Background. Prediction of HBsAg seroclearance, defined as the loss of circulating HBsAg with or without development of antibodies for HBsAg in patients with chronic hepatitis B (CHB), is highly difficult and challenging due to its low incidence. This study is aimed at developing and validating a nomogram for prediction of HBsAg loss in CHB patients. Methods. We analyzed a total of 1398 patients with CHB. Two-thirds of the patients were randomly assigned to the training set (), and one-third were...
Fri Aug 14, 2020 16:50
Background. Intervertebral disc degeneration is related to tissue fibrosis. ADAMTS can degrade the important components of the ECM during the process of intervertebral disc degeneration, ultimately resulting in the loss of intervertebral disc function. sIL-13Rα2-Fc can inhibit fibrosis and slow down the degeneration process, but the mechanism involved remains unclear. Objective. To determine the mechanism by which sIL-13Rα2-Fc inhibits ECM degradation and reduces intervertebral disc tissue fibrosis...
Fri Aug 14, 2020 16:35
Using a base editor to generate monogenic disease models and correct pathogenic point mutations is a breakthrough technology for exploration and treatment of human diseases. As a burgeoning approach for genomic modification, the fused CRISPR/Cas9 with various deaminase separately has significantly increased the efficiency of producing a precise point mutation with minimal insertions or deletions (indels). Along with the flexibility and efficiency, a base editor has been widely used in many fields....
Fri Aug 14, 2020 16:20
The organization of the mouse spinal dorsal horn has been delineated in 2D for the six Rexed laminae in our publication Atlas of the Spinal Cord: Mouse, Rat, Rhesus, Marmoset, and Human. In the present study, the tissue clearing technique CLARITY was used to observe the cyto- and chemoarchitecture of the mouse spinal cord in 3D, using a variety of immunohistochemical markers. We confirm prior observations regarding the location of glycine and serotonin immunoreactivities. Novel observations include...
Fri Aug 14, 2020 16:20
Choosing an appropriate treatment for chronic pain remains problematic, and despite the available medication for its treatment, still, many patients complain about pain and appeal to the use of cannabis derivatives for pain control. However, few data have been provided to clinicians about the pharmacokinetic drug-drug interactions of cannabinoids with other concomitant administered medications. Therefore, the aim of this brief review is to assess the interactions between cannabinoids and pain medication...
Fri Aug 14, 2020 16:05
Background. Transforaminal lumbar interbody fusion (TLIF) may result in significant blood loss and an increase in blood transfusion. Though tranexamic acid (TXA) is widely studied for the hemostasis of arthroplasty, there is little information on the use of TXA for TLIF surgery. Methods. This prospective randomized, double-blind, placebo-controlled trial was conducted to study the influence of TXA (intravenous bolus of 10 mg/kg 15 minutes before skin incision followed by intravenous infusion of 6-8 mg/kg/h...
Fri Aug 14, 2020 16:05
Human gastric cancer is one of the most common malignant tumors with a poor prognosis. Cisplatin (CDDP) is a well-known first-line chemotherapeutic drug. Acquired resistance retards the clinical application of CDDP in gastric cancer. In this study, circular RNA circ_0026359 was demonstrated to be overexpressed in gastric cancer tissues/cells compared with normal gastric tissues/cells and was overexpressed in CDDP-resistant gastric cancer tissues/cells compared with CDDP-sensitive gastric cancer tissues/cells....
Fri Aug 14, 2020 10:05
Objective. Delays in skeletal maturity are related to bone mass and fracture risk in children, but the factors that determine it are unknown. We aimed to identify the association between insulin-like growth factor-1 (IGF-1) and skeletal maturation before and after growth hormone (GH) treatment. Methods. In this retrospective cohort study, we observed 783 short children and adolescents, 229 of whom received GH therapy. Skeletal maturation was assessed based on the difference between bone age (BA)...
Fri Aug 14, 2020 09:05
Objectives. To study the quantification of the components in rat plasma after oral administration of Shenyanyihao oral solution. Methods. Shenyanyihao oral solution has been traditionally used for the treatments of chronic nephritis in clinics. Stachydrine, Danshensu, chlorogenic acid, protocatechuic acid, plantamajoside, aesculetin, isoquercitrin, ferulic acid, baicalin, and baicalein are regarded as the main compounds in Shenyanyihao oral solution. A sensitive, efficient, and precise UPLC-MS/MS...
Fri Aug 14, 2020 09:05
Abstract Performing uncertainty quantification (UQ) and sensitivity analysis (SA) is vital when developing a patient‐specific physiological model because it can quantify model output uncertainty and estimate the effect of each of the model’s input parameters on the mathematical model. By providing this information, UQ and SA act as diagnostic tools to evaluate model fidelity and compare model characteristics with expert knowledge and real world observation. Computational efficiency is an important...
