Publication date: Available online 2 August 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Teresa Somma, Cinzia Baiano, Laura Santi, Giovanni Sabatino, Giuseppe Maria della Pepa, Giuseppe La Rocca, Paolo Cappabianca, Alessandro Olivi, Miran Skrap, Tamara Ius
Sun Aug 02, 2020 17:54
Publication date: Available online 1 August 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Fadi Al Saiegh, Jacob Mazza, Karim Hafazalla, Michael P. Baldassari, Thana Theofanis, Donald Ye, Christian Hoelscher, James Harrop, James J Evans, Pascal Jabbour, Robert H. Rosenwasser, Ashwini D. Sharan
Sun Aug 02, 2020 17:54
Publication date: Available online 31 July 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Murat Şakir Ekşi, Emel Ece Özcan-Ekşi, Ömer Orhu, veli Umut Turgut, M. Necmettin Pamir
Sat Aug 01, 2020 15:54
Publication date: Available online 31 July 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Jiyoung Kim, Won Gu Lee, Seongho Park, Kang Min Park
Sat Aug 01, 2020 15:54
Publication date: Available online 31 July 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Joseph Ifrach, Rohan Basu, Disha S. Joshi, Tracy M. Flanders, Ali K. Ozturk, Neil R. Malhotra, Rachel Pessoa, Michael J. Kallan, Eileen Maloney, William C. Welch, Zarina S. Ali
Fri Jul 31, 2020 21:38
Abstract Purpose of Review Advanced Parkinson’s disease (APD) is marked by significant motor and non-motor complications affecting the patient’s quality of life. Optimization of standard oral therapies (SOT) at some point fails to provide adequate relief. Among the available device-aided therapies, infusion therapies (IT) work on the rationale that continuous striatal dopaminergic stimulation can significantly reduce the motor...
Sat Aug 01, 2020 03:00
Abstract Selected types of neurons in the central nervous system are associated with a specialized form of extracellular matrix. These so‐called perineuronal nets (PNs) are supramolecular structures surrounding neuronal somata, proximal dendrites and axon initial segments. PNs are involved in the regulation of plasticity and synaptic physiology. In addition, PNs were proposed to carry neuroprotective functions as PN‐ensheathed neurons are mostly spared of tau pathology in brains of Alzheimer patients....
Sat Aug 01, 2020 11:55
Abstract While it is well known that vision guides movement, less appreciated is that the motor cortex also provides input to the visual system. Here we asked whether neural processing of visual stimuli is acutely modulated during motor activity, hypothesizing that visual evoked responses are enhanced when engaged in a motor task that depends on the visual stimulus. To test this, we told participants that their brain activity was controlling a video game that was in fact the playback of a prerecorded...
Fri Jul 31, 2020 21:43
Abstract It is known that bipolar disorder has a multifactorial etiology where the interaction between genetic and environmental factors are responsible for it development. Because of this, epigenetics has been largely studied in psychiatric disorders. The present study aims to evaluate the effects of histone deacetylase inhibitors on epigenetic enzymes alterations in rats or mice submitted to animal models of mania induced by dextro‐amphetamine or sleep deprivation respectively. Adult male Wistar...
Fri Jul 31, 2020 20:53
Abstract We move our eyes to place the fovea into the part of a viewed scene currently of interest. Recent evidence suggests that each human has signature patterns of eye movements like handwriting which depend on their sensitivity, allocation of attention and experience. Use of implicit knowledge of how earth’s gravity influences object motion has been shown to aid dynamic perception. We used a projected ball tracking task with a plain background offering no context cues to probe the effect of...
Thu Jul 30, 2020 11:48
Abstract Executive function entails the core components of response inhibition, working memory and cognitive flexibility. An accumulating literature has shown that a single bout of exercise improves the response inhibition and working memory components of executive function; however, limited work has examined a putative exercise-related improvement to cognitive flexibility. To address this limitation, Experiment 1 entailed a 20-min session of moderate intensity aerobic exercise...
Sun Aug 02, 2020 03:00
Abstract Aiming movements of the upper limbs can be classified either as discrete, or reciprocal, or cyclic. The control of these movements after a stroke can be affected. The aim of this experimental, cross-sectional study was to characterize the performance of these movements after the right and left hemisphere chronic stroke. Thirty-six individuals aged between 40 and 70 years, right-handed, were allocated into three groups (control, right stroke, and left stroke). Participants...
