STRASBOURG, France & LUND, Suède--(BUSINESS WIRE)--Regulatory News: Transgene (Paris:TNG) (Euronext Paris : TNG), société de biotechnologie qui conçoit et développe des immunothérapies du cancer reposant sur des vecteurs viraux, et BioInvent International AB (OMXS : BINV), société de biotechnologie dédiée à la découverte et au développement d’anticorps immunomodulateurs innovants contre le cancer, annoncent aujourd’hui qu’elles présenteront des données précliniques portant sur BT-001 à plusieur
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STRASBOURG, France & LUND, Sweden--(BUSINESS WIRE)-- #BT001--Regulatory News: Transgene (Paris:TNG) (Euronext Paris: TNG), a biotech company that designs and develops virus-based immunotherapies for the treatment of cancer, and BioInvent International AB (“BioInvent”) (OMXS: BINV), a biotech company focused on the discovery and development of novel and first-in-class immune-modulatory antibodies for cancer immunotherapy, today announce that they will be presenting preclinical data on BT-001 at...
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PARIS--(BUSINESS WIRE)-- #BiomorphicProgrammablePolymers--TISSIUM, une société privée spécialisée dans les sciences de la vie et développant des polymères programmables biomorphiques entièrement synthétiques, a annoncé aujourd'hui avoir obtenu un financement de €2,2M lui permettant d'accélérer le développement de ses adhésifs bioactifs et de répondre aux besoins non satisfaits des patients atteints de rhinosinusite chronique (RSC). Ce financement est issu du Programme d'Investissements d'Avenir (PIA)...
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BOSTON--(BUSINESS WIRE)--PureTech Announces First Participant Dosed in Clinical Trial of Wholly-Owned Lymphedema Candidate LYT-100
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LIÈGE, Belgium & GRENOBLE, France--(BUSINESS WIRE)--PDC*line Pharma, a clinical stage biotech company developing a new class of potent and scalable active immunotherapies for cancers, announces today that the first patient was dosed with its innovative medicinal product candidate PDC*lung01 in a phase I/II trial in non-small cell lung cancer (NSCLC). This patient is under the supervision of Dr. Anne Sibille, principal investigator for the Liege University Hospital (Belgium). The objectives of...
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We welcome Howard’s article on how difficult it is for general practitioners to get the right care for patients with gender dysphoria, and we share the concerns that GPs might be expected to fill the...
Fri Feb 28, 2020 13:16
The health secretary Matt Hancock has vowed to stamp out what he described as the “absurd” and “unwarranted” postcode variations in access to certain clinical services on the NHS.In a keynote speech...
Fri Feb 28, 2020 12:56
Neurosurgeons assess, diagnose, and undertake surgery to treat disorders of the central nervous system, including the brain and spine.The work is varied and challenging. Neurosurgeons deal with...
Fri Feb 28, 2020 12:41
At The BMJ we try to practise what we preach—just as in healthcare, our decisions should be based on solid evidence. Of course, solid evidence can only be generated by solid research that is well...
Fri Feb 28, 2020 12:30
Mon Mar 02, 2020 02:00
Mon Mar 02, 2020 02:00
Oncogenesis, Published online: 27 February 2020; doi:10.1038/s41389-020-0211-6Retraction Note: α2,6-Sialylation mediates hepatocellular carcinoma growth in vitro and in vivo by targeting the Wnt/β-catenin pathway
Thu Feb 27, 2020 02:00
Abstract Static in vitro cell culture studies cannot capture the dynamic concentration profiles of drugs, nutrients, and other factors that cells experience in physiological systems. This limits the confidence in the translational relevance of in vitro experiments and increases the reliance on empirical testing of exposure-response relationships and dose optimization in animal models during preclinical drug development, introducing additional challenges owing to species-specific...
Mon Mar 02, 2020 02:00
Background Social anxiety is common in autistic adolescents. While emerging evidence indicates the importance of several mechanisms (including intolerance of uncertainty (IU), alexithymia and sensory processing) for maintaining anxiety, limited research has explored how these factors are associated with social anxiety in autistic adolescents. Methods We investigated whether IU, emotional and sensory processing are related to social anxiety in autistic and neurotypical adolescents, gathering...