Thu Aug 13, 2020 21:09
With the COVID-19 pandemic set to continue for the foreseeable future, efforts to deal with the virus in healthcare facilities are of the utmost importance. Reducing viral transmission will protect patients and clinicians alike. A key part of this is disinfecting frequently touched surfaces, including those of portable medical equipment such as wheelchairs. Medgadget recently featured the UV-C Enclosure from UV-Concepts, an Englewood, Colorado firm. The device acts to disinfect...
Fri Aug 14, 2020 23:57
Canon Medical is releasing a compact new mobile digital X-ray. The SOLTUS 500, powered by a 40kW generator, has touch screens both at the main unit and at the collimator, making it easier and quicker to operate it around patients. Detectors are charged right on the device and stored within a special bin, plus special Canon technology allow the detectors operate at a long range when necessary. “Today’s hospitals are challenged with productivity demands and it’s imperative that their...
Fri Aug 14, 2020 22:14
Routinely censusing rhinoceros’ populations is central to their conservation and protection from illegal killing. In Namibia, both white (Ceratotherium simum) and black (Diceros bicornis) rhinoceros occur on private land, in the latter case under a custodianship program of the Namibian Ministry of Environment and Tourism (MET). Black rhinoceros custodian landowners are responsible for the protection of the rhinoceroses on their land and are required to report regularly to the MET. Monitoring imposes...
Fri Aug 14, 2020 03:00
This paper investigates the capabilities of the evolutionary fuzzy genetic (FG) approach and compares it with three neuro-fuzzy methods—neuro-fuzzy with grid partitioning (ANFIS-GP), neuro-fuzzy with subtractive clustering (ANFIS-SC), and neuro-fuzzy with fuzzy c-means clustering (ANFIS-FCM)—in terms of modeling long-term air temperatures for sustainability based on geographical information. In this regard, to estimate long-term air temperatures for a 40-year (1970–2011) period, the models were developed...
Fri Aug 14, 2020 03:00
Cytokine signaling in the epidermis has an important role in maintaining barrier function and is perturbed in pathological conditions. Environmental exposures, such as to metal compounds, are of interest for their potential contribution to skin disease. Present work explores the possibility that vanadate is a more effective protein tyrosine phosphatase inhibitor in human keratinocytes than previously observed in fibroblasts. It focuses on the state of phosphorylation of signal transducer and activator...
Fri Aug 14, 2020 03:00
The kiwifruit bacterial canker (Pseudomonas syringae pv. actinidiae; Psa) causes severe damage to kiwifruit production worldwide. Psa biovar 6 (Psa6), which was isolated in Japan in 2015, produces two types of phytotoxins: coronatine and phaseolotoxin. To elucidate the unique virulence of Psa6, we performed transcriptomic analysis of phytotoxin synthesis genes and type III effector genes in in vitro cultivation using various media. The genes related to phytotoxin synthesis and effectors of Psa6 were...
Fri Aug 14, 2020 03:00
Background The southern California biodiversity hotspot has had a complex geological history, with both plate tectonic forces and sea level changes repeatedly reconfiguring the region, and likely driving both lineage splittings and extinctions. Here we investigate patterns of genetic divergence in two species of slender salamanders (Plethodontidae: Batrachoseps) in this region. The complex geological history in combination with several organismal traits led us to predict that these...
Fri Aug 14, 2020 03:00
Chronic kidney disease (CKD) is a common disease in elderly dogs. The present study aims to evaluate the efficacy of a dietary supplement containing calcium carbonate, calcium-lactate gluconate, chitosan and sodium bicarbonate in dogs with IRIS stage 3 of CKD. Twenty dogs were enrolled in the study, ten were administered the new dietary supplementation for 180 days (T group) while the others were used as control group (C group). Haematologic, biochemical and urinalysis were performed every 30 days....
Fri Aug 14, 2020 03:00
Background Botrytis cinerea causes serious gray mold disease in many plants. This pathogen has developed resistance to many fungicides. Thus, it has become necessary to look for new safe yet effective compounds against B. cinerea. Methods Essential oils (EOs) from 17 plant species were assayed against B. cinerea, of which Origanum vulgare essential oil (OVEO) showed strong antifungal activity, and accordingly its main components were detected by GC/MS. Further study was conducted on the...
Fri Aug 14, 2020 03:00
Background Signaling pathway analysis methods are commonly used to explain biological behaviors of disease cells. Effector genes typically decide functional attributes (associated with biological behaviors of disease cells) by abnormal signals they received. The signals that the effector genes receive can be quite different in normal vs. disease conditions. However, most of current signaling pathway analysis methods do not take these signal variations into consideration. Methods In this...
