Abstract The current gold standard diagnostic test for colorectal cancer remains histological inspections of endoluminal neoplasia in biopsy specimens. However, biopsy site selection requires visual inspection of the bowel, typically with a white‐light endoscope. Therefore, this technique is poorly suited to detect small or innocuous‐appearing lesions. We hypothesize that an alternative modality – multi‐wavelength spatial frequency domain imaging (SFDI) – would be able to differentiate various...
04:30
Abstract Having the least lenses, the significant feature of the singlet imaging system, helps the development of the portable and cost‐effective microscopes. A novel method of monochromatic/color singlet microscopy, which is combined with only one aspheric lens and deep learning computational imaging technology, is proposed in this manuscript. The designed singlet aspheric lens is an approximate linear signal system, which means modulation‐transfer‐function curves on all field‐of‐views (5mm diagonally)...
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03:47
Abstract Data on antimicrobial resistance (AMR) in zoonotic and indicator bacteria from humans, animals and food are collected annually by the EU Member States (MSs), jointly analysed by EFSA and ECDC and reported in a yearly EU Summary Report. The annual monitoring of AMR in animals and food within the EU is targeted at selected animal species corresponding to the reporting year. The 2017 monitoring specifically focussed on pigs and calves under 1 year of age, as well as their derived carcases/meat,...
04:28
Abstract In accordance with Article 43 of Regulation (EC) No 396/2005, the European Commission requested EFSA to carry out a consumer exposure assessment in relation to the maximum residue levels (MRLs) for chlordecone in products of animal origin recommended by the French Agency for Food, Environmental and Occupational Health and Safety (ANSES) in an assessment performed in 2018. The MRL proposals under assessment are lower than the current EU MRLs established under Regulation (EC) 396/2005. The...
04:28
Abstract Local adaptation patterns have been found in many plants and animals, highlighting the genetic heterogeneity of species along their range of distribution. In the next decades, global warming is predicted to induce a change in the selective pressures that drive this adaptive variation, forcing a reshuffling of the underlying adaptive allele distributions. For species with low dispersion capacity and long generation time such as trees, the rapidity of the change could imped the migration...
04:23
Abstract Sperm cells exhibit extraordinary phenotypic diversity and rapid rates of evolution, yet the adaptive value of most sperm traits remains equivocal. Recent findings suggest that to understand how selection targets ejaculates we must recognize that female‐imposed physiological conditions often alter sperm phenotypes. These phenotypic changes may influence the relationships among sperm traits and their association with fitness. Here, we show that chemical substances released by eggs (known...
04:23
Overexpression of transcription factor 3 in Alveolar soft part sarcoma(ASPS) results in upregulation of cell proliferation pathways. No standard treatment algorithm exists for ASPS; multi-kinase inhibitors(TKI) and immune checkpoint inhibitors(ICI) have shown clinical benefit. To date, no studies have reported on management strategies or sequencing of therapy. We evaluated ASPS treatment patterns and responses in an experimental therapeutics clinic. Genomic and morphoproteomic analysis was performed...
Tue Mar 03, 2020 16:59
This first-in-human phase 1 study evaluated the pharmacokinetics, safety, and preliminary efficacy of telisotuzumab, formerly called ABT-700, an antagonistic antibody directed against c-Met. For dose-escalation (3+3 design), three to six patients with advanced solid tumors were enrolled into four dose cohorts (5-25 mg/kg). In the dose-expansion phase, a subset of patients were prospectively selected for MET amplification (FISH screening). Patients received telisotuzumab intravenously on day 1 every...
Tue Mar 03, 2020 16:59
Expression of the DNA/RNA helicase schlafen family member 11 (SLFN11) has been identified as a sensitizer of tumor cells to DNA damaging agents including platinum chemotherapy. We assessed the impact of SLFN11 expression on response to platinum chemotherapy and outcomes in patients with metastatic castration-resistant prostate cancer (CRPC). Tumor expression of SLFN11 was assessed in 41 CRPC patients treated with platinum chemotherapy by RNAseq of metastatic biopsy tissue (n=27) and/or immunofluorescence...
