Cancers, Vol. 12, Pages 2193: Immune-Modulating Effects of Conventional Therapies in Colorectal Cancer Cancers doi: 10.3390/cancers12082193 Authors: Erta Kalanxhi Sebastian Meltzer Anne Hansen Ree Biological heterogeneity and low inherent immunogenicity are two features that greatly impact therapeutic management and outcome in colorectal cancer. Despite high local control rates, systemic tumor dissemination remains the main cause of treatment failure and stresses the need for new...
Thu Aug 06, 2020 03:00
Cancers, Vol. 12, Pages 2195: Menopausal Hormone Therapy and Risk of Endometrial Cancer: A Systematic Review Cancers doi: 10.3390/cancers12082195 Authors: Clemens B. Tempfer Ziad Hilal Peter Kern Ingolf Juhasz-Boess Günther A. Rezniczek Background: Menopausal hormone therapy (MHT) is an appropriate treatment for women with the climacteric syndrome. The estrogen component of MHT effectively alleviates climacteric symptoms but also stimulates the endometrium and thus may increase...
Thu Aug 06, 2020 03:00
Cancers, Vol. 12, Pages 2197: Extracellular Glutathione Peroxidase GPx3 and Its Role in Cancer Cancers doi: 10.3390/cancers12082197 Authors: Caroline Chang Beth L. Worley Rébécca Phaëton Nadine Hempel Mammalian cells possess a multifaceted antioxidant enzyme system, which includes superoxide dismutases, catalase, the peroxiredoxin/thioredoxin and the glutathione peroxidase systems. The dichotomous role of reactive oxygen species and antioxidant enzymes in tumorigenesis and cancer...
Thu Aug 06, 2020 03:00
Cancers, Vol. 12, Pages 2196: Two Antagonistic Microtubule Targeting Drugs Act Synergistically to Kill Cancer Cells Cancers doi: 10.3390/cancers12082196 Authors: Lauralie Peronne Eric Denarier Ankit Rai Renaud Prudent Audrey Vernet Peggy Suzanne Sacnicté Ramirez-Rios Sophie Michallet Mélanie Guidetti Julien Vollaire Daniel Lucena-Agell Anne-Sophie Ribba Véronique Josserand Jean-Luc Coll Patrick Dallemagne J. Fernando Díaz María Ángela Oliva Karin...
Thu Aug 06, 2020 03:00
Cancers, Vol. 12, Pages 2194: Next Generation Sequencing in MPNs. Lessons from the Past and Prospects for Use as Predictors of Prognosis and Treatment Responses Cancers doi: 10.3390/cancers12082194 Authors: Vibe Skov The myeloproliferative neoplasms (MPNs) are acquired hematological stem cell neoplasms characterized by driver mutations in JAK2, CALR, or MPL. Additive mutations may appear in predominantly epigenetic regulator, RNA splicing and signaling pathway genes. These molecular...
Thu Aug 06, 2020 03:00
Cancers, Vol. 12, Pages 2198: Key MicroRNA’s and Their Targetome in Adrenocortical Cancer Cancers doi: 10.3390/cancers12082198 Authors: Marthe Chehade Martyn Bullock Anthony Glover Gyorgy Hutvagner Stan Sidhu Adrenocortical Carcinoma (ACC) is a rare but aggressive malignancy with poor prognosis and limited response to available systemic therapies. Although complete surgical resection gives the best chance for long-term survival, ACC has a two-year recurrence rate of 50%,...
Thu Aug 06, 2020 03:00
Cancers, Vol. 12, Pages 2199: Tumor Budding and Poorly Differentiated Clusters in Small Intestinal Adenocarcinoma Cancers doi: 10.3390/cancers12082199 Authors: Sun-Young Jun Joon-Yong Chung Nara Yoon Eun Sun Jung Young-Ha Oh Seung-Mo Hong The clinicopathologic and prognostic significances of tumor budding (TB) and poorly-differentiated clusters (PDC) have not been investigated in small intestinal adenocarcinomas (SIACs). In 236 surgically-resected SIACs, we counted TB...
Thu Aug 06, 2020 03:00
Cancers, Vol. 12, Pages 2191: Development of [18F]ICMT-11 for Imaging Caspase-3/7 Activity during Therapy-Induced Apoptosis Cancers doi: 10.3390/cancers12082191 Authors: Segundo Francisco García-Argüello Beatriz Lopez-Lorenzo Bart Cornelissen Graham Smith Insufficient apoptosis is a recognised hallmark of cancer. A strategy to quantitatively measure apoptosis in vivo would be of immense value in both drug discovery and routine patient management. The first irreversible step...
