Abstract Background Macrophages control innate and acquired immunity but their role in severe asthma remains ill‐defined. We investigated gene signatures of macrophage subtypes in the sputum of 104 asthmatics and 16 healthy volunteers from the U‐BIOPRED cohort. Methods Forty‐nine gene signatures (modules) for differentially stimulated macrophages, one to assess lung tissue‐resident cells (TR‐Mφ) and two for their polarization (classically‐ and alternatively‐activated macrophages: M1 and...
Sat Aug 01, 2020 21:15
Abstract The average global temperatures on our planet are increasing due to rising anthropogenic greenhouse gases in the atmosphere, in particular carbon dioxide (CO2).1,2There is an urgent need to call for action on global warming, which is resulting in extreme weather and related catastrophes.1 ,2The Earth’s rising temperature is evidenced by warming of the oceans, melting glaciers, rising sea levels, and the diminished snow cover in the Northern Hemisphere. Climate‐related factors can affect...
Sat Aug 01, 2020 17:08
Abstract Background Multiplex tests allow for measurement of allergen‐specific IgE responses to multiple extracts and molecular allergens and have several advantages for large cohort studies. Due to significant methodological differences, test systems are difficult to integrate in meta‐analyses/systematic reviews since there is a lack of datasets with direct comparison. We aimed to create models for statistical integration of allergen‐specific IgE to peanut/tree nut allergens from three IgE‐test...
Sat Aug 01, 2020 12:41
Abstract Intestinal sensing is critical to maintain homeostasis. The gut epithelium is predominantly inhabited by enterocytes that, in addition to their barrier and absorptive function, may play a surveillance role during nutrient uptake. Even insects such as Drosophila melanogaster possess a sophisticated nutrient‐sensing system. This suggests that enterocytes translate nutrient cues into signals that regulate the local intestinal epithelium and likely impact the entire organism (growth and development,...
Sat Aug 01, 2020 12:24
Abstract Under the concept of ‘united airway diseases’, the airway is a single organ wherein upper and lower airway diseases are commonly comorbid. The upper and lower airways are lined with respiratory epithelium that plays a vital role in immune surveillance and modulation as the first line of defense to various infective pathogens, allergens and physical insults. Recently, there is a common hypothesis emphasizing epithelium‐derived cytokines, namely IL‐25, IL‐33, and TSLP, as key regulatory factors...
Sat Aug 01, 2020 11:59
Publication date: Available online 1 August 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Stephen Shih-Teng Kao, Ahmed Bassiouni, Mahnaz Ramezanpour, John Finnie, Nusha Chegeni, Alex D. Colella, Timothy K. Chataway, Peter-John Wormald, Sarah Vreugde, Alkis James Psaltis
Sun Aug 02, 2020 17:29
Publication date: Available online 1 August 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): James W. Verbsky, Mary K. Hintermeyer, Pippa M. Simpson, Mingen Feng, Jody Barbeau, Nagarjun Rao, Carlyne D. Cool, Luis A. Sosa-Lozano, Dhiraj Baruah, Erin Hammelev, Alyssa Busalacchi, Amy Rymaszewski, Jeff Woodliff, Shaoying Chen, Mary Bausch-Jurken, John M. Routes
Sat Aug 01, 2020 15:33
Publication date: Available online 1 August 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Jacqueline L. Johnson, Ruchi S. Gupta, Lucy A. Bilaver, Jack W. Hu, Jennifer Martin, Jialing Jiang, Alexandria Bozen, Matthew M. Davis, Jamie Reese, Susan Cooper, Alkis Togias, Samuel J. Arbes
Sat Aug 01, 2020 15:33
Publication date: Available online 31 July 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Rianne de Vries, Peter J. Sterk
Sat Aug 01, 2020 15:33
Non-communicable diseases, such as allergies, are influenced by both genetic and epigenetic factors. Perinatal determinants conceivably modify the epigenetic makeup of the developing fetal immune system preven...
