Oncogenesis, Published online: 02 March 2020; doi:10.1038/s41389-020-0214-3Enhanced DNA-repair capacity and resistance to chemically induced carcinogenesis upon deletion of the phosphatase regulator NIPP1
Mon Mar 02, 2020 02:00
Oncogenesis, Published online: 02 March 2020; doi:10.1038/s41389-020-0215-2Long noncoding RNA TRPM2-AS acts as a microRNA sponge of miR-612 to promote gastric cancer progression and radioresistance
Mon Mar 02, 2020 02:00
Abstract Purpose IHC, FISH, and NGS are common methods of ALK evaluation in NSCLC. The purpose of this study was to investigate whether ALK false positives or false negatives occurred more often in daily routines. An approach to identify ALK fusion was then proposed. Materials and methods We analyzed 1815 cases of NSCLC, including 83 (4.6%) ALK IHC...
Tue Mar 03, 2020 02:00
Publication date: Available online 3 March 2020Source: Ultrasound in Medicine & BiologyAuthor(s): Yoann Hériveaux, Bertrand Audoin, Christine Biateau, Vu-Hieu Nguyen, Guillaume Haïat
Tue Mar 03, 2020 21:12
Publication date: Available online 2 March 2020Source: Ultrasound in Medicine & BiologyAuthor(s): Christian Fischer, Martin Krix, Marc-André Weber, Alexander Loizides, Hannes Gruber, Ernst-Michael Jung, Andrea Klauser, Maija Radzina, Christoph Frank Dietrich
Tue Mar 03, 2020 21:12
Objective: To introduce the concept of ambient pressure tympanometry (APT) and its association with pathologies that may present with objective tinnitus. Study Design: Retrospective case series. Setting: Tertiary referral center. Subjects and Methods: Audiologists performed APT on adult patients as part of routine audiological testing. Ears with myoclonus and patulous Eustachian tube (PET) were identified via review of patient history and physical examination. All other conditions...
Tue Mar 03, 2020 11:36
Hypothesis: 3D technologies, including structured light scanning (SLS), microcomputed tomography (micro-CT), and 3D printing, are valuable tools for reconstructing temporal bone (TB) models with high anatomical fidelity and cost-efficiency. Background: Operations involving TB require intimate knowledge of neuroanatomical structures—a demand that is currently met through dissection of limited cadaveric resources. We aimed to document the volumetric reconstruction of TB models using 3D technologies...
Tue Mar 03, 2020 11:35
Abstract Cells represent the basic building blocks of living organisms. Accurate characterisation of cellular phenotype, intercellular signalling networks, and the spatial organisation of cells within organs is crucial to deliver a better understanding of the processes underpinning physiology, and the perturbations that lead to disease. Single‐cell methodologies have rapidly increased in scale and scope in recent years and are set to generate important insights into human disease. Here, we review...
Tue Mar 03, 2020 21:04
Publication date: June 2020Source: Biomedicine & Pharmacotherapy, Volume 126Author(s): Feng Zhu, Huarong Li, Yujin Liu, Chen Tan, Xingxing Liu, Heng Fan, Hui Wu, Yalan Dong, Ting Yu, Si Chu, Hongxia He, Xiwen Zhu
Tue Mar 03, 2020 20:58
Publication date: June 2020Source: Biomedicine & Pharmacotherapy, Volume 126Author(s): Hanhan Wu, Jing Xu, Xiaoye Du, Jingang Cui, Teng Zhang, Yu Chen
Tue Mar 03, 2020 20:58
Disease is but the most obvious part of an epidemic. As coronavirus spreads, it fuels many other kinds of contagious forces. AN editor’s note: How can anthropology help us to understand the current coronavirus? How do anthropologists respond to news coverage of and data about the spread of Covid-19? We invite anthropologists with expertise on infectious disease, anthropological approaches to epidemic and pandemic threats and “contagion,” zoonotic diseases, and government and health care infrastructure...
