Related ArticlesA systematic review of different treatment strategies for the squamous cell carcinoma of the posterior pharyngeal wall. Eur Arch Otorhinolaryngol. 2020 May 02;: Authors: De Virgilio A, Russo E, Costantino A, Malvezzi L, Colombo G, Cugini G, Miceli S, Rossi V, Spriano G, Mercante G Abstract OBJECTIVE: To perform a systematic review of the literature available about the posterior pharyngeal wall squamous cell carcinomas, with a special...
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Related ArticlesAdvances of droplet-based microfluidics in drug discovery. Expert Opin Drug Discov. 2020 Apr 30;:1-11 Authors: Wang Y, Chen Z, Bian F, Shang L, Zhu K, Zhao Y Abstract Introduction: Drug discovery through a large number of candidates with nearly unlimited possibilities is laborious, time-consuming, and incurs massive costs. It thus calls for fast and robust methods that allow for handling small amounts of reagents, automation, and high-throughput...
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Aim The infection of Helicobacter pylori (H. pylori) has a close association with gastric ulcers and gastric adenocarcinoma. This study was designed to assess the efficacy and safety of quadruple regimen with amoxicillin plus berberine vs tetracycline plus furazolidone in H. pylori rescue treatment. Methods We conducted a randomized, open‐label, multicenter, noninferiority trial. Subjects with previous treatment failures recruited from 5 centers were randomized (1:1) to accept regimen...
Objective To elucidate the long‐term outcomes of permanent endoscopic biliary stenting (EBS) and risk factors for recurrent biliary obstruction (RBO) in high‐risk or elderly patients with common bile duct (CBD) stones. Methods The electronic database of Hakodate Municipal Hospital was searched to identify elderly or high‐risk patients with CBD stones who had undergone permanent EBS using a plastic stent without stone removal and were followed up between April 2011 and May 2019, with no...
Objective To investigate histopathologic changes of muscularis mucosae (MM) and submucosa in the gastric cardia. Methods We performed a histopathology study of 50 distal esophagectomies with proximal gastrectomies for esophageal squamous cell carcinoma as the study (non‐cancerous cardiac) group and 60 gastrectomies for early gastric cardiac carcinoma as the cancer group. The gastroesophageal junction was defined as the distal end of squamous epithelium, multilayered epithelium, or deep...
Aim Although there are established guidelines for first surveillance colonoscopy (FSC) after polypectomy, there is no consensus on second surveillance colonoscopy (SSC), especially in Asian countries. The study aimed to investigate the association of SSC findings with index total colonoscopy (TCS) and FSC results. Methods This was a single‐center retrospective cohort study involving 1,928 consecutive Japanese patients who received three or more colonoscopies. High‐risk findings were defined...
Aims The diagnostic performance of liver stiffness measurement (LSM) is important to evaluate fibrosis stages in non‐alcoholic fatty liver disease (NAFLD) patients. However, whether LSM differs between non‐obese vs. obese NAFLD is unknown. Methods Patients diagnosed as NAFLD by liver biopsy according to NASH CRN scoring system were consequentially enrolled in this study. Non‐obese was defined as BMI less than 25 kg/m2. LSM measurement was performed by experienced physicians within 2 weeks...
AIM There is limited data on the combined use of more than one biologic or small molecule in the treatment of patients with inflammatory bowel disease. METHODS We identified patients with Crohn's disease or ulcerative colitis who received treatment with a combination of two biologics or a biologic and small molecule from 2015 to 2019 for persistent disease activity or concomitant rheumatologic or dermatologic disease. The primary endpoint was effectiveness based on improvement in inflammatory...
Background Systemic therapy, such as sorafenib, is clinically adapted to treat the patients with advanced stage, or BCLC stage C hepatocellular carcinoma (HCC). The aim of the study was to evaluate the therapeutic benefit of combined sorafenib and transarterial chemoembolization (TACE) to this group of patients. Methods Data on patients with BCLC stage C HCC from August 2012 to September 2017 was collected. The cases who accepted sorafenib alone or sorafenib and TACE were classified as...
