IJMS, Vol. 21, Pages 5925: CD163 as a Biomarker in Colorectal Cancer: The Expression on Circulating Monocytes and Tumor-Associated Macrophages, and the Soluble Form in the Blood International Journal of Molecular Sciences doi: 10.3390/ijms21165925 Authors: Daniëlle Krijgsman Natasja L. De Vries Morten N. Andersen Anni Skovbo Rob A.E.M. Tollenaar Holger J. Møller Marianne Hokland Peter J.K. Kuppen The macrophage-associated molecule CD163 has been reported as a prognostic...
Tue Aug 18, 2020 03:00
IJMS, Vol. 21, Pages 5921: P38 Regulates Kainic Acid-Induced Seizure and Neuronal Firing via Kv4.2 Phosphorylation International Journal of Molecular Sciences doi: 10.3390/ijms21165921 Authors: Jia-hua Hu Cole Malloy Dax A. Hoffman The subthreshold, transient A-type K+ current is a vital regulator of the excitability of neurons throughout the brain. In mammalian hippocampal pyramidal neurons, this current is carried primarily by ion channels comprising Kv4.2 α-subunits....
Tue Aug 18, 2020 03:00
IJMS, Vol. 21, Pages 5922: The Role of Atypical Cannabinoid Ligands O-1602 and O-1918 on Skeletal Muscle Homeostasis with a Focus on Obesity International Journal of Molecular Sciences doi: 10.3390/ijms21165922 Authors: Anna C. Simcocks Lannie O’Keefe Kayte A. Jenkin Lauren M. Cornall Esther Grinfeld Michael L. Mathai Deanne H. Hryciw Andrew J. McAinch O-1602 and O-1918 are atypical cannabinoid ligands for GPR55 and GPR18, which may be novel pharmaceuticals for the...
Tue Aug 18, 2020 03:00
IJMS, Vol. 21, Pages 5920: Ursolic Acid-Based Derivatives as Potential Anti-Cancer Agents: An Update
IJMS, Vol. 21, Pages 5920: Ursolic Acid-Based Derivatives as Potential Anti-Cancer Agents: An Update International Journal of Molecular Sciences doi: 10.3390/ijms21165920 Authors: Vuyolwethu Khwaza Opeoluwa O. Oyedeji Blessing A. Aderibigbe Ursolic acid is a pharmacologically active pentacyclic triterpenoid derived from medicinal plants, fruit, and vegetables. The pharmacological activities of ursolic acid have been extensively studied over the past few years and various reports...
Tue Aug 18, 2020 03:00
IJMS, Vol. 21, Pages 5918: PD-L1 in Systemic Immunity: Unraveling Its Contribution to PD-1/PD-L1 Blockade Immunotherapy International Journal of Molecular Sciences doi: 10.3390/ijms21165918 Authors: Ana Bocanegra Ester Blanco Gonzalo Fernandez-Hinojal Hugo Arasanz Luisa Chocarro Miren Zuazo Pilar Morente Ruth Vera David Escors Grazyna Kochan The use of monoclonal antibodies targeting PD-1/PD-L1 axis completely changed anticancer treatment strategies. However,...
Tue Aug 18, 2020 03:00
IJMS, Vol. 21, Pages 5919: Basic and Translational Models of Cooperative Oncogenesis International Journal of Molecular Sciences doi: 10.3390/ijms21165919 Authors: Helena E. Richardson Julia B. Cordero Daniela Grifoni n/a
Tue Aug 18, 2020 03:00
JCM, Vol. 9, Pages 2673: Optimal Antithrombotic Treatment of Patients with Atrial Fibrillation Early after an Acute Coronary Syndrome—Triple Therapy, Dual Antithrombotic Therapy with an Anticoagulant… Or, Rather, Temporary Dual Antiplatelet Therapy? Journal of Clinical Medicine doi: 10.3390/jcm9082673 Authors: Ugo Limbruno Francesco De Sensi Alberto Cresti Andrea Picchi Fabio Lena Raffaele De Caterina The combination of atrial fibrillation (AF) and acute coronary syndrome...
Tue Aug 18, 2020 03:00
JCM, Vol. 9, Pages 2680: Application of Anti-Inflammatory Agents in Prostate Cancer Journal of Clinical Medicine doi: 10.3390/jcm9082680 Authors: Hatano Fujita Nonomura Chronic inflammation is a major cause of human cancers. The environmental factors, such as microbiome, dietary components, and obesity, provoke chronic inflammation in the prostate, which promotes cancer development and progression. Crosstalk between immune cells and cancer cells enhances the secretion of intercellular...
