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Δευτέρα 2 Μαρτίου 2020


Umbelliferone stimulates glucose uptake; modulates gluconeogenic and nucleotide-hydrolyzing enzymes activities, and dysregulated lipid metabolic pathways in isolated psoas muscle
Publication date: April 2020Source: Journal of Functional Foods, Volume 67Author(s): Veronica F. Salau, Ochuko L. Erukainure, Collins U. Ibeji, Neil A. Koorbanally, Md. Shahidul Islam
Functional Foods
Fri Feb 28, 2020 14:43
Lycopene prevents lipid accumulation in hepatocytes by stimulating PPARα and improving mitochondrial function
Publication date: April 2020Source: Journal of Functional Foods, Volume 67Author(s): Jia Wang, Tonghui Geng, Qianhui Zou, Ningru Yang, Weiyang Zhao, Yitong Li, Xintong Tan, Tian Yuan, Xuebo Liu, Zhigang Liu
Functional Foods
Fri Feb 28, 2020 14:43
A polyphenol-rich Calafate (<em>Berberis microphylla</em>) extract rescues glucose tolerance in mice fed with cafeteria diet
Publication date: April 2020Source: Journal of Functional Foods, Volume 67Author(s): J. Soto-Covasich, M. Reyes-Farias, R.F. Torres, K. Vasquez, L. Duarte, J. Quezada, P. Jimenez, M.T. Pino, L. Garcia-Nannig, L. Mercado, D.F. Garcia-Diaz
Functional Foods
Fri Feb 28, 2020 14:43
Differential effects of inulin or its fermentation metabolites on gut barrier and immune function of porcine intestinal epithelial cells
Publication date: April 2020Source: Journal of Functional Foods, Volume 67Author(s): Julie Uerlings, Martine Schroyen, Els Willems, Sofie Tanghe, Geert Bruggeman, Jérôme Bindelle, Nadia Everaert
Functional Foods
Fri Feb 28, 2020 14:43
<em>Lactobacillus plantarum</em> AR113 alleviates DSS-induced colitis by regulating the TLR4/MyD88/NF-κB pathway and gut microbiota composition
Publication date: April 2020Source: Journal of Functional Foods, Volume 67Author(s): Yongjun Xia, Yan Chen, Guangqiang Wang, Yijin Yang, Xin Song, Zhiqiang Xiong, Hui Zhang, Phoency Lai, Shijie Wang, Lianzhong Ai
Functional Foods
Fri Feb 28, 2020 14:43
Macrophage-stimulating activities of a novel low molecular weight saccharide fragment prepared from ascophyllan with alginate lyase
Publication date: April 2020Source: Journal of Functional Foods, Volume 67Author(s): Zedong Jiang, Gang Yu, Qingyun Bao, Xu Xu, Yanbing Zhu, Hui Ni, Qingbiao Li, Tatsuya Oda
Functional Foods
Fri Feb 28, 2020 14:43
Laboratory abnormalities in patients with COVID-2019 infection
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Clinical Chemistry and Laboratory Medicine (CCLM)
Mon Mar 02, 2020 22:30
UPLC-MS/MS method for determination of retinol and α-tocopherol in serum using a simple sample pretreatment and UniSpray as ionization technique to reduce matrix effects
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Clinical Chemistry and Laboratory Medicine (CCLM)
Sat Feb 29, 2020 12:31
Challenges of LC-MS/MS ethyl glucuronide analysis in abstinence monitoring of liver transplant candidates
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Clinical Chemistry and Laboratory Medicine (CCLM)
Sat Feb 29, 2020 12:31
Frontmatter
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Volume: 58Issue: 4Pages: i-v
Clinical Chemistry and Laboratory Medicine (CCLM)
Sat Feb 29, 2020 02:00
Corrigendum to: Pediatric reference intervals for 29 Ortho VITROS 5600 immunoassays using the CALIPER cohort of healthy children and adolescents
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Volume: 58Issue: 4Pages: 635-637
Clinical Chemistry and Laboratory Medicine (CCLM)
Wed Feb 12, 2020 02:00
Macro-aspartate aminotransferase syndrome: a case report
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Volume: 58Issue: 4Pages: e96-e99
Clinical Chemistry and Laboratory Medicine (CCLM)
Sat Feb 29, 2020 02:00
Neuroprotective effects of gallic acid against neurotoxicity induced by sodium arsenite in rats
Abstract Arsenic causes a wide range of neurological complications including cognitive impairment, short-term memory and concentration problems. The present study investigated effects of gallic acid (GA) against sodium arsenite (SA)-induced neurotoxicity in rats. Thirty-five adult male rats were randomly divided into five groups. Group 1 received normal saline (2 ml/kg, P.O.) for 21 days. Group 2 received SA (10 mg/kg, P.O., for 14 days). Groups 3 and 4 received GA (10 and 30 mg/kg,...
