Antibiotics, Vol. 9, Pages 525: Amoxicillin-Clavulanic Acid Empirical Oral Therapy for the Management of Children with Acute Haematogenous Osteomyelitis Antibiotics doi: 10.3390/antibiotics9080525 Authors: Elena Serrano Irene Ferri Luisa Galli Elena Chiappini According to the Guidelines of the European Society of Pediatric Infectious Diseases (ESPID), in low methicillin-resistant Staphylococcus aureus (MRSA) prevalence settings, short intravenous therapy is recommended in uncomplicated...
Tue Aug 18, 2020 03:00
Antibodies, Vol. 9, Pages 43: Severe Intraoperative Anaphylaxis Related to Thymoglobulin during Living Donor Kidney Transplantation Antibodies doi: 10.3390/antib9030043 Authors: Muhammad I. Saeed Ryan D. Nicklas Vikas Kumar Rajan Kapoor Imran Y. Gani Anaphylaxis secondary to thymoglobulin (anti-thymocyte globulin) is a rare condition that can be life threatening. Thymoglobulin is a rabbit-derived T-cell depleting polyclonal immunoglobulin. It is commonly used for induction...
Tue Aug 18, 2020 03:00
Antioxidants, Vol. 9, Pages 769: Ablation of Peroxiredoxin V Exacerbates Ischemia/Reperfusion-Induced Kidney Injury in Mice Antioxidants doi: 10.3390/antiox9080769 Authors: Jiyoung Park Eun Gyeong Lee Ho Jin Yi Nam Hee Kim Sue Goo Rhee Hyun Ae Woo Ischemia/reperfusion (I/R) is one of the major causes of acute kidney injury (AKI) and associated with increased mortality and progression to chronic kidney injury (CKI). Molecular mechanisms underlying I/R injury involve the...
Tue Aug 18, 2020 03:00
Antioxidants, Vol. 9, Pages 766: Oxidative Stress Response Is Mediated by Overexpression and Spatiotemporal Regulation of Caveolin-1 Antioxidants doi: 10.3390/antiox9080766 Authors: Andreas Goutas Ioanna Papathanasiou Evanthia Mourmoura Konstantinos Tsesmelis Aspasia Tsezou Varvara Trachana Oxidative stress (OS) has been linked to the aetiology of many diseases including osteoarthritis (OA). Recent studies have shown that caveolin-1—a structural protein of plasma...
Tue Aug 18, 2020 03:00
Antioxidants, Vol. 9, Pages 767: The Impact of Formulation on Lutein, Zeaxanthin, and meso-Zeaxanthin Bioavailability: A Randomised Double-Blind Placebo-Controlled Study Antioxidants doi: 10.3390/antiox9080767 Authors: Marina Green-Gomez Alfonso Prado-Cabrero Rachel Moran Tommy Power Laura G. Gómez-Mascaraque Jim Stack John M. Nolan Lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ) have been the focus of research and commercial interest for their applications in...
Tue Aug 18, 2020 03:00
Antioxidants, Vol. 9, Pages 768: Cotinine and 6-Hydroxy-L-Nicotine Reverses Memory Deficits and Reduces Oxidative Stress in Aβ25-35-Induced Rat Model of Alzheimer’s Disease Antioxidants doi: 10.3390/antiox9080768 Authors: Razvan Stefan Boiangiu Marius Mihasan Dragos Lucian Gorgan Bogdan Alexandru Stache Brindusa Alina Petre Lucian Hritcu The nicotinic derivatives, cotinine (COT), and 6-hydroxy-L-nicotine (6HLN), showed promising cognitive-improving effects without exhibiting...
Tue Aug 18, 2020 03:00
Antioxidants, Vol. 9, Pages 765: TXNIP/TBP-2: A Master Regulator for Glucose Homeostasis Antioxidants doi: 10.3390/antiox9080765 Authors: Eiji Yoshihara Identification of thioredoxin binding protein-2 (TBP-2), which is currently known as thioredoxin interacting protein (TXNIP), as an important binding partner for thioredoxin (TRX) revealed that an evolutionarily conserved reduction-oxidation (redox) signal complex plays an important role for pathophysiology. Due to the reducing activity...
Tue Aug 18, 2020 03:00
Atmosphere, Vol. 11, Pages 882: Ambient Air Quality as a Condition of Effective Healthcare Therapy on the Example of Selected Polish Health Resorts Atmosphere doi: 10.3390/atmos11080882 Authors: Dominik Kobus Beata Merenda Izabela Sówka Anna Chlebowska-Styś Alicja Wroniszewska This article discusses the importance of air quality for the organization and functioning of health resorts. Ten different types of resorts located in various regions of Poland were compared in terms...