Thu Aug 06, 2020 03:00
Cancers, Vol. 12, Pages 2190: Molecular and Immunological Characterization of Biliary Tract Cancers: A Paradigm Shift Towards a Personalized Medicine Cancers doi: 10.3390/cancers12082190 Authors: Ines Malenica Matteo Donadon Ana Lleo Biliary tract cancers (BTCs) are a group of rare cancers that account for up to 3–5% of cancer patients worldwide. BTCs include cholangiocarcinoma (CCA), gallbladder cancer (GBC), and ampulla of Vater cancer (AVC). They are frequently diagnosed...
Thu Aug 06, 2020 03:00
Cancers, Vol. 12, Pages 2192: First-Line Treatment for Primary Breast Diffuse Large B-Cell Lymphoma Using Immunochemotherapy and Central Nervous System Prophylaxis: A Multicenter Phase 2 Trial Cancers doi: 10.3390/cancers12082192 Authors: Ho-Young Yhim Dok Hyun Yoon Seok Jin Kim Deok-Hwan Yang Hyeon-Seok Eom Kyoung Ha Kim Yong Park Jin Seok Kim Hyo Jung Kim Cheolwon Suh Won Seog Kim Jae-Yong Kwak There are limited data from prospective controlled trials...
Thu Aug 06, 2020 03:00
Cells, Vol. 9, Pages 1849: Cross-Talk between NADPH Oxidase and Mitochondria: Role in ROS Signaling and Angiogenesis Cells doi: 10.3390/cells9081849 Authors: Tohru Fukai Masuko Ushio-Fukai Angiogenesis, a new vessel formation from the pre-existing ones, is essential for embryonic development, wound repair and treatment of ischemic heart and limb diseases. However, dysregulated angiogenesis contributes to various pathologies such as diabetic retinopathy, atherosclerosis and cancer....
Thu Aug 06, 2020 03:00
Cells, Vol. 9, Pages 1848: Schwann Cell Cultures: Biology, Technology and Therapeutics Cells doi: 10.3390/cells9081848 Authors: Paula V. Monje Schwann cell (SC) cultures from experimental animals and human donors can be prepared using nearly any type of nerve at any stage of maturation to render stage- and patient-specific populations. Methods to isolate, purify, expand in number, and differentiate SCs from adult, postnatal and embryonic sources are efficient and reproducible as these...
Thu Aug 06, 2020 03:00
Cells, Vol. 9, Pages 1845: Cystic Fibrosis Defective Response to Infection Involves Autophagy and Lipid Metabolism Cells doi: 10.3390/cells9081845 Authors: Alessandra Mingione Emerenziana Ottaviano Matteo Barcella Ivan Merelli Lorenzo Rosso Tatiana Armeni Natalia Cirilli Riccardo Ghidoni Elisa Borghi Paola Signorelli Cystic fibrosis (CF) is a hereditary disease, with 70% of patients developing a proteinopathy related to the deletion of phenylalanine 508. CF...
Thu Aug 06, 2020 03:00
Cells, Vol. 9, Pages 1842: Context-Dependent Tumorigenic Effect of Testis-Specific Mitochondrial Protein Tiny Tim 2 in Drosophila Somatic Epithelia Cells doi: 10.3390/cells9081842 Authors: Cristina Molnar Anxela Louzao Cayetano Gonzalez We have undertaken a study towards understanding the effect of ectopic expression of testis proteins in the soma in Drosophila. Here, we show that in the larval neuroepithelium, ectopic expression of the germline-specific component of the inner...
Thu Aug 06, 2020 03:00
Cells, Vol. 9, Pages 1847: Amelioration of Congenital Tufting Enteropathy in EpCAM (TROP1)-Deficient Mice via Heterotopic Expression of TROP2 in Intestinal Epithelial Cells Cells doi: 10.3390/cells9081847 Authors: Gaku Nakato Sohshi Morimura Michael Lu Xu Feng Chuanjin Wu Mark C. Udey TROP1 (EpCAM) and TROP2 are homologous cell surface proteins that are widely expressed, and often co-expressed, in developing and adult epithelia. Various functions have been ascribed to...