Aim We aimed to evaluate whether patients with malignant biliary obstruction (MBO) could benefit from balloon dilation before the placement of self‐expanding metal stent (SEMS) for palliative biliary drainage. Methods Consecutive patients who underwent ERCP with SEMS placement for palliative management of MBO were retrospectively included. Comparative analyses were performed on decreased serum bilirubin levels, post‐procedural adverse events, patency duration, stent dysfunction and survival...
Aim The lack of risk profile data regarding changes in multiple polyps identified by colonoscopy constrains the creation of evidence‐based guidelines. This retrospective case–control study addresses this issue by characterizing the relationship between size, location and histology of multiple polyps, in addition to population‐associated features in a large teaching hospital‐based Chinese population. Methods A large, case–control retrospective analysis was conducted on polyps obtained...
An epidemic of an acute respiratory syndrome caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in Wuhan, China, now known as coronavirus disease 2019 (COVID‐19), beginning in December 2019 has attracted an intense amount of attention worldwide. As the natural history and variety of clinical presentations of this disease unfolds, the extrapulmonary symptoms of the disease have emerged, especially the symptoms related to the digestive system. While the respiratory mode of transmission...
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Related ArticlesBody mass and cardiorespiratory fitness are associated with altered brain metabolism. Metab Brain Dis. 2020 Apr 29;: Authors: Larsen RJ, Raine LB, Hillman CH, Kramer AF, Cohen NJ, Barbey AK Abstract Magnetic Resonance Spectroscopy provides measures of brain chemistry that are sensitive to cardiorespiratory fitness and body composition. The concentration of N-acetyl aspartic acid (NAA) is of interest because it is a marker of neuronal...
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Related ArticlesThe Dysphagia in Multiple Sclerosis Questionnaire Correlates with Fiber-Optic Endoscopic Examination for Detecting Swallowing Deficits in MS. Dysphagia. 2020 Apr 30;: Authors: Grasso MG, Gamberini G, Patti F, D'Amico E, Bergamaschi R, Berra E, Giusti A, Cuccaro A, Messmer Uccelli M, Solaro C Abstract Multiple sclerosis (MS) refers to chronic inflammation of the central nervous system including the brain and spinal cord. Assessing for...
Related ArticlesPentoxifylline and vitamin E reduce the severity of radiotherapy-induced oral mucositis and dysphagia in head and neck cancer patients: a randomized, controlled study. Med Oncol. 2019 Nov 21;37(1):8 Authors: Sayed R, El Wakeel L, Saad AS, Kelany M, El-Hamamsy M Abstract The purpose of this study was to assess the impact of pentoxifylline and vitamin E on the incidence and severity of radiotherapy-induced oral mucositis and dysphagia...
Related ArticlesSputum proteomic signature of gastro-oesophageal reflux in patients with severe asthma. Respir Med. 2019 04;150:66-73 Authors: Tariq K, Schofield JPR, Nicholas BL, Burg D, Brandsma J, Bansal AT, Wilson SJ, Lutter R, Fowler SJ, Bakke, Caruso M, Dahlen B, Horváth I, Krug N, Montuschi P, Sanak M, Sandström T, Geiser T, Pandis I, Sousa AR, Adcock IM, Shaw DE, Auffray C, Howarth PH, Sterk PJ, Chung KF, Skipp PJ, Dimitrov B, Djukanović R, U-BIOPRED Study Group...
Related Articles[Hiatal hernia: Current evidence and controversies in treatment]. Ther Umsch. 2019;76(10):585-590 Authors: Kröll D, Chopra S, Pratschke J, Biebl M Abstract Hiatal hernia: Current evidence and controversies in treatment Abstract. A hiatal hernia describes an enlarged diaphragmatic hiatus esophageus, through which the gastroesophageal transition occurs. In its maximum variant, the entire stomach and other intestinal organs can be shifted...
