Analytical ChemistryDOI: 10.1021/acs.analchem.0c01405
Fri May 01, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01219
Fri May 01, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00760
Fri May 01, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01095
Fri May 01, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00697
Fri May 01, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00818
Thu Apr 30, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05738
Thu Apr 30, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00317
Thu Apr 30, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00746
Thu Apr 30, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05659
Thu Apr 30, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05432
Thu Apr 30, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00544
Thu Apr 30, 2020 07:00
Photosymbiotic associations between metazoan hosts and photosynthetic dinoflagellates are crucial to the trophic and structural integrity of many marine ecosystems, including coral reefs. Although extensive ef...
Fri May 01, 2020 03:00
Sympatric sister species provide an opportunity to investigate the genetic mechanisms and evolutionary forces that maintain species boundaries. The persistence of morphologically and genetically distinct popul...
Wed Apr 29, 2020 03:00
The reversion-inducing cysteine-rich protein with kazal motifs (RECK) gene was described as a tumor suppressor gene two decades ago. Recently, novel alternatively spliced products of this gene have been identified. Of these, the transcript variant 3 (RECKVar3) was shown to display tumor-facilitating effects in astrocytoma cells in vitro, with a higher RECKVar3/canonical RECK expression ratio being correlated with lower survival rates of patients. However, the regulatory mechanisms through which the...
Sat May 02, 2020 00:43
In patients with metastatic cancer, gut microbiome composition differs between responder and non-responders to immune checkpoint inhibitors. However, there is little consensus on the microbiome taxa associated with response or lack of response. Additionally, recognized confounders of gut microbiome composition have generally not been taken into account. In this study, metagenomic shotgun sequencing was performed on freshly frozen pre-treatment stool samples from 25 patients (12 responders and 13...
Sat May 02, 2020 00:43
Iris melanoma is a rare tumour that accounts for ~3–4% of all uveal melanoma cases. In the past, surgical resection was the sole treatement option, whereas nowadays, it has been replaced by brachytherapy as treatment of choice. Surgical resection is still in use in selected cases but combined with adjuvant radiotherapy in cases of incomplete resection. Herein, we report the case of a very late recurrence, 45 years after surgical resection. A literature review was performed to detect the latest recurrence...
Sat May 02, 2020 00:43
Individuals with multiple primary melanomas have rates of germline CDKN2A pathogenic variants of 3%–18%, and are also frequent carriers of variants in the melanocortin-1 receptor. Few patients with numerous (≥3) primary melanomas have been studied with respect to these or other potential germline pathogenic variants. We investigated 46 patients with ≥3 primary melanomas (3, n = 17; 4, n = 14; 5–14, n = 15) to determine if higher rates of germline pathogenic variants of CDKN2A, MC1R, or other cancer...
Sat May 02, 2020 00:43
Numerous studies on the epidemiology of cutaneous melanoma (CM) have been reported for Caucasians, but rarely for Asian populations including Korea. The aim of this study was to investigate the epidemiology of CM and melanoma in situ (MIS) in the Korean population. We investigated a nationally representative sample cohort of over one million Koreans for patients diagnosed with CM and MIS. Annual and overall incidence rates, as well as the survival rate of CM during the study period (2004–2013), were...
Sat May 02, 2020 00:43
Approximately, 50% of patients with uveal melanoma develop distant metastasis for which no standard therapy is established. In contrast to cutaneous melanoma, the anti-CTLA-4 antibody ipilimumab showed no clinical activity in uveal melanoma. Liver directed therapies improve local control, but fail to show overall survival (OS) benefit. Preclinical experiments demonstrated that radiofrequency ablation (RFA) induced durable responses in combination with anti-CTLA-4. The aim of this phase Ib/II study...
Sat May 02, 2020 00:43
Combined BRAF and MEK inhibition is one of the first-line treatment strategies for patients with advanced BRAF-mutant melanoma. Sarcoid-like reactions (SLRs) have occasionally been described with melanoma systemic treatments such as immunotherapy or the BRAF inhibitor vemurafenib, but very few cases have been reported with dabrafenib and trametinib. Our aim was to better characterize SLR induced by this combination. We conducted a monocentric retrospective observational study among patients treated...
Sat May 02, 2020 00:43
In clinical trials, dabrafenib plus trametinib improved overall survival (OS) compared with single-agent BRAF inhibitors (BRAFi) in patients with BRAF V600-mutant unresectable or metastatic melanoma. We investigated dabrafenib plus trametinib therapy in a compassionate-use setting [Named Patient Program (NPP); DESCRIBE II]. A retrospective chart review of patients with BRAF V600-mutated unresectable stage III/IV melanoma receiving dabrafenib plus trametinib as compassionate use was conducted. Treatment...