Latest Results for Comparative Clinical Pathology
Mon Mar 02, 2020 02:00
Methanol extract of Napoleona vogelii demonstrates anti-nociceptive and anti-inflammatory activities through dopaminergic mechanism and inhibition of inflammatory mediators in rodents
Abstract Napoleona vogelii (Lecythidaceae) is used in traditional medicine for the management of pain and inflammatory disorders. This study was conducted to investigate the anti-nociceptive and anti-inflammatory activity of the methanol stem bark extract of N. vogelii in rodents. The extract (100–400 mg/kg) was administered 1 h before intraperitoneal and intraplantar injection of 0.2 mL of 0.6% v/v acetic acid and 0.05 mL of 2% v/v formalin, respectively. Anti-inflammatory activity...
Latest Results for Comparative Clinical Pathology
Fri Feb 28, 2020 02:00
Histological examination of the potential arrhythmic substrates in the setting of Ebstein’s malformation
The sections are stained using Masson’s trichrome technique with myocardial tissues coloured brown, and the insulating fibrous tissues coloured blue‐green and show abnormal connections through the insulating plane joining the base of the compact atrioventricular node to the crest of the muscular ventricular septum. These are the so‐called nodoventricular connections, and they have the potential capacity either to produce ventricular pre‐excitation or to participate in abnormal re‐entry circuits....
Journal of Anatomy
Mon Mar 02, 2020 22:24
A retrospective analysis to determine if exercise training‐induced thermoregulatory adaptations are mediated by increased fitness or heat acclimation
New Findings What is the central question of this study? Are fitness‐related improvements in thermoregulatory responses during uncompensable heat stress mediated by aerobic capacity (VO2max) or is it the partial acclimation associated with training? What is the main finding and its importance? During uncompensable heat stress, individuals with high and low VO2max displayed similar sweating and core temperature responses whereas exercise training in previously untrained individuals resulted...
Experimental Physiology
Mon Mar 02, 2020 22:21
Editorial Board
Experimental Physiology
Sat Feb 29, 2020 19:04
Generation of a Human iPSC-Based Blood-Brain Barrier Chip
The blood-brain barrier (BBB) is a multicellular neurovascular unit tightly regulating brain homeostasis. By combining human iPSCs and organ-on-chip technologies, we have generated a personalized BBB chip, suitable for disease modeling and CNS drug penetrability predictions. A detailed protocol is described for the generation and operation of the BBB chip.
JoVE: Journal of Visualized Experiments
Mon Mar 02, 2020 21:00
Assembly and Characterization of Polyelectrolyte Complex Micelles
We provide protocols and representative data for designing, assembling, and characterizing polyelectrolyte complex micelles, core-shell nanoparticles formed by polyelectrolytes and hydrophilic charged-uncharged block copolymers.
JoVE: Journal of Visualized Experiments
Mon Mar 02, 2020 21:00
Posterior Approach for Debridement of the Psoas Abscess
This is a cadaveric study investigating the landmarks for the posterior approach for irrigation and debridement of the psoas abscess. The interval between the transverse processes (TP) was used to access the substance of the psoas muscle.
JoVE: Journal of Visualized Experiments
Mon Mar 02, 2020 20:00
Visualization of Bacterial Resistance using Fluorescent Antibiotic Probes
Fluorescently tagged antibiotics are powerful tools that can be used to study multiple aspects of antimicrobial resistance. This article describes the preparation of fluorescently tagged antibiotics and their application to studying antibiotic resistance in bacteria. Probes can be used to study mechanisms of bacterial resistance (e.g., efflux) by spectrophotometry, flow cytometry, and microscopy.