Tue Mar 03, 2020 16:59
There is a need to develop novel approaches to improve the balance between efficacy and toxicity for transcription factor targeted therapies. In this study, we exploit context dependent differences in RNAPII processivity as an approach to improve the activity and limit the toxicity of the EWS-FLI1 targeted small molecule, mithramycin, for Ewing sarcoma. The clinical activity of mithramycin for Ewing sarcoma is limited by off-target liver toxicity that restricts the serum concentration to levels...
Tue Mar 03, 2020 16:59
The development of efficacious therapies targeting metastatic spread of breast cancer to the brain represents an unmet clinical need. Accordingly, an improved understanding of the molecular underpinnings of central nervous system spread and progression of breast cancer brain metastases (BCBM) is required. In this study, the clinical burden of disease in BCBM was investigated, as well as the role of aldehyde dehydrogenase 1A3 (ALDH1A3) in the metastatic cascade leading to BCBM development. Initial...
Tue Mar 03, 2020 16:59
Gastrointestinal stromal tumor (GIST), the most common sarcoma, is characterized by KIT protein overexpression, and tumors are frequently driven by oncogenic KIT mutations. Targeted inhibition of KIT revolutionized GIST therapy and ushered in the era of precision medicine for the treatment of solid malignancies. Here, we present the first use of a KIT-specific DNA aptamer for targeted labeling of GIST. We found that an anti-KIT DNA aptamer bound cells in a KIT-dependent manner and was highly specific...
Tue Mar 03, 2020 16:59
Objectives/Hypothesis Empty nose syndrome (ENS) is a controversial disorder and the change of histopathology has never been discussed. This study aimed to conduct a structured histological review to improve the diagnosis and understanding of ENS. Further immunohistochemical staining of transient receptor potential channel melastatin 8 (TRPM8) was performed. Study Design A prospective case–control study in a tertiary medical center. Methods Consecutive patients with ENS who were...
04:09
Objectives/Hypothesis Systemic infusions of lidocaine have been widely used as perioperative analgesic adjuvants. The aim of this randomized, double‐blinded, controlled trial was to investigate the effect of perioperative lidocaine infusion on postoperative early recovery quality in upper airway surgery. Study Design Prospective, randomized, double‐blinded, placebo‐controlled trial. Methods A total of 99 patients were randomly assigned to the lidocaine group (group L) or the...
04:09
Objectives/Hypothesis Otolaryngologic symptoms of obstructive sleep apnea (OSA) and their diagnostic utility are not well studied. We aimed to elucidate the prevalence of otolaryngologic symptoms among patients being evaluated for OSA. Given findings that the Reflux Symptom Index (RSI) was strongly associated with OSA status, we evaluated the diagnostic utility of the RSI for predicting OSA status. Study Design Cross‐sectional. Methods We recruited 101 adults presenting for...
04:09
Abstract Combined training (CT) has been associated with positive responses in the clinical status of patients with chronic heart failure (CHF). Other non‐pharmacological tools, such as amino acid supplementation, may further enhance its adaptation. However, the effects of β‐alanine and L‐histidine supplementation in CHF remain unclear. In the present study, the aim was to test whether supplementing carnosine precursors with CT could present improved responses in the functional capacity and echocardiographic...
04:09
NEW FINDINGS What is the central question of this study? A bout of exercise increases subsequent insulin‐stimulated vasodilation; however, the mechanisms remain to be elucidated. A potential role for Angiotensin‐(1‐7), a vasoactive peptide of the Renin‐Angiotensin System, in this effect has not been previously reported. What is the main finding and its importance? We show that Angiotensin‐(1‐7) through Mas receptor participates in enhanced insulin‐induced vasorelaxation after exercise...
04:09
Abstract The impacts of road infrastructure on wildlife are of mounting concern. Amidst a growing body of literature on vehicle–wildlife collisions, few studies focus on primates. We examined a long-term dataset (2000–2018) of community-reported welfare cases for four species of monkeys: colobus (Colobus angolensis palliatus), Sykes’s monkey (Cercopithecus mitis albogularis), vervet (Chlorocebus pygerythrus hilgerti), and baboon (Papio cynocephalus cynocephalus). We analyzed collision...
