ABSTRACT The innate immune lymphocytes (ILCs), discovered about a decade ago, exhibit functional features of T cells but lack antigen‐specific receptors (i.e., TCR). ILCs modulate mucosal immunity, inflammation, and tissue homeostasis.
Tue Jun 16, 2020 21:18
Tue Jun 16, 2020 20:58
Tue Jun 16, 2020 15:10
Abstract Objective This study aimed to discern preferences for receiving somatic molecular profiling (MP) results in cancer patients who have given consent to undergo testing. Methods We conducted a mixed‐methods study to explore patients’ views on which MP results they would like to receive and why. Advanced cancer patients (n=1299) completed questionnaires after giving consent to participate in a parent genomics study and undergoing MP. A subset of patients (n=20) participated in qualitative...
Tue Jun 16, 2020 20:35
Tue Jun 16, 2020 20:34
Abstract Social scientists have long appreciated that relationships between individuals cannot be described from observing a single domain, and that the structure across domains of interaction can have important effects on outcomes of interest (e.g., cooperation; Durkheim, 1893). One debate explicitly about this surrounds food sharing. Some argue that failing to find reciprocal food sharing means that some process other than reciprocity must be occurring, whereas others argue for models that allow...
Tue Jun 16, 2020 22:00
Abstract Background The prognostic value of lymph node yield (LNY) and lymph node ratio (LNR), or the ratio of number of metastatic LNs to total number dissected, has not been well established in p16‐associated oropharyngeal squamous cell carcinoma (OPSCC). Methods This retrospective cohort study evaluated locoregional disease‐free survival (LRDFS) in 82 patients with p16+ OPSCC who underwent neck dissection at a single institution from 2009 to 2017. LNR and LNY cutoffs were estimated using...
Tue Jun 16, 2020 15:13
Abstract Background There are no published reports evaluating the ability of artificial intelligence (AI) in the endoscopic diagnosis of superficial laryngopharyngeal cancer (SLPC). We presented our newly developed diagnostic AI model for SLPC detection. Methods We used RetinaNet for object detection. SLPC and normal laryngopharyngeal mucosal images obtained from narrow‐band imaging were used for the learning and validation data sets. Each independent data set comprised 400 SLPC and 800...
Tue Jun 16, 2020 15:10
Abstract Background Prognostic significance of posterior cervical lymph node metastasis in nasopharyngeal cancer is largely unknown. This study aims to determine the added prognostic significance of cervical lymph node group V to the standard American Joint Committee on Cancer (AJCC) staging system (eighth edition AJCC) of nasopharyngeal patients with cancer treated with intensity‐modulated radiation therapy (IMRT) in terms of overall survival (OS), distant metastatic‐free survival (DMFS), and...
Tue Jun 16, 2020 15:03
Abstract Background This study aimed to evaluate whether computed tomography (CT)‐based volumetric body composition analysis has prognostic value in head and neck cancer (HNC) patients. Methods This single‐center retrospective study included 79 patients with HNC treated with definitive radiotherapy from March 2009 to December 2018. The patients were assessed for (a) weight‐based variables and (b) pretreatment and posttreatment CT‐based body composition variables. Overall survival (OS) and...
Tue Jun 16, 2020 14:59
Abstract Background To describe sociodemographic factors associated with head and neck cancer (HNC) survival among patients with distant metastatic disease. Methods We retrospectively analyzed national data for 2889 adult patients with metastatic HNC (2007‐2015). We used Fine and Gray competing risks proportional hazard models, stratified by oropharyngeal cancer status, controlled for sociodemographic factors (age, sex, race/ethnicity, marital status, and insurance status), and accounted...
Tue Jun 16, 2020 14:43
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Tue Jun 16, 2020 14:33
Objectives/Hypothesis To determine the incidence of abnormal fiberoptic endoscopic evaluation of swallowing (FEES) findings in patients with progressive neurologic disorders and identify the most commonly implemented dysphagia management strategies. Study Design Retrospective Review. Methods A retrospective review was performed of patients with neurodegenerative disease who underwent FEES at a tertiary‐care center between 2008 and 2019. Patient demographics, diagnosis, and Eating Assessment...
Tue Jun 16, 2020 14:13
Tue Jun 16, 2020 13:58
Abstract Background The Paris System of Reporting Urine Cytology aims to screen samples for HGUC and to provide a universally acceptable reporting format for urine cytology specimens. However, studies detailing the reproducibility of this system, especially on cyto‐centrifuge preparations, are lacking. Methods 149 voided urine samples received in Department of Pathology were reviewed independently by five cytopathologists. To estimate the overall agreement, Gwet's AC and AC1statistics between...
