Journal of Biophotonics

Laser‐Induced Optothermal Response of Gold Nanoparticles: from a Physical Viewpoint to Cancer Treatment Application

ABSTRACT Gold nanoparticles (GNPs)‐based photothermal therapy (PTT) is a promising minimally invasive thermal therapy for the treatment of focal malignancies. Although GNPs‐based PTT has been known for over two decades and GNPs possess unique properties as therapeutic agents, the delivery of a safe and effective therapy is still an open question. This review aims at providing relevant and recent information on the usage of GNPs in combination with the laser to treat cancers, pointing out the practical...

Journal of Biophotonics

Thu Aug 06, 2020 11:31

Cortex‐wide microcirculation mapping with ultrafast large‐field multifocal illumination microscopy

Abstract The recently introduced large‐field multifocal illumination (LMI) fluorescence microscopy technique opened new possibilities for transcranial observations of mouse brain dynamics with a unique combination of capillary level resolution and centimeter‐scale field‐of‐view (FOV). Here we report on a new acceleration scheme for LMI based on raster scan of a lattice pattern combined with a parallel camera exposure scheme, which attains 200 Hz frame rate over 12×12 mm2 FOV with 7.5 μm spatial...

Journal of Biophotonics

Wed Aug 05, 2020 21:13

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 Lasers in Surgery and Medicine

Involvement of Aquaporins in the Intense Pulsed Light‐Enhanced Wound Healing in Diabetic Rats

Background and Objectives We previously demonstrated that intense pulsed light (IPL) irradiation prior to wounding improved the wound healing in rats with diabetes mellitus (DM). Also, we found that IPL upregulated the expression of aquaporin 3 (AQP3), a protein that is crucial for wound healing, in normal rats. This present study aimed to examine the involvement of AQPs in the IPL‐enhanced wound healing in diabetic rats. Study Design/Materials and Methods Streptozotocin was used to induce...

Lasers in Surgery and Medicine

Wed Aug 05, 2020 15:32

One‐Year Functional and Anatomical Outcomes After Selective Retina Therapy With Real‐Time Feedback‐Controlled Dosimetry in Patients With Intermediate Age‐Related Macular Degeneration: A Pilot Study

Background and Objectives This pilot study sought to evaluate changes in macular function and drusen volume (DV) after selective retina therapy (SRT) in patients with intermediate age‐related macular degeneration (iAMD). Study Design/Materials and Methods Twenty participants with bilateral iAMD were included in this prospective interventional case series study. After titrating pulse energy by real‐time feedback‐controlled dosimetry, SRT with a wavelength of 527 nm was applied around the macula...

Lasers in Surgery and Medicine

Wed Aug 05, 2020 15:32

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