Thu Aug 06, 2020 03:00
Cells, Vol. 9, Pages 1844: Glucose-Regulated Protein 94 (GRP94): A Novel Regulator of Insulin-Like Growth Factor Production Cells doi: 10.3390/cells9081844 Authors: Yair Argon Sophie E. Bresson Michal T. Marzec Adda Grimberg Mammals have two insulin-like growth factors (IGF) that are key mediators of somatic growth, tissue differentiation, and cellular responses to stress. Thus, the mechanisms that regulate the bioavailability of IGFs are important in both normal and aberrant...
Thu Aug 06, 2020 03:00
Cells, Vol. 9, Pages 1843: Brain-Specific Serine-47 Modification of Cytochrome c Regulates Cytochrome c Oxidase Activity Attenuating ROS Production and Cell Death: Implications for Ischemia/Reperfusion Injury and Akt Signaling Cells doi: 10.3390/cells9081843 Authors: Hasini A. Kalpage Junmei Wan Paul T. Morse Icksoo Lee Maik Hüttemann We previously reported that serine-47 (S47) phosphorylation of cytochrome c (Cytc) in the brain results in lower cytochrome c oxidase (COX)...
Thu Aug 06, 2020 03:00
Cells, Vol. 9, Pages 1841: Protein-Related Circular RNAs in Human Pathologies Cells doi: 10.3390/cells9081841 Authors: Olga Wawrzyniak Żaneta Zarębska Konrad Kuczyński Anna Gotz-Więckowska Katarzyna Rolle Circular RNAs (circRNAs) are a distinct family of RNAs derived from alternative splicing which play a crucial role in regulating gene expression by acting as microRNA (miRNA) and RNA binding protein (RBP) sponges. However, recent studies have also reported the multifunctional...
Thu Aug 06, 2020 03:00
Cells, Vol. 9, Pages 1846: Caenorhabditis elegans Deficient in DOT-1.1 Exhibit Increases in H3K9me2 at Enhancer and Certain RNAi-Regulated Regions Cells doi: 10.3390/cells9081846 Authors: Ruben Esse Alla Grishok The methylation of histone H3 at lysine 79 is a feature of open chromatin. It is deposited by the conserved histone methyltransferase DOT1. Recently, DOT1 localization and H3K79 methylation (H3K79me) have been correlated with enhancers in C. elegans and mammalian cells. Since...
Thu Aug 06, 2020 03:00
Chemosensors, Vol. 8, Pages 65: Wicking in Paper Strips under Consideration of Liquid Absorption Capacity Chemosensors doi: 10.3390/chemosensors8030065 Authors: Surasak Kasetsirikul Muhammad J. A. Shiddiky Nam-Trung Nguyen Paper-based microfluidic devices have the potential of being a low-cost platform for diagnostic devices. Electrical circuit analogy (ECA) model has been used to model the wicking process in paper-based microfluidic devices. However, material characteristics such...
Thu Aug 06, 2020 03:00
Children, Vol. 7, Pages 93: Understanding the Psychosocial and Parenting Needs of Mothers with Irritable Bowel Syndrome with Young Children Children doi: 10.3390/children7080093 Authors: Lexa K. Murphy Tanera R. van Diggelen Rona L. Levy Tonya M. Palermo Women of childbearing age experience the highest prevalence of irritable bowel syndrome (IBS), yet little is known about their psychosocial and parenting needs, which may influence their children’s experience of future...
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Children, Vol. 7, Pages 92: Permanent Maxillary and Mandibular Central Incisor Width as Predictor of Permanent Maxillary Canine Width in a Kurdish Population: A Pilot Study Children doi: 10.3390/children7080092 Authors: Fadil Abdullah Kareem Background: Estimation of the mesio-distal width of permanent maxillary canines (PMCs) is a critical part of mixed dentition space analysis. The aim of this pilot study is to find a specific prediction equation for the estimation of the mesio-distal...
Thu Aug 06, 2020 03:00
Children, Vol. 7, Pages 91: Molar Incisor Hypomineralisation—To Extract or to Restore beyond the Optimal Age? Children doi: 10.3390/children7080091 Authors: Mustafa Elhussein Hasan Jamal The management of compromised first permanent molars (FPMs) in children presents a clinical challenge to the dental team. Hypomineralised FPMs in molar incisor hypomineralisation (MIH) conditions could undergo post-eruptive breakdown, making them susceptible to caries, leading to their subsequent...