Tue Aug 18, 2020 03:00
JCM, Vol. 9, Pages 2678: Difference in Pupillary Diameter as an Important Factor for Evaluating Amplitude of Accommodation: A Prospective Observational Study Journal of Clinical Medicine doi: 10.3390/jcm9082678 Authors: Kubota Kubota Kobashi Ayaki Negishi Tsubota Presbyopia is increasing globally due to aging and the widespread use of visual display terminals. Presbyopia is a decrease in the eye’s amplitude of accommodation (AA) due to loss of crystalline...
Tue Aug 18, 2020 03:00
JCM, Vol. 9, Pages 2677: Macular Perfusion Impairment in Von Hippel-Lindau Disease Suggests a Generalized Retinal Vessel Alteration Journal of Clinical Medicine doi: 10.3390/jcm9082677 Authors: Pilotto Nacci Ferrara De Mojà Zovato Midena Background: To evaluate macular perfusion in patients with Von Hippel–Lindau (VHL) disease. Methods: VHL patients with or without peripheral retinal hemangioblastomas (RHs) were consecutively enrolled. A group of healthy...
Tue Aug 18, 2020 03:00
JCM, Vol. 9, Pages 2674: Comparative Analysis of Blood and Bone Marrow for the Detection of Circulating and Disseminated Tumor Cells and Their Prognostic and Predictive Value in Esophageal Cancer Patients Journal of Clinical Medicine doi: 10.3390/jcm9082674 Authors: Florian Richter Annette Baratay Christian Röder Jan-Hendrik Egberts Holger Kalthoff Thomas Becker Susanne Sebens Hematogenic tumor cell spread is a key event in metastasis. However, the clinical significance...
Tue Aug 18, 2020 03:00
JCM, Vol. 9, Pages 2676: Scores of Health-Related Quality of Life Questionnaire Worsen Consistently in Patients of COPD: Estimating Disease Progression Over 30 Years by SReFT with Individual Data Collected in SUMMIT Trial Journal of Clinical Medicine doi: 10.3390/jcm9082676 Authors: Kawamatsu Jin Araki Yoshioka Sato Sato Hisaka The aim of this study was to elucidate the lifelong disease progression of chronic obstructive pulmonary disease (COPD) with biomarker...
Tue Aug 18, 2020 03:00
JCM, Vol. 9, Pages 2675: Applications of the Amniotic Membrane in Vitreoretinal Surgery Journal of Clinical Medicine doi: 10.3390/jcm9082675 Authors: Tomaso Caporossi Ruggero Tartaro Daniela Bacherini Bianca Pacini Lorenzo De Angelis Lorenzo Governatori Laura Di Leo Leandro Oliverio Stanislao Rizzo Recently, the use of the human amniotic membrane (hAM) has been extended to treat retinal disorders, such as macular holes that failed to close and retinal tears. The...
Tue Aug 18, 2020 03:00
JCM, Vol. 9, Pages 2679: Management of Acute Kidney Injury Following Major Abdominal Surgery: A Contemporary Review Journal of Clinical Medicine doi: 10.3390/jcm9082679 Authors: Joana Gameiro José Agapito Fonseca Filipe Marques José António Lopes Acute kidney injury (AKI) is a frequent occurrence following major abdominal surgery and is independently associated with both in-hospital and long-term mortality, as well as with a higher risk of progressing to chronic kidney disease...
Tue Aug 18, 2020 03:00
JCM, Vol. 9, Pages 2669: Oxidative Stress, Telomere Shortening, and Apoptosis Associated to Sarcopenia and Frailty in Patients with Multimorbidity Journal of Clinical Medicine doi: 10.3390/jcm9082669 Authors: Máximo Bernabeu-Wittel Raquel Gómez-Díaz Álvaro González-Molina Sofía Vidal-Serrano Jesús Díez-Manglano Fernando Salgado María Soto-Martín Manuel Ollero-Baturone on behalf of the PROTEO RESEARCHERS Background: The presence of oxidative stress, telomere shortening,...
Tue Aug 18, 2020 03:00
JCM, Vol. 9, Pages 2672: Corneal Epithelial Toxicity after Intravitreal Methotrexate Injection for Vitreoretinal Lymphoma: Clinical and In Vitro Studies Journal of Clinical Medicine doi: 10.3390/jcm9082672 Authors: Yoon Jeong Jin Suk Ryu Un Chul Park Joo Youn Oh Methotrexate is widely used as an intraocular chemotherapy for vitreoretinal lymphoma (VRL). Although corneal toxicity has been reported in patients after intravitreal methotrexate injections, the incidence, outcome,...
