In craniomaxillofacial surgery we often deal with hypoplastic mandibles and mandibular asymmetries, the correction of which is critical to obtaining acceptable aesthetic results. In all of them we find common skeletal problems once growth has finished, such as an inclined occlusal plane and facial asymmetry with a stable dental occlusion. Simultaneous maxillomandibular distraction, which involves a Le Fort I osteotomy and a mandibular osteotomy with intermaxillary fixation during the period of active...
Tue Mar 03, 2020 02:00
Oromandibular dystonia (OMD) is characterised by sustained or repetitive involuntary movements of the jaw, face, and tongue. People with the condition may present to their dentist, general practitioner, or a secondary care specialist with non-specific symptoms including jaw or facial pain, bruxism, subluxations or dislocations of the jaw; fractured teeth or dental restorations, or both; or jaw tremor. Many clinicians are not aware of the disorder and this can lead to delayed diagnoses, unnecessary...
Tue Mar 03, 2020 02:00
The aim of this review was to critically investigate and assess the evidence relating to the use and efficacy of botulinum toxin (BTX) in the management of temporomandibular joint disorders (TMD) and masticatory myofascial pain. A comprehensive search was conducted of PubMed, Scopus, Embase, and Cochrane CENTRAL, to find relevant studies from the last 30 years up to the end of July 2018. Seven were identified. Three showed a significant reduction in pain between the BTX and placebo groups and one...
Tue Mar 03, 2020 02:00
Global environmental impact and sustainability has been a heated topic in the recent years. Plastics and single-use items are widely, and perhaps unnecessary, used in the healthcare sector. Various recent articles 1,2 discuss the negative impacts of this in the surgical world, but can we look at the NHS sustainability as a bigger picture?
Tue Mar 03, 2020 02:00
MIME Technologies, a startup originating at Aberdeen University in Scotland, unveiled the Aiber in-flight telemedicine system designed to be used by flight attendants to help stricken passengers. Using a tablet computer, flight attendants can communicate with physicians on the ground, transmitting observable symptoms, but also streaming data from sensors that can be stuck to the body of the victim. These can include heart rate, temperature, and respiration rate sensors, and the system includes...
00:06
CryoLife, based in Kennesaw, Georgia, won EU regulatory clearance for the On-X Ascending Aortic Prosthesis (AAP) as a treatment option for people with poorly functioning aortic valves with a nearby ascending aortic aneurysm. The device, which combines a prosthetic valve and an ascending aortic prosthesis, can be implanted to address injured, damaged, or malfunctioning native or prosthetic valves. The valve of the On-X is made of pure pyrolitic carbon, which is a thromboresistant material...
Tue Mar 03, 2020 22:00
Access Vascular, based in Bedford, Massachusetts, won FDA clearance for the latest version of its HydroPICC anti-thrombogenic central line catheter. As with the original, which was cleared two years ago, the new device features Access’s unique “bulk-hydrophilic” material that prevents clogging by being rich in water while carrying a neutral surface charge. Proteins and other biomaterials tend not to stick to such surfaces and the material has been shown not to initiate a thrombosis cascade as it...
Tue Mar 03, 2020 19:17
Masimo just received the first FDA clearance for a fingertip pulse oximeter that can measure respiration rate. The MightySat Rx spot-check pulse oximeter includes a technology known as Respiration Rate from the Pleth (RRP) that makes it unnecessary to perform manual counts or use chest electrodes to measure respiration rate. The device can be used in the clinic, but is now also indicated for at-home use. In addition to respiration rate, it measures oxygen saturation, pulse rate, perfusion...
Tue Mar 03, 2020 18:48
Swappable pods would supply the reCharge with material to create its treads. (Goodyear/)The Geneva Auto Show isn’t happening this year due to concerns about the coronavirus, but the new cars and concepts are still trickling out into the world digitally. Tire manufacturer Goodyear typically uses Geneva as a platform to show off its most outlandish and futuristic ideas that it calls “stretch concepts.” This year’s concept is called reCharge and it envisions a complete wheel system that dynamically...
Tue Mar 03, 2020 23:00
The cover of The Invention of Surgery (Pegasus Books/)The following is an excerpt adapted from The Invention of Surgery by David Schneider.Amputating a man’s arm is a gut-wrenching and shocking act. Regardless of the clinical justification and no matter the years of practice, severing a limb from a body requires stubborn resolve and intense personal subordination. Perhaps some surgeons grow callous to cutting off a limb—I never have.I am a surgical intern at Pennsylvania State University and all...
01:36
Most of the drugs we take are packed with ingredients from Asian factories. (Pexels/)Lagging tests, uncertain quarantine procedures, and dwindling supplies of medical masks: COVID-19 has revealed issues with how the US handles major disease outbreaks. Now there’s one more problem to worry about. On Thursday, Food and Drug Administration Commissioner Stephen Hahn released a statement that announced the first drug shortage related to the COVID-19 epidemic—but stopped short of saying what drug it was.Some...
