Related Articles Apolipoprotein A-IV Enhances Fatty Acid Uptake by Adipose Tissues of Male Mice via Sympathetic Activation. Endocrinology. 2020 04 01;161(4): Authors: Zhu Q, Weng J, Shen M, Fish J, Shen Z, Coschigano KT, Davidson WS, Tso P, Shi H, Lo CC Abstract Apolipoprotein A-IV (ApoA-IV) synthesized by the gut regulates lipid metabolism. Sympathetic innervation of adipose tissues also controls lipid metabolism. We hypothesized that ApoA-IV...
Sat Aug 01, 2020 14:38
Related Articles The alcohol dehydrogenase gene family in sugarcane and its involvement in cold stress regulation. BMC Genomics. 2020 Jul 29;21(1):521 Authors: Su W, Ren Y, Wang D, Su Y, Feng J, Zhang C, Tang H, Xu L, Muhammad K, Que Y Abstract BACKGROUND: Alcohol dehydrogenases (ADHs) in plants are encoded by a multigene family. ADHs participate in growth, development, and adaptation in many plant species, but the evolution and function of...
Fri Jul 31, 2020 14:59
Related Articles MLP-deficient human pluripotent stem cell derived cardiomyocytes develop hypertrophic cardiomyopathy and heart failure phenotypes due to abnormal calcium handling. Cell Death Dis. 2019 08 13;10(8):610 Authors: Li X, Lu WJ, Li Y, Wu F, Bai R, Ma S, Dong T, Zhang H, Lee AS, Wang Y, Lan F Abstract Muscle LIM protein (MLP, CSRP3) is a key regulator of striated muscle function, and its mutations can lead to both hypertrophic cardiomyopathy...
Fri Jul 31, 2020 14:59
Related Articles Noradrenaline-Specific, Efficient Visualization in Brain Tissue Triggered by Unique Cascade Nucleophilic Substitution. Anal Chem. 2019 02 05;91(3):2255-2259 Authors: Yue Y, Huo F, Yin C Abstract Noradrenaline as one of the most important neurotransmitters in the sympathetic nervous system plays key roles in all of the forebrain activities such as perception, memory, learning, and homeostasis, and its dysfunction is closely...
Fri Jul 31, 2020 14:59
Abstract Traumatic brain injury (TBI) and Alzheimer’s disease (AD) are prominent neurological conditions whose neural and cognitive commonalities are poorly understood. The extent of TBI-related neurophysiological abnormalities has been hypothesized to reflect AD-like neurodegeneration because TBI can increase vulnerability to AD. However, it remains challenging to prognosticate AD risk partly because the functional relationship between acute posttraumatic sequelae and chronic...
Sun Aug 02, 2020 03:00
Abstract The impairment of mitochondrial metabolism is a hallmark of aging. Mitonuclear imbalance and the mitochondrial unfolded protein response (UPRmt) are two conserved mitochondrial mechanisms that play critical roles in ensuring mitochondrial proteostasis and function. Here, we combined bioinformatics, physiological, and molecular analyses to examine the role of mitonuclear imbalance and UPRmt in the skeletal muscle of aged rodents and humans. The analysis of transcripts from...
Fri Jul 31, 2020 03:00
Maysin plays a protective role against α-Synuclein oligomers cytotoxicity by triggering autophagy activation. Food Chem Toxicol. 2020 Jul 29;:111626 Authors: Leri M, Vasarri M, Palazzi L, Barletta E, Nielsen E, Bucciantini M, Degl'Innocenti D Abstract Parkinson's disease (PD) is a widespread neurodegenerative disorder characterized by the progressive loss of neurons. The accumulation of aggregated forms of the α-Synuclein (Syn) protein is the...
Sun Aug 02, 2020 16:44
Individual Differences in Within-Subject Weight Variability: There's a Signal in the Noise. Physiol Behav. 2020 Jul 29;:113112 Authors: Lowe MR, Benson L, Singh S Abstract Humans show a high degree of stability in their body weights over time, a phenomenon explained by powerful, redundant homeostatic mechanisms. Nonetheless, human populations are also highly susceptible to develop epidemic levels of overweight in an obesogenic environment....
Sun Aug 02, 2020 16:44
Related Articles Circulating microRNAs modulating glycolysis as non-invasive prognostic biomarkers of HNSCC. Eur Arch Otorhinolaryngol. 2020 Jul 31;: Authors: Avilés-Jurado FX, Muñoz C, Meler C, Flores JC, Gumà J, Benaiges E, Mora J, Camacho M, León X, Vilaseca I, Terra X Abstract BACKGROUND: The identification of prognostic non-invasive biomarkers is a priority for cancer patients' care. Circulating microRNA (miRNAs) have been described in...
Sun Aug 02, 2020 16:44
Related Articles The esophageal gland mediates host immune evasion by the human parasite Schistosoma mansoni. Proc Natl Acad Sci U S A. 2020 Jul 31;: Authors: Lee J, Chong T, Newmark PA Abstract Schistosomes are parasitic flatworms that cause schistosomiasis, a neglected tropical disease affecting over 200 million people. Schistosomes develop multiple body plans while navigating their complex life cycle, which involves two different hosts: a...
Sun Aug 02, 2020 16:44
Related Articles Promoter Proximal Pausing Limits Tumorous Growth Induced by the Yki Transcription Factor in Drosophila. Genetics. 2020 Jul 31;: Authors: Nagarkar S, Wasnik R, Govada P, Cohen S, Shashidhara LS Abstract Promoter proximal pausing (PPP) of RNA Polymerase II has emerged as a crucial rate-limiting-step in the regulation of gene expression. Regulation of PPP is brought about by complexes 7SK snRNP, P-TEFb (Cdk9/cycT) and the Negative...
Sun Aug 02, 2020 16:44
Related Articles Investigating Microglia in Health and Disease: Challenges and Opportunities. Trends Immunol. 2020 Jul 28;: Authors: Miron VE, Priller J Abstract Microglia are tissue-resident macrophages implicated in central nervous system (CNS) development, homeostasis, and response to injury. Recent advances in transcriptomics, multiplex protein expression analysis, and experimental depletion of microglia have cemented their importance. However,...
Sun Aug 02, 2020 16:44
Related Articles Neurophysiological and cognitive changes in pregnancy. Handb Clin Neurol. 2020;171:25-55 Authors: Grattan DR, Ladyman SR Abstract The hormonal fluctuations in pregnancy drive a wide range of adaptive changes in the maternal brain. These range from specific neurophysiological changes in the patterns of activity of individual neuronal populations, through to complete modification of circuit characteristics leading to fundamental...
Sun Aug 02, 2020 16:44
48 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human homeostasis These pubmed results were generated on 2020/08/01PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Aug 01, 2020 17:09
48 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human homeostasis These pubmed results were generated on 2020/08/01PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Aug 01, 2020 13:15
36 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human homeostasis These pubmed results were generated on 2020/07/31PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Fri Jul 31, 2020 17:38
36 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human homeostasis These pubmed results were generated on 2020/07/31PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Fri Jul 31, 2020 13:42
Analysis of Menstrual Blood Stromal Cells Reveals SOX15 Triggers Oocyte-Based Human Cell Reprogramming. iScience. 2020 Jul 16;23(8):101376 Authors: Lopez-Caraballo L, Martorell-Marugan J, Carmona-Saez P, Gonzalez-Muñoz E Abstract Cell reprogramming has revolutionized cell and regenerative biology field. However, human iPS derivation remains inefficient and variable. A better knowledge of molecular processes and the rationale underlying the...