Tue Aug 18, 2020 03:00
Atmosphere, Vol. 11, Pages 880: Gravity Wave Investigations over Comandante Ferraz Antarctic Station in 2017: General Characteristics, Wind Filtering and Case Study Atmosphere doi: 10.3390/atmos11080880 Authors: Gabriel Augusto Giongo José Valentin Bageston Cosme Alexandre Oliveira Barros Figueiredo Cristiano Max Wrasse Hosik Kam Yong Ha Kim Nelson Jorge Schuch This work presents the characteristics of gravity waves observed over Comandante Ferraz Antarctic Station...
Tue Aug 18, 2020 03:00
Atmosphere, Vol. 11, Pages 881: Space-Borne Monitoring of NOx Emissions from Cement Kilns in South Korea Atmosphere doi: 10.3390/atmos11080881 Authors: Hyun Cheol Kim Changhan Bae Minah Bae Okgil Kim Byeong-Uk Kim Chul Yoo Jinsoo Park Jinsoo Choi Jae-bum Lee Barry Lefer Ariel Stein Soontae Kim Nitrogen oxide (NOx) emissions from the South Korean cement industry are investigated with remote-sensing measurements, surface observations, and in situ aircraft...
Tue Aug 18, 2020 03:00
Atmosphere, Vol. 11, Pages 878: A Chemical Transport Model Emulator for the Interactive Evaluation of Mercury Emission Reduction Scenarios Atmosphere doi: 10.3390/atmos11080878 Authors: Francesco De Simone Francesco D’Amore Francesco Marasco Francesco Carbone Mariantonia Bencardino Ian M. Hedgecock Sergio Cinnirella Francesca Sprovieri Nicola Pirrone Implementation of the Minamata Convention on Mercury requires all parties to “control, and where feasible,...
Tue Aug 18, 2020 03:00
Atmosphere, Vol. 11, Pages 879: Hurricane Dorian Outer Rain Band Observations and 1D Particle Model Simulations: A Case Study Atmosphere doi: 10.3390/atmos11080879 Authors: Viswanathan Bringi Axel Seifert Wei Wu Merhala Thurai Gwo-Jong Huang Christoph Siewert The availability of high quality surface observations of precipitation and volume observations by polarimetric operational radars make it possible to constrain, evaluate, and validate numerical models with a wide...
Tue Aug 18, 2020 03:00
Atmosphere, Vol. 11, Pages 877: The Summer Surface Energy Budget of the Ice-Free Area of Northern James Ross Island and Its Impact on the Ground Thermal Regime Atmosphere doi: 10.3390/atmos11080877 Authors: Klára Ambrožová Filip Hrbáček Kamil Láska Despite the key role of the surface energy budget in the global climate system, such investigations are rare in Antarctica. In this study, the surface energy budget measurements from the largest ice-free area on northern James Ross Island,...
Tue Aug 18, 2020 03:00
Biology, Vol. 9, Pages 236: Stress Changes the Resting-State Cortical Flow of Information from Distributed to Frontally Directed Patterns Biology doi: 10.3390/biology9080236 Authors: Soheil Keshmiri Despite converging evidence on the involvement of large-scale distributed brain networks in response to stress, the effect of stress on the components of these networks is less clear. Although some studies identify higher regional activities in response to stress, others observe an opposite...
Tue Aug 18, 2020 03:00
Biology, Vol. 9, Pages 234: Conservation of Cell Communication Systems in Invertebrate Host–Defence Mechanisms: Possible Role in Immunity and Disease Biology doi: 10.3390/biology9080234 Authors: Manon Auguste Teresa Balbi Caterina Ciacci Laura Canesi Innate immunity is continuously revealing multiple and highly conserved host–defence mechanisms. Studies on mammalian immunocytes are showing different communication systems that may play a role in coordinating innate immune responses...
Tue Aug 18, 2020 03:00
Biology, Vol. 9, Pages 235: ACE2 Protein Landscape in the Head and Neck Region: The Conundrum of SARS-CoV-2 Infection Biology doi: 10.3390/biology9080235 Authors: Géraldine Descamps Laurine Verset Anne Trelcat Claire Hopkins Jérome R. Lechien Fabrice Journe Sven Saussez The coronavirus pandemic raging worldwide since December 2019 is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which invades human cells via the angiotensin-converting enzyme...
