American Journal of Physical Anthropology

Secular change in morphological cranial and mandibular trait frequencies in European Americans born 1824–1987

Abstract Objectives Secular change in cranial and postcranial morphometrics and morphological traits has been documented in several studies. However, to date, few studies have addressed temporal changes occurring in the expression of cranial morphological traits commonly used in ancestry estimation. This study examines secular change in the expression of 23 cranial and mandibular morphological traits; accounting for age‐at‐death, sex, and year‐of‐birth. Materials & Methods Data were...

American Journal of Physical Anthropology

Sat Aug 15, 2020 19:08

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 Journal of Human Evolution

Three-dimensional geometric morphometrics of thorax-pelvis covariation and its potential for predicting the thorax morphology: A case study on Kebara 2 Neandertal

Publication date: October 2020Source: Journal of Human Evolution, Volume 147Author(s): Nicole Torres-Tamayo, Stefan Schlager, Daniel García-Martínez, Juan Alberto Sanchis-Gimeno, Shahed Nalla, Naomichi Ogihara, Motoharu Oishi, Sandra Martelli, Markus Bastir

Journal of Human Evolution

Sat Aug 15, 2020 21:13

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 Journal of Internal Medicine

Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans

Abstract Background The metabolism of tryptophan (Trp) along the kynurenine pathway has been shown to carry strong immunoregulatory properties. Several experimental studies indicate that this pathway is a major regulator of vascular inflammation and influences atherogenesis. Knowledge of the role of this pathway in human atherosclerosis remains incomplete. Objectives In this study, we performed a multiplatform analysis of tissue samples, in vitro and in vivo functional assays...

Journal of Internal Medicine

Fri Aug 14, 2020 12:09

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 JoVE: Journal of Visualized Experiments

Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons

Here, we present a detailed protocol to study neuronal α-synuclein accumulation in primary mouse dopamine neurons. Phosphorylated α-synuclein aggregates in neurons are induced with pre-formed α-synuclein fibrils. Automated imaging of immunofluorescently labeled cells and unbiased image analysis make this robust protocol suitable for medium-to-high throughput screening of drugs that inhibit α-synuclein accumulation.

JoVE: Journal of Visualized Experiments

Sun Aug 16, 2020 19:30

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans

Here, we introduce and describe widely accessible methodologies utilizing some versatile nematode models, including hyperactivated ion channel-induced necrosis and protein aggregate-induced neurotoxicity, to monitor and dissect the cellular and molecular underpinnings of age-associated neurodegenerative diseases.

JoVE: Journal of Visualized Experiments

Sat Aug 15, 2020 21:15

WheelCon: A Wheel Control-Based Gaming Platform for Studying Human Sensorimotor Control

WheelCon is a novel, free and open-source platform to design video games that noninvasively simulates mountain biking down a steep, twisting, bumpy trail. It contains components presenting in human sensorimotor control (delay, quantization, noise, disturbance, and multiple feedback loops) and allows researchers to study the layered architecture in sensorimotor control.

JoVE: Journal of Visualized Experiments

Sat Aug 15, 2020 20:16

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 ScienceDirect Publication: Medical Hypotheses

Patients with interferon expressing oral pathologies are susceptible to COVID-19 infection

Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Gargi S. Sarode, Sachin C. Sarode, Amol R. Gadbail, Shailesh Gondivkar, Nilesh Kumar Sharma, Shankargouda Patil

ScienceDirect Publication: Medical Hypotheses

Sat Aug 15, 2020 17:04

COVID-19: Electrophysiological mechanisms underlying sudden cardiac death during exercise with facemasks

Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Sharen Lee, Guoliang Li, Tong Liu, Gary Tse

ScienceDirect Publication: Medical Hypotheses

Sat Aug 15, 2020 17:04

The AI-discovered Aetiology of COVID-19 and Rationale of the Irinotecan+ Etoposide Combination Therapy for Criti- cally Ill COVID-19 Patients

Publication date: Available online 15 August 2020Source: Medical HypothesesAuthor(s): Bragi Lovetrue

ScienceDirect Publication: Medical Hypotheses

Sat Aug 15, 2020 17:04

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