Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00300
Tue Mar 03, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01003
Tue Mar 03, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b13876
Tue Mar 03, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b12998
Tue Mar 03, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05729
Tue Mar 03, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04578
Tue Mar 03, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00754
Tue Mar 03, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00300
Tue Mar 03, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05420
Tue Mar 03, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05616
Tue Mar 03, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05679
Tue Mar 03, 2020 07:00
Abstract New therapeutic options for severe asthma have recently emerged, mostly in the form of monoclonal antibodies (“biologicals”) targeting relevant inflammatory pathways. Currently available agents target different aspects of ‘Type 2’ immunity and their indications often include overlapping patient groups. We present a round table discussion that took place during the Annual Meeting of the Respiratory Effectiveness Group (REG), on the reasoning behind the use of different add‐on medications...
03:39
Abstract Regulatory T (Treg) cells potentially suppress the deleterious activities of effector T cells and maintain a state of tolerance against antigens in the airway mucosa. A decrease in the number and function of Treg cells is observed in T helper 2 (Th2)‐biased allergic airway diseases. However, adoptive transfer of naturally occurring Treg (tTreg) cells or peripherally derived Treg (pTreg) cells in asthmatic mouse models did not yield satisfactory results in any previous studies. Here, we...
03:39
Abstract Objectives To determine the prognostic significance of preoperative prognostic nutritional index (PNI) in patients with primary oral squamous cell carcinoma (OSCC) after ablative surgery. Materials and Methods A total of 333 patients from two tertiary referral centers were enrolled as training and validation cohorts. The PNI was calculated as 10× serum albumin (g/dL) + 0.005× total lymphocyte number (per mm3) and its optimal cutoff value for patient stratification was identified...
03:32
Abstract Objectives This study aimed to characterize surface properties such as roughness (Ra) and surface free energy (SFE) of glazed and polished yttria‐stabilized zirconia and to evaluate in vitro adherence of fungus Candida albicans and salivary bacteria, Staphylococcus epidermidis, mixed with C. albicans to these substrata. Additionally, the influence of salivary proteins (albumin, mucin and α– amylase) on yeast adhesion was studied. Material and methods Ra and SFE of glazed...
03:32
Abstract Insufficient sleep has been considered a seizure trigger in people with epilepsy for thousands of years. Here, we reviewed the evidence upon which this axiomatic association might be predicated. After evaluating evidence suggesting insufficient sleep as an EEG activator, we systematically reviewed the literature for longitudinal studies measuring the effect of insufficient sleep on seizure risk. Ultimately, published works designed to prove a causal relationship were of low level of evidence...
03:15
Abstract Objectives Podcasts are audio recordings distributed via the Internet. We review the availability of podcasts on the topic of radiology. Methods A search for podcasts relating to radiology was performed using search engines and free public websites that either hosted or distributed podcasts. Only English language podcast series...
02:00
Abstract Objectives This study aimed to investigate the application of shear wave elastography (SWE) in the early damage detection through assessing the endometrial elasticity after artificial abortion. Methods A total of nulliparous women (20–30 years) who received ultrasonography in our hospital were recruited between January 2017 and...
02:00
Abstract Background Ninety years after the Dutch theoretical physicist H.A. Lorentz died, detailed investigation of his scientific heritage yielded the set of nine original prints of radiographs that W.C. Roentgen made during his experiments and had sent him, among half a dozen other scientists, on January 1st, 1896. Main text Through...
Tue Mar 03, 2020 02:00
Abstract The aim of the study is to perform an analysis of the results that have been compiled in the nine years that the examination has existed.
Tue Mar 03, 2020 02:00
Fecal metabolic profiling of patients with IBS‐D was clearly differentiated from that of healthy controls administered laxatives or not. Five disease‐relevant potential biomarkers (cadaverine, putrescine, threonine, tryptophan, and phenylalanine) were found in patients with IBS‐D, excluding the effects of fast colon transit. It provides fundamental information for developing novel therapies for IBS‐D. Abstract Background Gut microbiota are known to be closely related to irritable bowel syndrome...
03:00
High‐resolution colonic manometry allows detailed assessment of human colon motor function and dysfunction. Here, a cyclic motor pattern at ~12 cycles/min follows a high‐amplitude propagating pressure wave at 160 mm Hg. It may restore the absorption and mixing condition after a mass movement of content. Abstract Background High‐resolution colonic manometry gives an unprecedented window into motor patterns of the human colon. Our objective was to characterize motor activities throughout the entire...
03:00
Laryngo-Rhino-OtolDOI: 10.1055/a-1089-8088© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Tue Mar 03, 2020 01:00
Stem Cells and Development, Volume 29, Issue 5, Page 263-265, March 1, 2020.
Thu Feb 27, 2020 10:00
Abstract Objective To translate and cross‐cultural adapt the Craniofacial Pain and Disability Inventory (CF‐PDI) into Chinese and, to evaluate measurement properties of the web‐based version of the CF‐PDI. Methods The Chinese version (CF‐PDI/C) was first produced according the guidelines. Then, the web‐based version of CF‐PDI/C (eCF‐PDI/C) was developed by our team and a third‐party survey provider. The eCF‐PDI/C was distributed to patients with painful TMD with or without headache...