Sun Aug 02, 2020 13:37
Predictors of performance in Amateur Olympic distance triathlon: Predictors in amateur triathlon. Physiol Behav. 2020 Jul 29;:113110 Authors: Puccinelli PJ, Lima GHO, Pesquero JB, de Lira CAB, Vancini RL, Nikolaids PT, Knechtle B, Andrade MS Abstract OBJECTIVE: Present study examines predictors of the overall race time and disciplines in the Olympic distance triathlon. METHODS: Thirty-nine male and six female triathletes were evaluated...
Sun Aug 02, 2020 13:37
Arrhythmogenic Cardiomyopathy: An In-Depth Look at Molecular Mechanisms and Clinical Correlates. Trends Cardiovasc Med. 2020 Jul 29;: Authors: Costa S, Cerrone M, Saguner AM, Brunckhorst C, Delmar M, Duru F Abstract Arrhythmogenic cardiomyopathy (ACM) is a familial disease, with approximately 60% of patients displaying a pathogenic variant. The majority of genes linked to ACM code for components of the desmosomes: plakophilin-2 (PKP2), desmoglein-2...
Sun Aug 02, 2020 13:37
Palmitoleic acid reduces high fat diet-induced liver inflammation by promoting PPAR-γ-independent M2a polarization of myeloid cells. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Jul 29;:158776 Authors: Souza CO, Teixeira AAS, Biondo LA, Silveira LS, de Souza Breda CN, Braga TT, Camara NOS, Belchior T, Festuccia WT, Diniz TA, Ferreira GM, Hirata MH, Chaves-Filho AB, Yoshinaga MY, Myiamoto S, Calder PC, Sethi JK, Rosa Neto JC Abstract Palmitoleic...
Sun Aug 02, 2020 13:37
Light and hormones in seasonal regulation of reproduction and mood. Endocrinology. 2020 Aug 01;: Authors: Chen J, Okimura K, Yoshimura T Abstract Organisms that inhabit the temperate zone exhibit various seasonal adaptive behaviors, including reproduction, hibernation, molting, and migration. Day length, known as photoperiod, is the most noise-free and widely used environmental cue that enables animals to anticipate the oncoming seasons and...
Sun Aug 02, 2020 13:37
Related Articles Prediction of distant metastases in patients with squamous cell carcinoma of head and neck using DWI and DCE-MRI. Head Neck. 2020 Aug 01;: Authors: Chawla S, Kim SG, Loevner LA, Wang S, Mohan S, Lin A, Poptani H Abstract BACKGROUND: The primary purpose was to evaluate the prognostic potential of diffusion imaging (DWI) and dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) in predicting distant metastases in squamous...
Sun Aug 02, 2020 13:37
Related Articles The Effect of Isotretinoin Therapy on Oxidative Damage in Rats Isotretinoin and Oxidative Damage in Rats. Dermatol Ther. 2020 Jul 31;: Authors: Daye M, Belviranlı M, Okudan N, Mevlitoglu I, Oz M Abstract Isotretinoin is prescribed in many dermatologic disorders, but mostly in acne. There is limited research about oxidative stress induced by isotretinoin and its effects on the liver tissue, muscle tissue, and blood. In this study,...
Sun Aug 02, 2020 13:37
Related Articles The Functional Role of the Secretin/Secretin Receptor Signaling During Cholestatic Liver Injury. Hepatology. 2020 Aug 01;: Authors: Wu N, Baiocchi L, Zhou T, Kennedy L, Ceci L, Meng F, Sato K, Wu C, Ekser B, Kyritsi K, Kundu D, Chen L, Meadows V, Franchitto A, Alvaro D, Onori P, Gaudio E, Lenci I, Francis H, Glaser S, Alpini G Abstract The gastrointestinal peptide, secretin (Sct) is an important homeostatic regulator of pancreatic...
Sun Aug 02, 2020 13:37
Related Articles Update on the ESCEO recommendation for the conduct of clinical trials for drugs aiming at the treatment of sarcopenia in older adults. Aging Clin Exp Res. 2020 Jul 31;: Authors: Reginster JY, Beaudart C, Al-Daghri N, Avouac B, Bauer J, Bere N, Bruyère O, Cerreta F, Cesari M, Rosa MM, Cooper C, Cruz Jentoft AJ, Dennison E, Geerinck A, Gielen E, Landi F, Laslop A, Maggi S, Prieto Yerro MC, Rizzoli R, Sundseth H, Sieber C, Trombetti A, Vellas B,...
Sun Aug 02, 2020 13:37
Related Articles Rare heterozygous GDF6 variants in patients with renal anomalies. Eur J Hum Genet. 2020 Jul 31;: Authors: Martens H, Hennies I, Getwan M, Christians A, Weiss AC, Brand F, Gjerstad AC, Christians A, Gucev Z, Geffers R, Seeman T, Kispert A, Tasic V, Bjerre A, Lienkamp SS, Haffner D, Weber RG Abstract Although over 50 genes are known to cause renal malformation if mutated, the underlying genetic basis, most easily identified in...
Sun Aug 02, 2020 13:37
Related Articles General and Disease-Specific Health Indicator Changes Associated with Inpatient Rehabilitation. J Am Med Dir Assoc. 2020 Jul 28;: Authors: Grote V, Unger A, Böttcher E, Muntean M, Puff H, Marktl W, Mur E, Kullich W, Holasek S, Hofmann P, Lackner HK, Goswami N, Moser M Abstract OBJECTIVES: Rehabilitation plays a vital role in the mitigation and improvement of functional limitations associated with aging and chronic conditions....
Sun Aug 02, 2020 13:37
131 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2020/08/01PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Aug 01, 2020 17:41
131 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2020/08/01PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Aug 01, 2020 13:42
119 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2020/07/31PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Fri Jul 31, 2020 17:47
119 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2020/07/31PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Fri Jul 31, 2020 13:48
1006 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2020/08/02PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sun Aug 02, 2020 16:27
3181 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2020/08/01PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Aug 01, 2020 16:34
2808 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2020/07/31PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Fri Jul 31, 2020 16:38
Whether you're keeping an eye out for hunting season or just trying to learn more about the local wildlife, trail cams can open a window into a new world. (Celine Geeurickx/Unsplash/)This story originally featured on Outdoor Life.If you think about all the components that go into building a trail camera—detection circuits, infrared emitters, view screen, lens, and the waterproof housing it comes in—you’re getting a pretty good deal for not a whole lot of money. A good trail cam that will last you...
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The Knoop Diamond Test measures how difficult it is to damage the glossy surface. (Corning /)It’s easy to forget how fragile smartphones used to be. If you were going to knock your phone off your desk a decade ago, it might as well fall into the Grand Canyon. Many of you know the familiar, unpleasant feeling of using a phone with a spiderweb of cracks running across the screen. Screens have gotten much tougher in recent years. And they’re about to get even tougher. Corning just introduced the latest...