Tue Mar 03, 2020 20:30
Mesenchymal stem cells (MSCs) have been a potential strategy in the pretreatment of pulmonary diseases, while the mechanisms of MSCs-conditioned medium (MSCs-CM) involved with microRNAs on the regulation of lung ion transport are seldom reported. We investigated the role of miR-124-5p in lipopolysaccharide-involved epithelial sodium channel (ENaC) dysfunction and explored the potential target of miR-124-5p. We observed the lower expression of miR-124-5p after the administration of MSCs-CM, and the...
Tue Mar 03, 2020 15:50
Aims. The aims of this study were to characterize nonatrophic and atrophic gastric mucosa under conventional endoscopy and probe-based confocal laser endomicroscopy (pCLE) modes and to define quantitative diagnostic parameters for these lesions under pCLE. Method. In phase I, 64 patients with gastric mucosal lesions diagnosed by gastrointestinal endoscopy were enrolled in the study. Normal mucosa and suspicious lesions were evaluated under normal white light imaging (WLI) and pCLE mode. Descriptive...
Tue Mar 03, 2020 15:50
Objective. The relationship between serum progesterone and the first trimester pregnancy outcome of threatened abortion is still controversial. Therefore, we aimed to further study the association between these two parameters. Methods. The present study is an observational retrospective cohort study. A total of 726 participants who had threatened abortion from a hospital in Guangdong, China, were included in this study from 17th August 2011 to 30th October 2018. The exposure variable and the outcome...
Tue Mar 03, 2020 15:35
Background. Percutaneous endoscopic transforaminal discectomy (PETD) is regarded as a viable alternative option for upper lumbar disc herniation (LDH). However, few studies have evaluated PETD for upper LDH, and no study has compared the advantages of endoscopic procedures versus conventional surgery. The present study was aimed at comparing the surgical outcome and safety of PETD versus conventional open lumbar discectomy in the treatment of upper LDH. Methods. Data from 42 patients treated for...
Tue Mar 03, 2020 14:50
Proteins are the most important component in sludge extracellular polymeric substances (EPS) and play a crucial role in the formation of sludge flocs, adsorption performance of sludge, and flocculation ability of sludge. This research is aimed at exploring the changes in proteins in EPS extracted from concentrated sludge after various nanoparticle (NP) treatments. The results showed that the protein content in EPS decreased by 40% after nanoalumina (Al2O3 NPs) treatment but increased at varying degrees...
Tue Mar 03, 2020 14:20
Objective. To construct a predictive signature based on autophagy-associated lncRNAs for predicting prognosis in lung adenocarcinoma (LUAD). Materials and Methods. Differentially expressed autophagy genes (DEAGs) and differentially expressed lncRNAs (DElncRNAs) were screened between normal and LUAD samples at thresholds of and value
Tue Mar 03, 2020 13:20
The protocol presents the optimized parameters for preparing thermosensitive liposomes using the staggered herringbone micromixer microfluidics device. This also allows co-encapsulation of doxorubicin and indocyanine green into the liposomes and the photothermal-triggered release of doxorubicin for controlled/triggered drug release.
Tue Mar 03, 2020 20:00
Nuclear surface spreads are an indispensable tool for studying chromosome events during meiosis. Here we demonstrate a method to prepare and visualize meiotic chromosomes during prophase I from zebrafish spermatocytes.
Tue Mar 03, 2020 19:00
The Zarit Burden Interview (ZBI) has been widely used to assess caregiver burden. Few research papers have investigated the Thai version of the ZBI. The study aimed to examine the psychometric properties of th...