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COVID-19 disease is characterized by serious clinical manifestations which could require urgent hospitalization. Prolonged hospitalization, with catabolism and immobilization, induces a decrease in weight and muscle mass which can result in sarcopenia, a condition that impairs respiratory and cardiac function, worsening the prognosis. In this scenario there is an urgent need of nutritional indications aimed to prevent or contrast hospital malnutrition by improving the patient’s response to therapy...
Short-bout exercise sessions of 20 minutes several times per day are key aspects of this ‘exercise-carrousel’ – a new exercise program specially tailored for patients suffering from dementia, which has been developed and evaluated at the LVR-Hospital in Cologne. Throughout the day, the exercises are applied in small groups of patients – twice in the morning, twice in the afternoon. “With these recurrent activity and rest periods, we are not only trying to increase physical activity, but also aiming...
“Neuropsychology and psychology are practical disciplines that provide the underpinnings for understanding etiology and formulating diagnoses, and they serve as the cornerstones of some of the most successful neurorehabilitative treatment approaches,” explained guest editor Dr. Vivian L. Begali, PsyD, Neuropsychology and Psychological Healthcare, Richmond, VA, USA. “This thematic issue aims to exemplify the advantages of neuropsychological and psychological principles and their influential role in...
Electromagnetic interference is a rare, but potentially catastrophic event for a CIED patient, resulting in pauses or cardiac arrest in pacemaker patients or inappropriate shock delivery in defibrillator patients. CIED patients frequently worry about triggering such events while interacting with appliances such as dishwashers, washing machines, and metal detectors. These concerns are often based on misconceptions and myths exacerbated the limited information available to physicians about the increasing...
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Related ArticlesOccult Thyroid Carcinoma without Malignant Thyroid Gland Findings during Preoperative Examination: Report of Three Cases. Case Rep Endocrinol. 2020;2020:4249067 Authors: Toda S, Iwasaki H, Suganuma N, Okubo Y, Hayashi H, Masudo K, Nakayama H, Masuda M Abstract Occult thyroid carcinoma preceded by clinical manifestations and findings from extrathyroidal tumors is rare. The lack of malignant findings in the thyroid during the preoperative...
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[Cognitive deficit in children with hyperkinetic disorder]. Zh Nevrol Psikhiatr Im S S Korsakova. 2020;120(3):126-131 Authors: Gasanov RF, Makarov IV, Emelina DA Abstract The review presents current data on the nature of cognitive deficit in children with hyperkinetic disorder, and possible pathophysiological mechanisms of the disease. Considering possible neurobiological components of hyperkinetic disorder, attention is given to pathological functional...
[Cerebrovascular diseases: matching ICD-10 and ICD-11 codes]. Zh Nevrol Psikhiatr Im S S Korsakova. 2020;120(3):119-125 Authors: Sorokin YN Abstract A comparison of the codes and wording of the ICD-11 with the previous version of the classification was carried out. It seems necessary to develop a new revision of the domestic classification of cerebrovascular pathology, consistent with the ICD-11 codes.PMID: 32323953 [PubMed - in process]
[Chronic pain syndrome in diseases of periarticular tissues]. Zh Nevrol Psikhiatr Im S S Korsakova. 2020;120(3):109-118 Authors: Shavlovskaya OA, Gordeeva IE, Ansarov KS, Prokofyeva YS Abstract The search for an effective method of treating diseases of the musculoskeletal system is a rather actual problem for a practicing physician nowadays in connection with the modern lifestyle of most people. A prolonged stay in the same position, as a rule, leads...
[Pathophysiological mechanisms of autism in children]. Zh Nevrol Psikhiatr Im S S Korsakova. 2020;120(3):97-108 Authors: Chernov AN Abstract Based on the analysis of literature, the authors describe the neuropathophysiological mechanism of the formation of synapses, synaptic transmission and plasticity, which may underlie the pathogenesis of autism. The results of some studies confirm the involvement of aberrant expression of genes and proteins of synaptic...
[The efficacy of ethylmethylhydroxypyridine in the rehabilitation treatment of poststroke patients].