Tue Aug 18, 2020 03:00
Biology, Vol. 9, Pages 233: Antimicrobial Peptides of Salmonid Fish: From Form to Function Biology doi: 10.3390/biology9080233 Authors: Sascha R. Brunner Joseph F. A. Varga Brian Dixon Antimicrobial peptides (AMPs) are small, usually cationic, and amphiphilic molecules that play a crucial role in molecular and cellular host defense against pathogens, tissue damage, and infection. AMPs are present in all metazoans and several have been discovered in teleosts. Some teleosts, such...
Tue Aug 18, 2020 03:00
Biomedicines, Vol. 8, Pages 291: miR-142-3p Reduces the Size, Migration, and Contractility of Endometrial and Endometriotic Stromal Cells by Targeting Integrin- and Rho GTPase-Related Pathways That Regulate Cytoskeletal Function Biomedicines doi: 10.3390/biomedicines8080291 Authors: Christin S. Börschel Anna Stejskalova Sebastian D. Schäfer Ludwig Kiesel Martin Götte Downregulated microRNA-142-3p signaling contributes to the pathogenesis of endometriosis, an invasive disease...
Tue Aug 18, 2020 03:00
Biomolecules, Vol. 10, Pages 1200: Mitochondrial Potassium Channels as Druggable Targets Biomolecules doi: 10.3390/biom10081200 Authors: Antoni Wrzosek Bartłomiej Augustynek Monika Żochowska Adam Szewczyk Mitochondrial potassium channels have been described as important factors in cell pro-life and death phenomena. The activation of mitochondrial potassium channels, such as ATP-regulated or calcium-activated large conductance potassium channels, may have cytoprotective effects...
Tue Aug 18, 2020 03:00
Biomolecules, Vol. 10, Pages 1199: The Protective Role of Decorin in Hepatic Metastasis of Colorectal Carcinoma Biomolecules doi: 10.3390/biom10081199 Authors: Andrea Reszegi Zsolt Horváth Katalin Karászi Eszter Regős Victoria Postniková Péter Tátrai András Kiss Zsuzsa Schaff Ilona Kovalszky Kornélia Baghy Decorin, the prototype member of the small leucine-rich proteoglycan gene family of extracellular matrix (ECM) proteins, acts as a powerful tumor suppressor...
Tue Aug 18, 2020 03:00
Biomolecules, Vol. 10, Pages 1198: CB2 Receptors and Neuron–Glia Interactions Modulate Neurotoxicity Generated by MAGL Inhibition Biomolecules doi: 10.3390/biom10081198 Authors: Estefania Rojo-Bustamante Ignacio Íñigo-Marco Miguel Angel Abellanas Rodrigo Vinueza-Gavilanes Ana Baltanás Esther Luquin Montserrat Arrasate Maria S. Aymerich Monoacylglycerol lipase inhibition (MAGL) has emerged as an interesting therapeutic target for neurodegenerative disease treatment...
Tue Aug 18, 2020 03:00
Biomolecules, Vol. 10, Pages 1197: Plasmodium falciparum Knockout for the GPCR-Like PfSR25 Receptor Displays Greater Susceptibility to 1,2,3-Triazole Compounds That Block Malaria Parasite Development Biomolecules doi: 10.3390/biom10081197 Authors: Benedito M. dos Santos Daniel T. G. Gonzaga Fernando C. da Silva Vitor F. Ferreira Celia R. S. Garcia The search for new compounds with antimalarial activity is urgent, as resistance to ones in the classical drug, has already been...
Tue Aug 18, 2020 03:00
Biosensors, Vol. 10, Pages 101: Electrochemical Detection of Neurotransmitters Biosensors doi: 10.3390/bios10080101 Authors: Saikat Banerjee Stephanie McCracken Md Faruk Hossain Gymama Slaughter Neurotransmitters are important chemical messengers in the nervous system that play a crucial role in physiological and physical health. Abnormal levels of neurotransmitters have been correlated with physical, psychotic, and neurodegenerative diseases such as Alzheimer’s, Parkinson’s,...
Tue Aug 18, 2020 03:00
Brain Sciences, Vol. 10, Pages 567: Expression of Dopamine-Related Genes in Four Human Brain Regions
Brain Sciences, Vol. 10, Pages 567: Expression of Dopamine-Related Genes in Four Human Brain Regions Brain Sciences doi: 10.3390/brainsci10080567 Authors: Stanfill Cao A better understanding of dopaminergic gene expression will inform future treatment options for many different neurologic and psychiatric conditions. Here, we utilized the National Institutes of Health’s Genotype-Tissue Expression project (GTEx) dataset to investigate genotype by expression associations...