02:06
When you build your own tote bag, you also get to carry around a feeling of success. (Vanessa Nirode/)You can never have too many tote bags, especially ones with zippers. They’re a great alternative to plastic while shopping, you can bring them to the gym, stuff them full of books, or haul your laptop around. The possibilities are endless.Most of the tote bags you get for free are made out of cheap, boring fabrics, usually with logos on them that make you look like a walking advertisement.And to...
Tue Mar 03, 2020 19:28
It's much harder to make garlic bread in a pop-up toaster. (Louis Hansel via Unsplash/)No kitchen appliance is so versatile and compact as the toaster oven. What other device can reheat last night’s pizza to bubbly perfection and enable your 11 p.m. tuna melt desires? Plus, these days consumers have a lot of ovens to choose from, including digital toasters that can double as dehydrators and air fryers. Below, some of our favorites.The toaster oven you can use with your eyes closed. (Amazon/)Are you...
Tue Mar 03, 2020 18:47
What causes these insane blasts of dusty catastrophe? (NOAA/)“Apocalyptic” might as well have been the forecast for Lubbock, Texas, on June 5, 2019.Around 6 p.m. that day, the local National Weather Service warned of an inbound rush of dust-laden, 60-mile-per-hour winds and severe thunderstorm, altogether deemed an “extremely dangerous situation.” Within an hour, Lubbock residents received their first dust storm warning in five years and the motorists among them were advised: “Pull aside, stay alive.”...
Tue Mar 03, 2020 18:00
Smile! (Lesly Juarez via Unsplash/)Manual toothbrushes are quickly becoming a thing of the past as more advanced, electronic options provide aid in maintaining your dental hygiene. Today, if you’re looking to buy some new bristles, it can be pretty overwhelming. Rest assured, there is a plaque-disrupting, bacteria-eliminating brush for everyone.The toothbrush that does the most. (Amazon/)The Oral-B 7000 electric toothbrush pairs with an app that gives you real-time feedback on your brushing. This...
Tue Mar 03, 2020 17:11
Be less scared in the dark. (Michael Henry via Unsplash/)There are a lot of super cheap flashlights on the market. But unless you’re raiding the supplies of your local hardware store right before a major weather event and are out of options, investing in something a bit more powerful is smart. Grab one for your car to aid you in changing a tire at night, have a pair for your emergency kit, or keep one handy at all times on your keychain. These four LED flashlights work in a variety of situations...
Tue Mar 03, 2020 16:54
Make life easier. (Maxim Selyuk via Unsplash/)Have you ever found excited about assembling a new piece of furniture, only to realize there’s a crucial design flaw or missing piece hours after you’ve meticulously screwed most of it together with a flimsy and awkward tool? It doesn’t have to be that way. Electric screwdrivers can help you put together furniture and tackle home improvement projects more quickly without giving up in frustration. Here are four great options to get you started—and finished.No...
Tue Mar 03, 2020 16:46
The 2020 Corvette Stingray. (Chevrolet/)On the street, the eighth-generation Chevrolet Corvette Stingray—aka the C8— draws waves and shouts like no Corvette in memory. The vehicles also fulfills a long-explored switch to a mid-engine layout, like the configuration of exotic European supercars from Ferrari and Lamborghini. At the track at Spring Mountain Motor Resort in Nevada, we were able to lap behind instructors from the Ron Fellows driving school who were in 2019 Corvette ZR1s. Before I slid...
Tue Mar 03, 2020 16:00
An air-based heat pump (DepositPhotos/)Many states have made ambitious goals to cut their greenhouse gas emissions in an attempt to meet the targets established by the Paris Climate Agreement. California wants to be carbon neutral by 2045, New York is aiming for a 100 percent cut from 1990 emissions by 2050, and Florida has committed to an 80 percent reduction over the same time frame.But if we’re going to have any shot at meeting these goals and averting some of the worst consequences of climate...
Tue Mar 03, 2020 15:11
Journal of Clinical Sleep Medicine, Ahead of Print.
Tue Mar 03, 2020 10:00
Journal of Clinical Sleep Medicine, Ahead of Print.
Mon Mar 02, 2020 10:00
Journal of Clinical Sleep Medicine, Ahead of Print.
Mon Mar 02, 2020 10:00
Journal of Clinical Sleep Medicine, Ahead of Print.
Mon Mar 02, 2020 10:00
Journal of Clinical Sleep Medicine, Ahead of Print.
Mon Mar 02, 2020 10:00
Journal of Clinical Sleep Medicine, Ahead of Print.
Mon Mar 02, 2020 10:00
Journal of Clinical Sleep Medicine, Ahead of Print.
Mon Mar 02, 2020 10:00
Surgical Infections, Ahead of Print.
Tue Mar 03, 2020 10:00
Thyroid, Ahead of Print.