Sun Aug 02, 2020 16:00
Alienware Aurora Ryzen (Jarren Vink/)Gaming on a console or phone is fun and all, but elite players rely on massive PCs with precision peripherals to wield their weapons with john wick–like agility. This rig is ready to smite every online foe.Tower Pro gamers demand smooth graphics rendering so there’s no fight-ruining lag between their commands and what happens onscreen. The burly multicore AMD processor inside the Alienware Aurora Ryzen stores data in an extra-large cache to avoid any hiccups.Razer...
Sun Aug 02, 2020 00:00
Easy access. (John Kennedy/)You’re in your kitchen, preparing to make a delicious dinner. You pick up your favorite knife and go to grab a cutting board from the pile in your pantry. There are too many. It’s like a loose deck of cards. They clatter to the floor. A toe-crushing waterfall of wood and plastic. Everything turns black and white. You’re in the bad part of an infomercial. A child screams. You scream. Panic.But there truly is a better way: Build a storage rack on the inside of a kitchen...
Sat Aug 01, 2020 12:00
Your browser of choice probably offers an more private mode—but how effective is it? (Michal Vavro/Unsplash/)Lorrie Cranor is a professor of Computer Science and of Engineering & Public Policy at Carnegie Mellon University. Hana Habib is a graduate research assistant at the Institute for Software Research at Carnegie Mellon University. This story was originally featured on The Conversation.Many people look for more privacy when they browse the web by using their browsers in privacy-protecting...
Fri Jul 31, 2020 23:00
HPV is the most common sexually transmitted infection in the United States. The new guidelines will prevent 13 percent more cervical cancers and 7 percent more cervical cancer deaths. (Pexels /)The American Cancer Society has updated its recommendations for cervical cancer screening to require less frequent tests and be easier to follow, the organization announced on July 30 in its publication CA: A Cancer Journal for Clinicians. The new guidelines bump up the recommended age for people with cervixes...
Fri Jul 31, 2020 21:00
Don't kid yourself—beaches will definitely be more crowded than this. (takahiro taguchi / Unsplash/)Follow all of PopSci’s COVID-19 coverage here, including tips on cleaning groceries, ways to tell if your symptoms are just allergies, and a tutorial on making your own mask.Summer is a time for fun. A time for the beach, vacations, and cookouts with friends and family. We get it—it’s hard to resist the temptation of hot sun, cool waves, and good company, even as a pandemic rages across the country.But...
Fri Jul 31, 2020 20:18
Game on! (Florian Olivo via Unsplash/)A good monitor can mean the difference between a win and a loss, or seeing a pixelated mess or brilliantly detailed world.Intro: One of the joys of PC gaming is being able to fine tune the visuals of your favorite games. For some players that can mean settings that sacrifice the fastest gameplay for jaw-dropping visuals; For others the perfect settings involve the fastest response times so that they can get off that head shot before anyone even knows they’re...
Fri Jul 31, 2020 18:42
Have fun in the sun and still be on time. (Collin Hardy via Unsplash/)Why settle for the limited battery life of a mechanical watch when you can make an affordable, worthwhile investment in renewable energy? Powered by sun and other ambient lighting, solar watches use solar cell units below the dial to convert light energy into electrical energy which is then stored in a rechargeable battery that lasts over 10 years. Even after 20 years they can retain up to 80 percent of their power reserve capacity....
Fri Jul 31, 2020 18:17
Cool treats to cool down. (Goran Ivos via Unsplash/)As the temperature dials up, you’ll likely want to cool down with some fresh frozen snacks. What better than a tray of homemade juice, smoothie, or yogurt popsicles? Wow your friends, kids, and family with these four whimsical and fabulous ice pop molds.A scary good dessert. (Amazon/)Fulfill those childhood monster hunter dreams and make a tray of ghoulish ice pops. The four different monster molds have ferocious detailed faces, foot handles, and...
Fri Jul 31, 2020 18:14
The iPhone 11 Pro debuted last September. The 12 may show up later in the year. (Apple/)Fall is iPhone season. Just as the leaves start to turn, we expect Tim Cook and his pals to get up on stage at an Apple keynote and show off Cupertino’s newest creation. This year, we may get the announcement in September, but it’s unlikely we’ll have any actual phones on shelves until October according to information released during Apple’s earnings call on Thursday. During the call, Apple CFC Luca Maestri said,...
Fri Jul 31, 2020 17:43
Don't eat, plant, or toss out any weird seeds that may appear on your doorstep. (Pexels/)The past six months have been rife with conspiracy claims and faulty facts, but now there’s another sketchy development to add to the list. This week, people in 30 US states reported getting mysterious seeds, including ones that looked like tiny cornflakes, in the mail from Chinese addresses. The US Department of Agriculture (USDA) states that it’s likely just a “brushing scam,” or a marketing trick to solicit...
Fri Jul 31, 2020 15:00
Mediterranean Diet and Telomere Length: A Systematic Review and Meta-Analysis. Adv Nutr. 2020 Jul 30;: Authors: Canudas S, Becerra-Tomás N, Hernández-Alonso P, Galié S, Leung C, Crous-Bou M, De Vivo I, Gao Y, Gu Y, Meinilä J, Milte C, García-Calzón S, Marti A, Boccardi V, Ventura-Marra M, Salas-Salvadó J Abstract Accelerated telomere shortening has been associated with several age-related diseases and/or decreased lifespan in humans. The Mediterranean...
Fri Jul 31, 2020 15:59
Related Articles MutEnricher: a flexible toolset for somatic mutation enrichment analysis of tumor whole genomes. BMC Bioinformatics. 2020 Jul 31;21(1):338 Authors: Soltis AR, Dalgard CL, Pollard HB, Wilkerson MD Abstract BACKGROUND: Analysis of somatic mutations from tumor whole exomes has fueled discovery of novel cancer driver genes. However, ~ 98% of the genome is non-coding and includes regulatory elements whose normal cellular functions...
Sun Aug 02, 2020 13:12
Related Articles IDSSIM: an lncRNA functional similarity calculation model based on an improved disease semantic similarity method. BMC Bioinformatics. 2020 Jul 31;21(1):339 Authors: Fan W, Shang J, Li F, Sun Y, Yuan S, Liu JX Abstract BACKGROUND: It has been widely accepted that long non-coding RNAs (lncRNAs) play important roles in the development and progression of human diseases. Many association prediction models have been proposed for...
Sun Aug 02, 2020 13:12
Related Articles ADMIXPIPE: population analyses in ADMIXTURE for non-model organisms. BMC Bioinformatics. 2020 Jul 29;21(1):337 Authors: Mussmann SM, Douglas MR, Chafin TK, Douglas ME Abstract BACKGROUND: Research on the molecular ecology of non-model organisms, while previously constrained, has now been greatly facilitated by the advent of reduced-representation sequencing protocols. However, tools that allow these large datasets to be efficiently...
Fri Jul 31, 2020 16:43
Related Articles Statistical shape analysis of tap roots: a methodological case study on laser scanned sugar beets. BMC Bioinformatics. 2020 Jul 29;21(1):335 Authors: Heeren B, Paulus S, Goldbach H, Kuhlmann H, Mahlein AK, Rumpf M, Wirth B Abstract BACKGROUND: The efficient and robust statistical analysis of the shape of plant organs of different cultivars is an important investigation issue in plant breeding and enables a robust cultivar description...