Tue Aug 18, 2020 03:00
Brain Sciences, Vol. 10, Pages 566: A Preliminary Study on Cranio-Facial Characteristics Associated with Minor Neurological Dysfunctions (MNDs) in Children with Autism Spectrum Disorders (ASD) Brain Sciences doi: 10.3390/brainsci10080566 Authors: Laura Maniscalco Bonnet-Brilhault Frédérique Michele Roccella Domenica Matranga Gabriele Tripi Background. Craniofacial anomalies and minor neurological dysfunction (MNDs) have been identified, in literature, as risk factors for...
Tue Aug 18, 2020 03:00
Cancers, Vol. 12, Pages 2332: Hypermethylation of SCAND3 and Myo1g Gene Are Potential Diagnostic Biomarkers for Hepatocellular Carcinoma Cancers doi: 10.3390/cancers12082332 Authors: Fei Xu Lulu Zhang Yuxia Xu Di Song Wenting He Xiaomeng Ji Jianyong Shao Presently, there is a lack of effective blood-based biomarkers facilitating the diagnosis of hepatocellular carcinoma (HCC). Thus, we aimed to investigate novel methylation markers for HCC diagnosis, and explore relationships...
Tue Aug 18, 2020 03:00
Cancers, Vol. 12, Pages 2333: 18F-FDG, 11C-Methionine, and 68Ga-Pentixafor PET/CT in Patients with Smoldering Multiple Myeloma: Imaging Pattern and Clinical Features Cancers doi: 10.3390/cancers12082333 Authors: Xiang Zhou Alexander Dierks Olivia Kertels Malte Kircher Andreas Schirbel Samuel Samnick Andreas K. Buck Sebastian Knorz David Böckle Lukas Scheller Janin Messerschmidt Mohammad Barakat K. Martin Kortüm Leo Rasche Hermann Einsele Constantin...
Tue Aug 18, 2020 03:00
Cancers, Vol. 12, Pages 2326: Engineering Solutions for Mitigation of Chimeric Antigen Receptor T-Cell Dysfunction Cancers doi: 10.3390/cancers12082326 Authors: Artemis Gavriil Marta Barisa Emma Halliwell John Anderson The clinical successes of chimeric antigen receptor (CAR)-T-cell therapy targeting cell surface antigens in B cell leukaemias and lymphomas has demonstrated the proof of concept that appropriately engineered T-cells have the capacity to destroy advanced cancer...
Tue Aug 18, 2020 03:00
Cancers, Vol. 12, Pages 2329: Real World Outcomes of Ipilimumab and Nivolumab in Patients with Metastatic Melanoma Cancers doi: 10.3390/cancers12082329 Authors: Nethanel Asher Guy Ben-Betzalel Shaked Lev-Ari Ronnie Shapira-Frommer Yael Steinberg-Silman Neta Gochman Jacob Schachter Tomer Meirson Gal Markel Background: Immunotherapy has drastically changed the outlook for melanoma patients over the past decade. Specifically, the dual blockade of immune checkpoints...
Tue Aug 18, 2020 03:00
Cancers, Vol. 12, Pages 2330: Organotypic Co-Cultures as a Novel 3D Model for Head and Neck Squamous Cell Carcinoma Cancers doi: 10.3390/cancers12082330 Authors: Luca Engelmann Julia Thierauf Natalia Koerich Laureano Hans-Juergen Stark Elena-Sophie Prigge Dominik Horn Kolja Freier Niels Grabe Chao Rong Philippe Federspil Karim Zaoui Peter K. Plinkert Nicole Rotter Magnus von Knebel Doeberitz Jochen Hess Annette Affolter Background: Head and...
Tue Aug 18, 2020 03:00
Cancers, Vol. 12, Pages 2327: Three-Dimensional Interactions Analysis of the Anticancer Target c-Src Kinase with Its Inhibitors Cancers doi: 10.3390/cancers12082327 Authors: Vibhu Jha Marco Macchia Tiziano Tuccinardi Giulio Poli Src family kinases (SFKs) constitute the biggest family of non-receptor tyrosine kinases considered as therapeutic targets for cancer therapy. An aberrant expression and/or activation of the proto-oncogene c-Src kinase, which is the oldest and most studied...
Tue Aug 18, 2020 03:00
Cancers, Vol. 12, Pages 2328: Tumour Progression Stage-Dependent Secretion of YB-1 Stimulates Melanoma Cell Migration and Invasion Cancers doi: 10.3390/cancers12082328 Authors: Corinna Kosnopfel Tobias Sinnberg Birgit Sauer Heike Niessner Alina Muenchow Birgit Fehrenbacher Martin Schaller Peter R. Mertens Claus Garbe Basant Kumar Thakur Birgit Schittek Secreted factors play an important role in intercellular communication. Therefore, they are not only indispensable...