JoVE: Journal of Visualized Experiments
Mon Mar 02, 2020 20:00
Isolation, Culture, and Adipogenic Induction of Neural Crest Original Adipose-Derived Stem Cells from Periaortic Adipose Tissue
We present a protocol for the isolation, culture, and adipogenic induction of neural crest derived adipose-derived stem cells (NCADSCs) from the periaortic adipose tissue of Wnt-1 Cre+/-;Rosa26RFP/+ mice. The NCADSCs can be an easily accessible source of ADSCs for modeling adipogenesis or lipogenesis in vitro.
JoVE: Journal of Visualized Experiments
Mon Mar 02, 2020 19:00
Design of an Open-Source, Low-Cost Bioink and Food Melt Extrusion 3D Printer
The aim of this work is to design and construct a reservoir-based melt extrusion three-dimensional printer made from open-source and low-cost components for applications in the biomedical and food printing industries.
JoVE: Journal of Visualized Experiments
Mon Mar 02, 2020 19:00
Proof-of-Concept for Gas-Entrapping Membranes Derived from Water-Loving SiO2/Si/SiO2 Wafers for Green Desalination
Presented here is a stepwise protocol for realizing gas-entrapping membranes (GEMs) from SiO2/Si wafers using integrated circuit microfabrication technology. When silica-GEMs are immersed in water, the intrusion of water is prevented, despite the water-loving composition of silica.
JoVE: Journal of Visualized Experiments
Sun Mar 01, 2020 21:00
Analysis of Complex Molecules and Their Reactions on Surfaces by Means of Cluster-Induced Desorption/Ionization Mass Spectrometry
Neutral SO2 clusters of low kinetic energy (
JoVE: Journal of Visualized Experiments
Sun Mar 01, 2020 20:00
Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors
The aim of this methodology is to identify cancer stem cells (CSC) in cancer cell lines and primary human tumor samples with the sphere-forming protocol, in a robust manner, using functional assays and phenotypic characterization with flow cytometry and Western blot.
JoVE: Journal of Visualized Experiments
Sun Mar 01, 2020 19:00
Post-Movie Subliminal Measurement (PMSM), for Investigating Implicit Social Bias
This protocol describes the use of movies to investigate brain mechanisms underlying implicit social biases during functional magnetic resonance imaging. When the face of a protagonist is presented after a movie subliminally, it evokes an implicit response based on knowledge of the protagonist gained during the movie.
JoVE: Journal of Visualized Experiments
Sat Feb 29, 2020 20:00
Intrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation
Intrathecally applied fluorescein is used to achieve intraoperative visualization of CSF leaks. This protocol describes a lumbar puncture, the application of 5% fluorescein, and intraoperative visualization using a fully digital microscope.
JoVE: Journal of Visualized Experiments
Sat Feb 29, 2020 19:00
Bioinspired Soft Robot with Incorporated Microelectrodes
A bioinspired scaffold is fabricated by a soft photolithography technique using mechanically robust and electrically conductive hydrogels. The micropatterned hydrogels provide directional cardiomyocyte cell alignment, resulting in a tailored direction of actuation. Flexible microelectrodes are also integrated into the scaffold to bring electrical controllability for a self-actuating cardiac tissue.
JoVE: Journal of Visualized Experiments
Fri Feb 28, 2020 20:00
A Novel Stromal Fibroblast-Modulated 3D Tumor Spheroid Model for Studying Tumor-Stroma Interaction and Drug Discovery
A novel three-dimensional spheroid model based on the heterotypic interaction of tumor cells and stromal fibroblasts is established. Here, we present coculture of tumor cells and stromal fibroblasts, time-lapse imaging, and confocal microscopy to visualize the formation of spheroids. This three-dimensional model offers a pertinent platform to study tumor-stroma interactions and test cancer therapeutics.
