Abstract 1. Combined radiation therapy and every‐3‐weeks high‐dose cisplatin has been often reported for head and neck cancer. However, this regimen can cause both severe acute complications and late complications. 2. The objective of this study is to evaluate the efficacy of combined weekly chemoradiation therapy using low‐dose platinum agent combined with radiation therapy. The 3‐ and 5‐year overall survival rates are comparable to those associated with combination high‐dose cisplatin and radiation...
Abstract Aims 1. To systematically review the currently available evidence investigating the association between olfactory dysfunction (OD) and the novel coronavirus (COVID‐19). 2. To analyse the prevalence of OD in patients who have tested positive on Polymerase Chain Reaction (PCR) for COVID‐19. 2. To perform a meta‐analysis of patients presenting with olfactory dysfunction, during the pandemic, and to investigate the Positive Predictive Value for a COOVID‐19 positive result in this population....
Abstract Objectives To demonstrate face and content validity of a home‐made simulation model as a training tool for front of neck access (FONA) procedures. Design This was a prospective evaluation study, in which experienced otolaryngologists and trainees were recruited to complete 3 tasks using our FONA model. Setting The study was completed during regular simulation training days and international conferences. Participants A total of 52 participants completed the questionnaire...
Abstract Aims The accuracy of toluidine blue (TB) and chemiluminescence for diagnosing oral cancer and precancer was evaluated. Methods Two authors (working independently) comprehensively reviewed six databases (PubMed, Cochrane database, Embase, Web of Science, SCOPUS, and Google Scholar) from their dates of inception until March 2020. Oral mucosal disorder, as detected by TB, was compared with that detected by chemiluminescence. True‐positive, true‐negative, false‐positive, and false‐negative...
Abstract Objective Radiotherapy (RT) for head and neck cancer (HNC) within 7 days of tooth extraction is contraindicated because it may increase the risk of osteoradionecrosis of the jaw (ORNJ). However, delayed RT could compromise survival in patients with HNC. By using a national health care database, we reviewed the contraindications and analysed other risk factors for ORNJ. Design A retrospective cohort study. Setting By using Taiwan’s National Health Insurance Research Database,...
Abstract Background Tonsillectomy is one of the most common surgical procedures in children but indications and surgical practice change over time. Objectives We aimedto identify trends in tonsillectomy procedures in children, in particular the number of procedures performed, the age of child undergoing tonsillectomy and the type of hospital in which the surgery was performed. Design Review of Scottish Morbidity Records data (SMR01) which are routinelycollected after every day case...
Abstract Large nasal septal perforations have higher extrusion rates with pre‐fabricated septal obturators. A prospective cohort study was conducted including patients with septal perforation who underwent custom‐made septal buttons and quality‐of‐life outcomes were measured. The mean total SNOT‐22 score improved after insertion of the prosthesis with highest change in perforation specific symptoms (crusting, bleeding, whistling). Accurate sizing and successful closure with 3‐D printing...
Abstract Objective The neurocognitive associationsinpediatric obstructive sleep apnea (OSA) are well known; however, whether polysomnographic features can predict these associations is unknown. Therefore, the primary objective of this study was to compare common polysomnographic parameters in children with OSA in the presence and absence of neurocognitive dysfunction. Methods Polysomnography datafor children ages3‐6 yearswith mild‐moderate OSA who as defined by AHI between 5‐10 were analyzed...
Abstract Objectives To evaluate the role of thrombin based hemostatic agent Surgiflo® (Ethicon, Somerville, USA) in improving the outcome of cricotracheal resection anastomosis. Design Randomized controlled clinical trial. Setting Otorhinolaryngology Department, Mansoura University Hospitals, Egypt. Participants This study included 55 patients with grade III and IV subglottic and/or cervical tracheal stenosis, who underwent cricotracheal resection anastomosis. Patients were...
Abstract We read with interest the systematic review on the incidence of thyroid malignancy in patients undergoing thyroidectomy for hyperthyroidism.1 Varadharajan and Choudhury reported a malignancy rate of 8.5%, postulated potential underlying mechanisms and proposed routine preoperative imaging in these patients.
Abstract The United Kingdom has been hit hard by the COVID‐19 pandemic with the highest death toll in Europe exceeding 40,000. London has been the epicentre of the UK outbreak, with more than 1600 positive recorded cases in our institution alone. Consequently, hospital specialities have had to adapt rapidly to the challenges COVID‐19 has posed.
Abstract Objectives We aimed to audit current United Kingdom (UK) practice of Head and Neck Cancer (HNC) post‐treatment surveillance against national guidelines, and determine the outcomes of these practices in detecting recurrence. Design National cross‐sectional study of current HNC surveillance practice. Setting UK HNC outpatient departments. Participants HNC patients reviewed for post‐treatment surveillance. Main outcome measures Compliance with UK multidisciplinary...
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