Tue Aug 18, 2020 03:00
JCM, Vol. 9, Pages 2671: A Novel Technique of Endoscopic Papillectomy with Hybrid Endoscopic Submucosal Dissection for Ampullary Tumors: A Proof-of-Concept Study (with Video) Journal of Clinical Medicine doi: 10.3390/jcm9082671 Authors: Naminatsu Takahara Yosuke Tsuji Yousuke Nakai Yukari Suzuki Akiyuki Inokuma Sachiko Kanai Kensaku Noguchi Tatsuya Sato Ryunosuke Hakuta Kazunaga Ishigaki Kei Saito Yoshiki Sakaguchi Tomotaka Saito Tsuyoshi Hamada Suguru...
Tue Aug 18, 2020 03:00
JCM, Vol. 9, Pages 2670: Role of Type2 Inflammatory Biomarkers in Chronic Obstructive Pulmonary Disease Journal of Clinical Medicine doi: 10.3390/jcm9082670 Authors: Keiji Oishi Kazuto Matsunaga Toshihiro Shirai Keita Hirai Yasuhiro Gon Airway inflammation in chronic obstructive pulmonary disease (COPD) is typically thought to be driven by Type1 immune responses, while Type2 inflammation appears to be present in definite proportions in the stable state and during exacerbations....
Tue Aug 18, 2020 03:00
JCM, Vol. 9, Pages 2668: Alcohol Induced Depression: Clinical, Biological and Genetic Features Journal of Clinical Medicine doi: 10.3390/jcm9082668 Authors: Adriana Farré Judit Tirado Nino Spataro María Alías-Ferri Marta Torrens Francina Fonseca Background: In clinical practice, there is the need to have clinical and biological markers to identify induced depression. The objective was to investigate clinical, biological and genetic differences between Primary Major Depression...
Tue Aug 18, 2020 03:00
JCM, Vol. 9, Pages 2667: Prediction of Long-Term Outcomes in ST-Elevation Myocardial Infarction and Non-ST Elevation Myocardial Infarction with and without Creatinine Kinase Elevation—Post-Hoc Analysis of the J-MINUET Study Journal of Clinical Medicine doi: 10.3390/jcm9082667 Authors: Shigeru Toyoda Masashi Sakuma Shichiro Abe Teruo Inoue Koichi Nakao Yukio Ozaki Kazuo Kimura Junya Ako Teruo Noguchi Satoru Suwa Kazuteru Fujimoto Yasuharu Nakama Takashi Morita...
Tue Aug 18, 2020 03:00
JCM, Vol. 9, Pages 2666: The Antitumor Effect of Heparin is not Mediated by Direct NK Cell Activation Journal of Clinical Medicine doi: 10.3390/jcm9082666 Authors: Gustavo R. Rossi Jenifer P. Gonçalves Timothy McCulloch Rebecca B. Delconte Robert J. Hennessy Nicholas D. Huntington Edvaldo S. Trindade Fernando Souza-Fonseca-Guimaraes Natural killer (NK) cells are innate lymphocytes responsible for the elimination of infected or transformed cells. The activation or...
Tue Aug 18, 2020 03:00
JCM, Vol. 9, Pages 2665: Clinical Profiles in Renal Patients with COVID-19 Journal of Clinical Medicine doi: 10.3390/jcm9082665 Authors: María Dolores Arenas Marta Crespo María José Pérez-Sáez Silvia Collado Dolores Redondo-Pachón Laura Llinàs-Mallol María Milagro Montero Judith Villar-García Carlos Arias-Cabrales Francesc Barbosa Anna Buxeda Carla Burballa Laia Sans Susana Vázquez Anna Oliveras Marisa Mir Sara Outón Isabel Galcerán Eulalia...
Tue Aug 18, 2020 03:00
JCM, Vol. 9, Pages 2664: Factors Associated with Adverse Cardiovascular Events in Cancer Patients Treated with Bevacizumab Journal of Clinical Medicine doi: 10.3390/jcm9082664 Authors: Doan T. M. Ngo Trent Williams Sophie Horder Leonard Kritharides Janette Vardy Hiren Mandaliya Ina I. C. Nordman James Lynam Tony Bonaventura Aaron L. Sverdlov Background: Bevacizumab, a vascular endothelial growth factor (VEGF) monoclonal antibody commonly used for the treatment...
