can develop into sepsis if not treated promptly. Signs and symptoms of gallstone disease are nausea/vomiting, right upper quadrant tenderness, and...
Sat Aug 01, 2020 13:1
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