Thu Aug 06, 2020 03:00
Climate, Vol. 8, Pages 90: Spatial and Temporal Distribution of Biomass Open Burning Emissions in the Greater Mekong Subregion Climate doi: 10.3390/cli8080090 Authors: Agapol Junpen Jirataya Roemmontri Athipthep Boonman Penwadee Cheewaphongphan Pham Thi Bich Thao Savitri Garivait Moderate Resolution Imaging Spectroradiometer (MODIS) burnt area products are widely used to assess the damaged area after wildfires and agricultural burning have occurred. This study improved...
Thu Aug 06, 2020 03:00
Clocks & Sleep, Vol. 2, Pages 325-333: Adverse Neurological Effects of Short-Term Sleep Deprivation in Aging Mice Are Prevented by SS31 Peptide Clocks & Sleep doi: 10.3390/clockssleep2030024 Authors: Jinzi Wu Yan Dou Warren C. Ladiges Sleep deprivation is a potent stress factor that disrupts regulatory pathways in the brain resulting in cognitive dysfunction and increased risk of neurodegenerative disease with increasing age. Prevention of the adverse effects of sleep deprivation...
Thu Aug 06, 2020 03:00
Dentistry Journal, Vol. 8, Pages 88: Laser-Assisted Depigmentation—An Introspection of the Science, Techniques, and Perceptions Dentistry Journal doi: 10.3390/dj8030088 Authors: Alex Mathews Muruppel B.S. Jagadish Pai Subraya Bhat Steven Parker Edward Lynch Background: Gingival hyperpigmentation is a major concern for a significant number of patients, as a relevant aesthetic or cosmetic need. Oral melanin pigmentation is considered to be multifactorial and could be related...
Thu Aug 06, 2020 03:00
Diagnostics, Vol. 10, Pages 565: Multimodal Brain Tumor Classification Using Deep Learning and Robust Feature Selection: A Machine Learning Application for Radiologists Diagnostics doi: 10.3390/diagnostics10080565 Authors: Muhammad Attique Khan Imran Ashraf Majed Alhaisoni Robertas Damaševičius Rafal Scherer Amjad Rehman Syed Ahmad Chan Bukhari Manual identification of brain tumors is an error-prone and tedious process for radiologists; therefore, it is crucial to adopt...
Thu Aug 06, 2020 03:00
Diseases, Vol. 8, Pages 30: “Tomorrow Never Dies”: Recent Advances in Diagnosis, Treatment, and Prevention Modalities against Coronavirus (COVID-19) amid Controversies Diseases doi: 10.3390/diseases8030030 Authors: Partha Laskar Murali M. Yallapu Subhash C. Chauhan The outbreak of novel coronavirus disease (2019-nCoV or COVID-19) is responsible for severe health emergency throughout the world. The attack of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is found to...
Thu Aug 06, 2020 03:00
Diversity, Vol. 12, Pages 306: Perceptions of Similarity Can Mislead Provenancing Strategies—An Example from Five Co-Distributed Acacia Species Diversity doi: 10.3390/d12080306 Authors: Maurizio Rossetto Peter D. Wilson Jason Bragg Joel Cohen Monica Fahey Jia-Yee Samantha Yap Marlien van der Merwe Ecological restoration requires balancing levels of genetic diversity to achieve present-day establishment as well as long-term sustainability. Assumptions based on distributional,...
Thu Aug 06, 2020 03:00
Foods, Vol. 9, Pages 1072: Multi-Extraction and Quality of Protein and Carrageenan from Commercial Spinosum (Eucheuma denticulatum) Foods doi: 10.3390/foods9081072 Authors: Alireza Naseri Charlotte Jacobsen Jimmy J.P. Sejberg Tommy Ewi Pedersen Jan Larsen Karin Meyer Hansen Susan L. Holdt Seaweeds contain many valuable compounds that can be used in the food industry. Carrageenan is a polysaccharide which has been extracted from seaweed for centuries and is used as a...
Thu Aug 06, 2020 03:00
Foods, Vol. 9, Pages 1073: Functionality of Native Starches in Food Systems: Cluster Analysis Grouping of Rheological Properties in Different Product Matrices Foods doi: 10.3390/foods9081073 Authors: Joanna Le Thanh-Blicharz Jacek Lewandowicz Industrial application of starch as a texture-forming agent is primarily limited to preparations obtained from waxy corn and potatoes. The main reason behind this is its functionality, which depends mostly on rheological properties. However,...