Fri Jul 31, 2020 16:43
Related Articles A topological data analysis based classification method for multiple measurements. BMC Bioinformatics. 2020 Jul 29;21(1):336 Authors: Riihimäki H, Chachólski W, Theorell J, Hillert J, Ramanujam R Abstract BACKGROUND: Machine learning models for repeated measurements are limited. Using topological data analysis (TDA), we present a classifier for repeated measurements which samples from the data space and builds a network graph...
Fri Jul 31, 2020 16:43
Related Articles Online patient simulation training to improve clinical reasoning: a feasibility randomised controlled trial. BMC Med Educ. 2020 Jul 31;20(1):245 Authors: Plackett R, Kassianos AP, Kambouri M, Kay N, Mylan S, Hopwood J, Schartau P, Gray S, Timmis J, Bennett S, Valerio C, Rodrigues V, Player E, Hamilton W, Raine R, Duffy S, Sheringham J Abstract BACKGROUND: Online patient simulations (OPS) are a novel method for teaching clinical...
Sun Aug 02, 2020 14:02
Related Articles Disparity of perspectives between teachers and learners on perioperative teaching and learning. BMC Med Educ. 2020 Jul 31;20(1):244 Authors: Chang YT, Lu PY, Lai CS Abstract BACKGROUND: To build a consensus about learning objectives in the operating room, the aim of the study was to evaluate both surgical teacher and learner perspectives on perioperative teaching and learning in Taiwan. METHODS: Twelve main technical...
Sun Aug 02, 2020 14:02
Related Articles A systematic scoping review of ethical issues in mentoring in medical schools. BMC Med Educ. 2020 Jul 31;20(1):246 Authors: Kow CS, Teo YH, Teo YN, Chua KZY, Quah ELY, Kamal NHBA, Tan LHE, Cheong CWS, Ong YT, Tay KT, Chiam M, Mason S, Krishna LKR Abstract BACKGROUND: Mentoring provides mentees and mentors with holistic support and research opportunities. Yet, the quality of this support has been called into question amidst suggestions...
Sun Aug 02, 2020 14:02
Related Articles Internal medicine residents identify gaps in medical education on outpatient referrals. BMC Med Educ. 2020 Jul 30;20(1):243 Authors: Slavin MJ, Rajan M, Kern LM Abstract BACKGROUND: Relevant clinical information is often missing when a patient sees a specialist after being referred by another physician in the ambulatory setting. This can result in missed or delayed diagnoses, delayed treatment, unnecessary testing, and drug...
Sat Aug 01, 2020 14:30
Related Articles How interprofessional education could benefit the future of healthcare - medical students' perspective. BMC Med Educ. 2020 Jul 29;20(1):242 Authors: Choudhury RI, Salam MAU, Mathur J, Choudhury SR Abstract As British medical students, we believe the impact that interprofessional education can have upon the future of healthcare to be a positive one. This is if it is implemented in health professions' pre-registration curricula...
Fri Jul 31, 2020 15:01
Related Articles Students' perceptions of the educational environment at King Abdulaziz University Faculty of Dentistry (KAUFD): a cross sectional study. BMC Med Educ. 2020 Jul 29;20(1):241 Authors: Sabbagh HJ, Bakhaider HA, Abokhashabah HM, Bader MU Abstract BACKGROUND: Prior research studies have found that dental students' educational environment has an impact on their academic achievement. Therefore, the aim of this cross-sectional study...
Fri Jul 31, 2020 15:01
Related Articles Massive open online course for Brazilian healthcare providers working with substance use disorders: curriculum design. BMC Med Educ. 2020 Jul 29;20(1):240 Authors: Monteiro EP, Gomide HP, Remor E Abstract BACKGROUND: Interpersonal and technical skills are required for the care of people living with substance use disorders. Considering the applicability and usability of online courses as continuing professional education initiatives,...
Fri Jul 31, 2020 15:01
Related Articles Addressing knowledge gaps in Parkinson's disease: a report on the Movement Disorder Society's Centre-to-Centre initiative to improve Parkinson's disease services in Lao People's Democratic Republic. BMC Med Educ. 2020 Jul 29;20(1):239 Authors: Phokaewvarangkul O, Vorachit S, Phoumindr A, Keosodsay S, Postuma RB, Meissner WG, Bhidayasiri R Abstract BACKGROUND: Lao People's Democratic Republic (Lao PDR) has only nine neurologists...
Fri Jul 31, 2020 15:01
Related Articles Factors associated with unsafe work behaviours in an Iranian petrochemical company: perspectives of workers, supervisors, and safety managers. BMC Public Health. 2020 Jul 31;20(1):1192 Authors: Zahiri Harsini A, Ghofranipour F, Sanaeinasab H, Amin Shokravi F, Bohle P, Matthews LR Abstract BACKGROUND: The petrochemical industry is hazardous, in part because of the inherently dangerous nature of the work conducted, and incidents...
Sun Aug 02, 2020 13:28
Related Articles Education and prevalence of overweight and obesity among reproductive age group women in Ethiopia: analysis of the 2016 Ethiopian demographic and health survey data. BMC Public Health. 2020 Jul 31;20(1):1189 Authors: Mengesha Kassie A, Beletew Abate B, Wudu Kassaw M Abstract BACKGROUND: Globally, the prevalence of overweight and obesity is escalating, particularly among women and wealthier people. In many developed countries,...
Sun Aug 02, 2020 13:28
Related Articles Public engagement in the development of the National Health Insurance: a study involving patients from a central hospital in South Africa. BMC Public Health. 2020 Jul 31;20(1):1191 Authors: Tandwa LA, Dhai A Abstract BACKGROUND: The National Health Insurance (NHI) is a proposed health policy in South Africa that aims to change the structure of the current health system. Public involvement in policy making is important and it...
Sun Aug 02, 2020 13:28
Related Articles Trends in urban/rural inequalities in physical growth among Chinese children over three decades of urbanization in Guangzhou: 1985-2015. BMC Public Health. 2020 Jul 31;20(1):1190 Authors: Hu Y, Lin W, Tan X, Liu Y, Wen Y, Xing Y, Ma Y, Liu H, Song Y, Liang J, Lam KBH, Lin S Abstract BACKGROUND: Great growth inequalities between urban and rural areas have been reported in China over the past years. By examining urban/rural inequalities...
Sun Aug 02, 2020 13:28
Related Articles Medication management in the context of mental illness: an exploratory study of young people living in Australia. BMC Public Health. 2020 Jul 30;20(1):1188 Authors: McMillan SS, Stewart V, Wheeler AJ, Kelly F, Stapleton H Abstract BACKGROUND: Young people face significant challenges when managing a mental illness, such as acquiring treatment autonomy, being inexperienced users of the healthcare system and associated peer-related...
Sat Aug 01, 2020 13:42
Related Articles Epidemiological and clinical characteristics of fall-related injuries: a retrospective study. BMC Public Health. 2020 Jul 29;20(1):1186 Authors: Mekkodathil A, El-Menyar A, Kanbar A, Hakim S, Ahmed K, Siddiqui T, Al-Thani H Abstract BACKGROUND: Fall-related injuries are important public health problem worldwide. We aimed to describe the epidemiological and clinical characteristics of fall-related injuries in a level 1 trauma...