Fri Jul 31, 2020 03:00
Publication date: Available online 31 July 2020Source: Journal of Neuroscience MethodsAuthor(s): Elnaz Lashgari, Dehua Liang, Uri Maoz
Sat Aug 01, 2020 17:05
Abstract Background Cerebral venous sinus thromboses (CVST) occur in children with a variety of etiologies. However, no standard treatment paradigm is established. We sought to identify what treatments have been applied, their outcomes, and the role of anticoagulation in pediatric patients with CVST. Methods A systematic review was conducted exploring...
Sun Aug 02, 2020 03:00
Sat Aug 01, 2020 03:00
Abstract Thoracolumbar fractures in children are relatively uncommon and should be regarded as a separate entity from those in adults. While percutaneous pedicle fixation has emerged as an effective alternative to open fixation in adults with unstable thoracolumbar fractures, this technique is rarely applied in children. We report a 6-year-old girl with an L3 chance fracture, which was treated via short-segment percutaneous pedicle fixation. We also discussed the technical challenges...
Sat Aug 01, 2020 03:00
Publication date: 1 November 2020Source: NeuroImage, Volume 221Author(s): Akitoshi Ogawa, Takahiro Osada, Masaki Tanaka, Koji Kamagata, Shigeki Aoki, Seiki Konishi
Sun Aug 02, 2020 20:48
Abstract Purpose Flow diverters (FD) have poor radiopacity, challenging visualization of deployment and vessel wall apposition with conventional neuroimaging modalities. We evaluated a novel cone beam computed tomography (CT) imaging technique that allows virtual dilution (VD) of contrast media to facilitate workflow and ensure accurate assessment of FD wall apposition. ...
Sat Aug 01, 2020 03:00
Abstract Purpose Deciding about whether an unruptured intracranial aneurysm (UIA) should be treated or not is challenging because robust data on rupture risks, endovascular treatment complication rates, and treatment success rates are limited. We aimed to investigate how neurointerventionalists conceptually approach endovascular treatment decision-making in UIAs. Methods...
Sat Aug 01, 2020 03:00
Background: Acute nonarteritic central retinal artery occlusion (CRAO) is an eye stroke with poor visual prognosis and no proven effective therapies. Given advances in acute stroke care, thrombolysis in CRAO merits critical re-examination. We review the evidence for intravenous (IV) and intra-arterial (IA) tissue plasminogen activator (tPA) in CRAO management. Evidence Acquisition: MEDLINE, Scopus, and Cochrane online databases were systematically searched from 1960 to present, for...
Thu Jul 30, 2020 03:00
In this issue of JNO Drs. M. Tariq Bhatti and Mark L. Moster discuss the following 6 articles: Powell G, Derry-Sumner H, Rajenderkumar D, Rushton SK, Sumner P. Persistent postural perceptual dizziness is on a spectrum in the general population. Neurology. 2020;94:e1929–e1938.Mackie SL, Dejaco C, Appenzeller S, Camellino D, Duftner C, Gonzalez-Chiappe S, Mahr A, Mukhtyar C, Reynolds G, de Souza AWS, Brouwer E, Bukhari M, Buttgereit F, Byrne D, Cid MC, Cimmino M, Direskeneli H, Gilbert K, Kermani...
Thu Jul 30, 2020 03:00
No abstract available
Thu Jul 30, 2020 03:00
Mediators of racial disparities in mortality rates after traumatic brain injury in childhood: data from the Trauma Quality Improvement Program. J Neurosurg Pediatr. 2020 Jul 31;:1-7 Authors: Piatt J Abstract OBJECTIVE: Social disparities in healthcare outcomes are almost ubiquitous, and trauma care is no exception. Because social factors cannot cause a trauma outcome directly, there must exist mediating causal factors related to the nature...
Sat Aug 01, 2020 13:10
The clinical utility of intraoperative electrocorticography in pediatric epilepsy surgical strategy and planning. J Neurosurg Pediatr. 2020 Jul 31;:1-10 Authors: Lesko R, Benova B, Jezdik P, Liby P, Jahodova A, Kudr M, Tichy M, Zamecnik J, Krsek P Abstract OBJECTIVE: In this study, the authors aimed to determine 1) whether the use of intraoperative electrocorticography (ECoG) affects outcomes and complication rates of children undergoing resective...