Fri Aug 14, 2020 03:00
Understanding the correlation between shrimp growth and their intestinal bacteria would be necessary to optimize animal’s growth performance. Here, we compared the bacterial profiles along with the shrimp’s gene expression responses and metabolites in the intestines between the Top and the Bottom weight groups. Black tiger shrimp (Penaeus monodon) were collected from the same population and rearing environments. The two weight groups, the Top-weight group with an average weight of 36.82 ± 0.41 g...
Fri Aug 14, 2020 03:00
Forchlorfenuron, N-(2-chloro-4-pyridyl)-N-phenylurea (CPPU), is often used to promote fruit growth and improve production. The role of CPPU in kiwifruit growth has been established. However, the correlation between fruit weight and nutritional metabolism during development after CPPU treatments remains largely undetermined. Here, we surveyed the variations in weight and nutrient components of the ‘Hongyang’ kiwifruit (Actinidia chinensis) when CPPU was sprayed on fruit 25 days after anthesis. The...
Fri Aug 14, 2020 03:00
The interpretation of sampling data plays a crucial role in policy response to the spread of a disease during an epidemic, such as the COVID-19 epidemic of 2020. However, this is a non-trivial endeavor due to the complexity of real world conditions and limits to the availability of diagnostic tests, which necessitate a bias in testing favoring symptomatic individuals. A thorough understanding of sampling confidence and bias is necessary in order make accurate conclusions. In this manuscript, we provide...
Fri Aug 14, 2020 03:00
Protein aggregation into highly-structured amyloid fibrils is linked to several neurodegenerative diseases. Such fibril formation by superoxide dismutase I (SOD1) is considered to be related to amyotrophic lateral sclerosis, a late-onset and fatal disorder. Despite much effort and the discovery of numerous anti-amyloid compounds, no effective cure or treatment is currently available. Methylene blue (MB), a phenothiazine dye, has been shown to modulate the aggregation of multiple amyloidogenic proteins....
Fri Aug 14, 2020 03:00
Publication date: Available online 14 August 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Edouard Romano, Raphaël Simon, Véronique Minard-Colin, Valentine Martin, Sophie Bockel, Sophie Espenel, Brice Fresneau, Lucy Metayer, Antonin Levy, Florent Guerin, Hélène Martelli, Isabelle Dumas, Stéphanie Bolle, Eric Deutsch, Christine Haie-Meder, Cyrus Chargari
Sat Aug 15, 2020 14:35
Publication date: Available online 14 August 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Sara St. James, Bryan Bednarz, Stanley Benedict, Jeffrey C. Buchsbaum, Yuni Dewaraja, Eric Frey, Robert Hobbs, Joseph Grudzinski, Emilie Roncali, George Sgouros, Jacek Capala, Ying Xiao
Sat Aug 15, 2020 14:35
Publication date: Available online 14 August 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Matthias Sammer, Annique C. Dombrowsky, Jannis Schauer, Kateryna Oleksenko, Sandra Bicher, Benjamin Schwarz, Sarah Rudigkeit, Nicole Matejka, Judith Reindl, Stefan Bartzsch, Andreas Blutke, Annette Feuchtinger, Stephanie E. Combs, Günther Dollinger, Thomas E. Schmid
Sat Aug 15, 2020 14:35
Publication date: Available online 14 August 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Matthew P. Deek, Kekoa Taparra, Dyda Dao, Luanna Chan, Ryan Phillips, Robert W. Gao, Eugene D. Kwon, Curtiland Deville, Daniel Y. Song, Stephen Greco, Michael A. Carducci, Mario Eisenberger, Theodore L. DeWeese, Samuel Denmeade, Kenneth Pienta, Channing J. Paller, Emmanuel S. Antonarakis, Kenneth R. Olivier, Sean S. Park, Bradley J. Stish
Fri Aug 14, 2020 17:53
Publication date: Available online 14 August 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Michael M. Dominello, Tim Sanders, Mitchell Anscher, John Bayouth, Kristy K. Brock, David J. Carlson, Geoffrey Hugo, Sabrina Joseph, Jonathan Knisely, Marc S. Mendonca, Omar Y. Mian, Eduardo G. Moros, Anurag K. Singh, James B. Yu
Fri Aug 14, 2020 17:53
Publication date: Available online 13 August 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Roshal R. Patel, Vivek Verma, Hampartsoum Barsoumian, Matthew S. Ning, Stephen G. Chun, Chad Tang, Joe Y. Chang, Percy P. Lee, Saumil Gandhi, Peter Balter, Joe Dan Dunn, Dawei Chen, Nahum Puebla-Osorio, Angelica Marie Cortez, James W. Welsh
Fri Aug 14, 2020 17:53
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