Mon Mar 02, 2020 21:23
Background A better understanding of the trajectories and economic burden of psychiatric and somatic disorders (multimorbidity) in ADHD from childhood to adulthood is important for guiding more targeted areas for treatment of ADHD and prevention of multimorbidity, and for forecasting demands on the medical infrastructure. This study aimed to investigate patterns of healthcare utilization and costs of multimorbidity across young adulthood in individuals with a childhood ADHD diagnosis, and additionally...
Mon Mar 02, 2020 21:23
Background Attention deficit/hyperactivity disorder (ADHD) is associated with emotional problems, and their co‐occurrence often leads to worse outcomes. We investigated the developmental associations between ADHD and emotional problems from childhood to early adolescence and examined the genetic and environmental contributions to their developmental link. We further tested whether this developmental association remained across the transition to young adulthood. Methods We used data from the...
Sat Feb 29, 2020 20:02
Abstract Background Surgical techniques for inguinal hernia repair have evolved rapidly from open methods to conventional laparoscopic totally extra-peritoneal (CTEP) and recently single-port TEP (STEP). As there is currently no randomized controlled trial (RCT) reporting long-term patient-reported outcomes between CTEP and STEP, we reviewed patients who were randomized to CTEP or STEP 5 years after surgery. ...
Mon Mar 02, 2020 02:00
Abstract Background Assessment of preoperative physiological status is crucial for optimizing clinical outcomes in patients undergoing surgery for esophageal carcinoma (EC). We aimed to evaluate the prognostic impact of pulmonary dysfunctions and their relationships with other physiological factors, especially sarcopenia, in EC patients receiving esophagectomy. Methods ...
Mon Mar 02, 2020 02:00
Abstract Background The ankle and heel are challenging regions to reconstruct functionally. Here, we explored the feasibility and clinical outcomes of a modified anterior tibial artery perforator-pedicled propeller flap for the repair of soft-tissue defects of the ankle and heel. Patients and methods Between January 2013 and December 2015, 12 patients with...
Mon Mar 02, 2020 02:00
Mon Mar 02, 2020 02:00
Zusammenfassung Diese Übersichtsarbeit beschreibt die international anerkannten Risikofaktoren für Plattenepithelkarzinome des Ösophagus und des Anus, deren Verbreitung in Deutschland sowie Präventionsansätze. Die Hauptrisikofaktoren für Plattenepithelkarzinome des Ösophagus sind in Deutschland der Tabak- und Alkoholkonsum, vor allem in Kombination miteinander. Ein riskantes Trinkverhalten weisen 14 % der Frauen und 18 % der Männer auf. Ein Rauschtrinken mindestens einmal im Monat...
Mon Mar 02, 2020 02:00
Zusammenfassung Hintergrund Patientenverfügungen und Vorsorgevollmachten sind wichtige Instrumente für eine selbstbestimmte gesundheitliche Vorausplanung. Insbesondere bei fortschreitenden Krebserkrankungen sind auch krankheitsspezifische Aspekte relevant. Ziel der Arbeit Es erfolgen die Darstellung der Rechtslage, kritische Reflexion der Situationsbeschreibungen...
Mon Mar 02, 2020 02:00
Zusammenfassung Hintergrund Die endokrin basierte Therapie ist laut allen nationalen und internationalen Leitlinien die erste Option in der Behandlung des hormonrezeptorpositiven (HR+) metastasierten Mammakarzinoms. Ziel Die Autoren werten die Evidenz der aktuell verfügbaren Substanzen und geben Empfehlungen für den klinischen Alltag. ...
Fri Feb 28, 2020 02:00
Zusammenfassung Hintergrund Checkpointinhibitoren haben sich in den letzten Jahren als Standard bei immunogenen Tumoren etabliert, die häufig durch eine hohe Mutationslast gekennzeichnet sind. Sowohl präklinische als auch klinische Daten beim Mammakarzinom zeigen, dass das Immunsystem nicht nur eine prognostische, sondern auch prädiktive Rolle für das Ansprechen auf eine Chemotherapie oder eine anti-HER2-gerichtete Therapie spielt. Sie...
Fri Feb 28, 2020 02:00
Abstract Necrotizing fasciitis is a rare rapidly progressive, devastating surgical emergency that results in necrosis of superficial fascia, and subcutaneous tissue. It most commonly affects the abdominal wall, extremities and perineum, while the involvement in the head and neck region is relatively rare. Here, we report a successfully treated case of necrotizing fasciitis of the craniofacial region caused by Mucor in an uncontrolled diabetic patient. Early diagnosis, early surgical...