Fri Jul 31, 2020 13:55
Related Articles Community health volunteers' contribution to tuberculosis patients notified to National Tuberculosis program through contact investigation in Kenya. BMC Public Health. 2020 Jul 29;20(1):1184 Authors: Abongo T, Ulo B, Karanja S Abstract BACKGROUND: Contact investigation is important in finding contacts of people who have Tuberculosis (TB) disease so that they can be given treatment and stop further transmission. The main objective...
Fri Jul 31, 2020 13:55
Related Articles Community knowledge and practices regarding antibiotic use in rural Mozambique: where is the starting point for prevention of antibiotic resistance? BMC Public Health. 2020 Jul 29;20(1):1183 Authors: Cambaco O, Alonso Menendez Y, Kinsman J, Sigaúque B, Wertheim H, Do N, Gyapong M, John-Langba J, Sevene E, Munguambe K Abstract BACKGROUND: Antibiotic misuse and other types of unnecessary use of antibiotics can contribute to accelerate...
Fri Jul 31, 2020 13:55
Related Articles Research protocol of a multifaceted prospective mixed-method longitudinal study: Navigating Through Life - Western Australian study of transitions from out-of-home care. BMC Public Health. 2020 Jul 29;20(1):1180 Authors: Parsons L, Chung D, Cordier R, Hodgson D, Lund S, Mendes P, O'Donnell M, Parsons R, Thoresen S Abstract BACKGROUND: Developing robust evidence is a challenge for researchers working with disadvantaged or vulnerable...
Fri Jul 31, 2020 13:55
Related Articles Mid-upper arm circumference as an indicator of underweight in adults: a cross-sectional study from Nepal. BMC Public Health. 2020 Jul 29;20(1):1187 Authors: Thorup L, Hamann SA, Kallestrup P, Hjortdal VE, Tripathee A, Neupane D, Patsche CB Abstract BACKGROUND: Undernourished people have an increased risk of premature mortality from both infectious and non-communicable diseases. Aside from screening purposes, assessment of nutritional...
Fri Jul 31, 2020 13:55
Related Articles Nutritional status and dietary diversity of school-age children living with HIV: a cross-sectional study in Phnom Penh, Cambodia. BMC Public Health. 2020 Jul 29;20(1):1181 Authors: Yasuoka J, Yi S, Okawa S, Tuot S, Murayama M, Huot C, Chhoun P, Yem S, Yuzuriha K, Mizutani T, Kikuchi K Abstract BACKGROUND: HIV/AIDS continues to be a major public health concern for children. Each day, worldwide, approximately 440 children became...
Fri Jul 31, 2020 13:55
Related Articles Sexually transmitted infections in male heterosexual Dutch clients who visited German cross-border female sex workers; a 3 year retrospective study. BMC Public Health. 2020 Jul 29;20(1):1182 Authors: Kampman CJG, Hoebe CJPA, Koene R, Kamp L, Jansen K, Koedijk FDH, Tostmann A, Hautvast JLA Abstract BACKGROUND: Some male heterosexual clients prefer to visit a cross-border Female Sex Worker (FSW) because of cheaper sex and unsafe...
Fri Jul 31, 2020 13:55
Related Articles Adapting and implementing training, guidelines and treatment cards to improve primary care-based hypertension and diabetes management in a fragile context: results of a feasibility study in Sierra Leone. BMC Public Health. 2020 Jul 29;20(1):1185 Authors: Zou G, Witter S, Caperon L, Walley J, Cheedella K, Senesi RGB, Wurie HR Abstract BACKGROUND: Sierra Leone, a fragile country, is facing an increasingly significant burden of...
Fri Jul 31, 2020 13:55
20 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "BMJ Open"[jour] These pubmed results were generated on 2020/08/02PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sun Aug 02, 2020 14:28
Related Articles Ways Ahead: developing a supported self-management programme for people living with low- and intermediate-grade gliomas - a protocol for a multi-method study. BMJ Open. 2020 Jul 29;10(7):e041465 Authors: Rimmer B, Dutton L, Lewis J, Burns R, Gallagher P, Williams S, Araujo-Soares V, Finch T, Sharp L Abstract INTRODUCTION: Living with and beyond a diagnosis of a low- and intermediate-grade glioma (LIGG) can adversely impact many...
Fri Jul 31, 2020 15:16
Related Articles Excess cases of influenza and the coronavirus epidemic in Catalonia: a time-series analysis of primary-care electronic medical records covering over 6 million people. BMJ Open. 2020 Jul 29;10(7):e039369 Authors: Coma Redon E, Mora N, Prats-Uribe A, Fina Avilés F, Prieto-Alhambra D, Medina M Abstract OBJECTIVES: There is uncertainty about when the first cases of COVID-19 appeared in Spain. We aimed to determine whether influenza...
Fri Jul 31, 2020 15:16
Related Articles Quality of life measured by EQ-5D at different treatment time points for coronary artery disease: protocol for a systematic review and meta-analysis. BMJ Open. 2020 Jul 29;10(7):e039311 Authors: Lum E, McCreanor V, Luo N, Graves N Abstract INTRODUCTION: Cardiovascular disease is estimated to affect 423 million people globally. It caused 18 million deaths in 2017 and is projected to cost US$1 trillion by 2030 worldwide. Coronary...
Fri Jul 31, 2020 15:16
Related Articles Menstrual health and period poverty among young people who menstruate in the Barcelona metropolitan area (Spain): protocol of a mixed-methods study. BMJ Open. 2020 Jul 29;10(7):e035914 Authors: Medina-Perucha L, Jacques-Aviñó C, Valls-Llobet C, Turbau-Valls R, Pinzón D, Hernández L, Briales Canseco P, López-Jiménez T, Solana Lizarza E, Munrós Feliu J, Berenguera A Abstract INTRODUCTION: The importance of menstrual health has...
Fri Jul 31, 2020 15:16
Related Articles Implementation of integrated operating rooms: how much time is saved and how do medical staff experience the upgrading? A mixed methods study in Denmark. BMJ Open. 2020 Jul 29;10(7):e034459 Authors: Carstensen K, Jensen EK, Madsen ML, Thomsen AML, Løvschall C, Tayyari Dehbarez N, Risør BW Abstract OBJECTIVES: To evaluate staff experiences of the implementation and use of integrated operating rooms (IORs) in comparison to conventional...
Fri Jul 31, 2020 15:16
Related Articles Magnitude of premenstrual dysphoric disorder and its correlation with academic performance among female medical and health science students at University of Gondar, Ethiopia, 2019: a cross-sectional study. BMJ Open. 2020 Jul 29;10(7):e034166 Authors: Minichil W, Eskindir E, Demilew D, Mirkena Y Abstract OBJECTIVE: To assess the magnitude of premenstrual dysphoric disorder (PMDD) and associated factors among female students of...