[The efficacy of ethylmethylhydroxypyridine in the rehabilitation treatment of poststroke patients]. Zh Nevrol Psikhiatr Im S S Korsakova. 2020;120(3):92-96 Authors: Zhuravleva MV, Prokofiev AB, Arkhipov VV, Serebrova SY, Gorodetskay GI, Demidova OA Abstract The analysis of the clinical efficacy and safety of ethylmethylhydroxypyridine succinate (mexidol) in the complex of rehabilitation measures in patients after ischemic stroke (IS) shows that course...
[Updated recommendations of the Council of Experts on the use and safety of alemtuzumab (Lemtrada)].
[Updated recommendations of the Council of Experts on the use and safety of alemtuzumab (Lemtrada)]. Zh Nevrol Psikhiatr Im S S Korsakova. 2020;120(3):82-91 Authors: Khachanova NV, Bakhtiyarova KZ, Boyko AN, Vlasov YV, Davydovskaya MV, Evdoshenko EP, Zakharova MN, Kotov SV, Popova EV, Sivertseva SA, Totolyan NA, Khabirov FA Abstract Alemtuzumab (Lemtrada) is a recombinant humanized IgG1 kappa monoclonal antibody to the surface cell glycoprotein, a CD52...
[Acute severe oral poisoning with 1,4-butandiol and ethanol with the development of coma]. Zh Nevrol Psikhiatr Im S S Korsakova. 2020;120(3):77-81 Authors: Sinenchenko AG, Lodyagin AN, Savello VE, Batotsyrenov BV, Antonova AM, Shumakova TA Abstract A case of acute oral poisoning by 1.4-butanediol, complicated by the development of severe hypoxia in a 34-year-old patient actively engaged in bodybuilding, is presented. The psychoactive substance was used...
[Alternating hemiplegia]. Zh Nevrol Psikhiatr Im S S Korsakova. 2020;120(3):72-76 Authors: Kulikova SL, Likhachev SA, Kashyna AR Abstract Alternating hemiplegia, a rare neurological disease that manifests in children under the age of 18 months, is characterized by transient episodes of hemiparesis of an alternating nature in the waking period. In addition to transient hemiparesis, neurological symptoms in the form of choreoathetosis, ataxia, dystonia,...
[Enterovirus meningitis in a child of one month in source of infection]. Zh Nevrol Psikhiatr Im S S Korsakova. 2020;120(3):67-71 Authors: Shishov AS, Mitrophanova IV, Kirychenko TV, Boytsov MV Abstract OBJECTIVE: To describe a rare case of enterovirus disease with meningitis in an infant. MATERIAL AND METHODS: Summary of medical records of the child and his mother were used. RESULTS AND CONCLUSION: The medical history, characteristics...
[Posterior reversible encephalopathy syndrome as a presentation of acute intermittent porphyria]. Zh Nevrol Psikhiatr Im S S Korsakova. 2020;120(3):60-66 Authors: Gudkova VV, Shanina TV, Kimelfeld EI, Salimov KA, Orekhova MA, Fedotov EV, Stakhovskaya LV Abstract The authors describe a clinical case of posterior reversible encephalopathy syndrome (PRES) in a 36-year-old female patient due to the first onset of not previously diagnosed acute intermittent...
[Epidemiological and clinical aspects of chronic neuroborreliosis with parkinsonism in the Yaroslavl region]. Zh Nevrol Psikhiatr Im S S Korsakova. 2020;120(3):53-59 Authors: Baranova NV, Spirin NN, Bykanova MA Abstract OBJECTIVE: To study clinical and epidemiological features of chronic neuroborreliosis (CB) with parkinsonism (PS) in the Yaroslavl region. MATERIALS AND METHODS: The study included the main group of patients (n=5) with CB and...
[The study of the association between the C677T polymorphism of the methylenetetrahydrofolate reductase gene and severity of symptoms in patients with schizophrenia]. Zh Nevrol Psikhiatr Im S S Korsakova. 2020;120(3):48-52 Authors: Korovaitseva GI, Gabaeva MV, Golimbet VE Abstract OBJECTIVE: To study the association of the C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene with the risk of schizophrenia in a large sample, including...
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