Tue Aug 18, 2020 03:00
Cancers, Vol. 12, Pages 2331: Intracellular Porphyromonas gingivalis Promotes the Tumorigenic Behavior of Pancreatic Carcinoma Cells Cancers doi: 10.3390/cancers12082331 Authors: JebaMercy Gnanasekaran Adi Binder Gallimidi Elias Saba Karthikeyan Pandi Luba Eli Berchoer Esther Hermano Sarah Angabo Hasna′a Makkawi Arin Khashan Alaa Daoud Michael Elkin Gabriel Nussbaum Porphyromonas gingivalis is a member of the dysbiotic oral microbiome associated with...
Tue Aug 18, 2020 03:00
Cancers, Vol. 12, Pages 2325: Sex Hormones and Hormone Therapy during COVID-19 Pandemic: Implications for Patients with Cancer Cancers doi: 10.3390/cancers12082325 Authors: Carlo Cattrini Melissa Bersanelli Maria Maddalena Latocca Benedetta Conte Giacomo Vallome Francesco Boccardo The novel coronavirus disease 2019 (COVID-19) shows a wide spectrum of clinical presentations, severity, and fatality rates. The reason older patients and males show increased risk of severe...
Tue Aug 18, 2020 03:00
Cancers, Vol. 12, Pages 2323: Clinical Course from Diagnosis to Death in Patients with Well-Differentiated Thyroid Cancer Cancers doi: 10.3390/cancers12082323 Authors: Hyunju Park Jun Park So Young Park Tae Hyuk Kim Sun Wook Kim Jae Hoon Chung Because of the low mortality rate of well-differentiated thyroid cancer (WDTC), investigation of the clinical course leading to death is limited. We analyzed the cause of death and clinical course from diagnosis to death in patients...
Tue Aug 18, 2020 03:00
Cancers, Vol. 12, Pages 2324: Extracellular Vesicle-Based Communication May Contribute to the Co-Evolution of Cancer Stem Cells and Cancer-Associated Fibroblasts in Anti-Cancer Therapy Cancers doi: 10.3390/cancers12082324 Authors: Gábor Valcz Edit I. Buzás Anna Sebestyén Tibor Krenács Zoltán Szállási Péter Igaz Béla Molnár Analogously to the natural selective forces in ecosystems, therapies impose selective pressure on cancer cells within tumors. Some tumor cells can...
Tue Aug 18, 2020 03:00
Cells, Vol. 9, Pages 1918: Correction: Yao, Y., et al. Activation of Slit2/Robo1 Signaling Promotes Tumor Metastasis in Colorectal Carcinoma through Activation of the TGF-β/Smads Pathway. Cells 2019, 8, 635 Cells doi: 10.3390/cells9081918 Authors: Yuying Yao Zijun Zhou Liuyou Li Junchen Li Lixun Huang Jiangchao Li Cuiling Qi Lingyun Zheng Lijing Wang Qian-Qian Zhang The author wishes to make the following correction to this paper [...]
Tue Aug 18, 2020 03:00
Cells, Vol. 9, Pages 1917: MiRNA let-7 from TPO(+) Extracellular Vesicles is a Potential Marker for a Differential Diagnosis of Follicular Thyroid Nodules Cells doi: 10.3390/cells9081917 Authors: Lidia Zabegina Inga Nazarova Margarita Knyazeva Nadezhda Nikiforova Maria Slyusarenko Sergey Titov Dmitry Vasilyev Ilya Sleptzov Anastasia Malek Background: The current approaches to distinguish follicular adenomas (FA) and follicular thyroid cancer (FTC) at the pre-operative...
Tue Aug 18, 2020 03:00
Cells, Vol. 9, Pages 1914: Decreased Equilibrative Nucleoside Transporter 1 (ENT1) Activity Contributes to the High Extracellular Adenosine Levels in Mesenchymal Glioblastoma Stem-Like Cells Cells doi: 10.3390/cells9081914 Authors: Sebastián Alarcón María de los Ángeles Toro Carolina Villarreal Rómulo Melo Rodrigo Fernández Angel Ayuso Sacido Daniel Uribe Rody San Martín Claudia Quezada Glioblastoma multiforme is one of the most malignant types of cancer. This...
Tue Aug 18, 2020 03:00
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