02:00
Abstract Emotional arousal is one of several factors that determines the strength of a memory and how efficiently it may be retrieved. The systems at play are multifaceted; on one hand, the dopaminergic mesocorticolimbic system evaluates the rewarding or reinforcing potential of a stimulus, while on the other, the noradrenergic stress response system evaluates the risk of threat, commanding attention, and engaging emotional and physical behavioral responses. Sex‐specific patterns in the anatomy...
04:00
Background The cervical cancer screening recommendation for transgender female‐to‐male (FTM) patients is the same as that for cisgender females. A lack of literature on testosterone‐induced changes in cervical cytology in these patients may result in interpretation errors, especially without a proper clinical history. The aim of this study was to delineate the Papanicolaou (Pap) test findings in this patient population. Methods A pathology laboratory information system was used to obtain...
03:57
Abstract The underlying mechanism of Seborrheic dermatitis (SD) is poorly understood but major scientific progress has been made in recent years related to microbiology, immunology and genetics. In light of this, the major goal of this article was to summarize the most recent articles on SD, specifically related to underlying pathophysiology. SD results from Malassezia hydrolyzation of free fatty acids with activation of the immune system by the way of pattern recognition receptors, inflammasome,...
03:53
Abstract Clinical laboratory diagnostic evaluation of the genomes of children with suspected genetic disorders, including chromosomal microarray and exome sequencing, cannot detect copy number neutral genomic rearrangements such as inversions, balanced translocations, and complex chromosomal rearrangements (CCRs). We describe an infant with a clinical diagnosis of Cornelia de Lange syndrome (CdLS) in whom chromosome analysis revealed a de novo complex balanced translocation, 46,XY,t(5;7;6)(q11.2;q32;q13)dn....
03:51
Abstract This study examined the health‐related quality of life (HRQoL) and psychological functioning of children and young adults with Gaucher disease, type 1 (GD1). Thirty‐two (17 pediatric, 15 young adult) patients with GD1 and one parent completed age‐appropriate assessments of HRQoL, emotional, and behavioral health. The HRQoL of children with GD1 was compared with a healthy sample and to children diagnosed with Fabry disease (FD; another lysosomal storage disease), while young adults were...
03:51
Abstract KBG syndrome (MIM #148050) is an autosomal dominant disorder characterized by developmental delay, intellectual disability, distinct craniofacial anomalies, macrodontia of permanent upper central incisors, skeletal abnormalities, and short stature. This study describes clinical features of 28 patients, confirmed by molecular testing of ANKRD11 gene, and three patients with 16q24 deletion encompassing ANKRD11 gene, diagnosed in a single center. Common clinical features are reported, together...
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Abstract Keratoacanthoma centrifugum marginatum (KCM) is a rare variant of keratoacanthoma (KA). This condition is difficult to diagnose because of its large size and expansive nature and may be diagnosed as a malignant tumor. There are various treatments such as surgery and oral retinoids; however, limited studies have verified their effectiveness. Here, we report a case of KCM on the anterior chest of a 50‐year‐old woman and evaluate the efficacy of oral retinoids. In this case, oral retinoids...
03:45
Abstract Basal cell carcinomas (BCC) are the most common types of skin neoplasm. The finger, toe, and nail unit are uncommon and rare locations of BCC. Only a few patients with foot BCC have been reported, and ungual BCC is even less frequent. We present a patient with a BCC on the left first toe. Clinically, it appeared as a brown‐colored plaque with an irregular border on the nail fold and dorsum of the left thumb. Histopathological findings were consistent with the pigmented type of BCC. Surgical...
03:45
Abstract Trichloroacetic acid (TCA) peeling may be effective in solar lentigines, but with concerns regarding potential tumorigenesis. Cryopeeling would be better with improving the whole sun‐damaged skin. We aimed to compare the efficacy and safety of cryopeeling and TCA 35% peeling for treatment of solar lentigines and assess their influence on the number of epidermal Langerhans cells (LC). Twenty‐five patients were treated with TCA 35% and cryopeeling on the right and left hands, respectively....
03:45
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b12250
Tue Mar 03, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b13295
Tue Mar 03, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02428
Tue Mar 03, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b12003
Tue Mar 03, 2020 07:00
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