Abstract Background The effects of different autograft types for anterior cruciate ligament reconstruction (ACL-R) on muscle function are sparsely investigated in randomized controlled trials. Our aim was to investigate the effects of quadriceps tendon autograft (QTB) vs. semitendinosus-gracilis autograft (StG) on thigh muscle strength and functional capacity, and a patient-reported outcome 1 year after ACL-R, and to compare the results...
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Unfortunately, in the published article the symbol “% ile” has incorrectly been published as “‰”. We have now corrected this in all the occurrences.
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Previous work has indicated that post-traumatic stress disorder (PTSD) symptoms, measured by the Clinician-Administered PTSD Scale (CAPS) within 60 days of trauma exposure, can reliably produce likelihood esti...
Mon Mar 02, 2020 02:00
Thyroid, Ahead of Print.
Mon Mar 02, 2020 10:00
Thyroid, Ahead of Print.
Mon Mar 02, 2020 10:00
Abstract Necrotizing fasciitis is a rare rapidly progressive, devastating surgical emergency that results in necrosis of superficial fascia, and subcutaneous tissue. It most commonly affects the abdominal wall, extremities and perineum, while the involvement in the head and neck region is relatively rare. Here, we report a successfully treated case of necrotizing fasciitis of the craniofacial region caused by Mucor in an uncontrolled diabetic patient. Early diagnosis, early surgical...
Mon Mar 02, 2020 02:00
AbstractCancer cell growth is characterized by reprogrammed glucose metabolism and subsequent high rate of glycolysis. The metabolic reprogramming is essential for cell proliferation and drug resistance of cancer cells including glioblastoma (GBM). MicroRNAs play pivotal roles during GBM development. In the present study, we discovered a significant downregulation of miR-1297 in GBM. Decreased miR-1297 expression was associated with prolonged overall survival of patients with glioma. Overexpression...
Mon Mar 02, 2020 00:00
AbstractHistopathological whole slide images of haematoxylin and eosin (H&E)-stained biopsies contain valuable information with relation to cancer disease and its clinical outcomes. Still, there are no highly accurate automated methods to correlate histolopathological images with brain cancer patients ’ survival, which can help in scheduling patients therapeutic treatment and allocate time for preclinical studies to guide personalized treatments. We now propose a new classifier, namely, DeepSurvNet...
Mon Mar 02, 2020 00:00
Conclusion: GNP-NN-32 showed an anticancer potential against human breast cancer cell lines. Analysis of detailed chemical characterization along with its cytotoxic property might help to perceive a new dimension of the anti-cancer potential of GNP-NN-32 that will enhance its biomedical function in near future. (Source: Journal of Venomous Animals and Toxins including Tropical Diseases)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social...
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The treatment of patients with advanced non –small cell lung cancer with anaplastic lymphoma kinase chromosomal rearrangements has been revolutionized by the development of tyrosine kinase inhibitors (TKIs). Excellent progress has been made over the past decade, with 4 TKIs now approved in the front-line setting. Alectinib is the preferred first-line option based on its efficacy and side-effect profile. The central nervous system (CNS) activity of alectinib and brigatinib has allowed for treatment...
Mon Mar 02, 2020 00:00
Immune checkpoint inhibitors have recently been demonstrated to improve survival in metastatic and locally advanced non-small cell lung cancer (NSCLC). Radiation therapy has a well-established role in the treatment of NSCLC and has more recently been shown to be immunostimulatory, with the potential to enhance the efficacy of immunotherapy. This comprehensive review details the current roles of radiation therapy and immune checkpoint inhibitors in NSCLC, discusses the intersection of these two modalities...
Mon Mar 02, 2020 00:00
Five-year survival rates for patients with early-stage non –small cell lung cancer have room for improvement. Adjuvant chemotherapy results in a small but significant increase in overall survival at 5 years. Efforts to improve outcomes by intensifying adjuvant treatment, utilizing cancer-specific vaccines or tyrosine kinase inhibitors in unselected patie nts, have been unsuccessful. In addition to research with immune checkpoint inhibitors that are addressed in a separate article, ongoing studies...
Mon Mar 02, 2020 00:00
This article covers genetic targets beyond EGFR, ALK and ROS1, their novel agents, challenges, and future directions. (Source: Thoracic Surgery Clinics)
Mon Mar 02, 2020 00:00
Over the past year, the combination of platinum-based chemotherapy and immunotherapy has become the standard of care for patients with metastatic non –small-cell lung cancer with any programmed death ligand 1 tumor proportion score. There is preclinical evidence demonstrating potential synergistic immunomodulation with combination therapy by enhancing immune-mediated tumor death and by disrupting the immunosuppressive tumor microenvironment tha t prevents immune detection. This potential synergy...