Sat Aug 01, 2020 13:10
Safety and efficacy of brainstem biopsy in children and young adults. J Neurosurg Pediatr. 2020 Jul 31;:1-11 Authors: Hersh DS, Kumar R, Moore KA, Smith LGF, Tinkle CL, Chiang J, Patay Z, Gajjar A, Choudhri AF, Lee-Diaz JA, Vaughn B, Klimo P Abstract OBJECTIVE: Biopsies of brainstem lesions are performed to establish a diagnosis in the setting of an atypical clinical or radiological presentation, or to facilitate molecular studies. A better...
Sat Aug 01, 2020 13:10
Publication date: Available online 31 July 2020Source: Brain Research BulletinAuthor(s): Jin Zhu, Cui-Ping Xu, Xi Zhang, Liang Qiao, Xue-Yuan Wang, Xiao-Ming Yan, Duan-Yu Ni, Tao Yu, Guo-Jun Zhang, Yong-Jie Li
Sat Aug 01, 2020 21:51
Publication date: Available online 31 July 2020Source: Brain Research BulletinAuthor(s): Athira K V, Arathy S Mohan, Sumana Chakravarty
Fri Jul 31, 2020 18:54
P-cadherin is overexpressed in various cancers and can be a target for radioimmunotherapy. We investigated the preclinical pharmacokinetics and pharmacology of FF-21101, an indium-111 (111In)- or yttrium-90 (90Y)-conjugated monoclonal antibody against P-cadherin, to evaluate its clinical applications. Methods: The radiochemical purity, binding affinity, and in vitro serum stability of 111In/90Y-labeled FF-21101 were evaluated. The pharmacokinetics of 111In/90Y-FF-21101 were compared in normal...
Sat Aug 01, 2020 01:48
Background: DNA double-strand breaks (DSBs) in cells of radionuclide-treated patients are quantifiable by immunofluorescence microscopy, using phosphorylation of histone variant H2AX (-H2AX) to mark radiation-induced foci (RIF). Based on this method, we compared excess RIF side-by-side in recipients of lutetium 177 (177Lu)-DOTATOC or -PSMA-617 radioligands. We also examined relations between blood dose and dose rate, RIF, and platelet counts. Material and Methods: Venous blood samples were obtained...
Sat Aug 01, 2020 01:48
As part of our continuous efforts to develop a suitable fluorine-18 labeled positron emission tomography (PET) radioligand with improved imaging characteristics for imaging the GluN2B-bearing N-Methyl-D-aspartate receptors (NMDARs), we investigated in the current work ortho- and meta-fluorinated analogues of 18F-PF-NB1, a 3-benzazepine-based radiofluorinated probe. Methods: OF-NB1 and MF-NB1 were prepared using a multi-step synthesis and their binding affinities towards GluN2B subunits and selectivity...
Sat Aug 01, 2020 01:48
Purpose: To evaluate and compare the clinical utility of simultaneously obtained quantitative 18F-fluorodeoxyglucose positron-emission-tomography (18F-FDG PET) and diffusion-weighted imaging (DWI) datasets for the prediction of histopathological therapy response of soft tissue sarcomas (STS) under neoadjuvant isolated limb perfusion (ILP). Methods: A total of 37 patients with confirmation of a STS of the extremities underwent an 18F-FDG PET/magnetic resonance imaging (MRI) examination before (1st...
Sat Aug 01, 2020 01:48
Amyloid-β deposition into plaques is a pathological hallmark of Alzheimer’s disease (AD) appearing years before the onset of symptoms. Although cerebral amyloid-β deposition occurs on a continuum, dichotomization into positive and negative groups has advantages for diagnosis, clinical management and population enrichment for clinical trials. 18F-AZD4694 (also known as 18F-NAV4694) is an amyloid-β imaging ligand with high affinity for amyloid-β plaques. Despite being employed in multiple academic...
Sat Aug 01, 2020 01:48
Publication date: September 2020Source: World Neurosurgery, Volume 141Author(s): Rebeca Pérez-Alfayate, Nuria Martínez-Moreno, Santiago Dario Rosati, Manuel Moreu-Gamazo, Carlos Pérez-García, Roberto Martínez-Alvarez
Sat Aug 01, 2020 15:08
Publication date: October 2020Source: World Neurosurgery, Volume 142Author(s): Ferhat Harman, Yahya Guvenc, Mumin Coskun, Oguz Baran
Fri Jul 31, 2020 14:41
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