Fri Jul 31, 2020 03:00
Anaphylaxis is an acute, life-threatening systemic allergic reaction that may have a wide range of clinical manifestations1. Some of those signs and symptoms are similar to those that happen during the acute respiratory distress caused by the novel coronavirus disease COVID-192.
Fri Jul 31, 2020 03:00
The data on the clinical characteristics and outcomes of asthmatics with SARS-CoV-2 infection are scarce, but are of paramount importance to evaluate the relationship between COVID-19 and asthma. Given the characteristics of the virus, one would expect to observe an increased prevalence of asthma and wheezing exacerbations in COVID-19 patients with allergy and asthma comorbidity, a typical consequence in case of a viral respiratory infection (1). In this single-centre, observational study, we investigated...
Fri Jul 31, 2020 03:00
A call to develop more clinician educators in allergy and immunology was recently published. 1 The authors communicated the paucity of Allergy/Immunology (A/I) specialists focused on medical education. This will foreseeably result in diminishing interest in the field of A/I for medical students and residents due to reduced exposure to these specialists. Waning interest in A/I as a career is already reflected in the declining numbers of candidates for every A/I fellowship position (1.7 in 2010 as...
Fri Jul 31, 2020 03:00
A novel patient-reported outcomes instrument assessing the side effects of peanut oral immunotherapy
Patients treated with peanut oral immunotherapy (OIT) may experience adverse reactions, particularly during up-dosing.
Fri Jul 31, 2020 03:00
Publication date: Available online 1 August 2020Source: Autoimmunity ReviewsAuthor(s): Arnon Blum, Mohammad Adawi
Sun Aug 02, 2020 18:07
Abstract Background Real‐world evidence describing the benefits of recommended therapies and their impact on the quality of life (QoL) of chronic urticaria (CU) patients is limited. Objective To investigate disease burden, current treatment schedule and the use of clinical resources by patients with H1‐antihistamine refractory CU in Europe. Methods AWARE (A World‐wide Antihistamine‐Refractory chronic urticaria patient Evaluation) is a global, prospective, non‐interventional study...
Fri Jul 31, 2020 11:39
ABSTRACT BACKGROUND It has become clear that healthcare workers are at high risk, and otolaryngology has been theorized to be among the highest risk specialties for COVID‐19. The purpose of this study is to detail the international impact of COVID‐19 among otolaryngologists, and to identify instructional cases. METHODS Country representatives of the Young Otolaryngologists ‐ International Federation of Otolaryngologic Societies (YO‐IFOS) surveyed otolaryngologists through various channels....
Fri Jul 31, 2020 13:12
Publication date: Available online 1 August 2020Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Marie Cavuoto Petrizzo, Doreen M. Olvet, Joel N.H. Stern
Sat Aug 01, 2020 16:56
Publication date: Available online 1 August 2020Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Alberto Alvarez-Perea, María Luisa Baeza
Sat Aug 01, 2020 16:56
Publication date: Available online 1 August 2020Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Carlo Lombardi, Elena Roca, Barbara Bigni, Marcello Cottini, Giovanni Passalacqua
Sat Aug 01, 2020 16:56
A novel patient-reported outcomes instrument assessing the side effects of peanut oral immunotherapy
Publication date: Available online 31 July 2020Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Diane M. Turner-Bowker, Jessica J. Jalbert, Meaghan Krohe, Andrew Yaworsky, Masami T. Kelly, Brad Padilla, Emily Chaston, Allen Radin, Vera Mastey, Kari C. Nadeau
Sat Aug 01, 2020 16:56
Publication date: Available online 31 July 2020Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Jonathan I. Silverberg, Emma Guttman-Yassky, Abhijit Gadkari, Andreas Kuznik, Usha G. Mallya, Vera Mastey, Haixin Zhang, Zhen Chen, Cheng Chen, Andrew Korotzer, Debra Sierka, Miriam C. Fenton, Mandeep Kaur, Jessica.J. Jalbert
Fri Jul 31, 2020 16:36
Publication date: Available online 31 July 2020Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Lianne Soller, Timothy Teoh, Ingrid Baerg, Tiffany Wong, Edmond S. Chan
Fri Jul 31, 2020 16:36
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