Tue Jun 16, 2020 13:48
Abstract Neuroscience of dance is an emerging field with important applications related to health and well‐being, as dance has shown potential to foster adaptive neuroplasticity and is increasingly popular as a therapeutic activity or adjunct therapy for people living with conditions such as Parkinson’s and Alzheimer’s Diseases. However, the multimodal nature of dance presents challenges to researchers aiming to identify mechanisms involved when dance is used to combat neurodegeneration or support...
Tue Jun 16, 2020 21:35
Abstract To investigate face individuation (FI), a critical brain function in the human species, an oddball fast periodic visual stimulation (FPVS) approach was recently introduced (Liu‐Shuang et al., 2014). In this paradigm, an image of an unfamiliar “base” facial identity is repeated at a rapid rate F (e.g., 6 Hz) and different unfamiliar “oddball” facial identities are inserted every nth item, at a F/n rate (e.g., every 5th item, 1.2 Hz). This stimulation elicits FI responses at F/n and its...
Tue Jun 16, 2020 13:26
Abstract The conventional approach to understanding neural responses underlying complex computations is to study across‐trial averages of repeatedly performed computations from single neurons. When neurons perform complex computations, such as processing stimulus‐related information or motor planning, it has been repeatedly shown, through measures such as the Fano factor (FF), that neural variability across trials decreases. However, multiple neurons contribute to a common computation on a single...
Tue Jun 16, 2020 12:54
The Journal of Antibiotics, Published online: 17 June 2020; doi:10.1038/s41429-020-0332-3Conglobatins B–E: cytotoxic analogues of the C2-symmetric macrodiolide conglobatin
Wed Jun 17, 2020 03:00
Wed Jun 17, 2020 03:00
Abstract In this retrospective study, we evaluated the predictive role of different immunohistochemical expression (IHC) of the mismatch repair proteins (MMR) in patients with colorectal liver metastasis (CRLM) submitted to liver resection. A total of 108 patients were retrieved, and 15 patients were excluded from the study because of the impossibility to obtain adequate formalin-fixed tissue blocks. The final analysis included 93 patients. Twenty-eight cases (30%) presented...
Wed Jun 17, 2020 03:00
Fish production has been practiced since ancient Egypt and China. It has become a fast-growing agricultural sector that provides animal protein for most people globally. While China is the leading country in the world, Egypt and Nigeria stand on the top in Africa. The overall fishery production potential of Ethiopian water bodies is estimated to be 94,500 tons per year, while the actual production is 38,370 tons. Despite more water bodies and more fish diversity in the region, fish production and...
Tue Jun 16, 2020 18:50
Journal of International Medical Research, Volume 48, Issue 6, June 2020. ObjectivesGastric cancer (GC) is the leading cause of cancer-related deaths worldwide; however, the underlying molecular mechanisms of GC remain unclear. This study investigated the role of the miR-877–AQP3 axis in GC tumorigenesis.MethodsThe levels of miR-877 expression were measured in GC tissues and cell lines by qRT-PCR. Functional assays were performed to elucidate the role of miR-877 in GC development.ResultsOur results...
Tue Jun 16, 2020 08:36
Journal of International Medical Research, Volume 48, Issue 6, June 2020. Traumatic diaphragmatic rupture (TDR) is an uncommon but life-threatening condition often caused by blunt or penetrating trauma. Symptoms may appear late resulting in delayed or missed diagnosis. We report here a case of a 28-year-old man who presented with left subcostal pain and vomiting after recently binge drinking alcohol. He had experienced bilateral rib fractures two years previously. Computed tomography (CT) showed...
Tue Jun 16, 2020 08:34
Abstract The recent article “Another (Internal) Epineurium: Beyond the Anatomical Barriers of Nerves” by Reina et al., elegantly describes and delineates the microanatomy of peripheral nerve layers (Reina et al., 2020). We believe this article also has applications for benign and malignant nerve disorders including intraneural ganglion cysts and neurolymphoma. Further investigation of how these layers change along the course of a nerve, such as at branching and junction points, would further help...
Tue Jun 16, 2020 14:08
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Fungal infections due to Fusarium species are mostly present in immunocompromised and patients with poorly controlled diabetes mellitus. We report a case of lower extremity skin infection caused by Fusarium species in a 61-year-old woman diagnosed with sickle cell disease. Single skin ulceration caused by Fusarium species can result from fungal inoculation into damaged tissue, so any condition that...
Tue Jun 16, 2020 15:04
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Choledochoduodenal fistula (CDF) is an abnormal communication between the common bile duct and the duodenum. It accounts for about 5% to 25% of the total biliary fistulas and is usually due to a perforated duodenal ulcer, choledocholithiasis, and complications secondary to tuberculosis or could be iatrogenic. Primary intrabilliary tumors usually cause obstructive jaundice and rarely biliary metastasis...
Tue Jun 16, 2020 15:03
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