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Πέμπτη 5 Μαρτίου 2020


What Are Two Days Worth? Facing Dilemmas Together at the End of Life
Mr. J. was 35 years old when he died. He had loved the ocean, playing music, and joking with family and hospital staff alike. As an inpatient palliative care consultant, I took care of him during his last week. Mr. J. had all the makings of a "difficult case": he was young with an invasive pelvic…
The New England Journal of Medicine: Search Results in Geriatrics\Aging
Thu Mar 05, 2020 02:00
Social Spending to Improve Population Health — Does the United States Spend as Wisely as Other Countries?
On average, Americans have worse health outcomes than their counterparts in other high-income countries, even though the United States spends far more on health care than those countries do. This disparity is often attributed to social factors that influence health, such as housing, nutrition, and…
The New England Journal of Medicine: Search Results in Geriatrics\Aging
Thu Mar 05, 2020 02:00
Incidence of muscle relaxant use in relation to diagnosis of Parkinson’s disease
Abstract Background Parkinson’s disease is the second most common neurodegenerative disorder. Motor and non-motor symptoms seem to precede the diagnosis of Parkinson’s disease. Objective To evaluate the incidence of muscle relaxant use in community-dwelling persons with and without Parkinson’s disease from 4 years before to 4 years after the diagnosis of Parkinson’s disease. Method Nationwide register-based cohort included all community-dwelling Finnish persons who received reimbursement...
Latest Results for International Journal of Clinical Pharmacy
02:00
Appropriateness of empirical antibiotics: risk factors of adult patients with sepsis in the ICU
Abstract Background The appropriateness of antibiotics is the basis for improving the survival of patients with sepsis. Objective This study aimed to determine the appropriateness of empirical antibiotics, reasons for non-appropriate empirical antibiotics, risk factors of mortality, length of stay in intensive care unit (ICU-LOS) and Acute Physiology And Chronic Health Evaluation II (APACHE II) score predictors in adult patients with sepsis. Setting An adult ICU of a tertiary...
Latest Results for International Journal of Clinical Pharmacy
02:00
Population pharmacokinetics of busulfan in Saudi pediatric patients undergoing hematopoietic stem cell transplantation
Abstract Background Busulfan is an antineoplastic drug that is used widely as part of a conditioning regimen in pediatric patients undergoing hematopoietic stem cell transplantation. It has a narrow therapeutic index and highly variable pharmacokinetics; therefore therapeutic drug monitoring is recommended to optimize busulfan dosing. Objective To study the population pharmacokinetics of busulfan in Saudi pediatric patients to optimize its dosing. Settings King Abdullah Specialist...
Latest Results for International Journal of Clinical Pharmacy
Thu Mar 05, 2020 02:00
Hypothalamic–pituitary–adrenal axis suppression by inhaled or nasal corticosteroids in HIV-infected patients
Abstract Background Inhaled or nasal corticosteroids can cause suppression of the hypothalamic–pituitary–adrenal (HPA) axis. Early detection is important because this suppression can be associated with significant morbidity. Objective To explore the adverse effect of hypothalamic–pituitary–adrenal suppression by local corticosteroids in HIV-infected patients. Method Ambulatory HIV-infected patients were selected if they used both antiretroviral treatment and inhaled or nasal corticosteroid....
Latest Results for International Journal of Clinical Pharmacy
Thu Mar 05, 2020 02:00
Influence of pharmaceutical promotion on prescribers in Jordan
Abstract Background Pharmaceutical promotion efforts should facilitate excellent quality patient care. However, there has been substantial debate about ethical principles related to pharmaceutical promotions. Objectives This study aimed to evaluate (i) attitudes toward pharmaceutical promotion among physicians in the private sector in Jordan, (ii) the impact of pharmaceutical promotion in influencing physicians’ prescribing practices, and (iii) the prospect of academic detailing...
Latest Results for International Journal of Clinical Pharmacy
Thu Mar 05, 2020 02:00
Medication exposure and frailty in older community-dwelling patients: a cross-sectional study
Abstract Objective To investigate the association between the medication exposure, measured by the polypharmacy/excessive polypharmacy and the anticholinergic and/or sedative drug exposure, on frailty status among French older community-dwelling patients. Setting day-care unit in France (Lyon), with retrospective data from July, 2017 to March, 2018. Method This monocentric cross-sectional study included community-dwelling patients aged 65 years and over and admitted at the day-care...
Latest Results for International Journal of Clinical Pharmacy
Thu Mar 05, 2020 02:00
Unfractionated heparin dosing in obese patients
Abstract Background The effect of obesity on the pharmacokinetics and pharmacodynamics of unfractionated heparin is not clearly understood, therefore to reduce the risk of bleeding, maximal dose (capped) nomograms are often used. This can lead to inadequate anticoagulation and increased mortality and morbidity. In Queensland, Australia, statewide nomograms recommend total-body-weight-based dosing, with capped initial bolus and maintenance doses. Objective To determine if current...
Latest Results for International Journal of Clinical Pharmacy
Thu Mar 05, 2020 02:00
Bullous pemphigoid associated with the use of dipeptidil peptidase-4 inhibitors: analysis from studies based on pharmacovigilance databases
Abstract Background Bullous pemphigoid has been associated to dipeptidase-4 inhibitors. Objectives Addressing the potential Bullous pemphigoid-dipeptidase-4 inhibitors association based on pharmacovigilance data currently available in Spain in order to obtain a composite disproportionality estimator from all the data generated by the case-non case studies conducted to this date. Setting The Spanish Pharmacovigilance System for Human Use Drugs database. Method Case-non case study...
Latest Results for International Journal of Clinical Pharmacy
Thu Mar 05, 2020 02:00

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