Mon Mar 02, 2020 02:00
Abstract Enhanced surveillance for CREs was established at national sentinel sites in South Africa. We aimed to apply an epidemiological and microbiological approach to characterise CREs and to assess trends in antimicrobial resistance from patients admitted to tertiary academic hospitals. A retrospective analysis was conducted on patients of all ages with CRE bacteraemia admitted at any one of 12 tertiary academic hospitals in four provinces (Gauteng, KwaZulu-Natal, Western Cape...
Mon Mar 02, 2020 02:00
Abstract Since at least the 1980s, police departments in the United States have embraced a set of practices that aim, not to enable the prosecution of past criminal activity, but to discourage (or even prevent) people from breaking the law in the first place. It is not clear that these practices effectively lower the crime rate. However, whatever its effect on the crime rate, I argue that preventive policing is essentially distinct from legal governance, and that excessive reliance...
Mon Mar 02, 2020 02:00
Publication date: Available online 2 March 2020Source: Journal of the American College of SurgeonsAuthor(s): Richard Frazee, Emily Garmon, Claire Isbell, Erin Bird, Harry Papaconstantinou
Mon Mar 02, 2020 21:06
Abstract X-ray repair cross-complementing group 1 (XRCC1) plays a key role in the base excision repair pathway, as a scaffold protein that brings together proteins of the DNA repair complex. Several studies have reported contradictory results for XRCC1 exon 6 C>T (rs1799782) gene polymorphism and cancer risk in Indian population has provided inconsistent results. Therefore, we have performed this meta-analysis to evaluate the relationship between XRCC1 exon 6 C>T gene polymorphism...
Mon Mar 02, 2020 02:00
Abstract We obtain the admissible sets on the unit circle to be the spectrum of a strict m-isometry on an n-finite dimensional Hilbert space. This property gives a better picture of the spectrum of an m-isometry. We determine that the only m-isometries on \(\mathbb {R}^2\) are 3-isometries and isometries giving by \(\pm I+Q\), where Q is a nilpotent operator. Moreover, on real Hilbert space, we obtain that m-isometries preserve volumes. Also, we present a way to construct a strict...
Mon Mar 02, 2020 02:00
Abstract In this paper, we classify filiform associative algebras of degree p over a field of characteristic zero. Moreover, over an algebraically closed field of characteristic zero, we also classify filiform nilpotent associative algebras and naturally graded quasi-filiform nilpotent associative algebras, described through the characteristic sequence \(C({\mathcal {A}})=(n-2,1,1)\) or \(C({\mathcal {A}})=(n-2,2)\).
Sat Feb 29, 2020 02:00
Abstract In this paper, we give a version of the Gleason–Kahane–Zelazko theorem for continuous linear functionals on some topological algebras and topological vector spaces of functions.
Fri Feb 28, 2020 02:00
Abstract Assume that \({\mathfrak {H}}\) and \({\mathfrak {K}}\) are two real or complex Hilbert spaces, A a linear relation from \({\mathfrak {H}}\) to \({\mathfrak {K}}\), and B a linear relation from \({\mathfrak {K}}\) to \({\mathfrak {H}}\), respectively. Necessary and sufficient conditions for B to be equal to the adjoint of A are provided. Several consequences are also presented. More precisely, new characterizations for closed, skew–adjoint, selfadjoint, normal linear...
Fri Feb 28, 2020 02:00
Abstract Candida species, including C. albicans in particular, can cause superficial or invasive disease, often in patients with known acquired immunodeficiencies or iatrogenic conditions. The molecular and cellular basis of these infections in patients with such risk factors remained largely elusive, until the study of inborn errors of immunity clarified the basis of the corresponding inherited and “idiopathic” infections. Superficial candidiasis, also known as chronic mucocutaneous...
Mon Mar 02, 2020 02:00
Abstract Human rhinoviruses (RV) are a frequent cause of respiratory tract infections with substantial morbidity and mortality in some patients. Nevertheless, the genetic basis of susceptibility to RV in humans has been relatively understudied. Experimental infections of mice and in vitro infections of human cells have indicated that various pathogen recognition receptors (TLRs, RIG-I, and MDA5) regulate innate immune responses to RV. However, deficiency of MDA5 is the only one...
Sat Feb 29, 2020 02:00
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