Fri Jul 31, 2020 15:16
Cardioprotection Generated by Aerobic Exercise Training is Not Related to the Proliferation of Cardiomyocytes and Angiotensin-(1-7) Levels in the Hearts of Rats with Supravalvar Aortic Stenosis. Cell Physiol Biochem. 2020 Jul 31;54(4):719-735 Authors: Mota GAF, de Souza SLB, da Silva VL, Gatto M, de Campos DHS, Sant'Ana PG, Vileigas DF, Padovani CR, Casarini DE, de Oliveira EM, Bazan SGZ, Fernandes T, Sugizaki MM, Gomes ERM, Cicogna AC Abstract ...
Fri Jul 31, 2020 15:24
Related Articles Fruit and Vegetable Purchasing Patterns and Supplemental Nutrition Assistance Program Participation: Findings From a Nationally Representative Survey. J Acad Nutr Diet. 2020 Jul 29;: Authors: Tseng M, Mastrantonio C, Glanz H, Volpe RJ, Neill DB, Nazmi A Abstract BACKGROUND: Previous studies suggest that Supplemental Nutrition Assistance Program (SNAP) participants purchase less produce than nonparticipants. Whether this is due...
Sun Aug 02, 2020 14:35
Related Articles Etiology Intervention Link Predicts Resolution of Nutrition Diagnosis: A Nutrition Care Process Outcomes Study from a Veterans' Health Care Facility. J Acad Nutr Diet. 2020 Jul 27;: Authors: Lewis SL, Wright L, Arikawa AY, Papoutsakis C Abstract In this article, we evaluate relationships between Nutrition Care Process (NCP) chain links and improvement or resolution of the nutrition diagnosis. We conducted a retrospective record...
Sat Aug 01, 2020 14:52
Related Articles Neuroblastoma-targeted nanoparticles and novel nanotechnology-based treatment methods. J Cell Physiol. 2020 Jul 31;: Authors: Mobasheri T, Rayzan E, Shabani M, Hosseini M, Mahmoodi Chalbatani G, Rezaei N Abstract Neuroblastoma is a complicated pediatric tumor, originating from the neural crest, which is the most prevalent in adrenal glands, but may rarely be seen in some other tissues as well. Studies are focused on developing...
Sat Aug 01, 2020 13:01
The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells. J Cell Physiol. 2020 Jul 30;: Authors: Huang YS, Lu KC, Chao HW, Chen A, Chao TK, Guo CY, Hsieh HY, Shih HM, Sytwu HK, Wu CC Abstract The downregulation of melatonin receptor 1A (MTNR1A) is associated with a range of pathological conditions, including membranous nephropathy. Knowledge of the mechanism underlying MTNR1A expression has been limited to the transcriptional...
Fri Jul 31, 2020 13:02
Maslinic acid prevents IL-1β-induced inflammatory response in osteoarthritis via PI3K/AKT/NF-κB pathways. J Cell Physiol. 2020 Jul 30;: Authors: Chen YL, Yan DY, Wu CY, Xuan JW, Jin CQ, Hu XL, Bao GD, Bian YJ, Hu ZC, Shen ZH, Ni WF Abstract Osteoarthritis (OA) is a degenerative joint disease characterized by destruction of articular cartilage. The inflammatory response is the most important factor affecting the disease process. As interleukin-1β...
Fri Jul 31, 2020 13:02
Site-specific contribution of Toll-like receptor 4 to intestinal homeostasis and inflammatory disease. J Cell Physiol. 2020 Jul 30;: Authors: Bruning EE, Coller JK, Wardill HR, Bowen JM Abstract Toll-like receptor 4 (TLR4) is a highly conserved protein of innate immunity, responsible for the regulation and maintenance of homeostasis, as well as immune recognition of external and internal ligands. TLR4 is expressed on a variety of cell types...
Fri Jul 31, 2020 13:02
MAGI2-AS3 inhibits breast cancer by downregulating DNA methylation of MAGI2. J Cell Physiol. 2020 Jul 30;: Authors: Xu X, Yuan X, Ni J, Guo J, Gao Y, Yin W, Li F, Wei L, Zhang J Abstract Breast cancer is one of the most threatening diseases for women. Long noncoding RNAs were reported to be involved in breast cancer development. In this study, we analyzed The Cancer Genome Atlas breast cancer tissue high-throughput sequencing data and screened...
Fri Jul 31, 2020 13:02
The conditioned medium of human embryonic stem cell-derived mesenchymal stem cells alleviates neurological deficits and improves synaptic recovery in experimental stroke. J Cell Physiol. 2020 Jul 30;: Authors: Asgari Taei A, Dargahi L, Nasoohi S, Hassanzadeh G, Kadivar M, Farahmandfar M Abstract The transplantation of mesenchymal stem cells (MSCs) is of main approaches in regenerative therapy for stroke. Due to the potential tumorigenicity...
Fri Jul 31, 2020 13:02
Reversion-inducing cysteine-rich protein with Kazal motifs and MT1-MMP promote the formation of robust fibrillin fibers. J Cell Physiol. 2020 Jul 30;: Authors: Matsuzaki T, Keene DR, Nishimoto E, Noda M Abstract Fibrillins (FBNs) form mesh-like structures of microfibrils in various elastic tissues. RECK and FBN1 are co-expressed in many human tissues, suggesting a functional relationship. We found that dermal FBN1 fibers show atypical morphology...
Fri Jul 31, 2020 13:02
Structural stability of the SARS-CoV-2 main protease: Can metal ions affect function? J Inorg Biochem. 2020 Jul 16;211:111179 Authors: Kozak JJ, Gray HB, Garza-López RA Abstract We have investigated the structural stability of the SARS (Severe acute respiratory syndrome)-CoV-2 main protease monomer (Mpro). We quantified the spatial and angular changes in the structure using two independent analyses, one based on a spatial metrics (δ, ratio),...
Sat Aug 01, 2020 16:41
Zn(II) complexes of (E)-4-(2-(pyridin-2-ylmethylene)hydrazinyl)quinazoline in combination with non-steroidal anti-inflammatory drug sodium diclofenac: Structure, DNA binding and photo-cleavage studies, antioxidant activity and interaction with albumin. J Inorg Biochem. 2020 Jul 18;211:111194 Authors: Kakoulidou C, Gritzapis PS, Hatzidimitriou AG, Fylaktakidou KC, Psomas G Abstract The interaction of the novel quinazoline (E)-4-(2-(pyridin-2-ylmethylene)hydrazinyl)quinazoline...
Sat Aug 01, 2020 16:41
Binuclear Ni(II) complexes containing ONS donor Schiff base ligands: Preparation, spectral characterization, X-ray crystallography and biological exploration. J Inorg Biochem. 2020 Jul 18;211:111176 Authors: Kalaiarasi G, Dharani S, Rajkumar SRJ, Lynch VM, Prabhakaran R Abstract Four binuclear Ni(II) complexes [[Ni2(H-DEAsal-tsc)2(μ-dppm)]·2Cl (1), [Ni2(DEAsal-mtsc)2(μ-dppm)] (2), [Ni2(DEAsal-etsc)2(μ-dppm)] (3) and [Ni2(DEAsal-ptsc)2(μ-dppm)]...