Mon Mar 02, 2020 02:00
Publication date: Available online 3 March 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Henry Leonhardt, Andreas Ziegler, Guenter Lauer, Adrian Franke
Tue Mar 03, 2020 20:04
Publication date: Available online 3 March 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Johannes J. Sidelmann, Jørgen B. Gram, Anne CM. Godtfredsen, Jens J. Thorn, Janne Ingerslev, Else M. Pinholt
Tue Mar 03, 2020 20:04
Abstract Myelin pathologies are an important cause of multifactorial, e.g., multiple sclerosis, and Mendelian, e.g., leukodystrophy, neurological disorders. CNP encodes a major component of myelin and its CNS expression is exclusive to myelin-forming oligodendrocytes. Deficiency of CNP in mouse causes a lethal white matter neurodegenerative phenotype. However, a corresponding human phenotype has not been described to date. Here, we describe a multiplex consanguineous family from...
Tue Mar 03, 2020 02:00
Nature Communications, Published online: 03 March 2020; doi:10.1038/s41467-020-14695-1Previously only humans and the great apes have been shown to use probabilities to make predictions about uncertain events, and integrate social and physical information into their predictions. Here, the authors demonstrate these capacities in a parrot species, the kea.
Tue Mar 03, 2020 02:00
Nature Communications, Published online: 03 March 2020; doi:10.1038/s41467-020-14952-3Little is known about von Economo neurons, which have been described in a subset of mammals and appear to be selectively lost in several human neurological diseases. Here, authors reveal the gene expression profile of these cells and show that they are likely long-distance projection neurons.
Tue Mar 03, 2020 02:00
Nature Communications, Published online: 03 March 2020; doi:10.1038/s41467-020-15001-9Hyperbolic plasmonic surfaces supporting highly directional propagating plasmon-polaritons have been realized in artificial metamaterials. Here, the authors demonstrate experimentally a hyperbolic plasmonic surface naturally occurring in thin films of WTe2, a type-II Weyl semimetal with layered structure.
Tue Mar 03, 2020 02:00
Nature Communications, Published online: 03 March 2020; doi:10.1038/s41467-020-14965-yMany animals show individual left/right biases in motor behaviour, but underlying neural substrates have proven elusive. Here the authors describe neurons that maintain individual, context-dependent lateralisation of swimming behaviour in zebrafish.
Tue Mar 03, 2020 02:00
Nature Communications, Published online: 03 March 2020; doi:10.1038/s41467-020-14880-2Organic LEDs (OLEDs) have generally been considered to be slow devices. Through engineering the structure and materials of OLEDs, the authors achieve a breakthrough in the high-speed operation of OLEDs and demonstrate a 1 Gbps optical wireless link using the OLEDs.
Tue Mar 03, 2020 02:00
Nature Communications, Published online: 03 March 2020; doi:10.1038/s41467-020-14845-5Intranasal oxytocin can affect brain function either by direct entry to the brain or by increasing oxytocin levels in blood plasma. Here, the authors show that increases in plasmatic oxytocin account for some but not all of the changes observed following intranasal oxytocin administration.
Tue Mar 03, 2020 02:00
Nature Communications, Published online: 03 March 2020; doi:10.1038/s41467-020-14900-1The spin texture in presence of both inversion and time-reversal symmetries has been difficult to observe. Here, Nakamura et al. report evidence of hidden entanglement between spin and momentum in antiperovskite Dirac material Sr3SnO.
Tue Mar 03, 2020 02:00
Nature Communications, Published online: 03 March 2020; doi:10.1038/s41467-020-14876-yThe deformation mechanisms of micron-sized twinned metals are well-understood, but it is not so for twinned nanocrystalline metals. Here, the authors use high resolution microscopy to image the deformation of nanocrystalline twinned platinum and show that grain boundary behaviors dominate plasticity below 6 nm.
Tue Mar 03, 2020 02:00
Nature Communications, Published online: 03 March 2020; doi:10.1038/s41467-020-14712-3Cleaner fish can cheat clients for higher rewards but this comes with a risk of punishment. Here, Truskanov et al. show that juvenile cleaner fish can learn by observing adults to behave more cooperatively themselves but also to prefer clients that are more tolerant to cheating.
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