01:25
The metaxins were originally identified as vertebrate proteins of the outer mitochondrial membrane involved in protein import into mitochondria. Metaxin proteins have also been found in diverse invertebrate phyla. The present study is concerned with examining whether metaxin-like proteins occur in plants and bacteria. Metaxin-like proteins were revealed by their homology with human metaxins and the possession of characteristic GST_Metaxin protein domains. The results demonstrate that metaxin-like...
Tue Mar 03, 2020 02:00
Through the analysis of linkage disequilibrium from genome-wide sequencing data for multiple individuals from eight populations, the general features of the recombinational landscape are revealed in the microcrustacean Daphnia pulex. The data suggest an exceptionally uniform pattern of recombination across the genome, while also confirming general patterns that are inconsistent with existing population-genetic models for the relationship between linkage disequilibrium and physical distances between...
Tue Mar 03, 2020 02:00
The origin of oxygen respiration in bacteria has long intrigued biochemists, microbiologists and evolutionary biologists. The earliest enzymes that consume oxygen to extract energy did not evolve in the same lineages of photosynthetic bacteria that released oxygen on primordial earth, leading to the great oxygenation event (GOE). A widespread type of such enzymes is proton pumping cytochrome c oxidase (COX) that contains heme A, a unique prosthetic group for these oxidases. Here we show that the...
Tue Mar 03, 2020 02:00
Divergent selection is a powerful driver of speciation and has been widely studied in relation to the physical characters of organisms. Because evolution of behavioural traits may contribute to evolutionary processes, we explored how consistent variation in behaviours may affect the process of adaptive divergence and speciation. We studied whether two sympatric morphs of Arctic charr (Salvelinus alpinus) have recently evolved genetically-based differences in personality that conform to their respective...
Tue Mar 03, 2020 02:00
The evolution of morphological allometry or scaling is a long-standing enigma in biology. Three types of allometric relationships have been defined: static, ontogenetic and evolutionary allometry. However, the theory of the interrelationship between these three types of allometry have not been tested in Orthopterans and to a lesser extent in hemimetabolous insects. Here, the ontogenetic allometry of hind femur length in the cricket Gryllus bimaculatus was observed to be slightly positive as compared...
Tue Mar 03, 2020 02:00
Synthetic gene drive technologies aim to spread transgenic constructs into wild populations even when they impose organismal fitness disadvantages. The properties of gene drive constructs are diverse and depend on their molecular construction, and differential selection pressure they impose in the varied ecological situations they encounter. The extraordinary diversity of conceivable drive mechanisms and the range of selective parameters they may encounter makes it very difficult to convey their...
Tue Mar 03, 2020 02:00
Antimicrobial therapeutic treatments are by definition applied after the onset of symptoms, which tend to correlate with infection severity. I use mathematical epidemiology models to explore how this link affects the coevolutionary dynamics between the virulence of an infection, measured via host mortality rate, and its susceptibility to chemotherapy. I show that unless resistance pre-exists in the population, drug resistant infections are initially more virulent than drug sensitive ones. As the...
Tue Mar 03, 2020 02:00
We introduce a new pattern of population genetic structure in a host-parasite system that can arise after secondary contact (SC) of previously isolated populations. Due to different generation time and therefore different tempo of molecular evolution the host and parasite populations reach different degrees of genetic differentiation during their separation (e.g. in refugia). Consequently, during the SC the host populations are able to re-establish a single panmictic population across the whole recolonized...
Tue Mar 03, 2020 02:00
Opsins are the primary light-sensing molecules in animals. Opsins have peak sensitivities to specific wavelengths which allows for color discrimination. The opsin protein family has undergone duplications and losses, dynamically expanding and contracting the number of opsins, throughout invertebrate evolution, but it is unclear what drives this diversity. Light availability, however, appears to play a significant role. Dim environments are associated with low opsin diversity in deep-sea fishes and...
Tue Mar 03, 2020 02:00
Abstract Sleep and opioid medications used to treat insomnia and chronic pain are associated with adverse side effects (falls and cognitive disturbance). Although behavioural treatments such as cognitive behavioral therapy for insomnia (CBT‐I) and pain (CBT‐P) improve sleep and clinical pain, their effects on sleep and opioid medication use are unclear. In this secondary analysis of published trial data, we investigated whether CBT‐I and CBT‐P reduced reliance on sleep/opioid medication in patients...
01:04
The reconstruction of large head and face missing structures in the craniofacial region in children is very challenging for plastic surgeons. Expanded local and expanded axial-pattern flaps are widely used for...
Tue Mar 03, 2020 02:00
Anaphylaxis is a serious potentially life-threatening allergic reaction. Most episodes of anaphylaxis are triggered through an immunologic mechanism involving immunoglobulin E (IgE) which leads to mast cell and basophil activation and the subsequent release of inflammatory mediators1. Anaphylaxis typically involves the cutaneous, respiratory, cardiovascular, and gastrointestinal systems, target organs all heavily populated with mast cells2. Death due to anaphylaxis usually occurs as a result of respiratory...
Tue Mar 03, 2020 02:00
In craniomaxillofacial surgery we often deal with hypoplastic mandibles and mandibular asymmetries, the correction of which is critical to obtaining acceptable aesthetic results. In all of them we find common skeletal problems once growth has finished, such as an inclined occlusal plane and facial asymmetry with a stable dental occlusion. Simultaneous maxillomandibular distraction, which involves a Le Fort I osteotomy and a mandibular osteotomy with intermaxillary fixation during the period of active...
Tue Mar 03, 2020 02:00
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