Fri Jul 31, 2020 13:12
Related Articles Prenatal, but not Postnatal, Curcumin Administration Rescues Neuromorphological and Cognitive Alterations in Ts65Dn Down Syndrome Mice. J Nutr. 2020 Jul 30;: Authors: Rueda N, Vidal V, García-Cerro S, Puente A, Campa V, Lantigua S, Narcís O, Bartesaghi R, Martínez-Cué C Abstract BACKGROUND: The cognitive dysfunction in Down syndrome (DS) is partially caused by deficient neurogenesis during fetal stages. Curcumin enhances neurogenesis...
Fri Jul 31, 2020 14:38
Related Articles Nitrate-Rich Beetroot Juice Reduces Blood Pressure in Tanzanian Adults with Elevated Blood Pressure: A Double-Blind Randomized Controlled Feasibility Trial. J Nutr. 2020 Jul 30;: Authors: Siervo M, Shannon O, Kandhari N, Prabhakar M, Fostier W, Köchl C, Rogathi J, Temu G, Stephan BCM, Gray WK, Haule I, Paddick SM, Mmbaga BT, Walker R Abstract BACKGROUND: In Sub-Saharan Africa, current strategies are struggling to control the...
Fri Jul 31, 2020 14:38
Related Articles In vitro ketone-supported mitochondrial respiration is minimal when other substrates are readily available in cardiac and skeletal muscle. J Physiol. 2020 Jul 31;: Authors: Petrick HL, Brunetta HS, Pignanelli C, Nunes EA, van Loon LJC, Burr JF, Holloway GP Abstract KEY POINTS: Ketone bodies are proposed to represent an alternative fuel source driving energy production, particularly during exercise. Biologically, the extent to...
Sat Aug 01, 2020 15:31
Related Articles Extracellular metabolism of the enteric inhibitory neurotransmitter β-nicotinamide adenine dinucleotide (β-NAD) in the murine colon. J Physiol. 2020 Jul 31;: Authors: Durnin L, Kurahashi M, Sanders KM, Mutafova-Yambolieva VN Abstract KEY POINTS: β-NAD is a key inhibitory neurotransmitter in the colon. The neuroeffector junction in the gut consists of enteric motor neurons and SIP syncytium, including smooth muscle cells (SMCs),...
Sat Aug 01, 2020 15:31
Related Articles Disproportionate loss of excitatory inputs to smaller phrenic motor neurons following cervical spinal hemisection. J Physiol. 2020 Jul 31;: Authors: Rana S, Zhan WZ, Mantilla CB, Sieck GC Abstract KEY POINTS: Motor units, comprising a motor neuron and the muscle fibre it innervates, are activated in an orderly fashion to provide varying amounts of force. A unilateral C2 spinal hemisection (C2SH) disrupts predominant excitatory...
Sat Aug 01, 2020 15:31
Collagen, stiffness, and adhesion: the evolutionary basis of vertebrate mechanobiology. Mol Biol Cell. 2020 Aug 01;31(17):1823-1834 Authors: Tang VW Abstract The emergence of collagen I in vertebrates resulted in a dramatic increase in the stiffness of the extracellular environment, supporting long-range force propagation and the development of low-compliant tissues necessary for the development of vertebrate traits including pressurized circulation...
Fri Jul 31, 2020 13:25
Related Articles Eco-evolutionary control of pathogens. Proc Natl Acad Sci U S A. 2020 Jul 31;: Authors: Lässig M, Mustonen V Abstract Control can alter the eco-evolutionary dynamics of a target pathogen in two ways, by changing its population size and by directed evolution of new functions. Here, we develop a payoff model of eco-evolutionary control based on strategies of evolution, regulation, and computational forecasting. We apply this model...
Sun Aug 02, 2020 14:09
Related Articles The synthesis of xyloglucan, an abundant plant cell wall polysaccharide, requires CSLC function. Proc Natl Acad Sci U S A. 2020 Jul 31;: Authors: Kim SJ, Chandrasekar B, Rea AC, Danhof L, Zemelis-Durfee S, Thrower N, Shepard ZS, Pauly M, Brandizzi F, Keegstra K Abstract Xyloglucan (XyG) is an abundant component of the primary cell walls of most plants. While the structure of XyG has been well studied, much remains to be learned...
Sun Aug 02, 2020 14:09
Related Articles Protein nanoribbons template enamel mineralization. Proc Natl Acad Sci U S A. 2020 Jul 31;: Authors: Bai Y, Yu Z, Ackerman L, Zhang Y, Bonde J, Li W, Cheng Y, Habelitz S Abstract As the hardest tissue formed by vertebrates, enamel represents nature's engineering masterpiece with complex organizations of fibrous apatite crystals at the nanometer scale. Supramolecular assemblies of enamel matrix proteins (EMPs) play a key role...
Sun Aug 02, 2020 14:09
Related Articles Parkinson's disease-related phosphorylation at Tyr39 rearranges α-synuclein amyloid fibril structure revealed by cryo-EM. Proc Natl Acad Sci U S A. 2020 Jul 31;: Authors: Zhao K, Lim YJ, Liu Z, Long H, Sun Y, Hu JJ, Zhao C, Tao Y, Zhang X, Li D, Li YM, Liu C Abstract Posttranslational modifications (PTMs) of α-synuclein (α-syn), e.g., phosphorylation, play an important role in modulating α-syn pathology in Parkinson's disease...
Sun Aug 02, 2020 14:09
Related Articles Lysosomal activity regulates Caenorhabditis elegans mitochondrial dynamics through vitamin B12 metabolism. Proc Natl Acad Sci U S A. 2020 Jul 31;: Authors: Wei W, Ruvkun G Abstract Mitochondrial fission and fusion are highly regulated by energy demand and physiological conditions to control the production, activity, and movement of these organelles. Mitochondria are arrayed in a periodic pattern in Caenorhabditis elegans muscle,...
Sun Aug 02, 2020 14:09
Related Articles Energetics and kinetics of substrate analog-coupled staphylococcal nuclease folding revealed by a statistical mechanical approach. Proc Natl Acad Sci U S A. 2020 Jul 31;: Authors: Mizukami T, Furuzawa S, Itoh SG, Segawa S, Ikura T, Ihara K, Okumura H, Roder H, Maki K Abstract Protein conformational changes associated with ligand binding, especially those involving intrinsically disordered proteins, are mediated by tightly coupled...
Sun Aug 02, 2020 14:09
Related Articles Regulatory T cells suppress Th17 cell Ca2+ signaling in the spinal cord during murine autoimmune neuroinflammation. Proc Natl Acad Sci U S A. 2020 Jul 30;: Authors: Othy S, Jairaman A, Dynes JL, Dong TX, Tune C, Yeromin AV, Zavala A, Akunwafo C, Chen F, Parker I, Cahalan MD Abstract T lymphocyte motility and interaction dynamics with other immune cells are vital determinants of immune responses. Regulatory T (Treg) cells prevent...
Sat Aug 01, 2020 13:38
Related Articles Observing 3-hydroxyanthranilate-3,4-dioxygenase in action through a crystalline lens. Proc Natl Acad Sci U S A. 2020 Jul 30;: Authors: Wang Y, Liu KF, Yang Y, Davis I, Liu A Abstract The synthesis of quinolinic acid from tryptophan is a critical step in the de novo biosynthesis of nicotinamide adenine dinucleotide (NAD+) in mammals. Herein, the nonheme iron-based 3-hydroxyanthranilate-3,4-dioxygenase responsible for quinolinic...