Mon Mar 02, 2020 00:00
AbstractThe development of effective immunosuppressive strategies has been a key to successful outcomes in heart transplantation. Immunosuppression however is a double-edged sword with consequences of rejection when underutilized and risk for infection, malignancy, and drug toxicity when used in excess. The search for non-invasive blood-based monitoring not only to assess allograft rejection but also to monitor overall state of immunosuppression remains very attractive, potentially reducing cost...
Mon Mar 02, 2020 00:00
Radiation cystitis, a severely debilitating condition characterized by fibrosis, vascular damage, and compromised bladder function, develops in cancer survivors who received pelvic radiation treatment. This is the first study to compare the effects of radiation on the bladder across different murine genetic backgrounds, which may explain differences in patients ’ sensitivity to developing radiation cystitis after radiation cancer treatment. AbstractA subset of patients receiving radiation therapy...
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Publication date: Available online 2 March 2020Source: Life SciencesAuthor(s): Mohammad Mirza-Aghazadeh-Attari, Elyad Mohammadi Ekrami, Seyyed Ali Mousavi Aghdas, Ainaz Mihanfar, Shahin Hallaj, Bahman Yousefi, Amin Safa, Maryam Majidinia (Source: Life Sciences)
Mon Mar 02, 2020 23:41
Publication date: Available online 2 March 2020Source: Life SciencesAuthor(s): Yang Liu, Yusheng Zhang, Qiang Chi, Zhen Wang, Boshi Sun (Source: Life Sciences)
Mon Mar 02, 2020 23:41
The functional state of the preexisting T cells in the tumor microenvironment is a key determinant for effective antitumor immunity and immunotherapy. Increasing evidence suggests that immunosenescence is an important state of T cell dysfunction that is distinct from exhaustion, a key strategy used by malignant tumors to evade immune surveillance and sustain the suppressive tumor microenvironment. Here, we discuss the phenotypic and functional characteristics of senescent T cells and their role in...
Mon Mar 02, 2020 23:38
Polychlorinated biphenyls (PCBs) are carcinogenic to humans and can be found in Fuller ’ s earth used for the regeneration of used transformer oil. This work describes a highly selective gas chromatographic-selected ion monitoring mass spectrometric method (GC-MS/SIM) for the simultaneous determination of three Aroclor PCB congener mixtures (1242, 1254, and 1260). The separation of the PCBs could be systematically varied by changing the temperature conditions of the chromatographic column. Methods...
Mon Mar 02, 2020 23:14
Epigenetic regulation of epithelial-mesenchymal transition: focusing on hypoxia and TGF- β signaling
Epithelial-mesenchymal transition (EMT) is an important process triggered during cancer metastasis. Regulation of EMT is mostly initiated by outside signalling, including TGF- β, growth factors, Notch ligand, W... (Source: Journal of Biomedical Science)
Mon Mar 02, 2020 01:00
This study validates the suitability of the agonist-bound orthosteric pocket in the MT receptor structures for the structure-based discovery of selective agonists. (Source: eLife)
Mon Mar 02, 2020 01:00
Authors: Yi-Kuang Yen Chen-Hsiang Chao Ya-Shin Yeh A graphene and poly (3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) modified conductive paper-based electrochemical impedance spectroscopy (EIS) aptasensor has been successfully fabricated by a simple and continuous coating process. A graphene/PEDOT:PSS modified paper electrode forms the nanocomposite providing a conductive and sensitive substrate for further aptamer functionalization of the biosensor. This low-cost...
Mon Mar 02, 2020 00:00
ConclusionIn a break from purely in silico approaches, we propose a simple and rapid pretherapeutic functional analysis of somaticBRCA1 variants potentially involved in splicing alterations. This approach will allow more ovarian cancer patients to benefit from new therapies targeting PARP. (Source: Molecular Diagnosis and Therapy)
Mon Mar 02, 2020 00:00
by Elba Raim úndez, Simone Keller, Karolin Ebert, Sabine Hug, Fabian J. Theis, Dieter Maier, Birgit Luber, Jan Hasenauer Targeted cancer therapies are powerful alternatives to chemotherapies or can be used complementary to these. Yet, the response to targeted treatments depends on a variety of factors, including mutations and expression levels, and therefore their outcome is difficult to predict. Here, we develop a mechanistic model of gastric cancer to study response and resistance factors for...
Mon Mar 02, 2020 00:00
AbstractX-ray repair cross-complementing group 1 (XRCC1) plays a key role in the base excision repair pathway, as a scaffold protein that brings together proteins of the DNA repair complex. Several studies have reported contradictory results forXRCC1 exon 6 C>T (rs1799782) gene polymorphism and cancer risk in Indian population has provided inconsistent results. Therefore, we have performed this meta-analysis to evaluate the relationship betweenXRCC1 exon 6 C>T gene polymorphism and risk of...