Thu Aug 06, 2020 03:00
Foods, Vol. 9, Pages 1068: Continuous Flow UV-C Irradiation Effects on the Physicochemical Properties of Aloe vera Gel and Pitaya (Stenocereus spp.) Blend Foods doi: 10.3390/foods9081068 Authors: Carmen O. Meléndez-Pizarro Arlet Calva-Quintana José C. Espinoza-Hicks Miguel Á. Sánchez-Madrigal Armando Quintero-Ramos Physicochemical properties of a blend of 10% Aloe vera gel with 5% pitaya juice subjected to UV-C doses of 16.5, 27.7, and 40 mJ/cm2 were evaluated at pH 3.5 and...
Thu Aug 06, 2020 03:00
Foods, Vol. 9, Pages 1069: Fraud in Animal Origin Food Products: Advances in Emerging Spectroscopic Detection Methods over the Past Five Years Foods doi: 10.3390/foods9081069 Authors: Abdo Hassoun Ingrid Måge Walter F. Schmidt Havva Tümay Temiz Li Li Hae-Yeong Kim Heidi Nilsen Alessandra Biancolillo Abderrahmane Aït-Kaddour Marek Sikorski Ewa Sikorska Silvia Grassi Daniel Cozzolino Animal origin food products, including fish and seafood, meat and poultry,...
Thu Aug 06, 2020 03:00
Foods, Vol. 9, Pages 1071: Modification of Physicochemical Properties of Breadfruit Flour Using Different Twin-Screw Extrusion Conditions and Its Application in Soy Protein Gels Foods doi: 10.3390/foods9081071 Authors: Shiqi Huang Laura Roman Mario M. Martinez Benjamin M. Bohrer The objective was to modify functional properties of breadfruit flours using twin-screw extrusion and test the physicochemical properties of the extruded flours. Extruded breadfruit flours were produced...
Thu Aug 06, 2020 03:00
Foods, Vol. 9, Pages 1067: Filtration Scheduling: Quality Changes in Freshly Produced Virgin Olive Oil Foods doi: 10.3390/foods9081067 Authors: Lorenzo Guerrini Carlotta Breschi Bruno Zanoni Luca Calamai Giulia Angeloni Piernicola Masella Alessandro Parenti Filtration is the most widespread stabilisation operation for extra virgin olive oil, preventing microbial and enzymatic changes. However, during the harvest, the workload of olive mills is at its peak. This results...
Thu Aug 06, 2020 03:00
Foods, Vol. 9, Pages 1066: New Formulation towards Healthier Meat Products: Juniperus communis L. Essential Oil as Alternative for Sodium Nitrite in Dry Fermented Sausages Foods doi: 10.3390/foods9081066 Authors: Vladimir Tomović Branislav Šojić Jovo Savanović Sunčica Kocić-Tanackov Branimir Pavlić Marija Jokanović Vesna Đorđević Nenad Parunović Aleksandra Martinović Dragan Vujadinović The effect of Juniperus communis L. essential oil (JEO) addition at concentrations...
Thu Aug 06, 2020 03:00
Foods, Vol. 9, Pages 1065: Comparison of Three Domestications and Wild-Harvested Plants for Nutraceutical Properties and Sensory Profiles in Five Wild Edible Herbs: Is Domestication Possible? Foods doi: 10.3390/foods9081065 Authors: Costanza Ceccanti Marco Landi Luca Incrocci Alberto Pardossi Francesca Venturi Isabella Taglieri Giuseppe Ferroni Lucia Guidi In this study, five wild edible herbs traditionally consumed in the Tuscany region (Italy) were evaluated for...
Thu Aug 06, 2020 03:00
Fractal Fract, Vol. 4, Pages 39: Parameter Identification in the Two-Dimensional Riesz Space Fractional Diffusion Equation Fractal and Fractional doi: 10.3390/fractalfract4030039 Authors: Rafał Brociek Agata Chmielowska Damian Słota This paper presents the application of the swarm intelligence algorithm for solving the inverse problem concerning the parameter identification. The paper examines the two-dimensional Riesz space fractional diffusion equation. Based on the values of...
Thu Aug 06, 2020 03:00
Healthcare, Vol. 8, Pages 257: GENE2D: A NoSQL Integrated Data Repository of Genetic Disorders Data Healthcare doi: 10.3390/healthcare8030257 Authors: Halima Samra Alice Li Ben Soh There are few sources from which to obtain clinical and genetic data for use in research in Saudi Arabia. Numerous obstacles led to the difficulty of integrating these data from silos and scattered sources to provide standardized access to large data sets for patients with common health conditions. To...
Thu Aug 06, 2020 03:00
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