Sat Aug 01, 2020 13:38
Related Articles Differences in the free energies between the excited states of Aβ40 and Aβ42 monomers encode their aggregation propensities. Proc Natl Acad Sci U S A. 2020 Jul 30;: Authors: Chakraborty D, Straub JE, Thirumalai D Abstract The early events in the aggregation of the intrinsically disordered peptide, amyloid-β (Aβ), involve transitions from the disordered free energy ground state to assembly-competent states. Are the fingerprints...
Sat Aug 01, 2020 13:38
Related Articles Interdependence and the cost of uncoordinated responses to COVID-19. Proc Natl Acad Sci U S A. 2020 Jul 30;: Authors: Holtz D, Zhao M, Benzell SG, Cao CY, Rahimian MA, Yang J, Allen J, Collis A, Moehring A, Sowrirajan T, Ghosh D, Zhang Y, Dhillon PS, Nicolaides C, Eckles D, Aral S Abstract Social distancing is the core policy response to coronavirus disease 2019 (COVID-19). But, as federal, state and local governments begin...
Sat Aug 01, 2020 13:38
Related Articles Historically rice-farming societies have tighter social norms in China and worldwide. Proc Natl Acad Sci U S A. 2020 Jul 30;: Authors: Talhelm T, English AS Abstract Data recently published in PNAS mapped out regional differences in the tightness of social norms across China [R. Y. J. Chua, K. G. Huang, M. Jin, Proc. Natl. Acad. Sci. U.S.A. 116, 6720-6725 (2019)]. Norms were tighter in developed, urbanized areas and weaker in...
Sat Aug 01, 2020 13:38
Related Articles REM sleep stabilizes hypothalamic representation of feeding behavior. Proc Natl Acad Sci U S A. 2020 Jul 30;: Authors: Oesch LT, Gazea M, Gent TC, Bandarabadi M, Gutierrez Herrera C, Adamantidis AR Abstract During rapid eye movement (REM) sleep, behavioral unresponsiveness contrasts strongly with intense brain-wide neural network dynamics. Yet, the physiological functions of this cellular activation remain unclear. Using in...
Sat Aug 01, 2020 13:38
Related Articles Specific targeting of ovarian tumor-associated macrophages by large, anionic nanoparticles. Proc Natl Acad Sci U S A. 2020 Jul 30;: Authors: Haber T, Cornejo YR, Aramburo S, Flores L, Cao P, Liu A, Mooney R, Gilchrist M, Tirughana R, Nwokafor U, Abidi W, Han E, Dellinger T, Wakabayashi MT, Aboody KS, Berlin JM Abstract Immunotherapy is emerging as one of the most effective methods for treating many cancers. However, immunotherapy...
Sat Aug 01, 2020 13:38
16 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Proc Natl Acad Sci U S A"[jour] These pubmed results were generated on 2020/07/31PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Fri Jul 31, 2020 17:14
16 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Proc Natl Acad Sci U S A"[jour] These pubmed results were generated on 2020/07/31PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Fri Jul 31, 2020 13:09
Σε μία από τις πρώτες μελέτες του είδους της που δημοσιεύεται στο Journal of Positive Psychology οι ερευνητές του Μίσιγκαν «μέτρησαν» την ευτυχία παντρεμένων, διαζευγμένων και singles όταν βρίσκονταν πλέον σε προχωρημένη ηλικία θέλοντας να διακριβώσουν ποιον ρόλο διαδραματίζουν τελικά η αγάπη και ο γάμος στη συνολική ευεξία. Στο «μικροσκόπιο» μπήκε το ερωτικό ιστορικό 7,532 ανθρώπων από τα 18 έως τα 60 τους χρόνια, οι οποίοι και σχημάτισαν τρεις κατηγορίες: Οι παντρεμένοι που πέρασαν το μεγαλύτερο...
Fri Jul 31, 2020 12:20
Σε μια ενδιαφέρουσα ανακάλυψη προέβησαν επιστήμονες από σχετικά με τους παράγοντες που επηρεάζουν την εμφάνιση διαβήτη τύπου 2 σε παχύσαρκα άτομα. Όπως έδειξαν τα ευρήματά τους, τα οποία δημοσιεύτηκαν στο Nature Metabolism, βακτήρια και μικροοργανισμοί που υπάρχουν στο περιβάλλον φαίνεται πως διαδραματίζουν κάποιο ρόλο στην εκδήλωση του διαβήτη. Οι ερευνητές πιστεύουν έντονα πως κάποιοι από τους παθογόνους μικροοργανισμούς βρίσκονται στο νερό και τα τρόφιμα. Ύστερα από μελέτη σε 40 παχύσαρκους...
Fri Jul 31, 2020 09:05
Την ιδανική προπόνηση για την καρδιά που προάγει την καρδιαγγειακή υγεία και βελτιώνει την κινητικότητα προτείνουν οι ερευνητές του Πανεπιστημίου του Μιζούρι. Σύμφωνα με το Αμερικανικό Εθνικό Γηριατρικό Ινστιτούτο οι άνω των 65 ετών είναι πιο πιθανό να υποφέρουν από καρδιαγγειακά νοσήματα και περιορισμένη κινητικότητα στις αρθρώσεις και τα άκρα του σώματός τους. Ο καθηγητής Stephen Sayers και η ομάδα του μελετούν τρόπους για τη διατήρησης της υγείας και της κινητικότητας των μεγαλύτερων ενηλίκων...
Fri Jul 31, 2020 08:30
Ένα διατροφικό πρόγραμμα με χαμηλή περιεκτικότητα σε υδατάνθρακες δεν θα σταματήσει την εξέλιξη του γλαυκώματος, θα μπορούσε ωστόσο ενδεχομένως να αποτελέσει ένα μέσο πρόληψης της σοβαρής οφθαλμικής νόσου σε ομάδες υψηλού κινδύνου, σύμφωνα με τους ερευνητές του Ιατρικού Κέντρου Mount Sinai στη Νέα Υόρκη που υπογράφουν τη μελέτη, η οποία δημοσιεύτηκε πρόσφατα στο Eye. Το γλαύκωμα αποτελεί την κύρια αιτία τύφλωσης σε άτομα ηλικίας άνω των 60 ετών και συχνά διαγιγνώσκεται δύσκολα καθώς τα συμπτώματα...
Fri Jul 31, 2020 08:20
Θα μπορούσε ένα φάρμακο εγκεκριμένο για τη ρευματοειδή αρθρίτιδα και νόσους του εντέρου να επιτρέψει σε πάσχοντες από κοιλιοκάκη να εντάξουν ανώδυνα τη γλουτένη στη διατροφή τους; Δείτε τι αναφέρουν ερευνητές από το Βέλγιο περιγράφοντας ένα χαρακτηριστικό case report που αφορά έναν ασθενή με κοιλιοκάκη και αλωπεκία. Σύμφωνα με μελέτη αναφοράς επιστημόνων στο Πανεπιστημιακό Νοσοκομείο του Λέβεν στο Βέλγιο, η οποία δημοσιεύτηκε στο Annals of Internal Medicine, η τοφασιτινίμπη, εκλεκτικός αναστολέας...
Fri Jul 31, 2020 08:05
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