Mon Mar 02, 2020 00:00
Authors: Yeon-Jin Cho Sun-Hye Choi Rami Lee Hongik Hwang Hyewhon Rhim Ik-Hyun Cho Hyoung-Chun Kim Jeong-Ik Lee Sung-Hee Hwang Seung-Yeol Nah Gintonin, a novel ginseng-derived glycolipoprotein complex, has an exogenous ligand for lysophosphatidic acid (LPA) receptors. However, recent lipid analysis of gintonin has shown that gintonin also contains other bioactive lipids besides LPAs, including linoleic acid and lysophosphatidylinositol (LPI). Linoleic acid, a free...
Mon Mar 02, 2020 00:00
Authors: Kristina Søborg Pedersen Christina Baun Karin Michaelsen Nielsen Helge Thisgaard Andreas Ingemann Jensen Fedor Zhuravlev Despite promising anti-cancer properties in vitro, all titanium-based pharmaceuticals have failed in vivo. Likewise, no target-specific positron emission tomography (PET) tracer based on the radionuclide 45Ti has been developed, notwithstanding its excellent PET imaging properties. In this contribution, we present liquid–liquid extraction (LLE)...
Mon Mar 02, 2020 00:00
Authors: Nanyak Galam Pinar Tulay Terin Adali Breast cancer ranks as the fifth leading cause of death worldwide. Chemotherapy is commonly used directly or as neo-adjuvant therapy for the management of breast cancer with its attendant adverse effects, underscoring the need to develop biocompatible bioactive compounds for pharmacological applications. The aim of this study is to encapsulate carboplatin (CP) with silk fibroin protein (SF) by using an ionic gelation method as a drug carrier...
Mon Mar 02, 2020 00:00
Publication date: Available online 2 March 2020Source: Meta GeneAuthor(s): Srivani L.S.S. Nagam, Rajeswari Jinka (Source: Meta Gene)
Mon Mar 02, 2020 22:12
ConclusionTestosterone replacement therapy could be considered for most men with late ‐onset hypogonadism regardless of their history of prostate disease. However, a discussion about the risks and benefits of testosterone replacement therapy is always advised, especially in men with prostate cancer. Appropriate monitoring is mandatory. (Source: Andrology)
Mon Mar 02, 2020 22:03
We describe the first case of VKHD during chemoimmunotherapy including pembrolizumab in a patient with NSCLC, which was successfully treated with corticosteroid without any sequela. (Source: Respirology Case Reports)
Mon Mar 02, 2020 21:06
Authors: Joanna Patrycja Wróblewska Michał Stefan Lach Adam Ustaszewski Katarzyna Kulcenty Matthew Ibbs Inga Jagiełło Wiktoria Maria Suchorska Andrzej Marszałek Uveal melanoma (UM) is the most common primary tumor of the eye diagnosed in adults, associated with a high risk of metastasis and thereby, poor prognosis. Among known risk factors for the development of metastatic disease is the loss of BAP1 expression and chromosome 3 monosomy in the primary tumor. However,...
Mon Mar 02, 2020 00:00
In this study, we aimed to explore the global mechanisms and interrelationships among cancer, development, and metastasis, which are currently poorly understood. First, we constructed a core gene regulatory network containing specific genes and microRNAs of CSCs, EMT, and cancer. We uncovered seven distinct states emerging from the underlying landscape, denoted normal, premalignant, cancer, stem cell, CSC, lesion, and hyperplasia. Given the biological definition of each state, we also discuss the...
Mon Mar 02, 2020 00:00
Oncogenic mutations in the RNA splicing factors SRSF2, SF3B1, and U2AF1 are the most frequent class of mutations in myelodysplastic syndromes and are also common in clonal hematopoiesis, acute myeloid leukemia, chronic lymphocytic leukemia, and a variety of solid tumors. They cause genome-wide splicing alterations that affect important regulators of hematopoiesis. Several mRNA isoforms promoted by the various splicing factor mutants comprise a premature termination codon (PTC) and are therefore potential...
Mon Mar 02, 2020 00:00
Oxidative and replication stress underlie genomic instability of cancer cells. Amplifying genomic instability through radiotherapy and chemotherapy has been a powerful but nonselective means of killing cancer cells. Precision medicine has revolutionized cancer therapy by putting forth the concept of selective targeting of cancer cells. Poly(ADP-ribose) polymerase (PARP) inhibitors represent a successful example of precision medicine as the first drugs targeting DNA damage response to have entered...
Mon Mar 02, 2020 00:00
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