Sat May 02, 2020 00:43
Industrial workers are exposed to occupational pollutants, which may cause diseases such as cancer, but links to melanoma are not established. The identification of industry-related risk factors for melanoma incidence and mortality might be of importance for workers, health providers, and insurance companies. To assess melanoma incidence and mortality among oil/petroleum, chemical, and electrical industry workers. All studies reporting standardized mortality ratios (SMR) and/or standardized incidence...
Sat May 02, 2020 00:43
Prognostic groups defined by lactate dehydrogenase concentration and number of organ sites containing metastases have been reported for patients treated with dabrafenib and trametinib for advanced melanoma. We aimed to validate these prognostic groups for patients treated with vemurafenib and cobimetinib in the coBRIM and BRIM-3 clinical studies. Eight hundred nine patients were included, 240 treated with vemurafenib plus cobimetinib and 569 with vemurafenib. For patients treated with vemurafenib...
Sat May 02, 2020 00:43
Our group described the oncogenic potential of a normal neuronal receptor, metabotropic glutamate receptor 1 (GRM1/mGluR1, gene/protein), when aberrantly expressed in melanocytes led to cell transformation in vitro and spontaneous metastatic tumors in vivo. Earlier, we demonstrated the accumulation of phosphorylated histone H2AX (γH2AX), a marker for DNA damage when mGluR1-expressing melanoma cells were treated with a functional inhibitor, riluzole. The precise mechanisms on how riluzole induces...
Sat May 02, 2020 00:43
The aim of this study was to evaluate metastatic latency and survival after the occurrence of metastases in patients with choroidal/ciliary body melanoma treated with proton therapy. This was a retrospective cohort study. All consecutive patients with choroidal/ciliary body melanoma treated with proton therapy between 1991 and 2010 were included. Overall survival, specific survival (SS), local recurrence-free interval, and metastasis-free interval (MFI) were calculated. There were 508 patients. The...
Sat May 02, 2020 00:43
Checkpoint inhibitor immunotherapy is a transformative treatment for advanced malignancies, but can be associated with numerous immune-related adverse events (irAEs). The majority of irAEs include those that closely resemble known cutaneous and neurocutaneous autoimmune or autoinflammatory diseases, such as scleroderma, psoriasis, and dermatomyositis. We present the case of a 63-year-old man with metastatic melanoma undergoing treatment with nivolumab who developed significant motor weakness, paresthesias...
Sat May 02, 2020 00:43
The aim of this study was to examine temporal trends in overall and stage-specific incidence of melanoma. Using population-based data on patients diagnosed with melanoma in East Anglia, England, 1996–2015, we estimated age-standardized time trends in annual incidence rates for each stage at diagnosis. Negative binomial regression was used to model trends over time adjusted for sex, age group and deprivation, and to subsequently examine variation in stage-specific trends by sex and age group. The...
Sat May 02, 2020 00:43
We report a case in which a renal transplant recipient with metastatic melanoma had an excellent response to treatment with second line programmed cell death protein 1 (PD-1) inhibitor therapy, pembrolizumab. Acute cellular allograft rejection on initiation of PD-1 inhibitor was successfully reversed with methylprednisolone. By converting the patient to sirolimus and giving predose prednisolone, pembrolizumab was continued with stable renal function and an excellent oncological response. This case...
Sat May 02, 2020 00:43
Before the onset of the Covid-19 pandemic, each day seemed to bring another headline about the crisis of physician burnout. The issue had been simmering for years and was brought to a boil by mounting changes in the health care system, most prominently the widespread implementation of the…
Fri May 01, 2020 03:00
To the Editor: Traditional approaches to respiratory virus surveillance may not identify novel pathogens in time to implement crucial public health interventions. The Seattle Flu Study is a multi-institutional, community-wide pandemic surveillance platform that was established in November 2018.…
Fri May 01, 2020 03:00
On March 11, 2020, the World Health Organization designated "coronavirus disease 2019" (Covid-19) a global pandemic. As the number of cases in the United States continues to grow, political leaders are encouraging physical (or "social") distancing to slow the rate of transmission. The goal of this…
Thu Apr 30, 2020 03:00
As Covid-19 spreads throughout the United States, schools and child care facilities are balancing their role of helping to prevent disease transmission with ensuring access to food for children who rely on the federal nutrition safety net. Together, the U.S. Department of Agriculture (USDA)…
Thu Apr 30, 2020 03:00
Persons with mental disorders are at increased risk for other types of mental disorders and for a range of general medical conditions. These medical conditions contribute to a decreased quality of life, increased health care utilization, and premature death in many persons with mental disorders.…
Thu Apr 30, 2020 03:00
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Fri May 01, 2020 03:00
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Fri May 01, 2020 03:00
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Fri May 01, 2020 03:00
No abstract available
Fri May 01, 2020 03:00
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