JoVE: Journal of Visualized Experiments
Fri Feb 28, 2020 19:00
Study protocol for a randomized controlled trial: prophylactic swallowing exercises in head-and-neck cancer patients treated with (chemo)radiotherapy (PRESTO trial)
Dysphagia is a common and serious complication after (chemo)radiotherapy (CRT) for head-and-neck cancer (HNC) patients. Prophylactic swallowing exercises (PSE) can have a significantly positive effect on post-...
Trials - Latest Articles
Mon Mar 02, 2020 02:00
Update on the EFFECTS study of fluoxetine for stroke recovery: a randomised controlled trial in Sweden
Studies have suggested that fluoxetine might improve neurological recovery after stroke, but the results remain inconclusive. The EFFECTS (Efficacy oF Fluoxetine – a randomisEd Controlled Trial in Stroke) reac...
Trials - Latest Articles
Fri Feb 28, 2020 02:00
Effect and safety of 4% albumin in the treatment of cardiac surgery patients: study protocol for the randomized, double-blind, clinical ALBICS (ALBumin In Cardiac Surgery) trial
In cardiac surgery with cardiopulmonary bypass (CPB), large amounts of fluids are administered. CPB priming with crystalloid solution causes marked hemodilution and fluid extravasation. Colloid solutions may r...
Trials - Latest Articles
Fri Feb 28, 2020 02:00
Mindfulness-based resilience training for aggression, stress and health in law enforcement officers: study protocol for a multisite, randomized, single-blind clinical feasibility trial
Law enforcement officers (LEOs) are exposed to significant stressors, elevating their risk for aggression and excessive use of force, as well as mental health consequences, including post-traumatic stress diso...
Trials - Latest Articles
Fri Feb 28, 2020 02:00
Scaling up Quality Improvement for Surgical Teams (QIST) – avoiding surgical site infection and anaemia at the time of surgery: protocol for a cluster randomised controlled trial
Measures shown to improve outcomes for patients often fail to be adopted into routine practice in the NHS. The Institute for Health Improvement Breakthrough Series Collaborative (BSC) model is designed to supp...
Trials - Latest Articles
Fri Feb 28, 2020 02:00
Comparison of the clinical benefits for non-small cell lung cancer patients between different volume of pleural lavage fluid following video-assisted thoracoscopic lobectomy and systematic mediastinal lymph node dissection: study protocol for a randomized controlled trial
Pleural lavage is regularly performed before closing the chest wall in pulmonary surgeries to prevent pleural implantation of tumor cells and postoperative infection. However, scant data could be found in the ...
Trials - Latest Articles
Thu Feb 27, 2020 02:00
The intrinsic cell type‐specific excitatory connectivity of the developing mouse subiculum is sufficient to generate synchronous epileptiform activity
Key points The activity of local excitatory circuits of the subiculum has been suggested to be involved in the initiation of pathological activity in epileptic patients and experimental animal models of temporal lobe epilepsy. We have taken advantage of multimodal techniques to classify subicular cells in distinct subclasses and have investigated their morphofunctional properties and connectivity in vitro. Our results indicate that local subicular excitatory circuits are connected in a cell...
The Journal of Physiology
Mon Mar 02, 2020 22:13
Nitric oxide metabolism in the human placenta during aberrant maternal inflammation
Key points NO is a gasotransmitter with important physiological and pathophysiological roles in pregnancy. There is limited information about the sources and metabolism of NO and its bioactive metabolites (NOx) in both normal and complicated pregnancies. This study characterized and quantified endogenous NOx in human and mouse placenta following determination of the stability of exogenous NOx in placental homogenates. NOx have differential stability in placental homogenates; NO and iron...
The Journal of Physiology
Mon Mar 02, 2020 22:13
Local sleep spindles in the human thalamus
Key points Sleep spindles have recently been shown to occur not only across multiple neocortical regions but also locally in restricted cortical areas. Here we show that local spindles are indeed present in the human posterior thalamus Thalamic local spindles had lower spectral power than non‐local ones. While non‐local thalamic spindles had equal local and non‐local cortical counterparts, local thalamic spindles had significantly more local cortical counterparts, i.e., occurring in a...
The Journal of Physiology
Mon Mar 02, 2020 22:13

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