Tue Mar 03, 2020 10:00
Summary Introduction Durvalumab has been shown to confer a survival benefit after definitive chemoradiotherapy in the patients with locally advanced non-small cell lung cancer, but no studies have attempted to identify risk factors for pneumonitis after durvalumab therapy. The purpose of this study was to investigate associations between clinical and radiation dose-volume factors, and the severity of pneumonitis. Methods We retrospectively assessed the cases of 30 patients who...
Tue Mar 03, 2020 02:00
Summary This phase 1 study sought to characterize the safety, tolerability, and pharmacokinetic behavior of VLX1570, a small molecule inhibitor of the deubiquitinases (DUBs) that remove sterically bulky ubiquitin chains from proteins during processing in the19S regulatory subunit of the proteasome, in patients with relapsed and refractory multiple myeloma (MM). Fourteen patients were treated with escalating doses of VLX1570 ranging from 0.05 to 1.2 mg/kg as a brief intravenous...
Tue Mar 03, 2020 02:00
Funktionelle Ergebnisse nach Rekonstruktion des weichen Gaumens bei Patienten mit Oropharynxkarzinom
Zusammenfassung Hintergrund Die operative Therapie von Karzinomen des Oropharynx mir Beteiligung des weichen Gaumens kann Einschränkungen in Bezug auf die Schluck‑, Stimm- und Sprechkompetenz hervorrufen. Die Rekonstruktion der resezierten Strukturen kann dazu beitragen, die Funktionalität posttherapeutisch wiederherzustellen. Ziel der Arbeit Ziel der durchgeführten...
Tue Mar 03, 2020 02:00
Background The goal of this study was to characterize the efficacy and safety of stereotactic body radiation therapy (SBRT) versus conventionally fractionated radiation therapy with concurrent chemotherapy (CFRT) for the definitive treatment of locally advanced pancreatic cancer. The primary outcome measure was efficacy, defined by 2‐year overall survival (OS). Secondary outcomes were incidence of any grade 3/4 toxicity and 1‐year OS. Methods A PICOS/PRISMA/MOOSE selection protocol was...
Tue Mar 03, 2020 21:41
Background Advances in radiotherapy (RT) have led to improved oncologic outcomes for women with gynecologic cancers; however, the long‐term effects and survivorship implications need further evaluation. The purpose of this study was to determine the incidence of pelvic fractures and changes in bone mineral density (BMD) after pelvic RT. Methods Two hundred thirty‐nine women who had pelvic RT for cervical, endometrial, or vaginal cancer between 2008 and 2015 were prospectively studied....
Tue Mar 03, 2020 21:41
Background There have been concerns regarding increased peritransplantation complications, especially severe acute graft‐versus‐host disease (aGVHD), in patients with prior use of checkpoint inhibitors (CPI) before hematopoietic stem cell transplantation (HSCT). Methods The authors performed a retrospective study of 43 patients with acute myeloid leukemia and/or myelodysplastic syndromes who were treated with an antiprogrammed cell death protein 1 (PD‐1) (32 patients) or anticytotoxic...
Tue Mar 03, 2020 21:41
Background The current study was performed to investigate whether circulating cell‐free Epstein‐Barr virus DNA (cfEBV DNA) would be useful for posttreatment surveillance in patients with nasopharyngeal carcinoma (NPC). Methods The authors identified a total of 1984 nondisseminated NPC patients from an institutional big‐data research platform. Blood samples were collected within 3 months of the completion of radiotherapy and every 3 to 12 months thereafter for cfEBV DNA analysis. Patients...
Tue Mar 03, 2020 21:41
Abstract The potential of indigenously isolated bacteria from the Estância Velha stream to reduce Cr(VI) was evaluated and also the chromium contamination over the past ten years was verified in one of the most important industrial centers of Brazil, the “Brazilian Capital of Tanneries,” Estância Velha municipality in the Rio Grande do Sul State, South Brazil. Samples were collected from the Estância Velha stream at the source (P1), as well as at upstream (P2) and downstream (P3)...
Tue Mar 03, 2020 02:00
Abstract In the current study, an extracellular cellulase belonging to symbiotic Bacillus subtilis Bc1 of the leopard moth is purified and characterized. The molecular mass of enzyme was 47.8 kDa using SDS-PAGE. The purified enzyme had optimum activity in temperature and pH around 60 °C and 8, respectively. The purified cellulase was introduced as a stable enzyme in a wide variety of temperature (20–80 °C) and pH (4–10) and remained active to more than 74% at 80 °C for 1 h. Moreover,...
Tue Mar 03, 2020 02:00
Abstract A radio-resistant bacterium labeled as strain TMC-6 was isolated from Thal desert, Pakistan and identified through 16S rRNA gene sequencing as Bacillus indicus strain TMC-6 (MN721293). The isolate was found to be resistant to UV radiation dose of 6.780 × 103 J/m2 and showed 50% survivability to mitomycin C (6 μg/ml) and H2O2 (30 mM). The bacterium showed yellowish orange coloration when grown on tryptone yeast glucose (TGY) medium. The cellular metabolite was extracted...
Tue Mar 03, 2020 02:00
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