Tue Aug 18, 2020 03:00
JoF, Vol. 6, Pages 139: Role of Voriconazole in the Management of Invasive Central Nervous System Aspergillosis: A Case Series from A Tertiary Care Centre in India Journal of Fungi doi: 10.3390/jof6030139 Authors: Gupta Kodan Mittal Singh Netto Ramteke Malla Kumar Kumar Singh Aggarwal Desai Soneja Xess Wig Invasive central nervous system (CNS) aspergillosis is acquired by either hematogenous dissemination or direct spread from...
Tue Aug 18, 2020 03:00
JoF, Vol. 6, Pages 138: The Quiet and Underappreciated Rise of Drug-Resistant Invasive Fungal Pathogens Journal of Fungi doi: 10.3390/jof6030138 Authors: Amir Arastehfar Cornelia Lass-Flörl Rocio Garcia-Rubio Farnaz Daneshnia Macit Ilkit Teun Boekhout Toni Gabaldon David S. Perlin Human fungal pathogens are attributable to a significant economic burden and mortality worldwide. Antifungal treatments, although limited in number, play a pivotal role in decreasing mortality...
Tue Aug 18, 2020 03:00
JPM, Vol. 10, Pages 93: Amerindian Ancestry Influences Genetic Susceptibility to Chronic Obstructive Pulmonary Disease Journal of Personalized Medicine doi: 10.3390/jpm10030093 Authors: Díaz-Peña Boekstegers Silva Jaime Hosgood III Miravitlles Agustí Lorenzo Bermejo Olloquequi The contribution of genetic ancestry on chronic obstructive pulmonary disease (COPD) predisposition remains unclear. To explore this relationship, we analyzed the associations between...
Tue Aug 18, 2020 03:00
Life, Vol. 10, Pages 154: Biologic Impact of Different Ultra-Low-Fluence Irradiations in Human Fibroblasts Life doi: 10.3390/life10080154 Authors: Masao Suzuki Yukio Uchihori Hisashi Kitamura Masakazu Oikawa Teruaki Konishi In this study, we aimed to evaluate the cellular response of healthy human fibroblasts induced by different types of ultra-low-fluence radiations, including gamma rays, neutrons and high linear energy transfer (LET) heavy ions. NB1RGB cells were pretreated...
Tue Aug 18, 2020 03:00
Medicina, Vol. 56, Pages 415: The Number of Traditional Cardiovascular Risk Factors Is Independently Correlated with Disease Activity in Patients with Psoriatic Arthritis Medicina doi: 10.3390/medicina56080415 Authors: Iván Ferraz-Amaro Diana Prieto-Peña Natalia Palmou-Fontana David Martínez-López Laura de Armas-Rillo Alicia García-Dorta Belén Atienza-Mateo Ricardo Blanco Susana Armesto Miguel Á. González-Gay Background and objectives: Psoriatic arthritis (PsA)...
Tue Aug 18, 2020 03:00
Membranes, Vol. 10, Pages 192: Towards Upscaling of La5.5WO11.25−δ Manufacture for Plasma Spraying-Thin Film Coated Hydrogen Permeable Membranes Membranes doi: 10.3390/membranes10090192 Authors: Sonia Escolástico Cecilia Solís Antonio Comite Fiorenza Azzurri Malko Gindrat Stefan Moser Johannes Rauch Gregory Szyndelman Rajiv Damani Jose M. Serra Lanthanum tungstate (La6WO12) is a promising material for the development of hydrogen separation membranes, proton...
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Membranes, Vol. 10, Pages 191: Long-Term Stable 1-butyl-3-methylimidazolium Hexafluorophosphate/Ag Metal Composite Membranes for Facilitated Olefin Transport Membranes doi: 10.3390/membranes10080191 Authors: Sang Wook Kang For the preparation of long-term stable ionic liquid/Ag nanoparticles composites, we compared the separation performance of 1-butyl-3-methylimidazolium tetrafluoroborate (BMIM+BF4−)/Ag, and 1-butyl-3-methylimidazolium hexafluorophosphate (BMIM+PF6−)/Ag...
Tue Aug 18, 2020 03:00
Metabolites, Vol. 10, Pages 335: Unraveling Arbuscular Mycorrhiza-Induced Changes in Plant Primary and Secondary Metabolome Metabolites doi: 10.3390/metabo10080335 Authors: Sukhmanpreet Kaur Vidya Suseela Arbuscular mycorrhizal fungi (AMF) is among the most ubiquitous plant mutualists that enhance plant growth and yield by facilitating the uptake of phosphorus and water. The countless interactions that occur in the rhizosphere between plants and its AMF symbionts are mediated through...
Tue Aug 18, 2020 03:00
MPs, Vol. 3, Pages 59: SARS-CoV-2 Detection for Diagnosis Purposes in the Setting of a Molecular Biology Research Lab Methods and Protocols doi: 10.3390/mps3030059 Authors: Damien Coupeau Nicolas Burton Noémie Lejeune Suzanne Loret Astrid Petit Srdan Pejakovic Florian Poulain Laura Bonil Gabrielle Trozzi Laetitia Wiggers Kévin Willemart Emmanuel André Lies Laenen Lize Cuypers Marc Van Ranst Pierre Bogaerts Benoît Muylkens Nicolas Albert Gillet...
Tue Aug 18, 2020 03:00
Microorganisms, Vol. 8, Pages 1255: A Genome-Scale Insight into the Effect of Shear Stress During the Fed-Batch Production of Clavulanic Acid by Streptomyces Clavuligerus Microorganisms doi: 10.3390/microorganisms8091255 Authors: David Gómez-Ríos Victor A. López-Agudelo Howard Ramírez-Malule Peter Neubauer Stefan Junne Silvia Ochoa Rigoberto Ríos-Estepa Streptomyces clavuligerus is a filamentous Gram-positive bacterial producer of the β-lactamase inhibitor...
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Microorganisms, Vol. 8, Pages 1253: Host–Pathogen Interactions between Xanthomonas fragariae and Its Host Fragaria × ananassa Investigated with a Dual RNA-Seq Analysis Microorganisms doi: 10.3390/microorganisms8081253 Authors: Michael Gétaz Joanna Puławska Theo H.M. Smits Joël F. Pothier Strawberry is economically important and widely grown, but susceptible to a large variety of phytopathogenic organisms. Among them, Xanthomonas fragariae is a quarantine bacterial pathogen threatening...
Tue Aug 18, 2020 03:00
Microorganisms, Vol. 8, Pages 1254: The Influence of Light and Nutrient Starvation on Morphology, Biomass and Lipid Content in Seven Strains of Green Microalgae as a Source of Biodiesel Microorganisms doi: 10.3390/microorganisms8081254 Authors: Lorenza Rugnini Catia Rossi Simonetta Antonaroli Arnold Rakaj Laura Bruno The development of clean and renewable energy sources is currently one of the most important challenges facing the world. Although research interests in algae-based...
Tue Aug 18, 2020 03:00
Microorganisms, Vol. 8, Pages 1251: First Cases of Natural Infections with Borrelia hispanica in Two Dogs and a Cat from Europe Microorganisms doi: 10.3390/microorganisms8081251 Authors: Gabriele Margos Nikola Pantchev Majda Globokar Javier Lopez Jaume Rodon Leticia Hernandez Heike Herold Noelia Salas Anna Civit Volker Fingerle Canine cases of relapsing fever (RF) borreliosis have been described in Israel and the USA, where two RF species, Borrelia turicatae...
Tue Aug 18, 2020 03:00
Microorganisms, Vol. 8, Pages 1252: The Absence of C-5 DNA Methylation in Leishmania donovani Allows DNA Enrichment from Complex Samples Microorganisms doi: 10.3390/microorganisms8081252 Authors: Bart Cuypers Franck Dumetz Pieter Meysman Kris Laukens Géraldine De Muylder Jean-Claude Dujardin Malgorzata Anna Domagalska Cytosine C5 methylation is an important epigenetic control mechanism in a wide array of eukaryotic organisms and generally carried out by proteins of...
Tue Aug 18, 2020 03:00
Molecules, Vol. 25, Pages 3765: Characterization of Volatile Organic Compounds Emitted from Endophytic Burkholderia cenocepacia ETR-B22 by SPME-GC-MS and Their Inhibitory Activity against Various Plant Fungal Pathogens Molecules doi: 10.3390/molecules25173765 Authors: Jian-Hua Chen Wei Xiang Ke-Xin Cao Xuan Lu Shao-Chang Yao Ding Hung Rong-Shao Huang Liang-Bo Li The use of antagonistic microorganisms and their volatile organic compounds (VOCs) to control plant fungal...
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Molecules, Vol. 25, Pages 3763: Polyphenols and Other Bioactive Compounds of Sideritis Plants and Their Potential Biological Activity Molecules doi: 10.3390/molecules25163763 Authors: Dorota Żyżelewicz Kamila Kulbat-Warycha Joanna Oracz Kacper Żyżelewicz Due to the growing problem of obesity associated with type 2 diabetes and cardiovascular diseases, causes of obesity are extensively investigated. In addition to a high caloric diet and low physical activity, gut microbiota...
Tue Aug 18, 2020 03:00
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