Colorectal cancer is one of most common tumors in developed countries and, despite improvements in treatment and diagnosis, mortality rate of patients remains high, evidencing the urgent need of novel biomarke...
Mon Jun 15, 2020 03:00
Hypoxia-induced alternative splicing is a potent driving force in tumour pathogenesis and progression. In this review, we update currents concepts of hypoxia-induced alternative splicing and how it influences ...
Mon Jun 15, 2020 03:00
Abstract To evaluate various factors that affects the auditory outcomes in pediatric patients with bilateral profound sensorineural hearing loss who underwent unilateral cochlear implantation. 50 prelingually deaf pediatric patients aged between 1 and 6 years with bilateral profound sensorineural hearing loss who underwent unilateral cochlear implantation between January 2016 and June 2018 at our tertiary centre were included in this study. Auditory performance was measured using...
Mon Jun 15, 2020 03:00
Publication date: Available online 15 June 2020Source: Academic RadiologyAuthor(s): Arnaldo Stanzione, Andrea Ponsiglione, Gianluca Armando Di Fiore, Stefano Giusto Picchi, Martina Di Stasi, Francesco Verde, Mario Petretta, Massimo Imbriaco, Renato Cuocolo
Mon Jun 15, 2020 22:40
Publication date: Available online 14 June 2020Source: Academic RadiologyAuthor(s): Qing Zhang, Haifeng Mi, Xubo Shi, Wei Li, Senlin Guo, Ping Wang, Hongna Suo, Ziyi Wang, Shanshan Jin, Fei Yan, Yantao Niu, Junfang Xian
Mon Jun 15, 2020 22:40
The aim of this study was to develop a porcine epiphyseal plate-derived extracellular matrix powder (PEPEP) for epiphyseal plate regeneration. PEPEP was characterized by chemical assay to determine the contents of DNA and epiphyseal plate complex chemical components (glycosaminoglycan and hydroxyproline). The effects of PEPEP on the viability, proliferation, and differentiation of human bone marrow mesenchymal stem cells (hBMSCs) were also evaluated. hBMSCs cultured in PEPEP exhibited a good distribution...
Mon Jun 15, 2020 18:07
A biobank is an organized collection of biological human material and its associated information stored for research according to regulations under institutional responsibility, without commercial purposes, being a mandatory and strategical activity for research, regenerative medicine, and innovation. Stem cells have largely been employed in research and frequently stored in biobanks, which have been used as an essential source of biological materials. Stem cells of human exfoliated deciduous teeth...
Mon Jun 15, 2020 10:07
Publication date: July 2020Source: Dental Materials, Volume 36, Issue 7Author(s):
Mon Jun 15, 2020 21:33
The original version of this article contained mistakes, and the authors would like to correct them.
Mon Jun 15, 2020 03:00
Presurgical evaluation of the alveolar cleft defect is an essential and crucial step for procedural success. In this study, three-dimensionally printed models derived from computed tomography scans were used to measure the alveolar defect volume before bone grafting. The authors also explored the influence of cleft type, age, and gender on alveolar bone defect volume. Ninety-four patients with unilateral alveolar cleft were enrolled in this study. One-way analysis of variance and multivariate analysis...
Thu Jun 11, 2020 03:00
Surgical management of spontaneous hypertensive brainstem hemorrhage remains a challenge for neurosurgeons, especially when the hemorrhage is located the ventral brainstem. Recently endoscopic endonasal approach has been applied for resection of ventral brainstem lesions, though no published literature has explored its utility in treating brainstem hemorrhage. Here we reported a successful evacuation of severe hypertensive brainstem hemorrhage through endoscopic endonasal transclival approach. A...
Thu Jun 11, 2020 03:00
Background: Respiratory distress is a frequent occurrence in neonates, typically caused by a variety of pulmonary conditions. Accurate diagnosis of the cause is vital to appropriately treat neonates and prevent long-term complications. Neck masses rarely cause respiratory distress in this setting but should be considered when clinical signs indicate. Methods: The authors present the patient with a neonate born at term who developed stertor, respiratory distress requiring intubation,...
Thu Jun 11, 2020 03:00
Introduction: Autologous reconstruction of segmental craniomaxillofacial bone defects is limited by insufficient graft material, donor site morbidity, and need for microsurgery. Reconstruction is challenging due to the complex three-dimensional (3D) structure of craniofacial skeleton. Customized 3D-printed patient-specific biologic scaffolds hold promise for reconstruction of the craniofacial skeleton without donor site morbidity. The authors report a porcine craniofacial defect model suitable...
Thu Jun 11, 2020 03:00
The reconstruction of full thickness scalp defects following oncologic resection poses a unique challenge that is further magnified in “extremely elderly” patients, defined as those in at least their ninth decade of life, who are often unsuitable candidates for complex reconstruction. A “simpler” option is two-stage reconstruction: placement of Integra dermal regenerative template (Integra Life Science, Plainsboro, NJ) followed by a split thickness skin graft (STSG). This case series illustrates...
Thu Jun 11, 2020 03:00
Cisplatin, a pharmacological agent widely used for treating many cancers, may cause serious side effects including ototoxicity, nephrotoxicity, and peripheral neuropathy. The present study aimed to investigate whether platelet-rich plasma (PRP) protects against cisplatin ototoxicity. Eight rats (16 ears) were divided into 2 groups: control group (4 rats, 8 ears) that received intratympanic saline and study group (4 rats, 8 ears) that received intratympanic PRP. Cisplatin (10 mg/day intraperitoneally)...
Thu Jun 11, 2020 03:00
Lingual lateral canal is a rare variation in the trajectory of the mandibular canal, and is usually detected as an incidental finding on radiographic exams, especially on cone-beam computed tomography. Due to its radiographic characteristics, this anatomical variation might be confused with a mandible fracture. Therefore, the knowledge of its presence is essential not only to differentiate it from a fracture, but also for the success of surgical procedures performed in the mandible, making it easier...
Thu Jun 11, 2020 03:00
Introduction: A closed globe trauma is often associated with orbital wall fractures. In addition to diplopia, further eye disturbances can be observed. The aim of this preliminary prospective study was to investigate the optical coherence tomography (OCT) findings in patients that presented with orbital fractures in association with diplopia but without decreased visual acuity or further ocular symptoms. Methods: Only patients who were admitted and surgically treated for orbital wall...
Thu Jun 11, 2020 03:00
The current outbreak of the highly contagious, animal origin SARS-CoV-2 virus causes the disease COVID-19. The disease is globally pandemic and as per World Health Organization (WHO) has spread to 235 countries. There is global lockdown for containment of the virus transmission. Testing of symptomatic patients, healthcare workers and suspected individuals and mass screening is vital. WHO recommends nasopharyngeal (NP) and oropharyngeal (OP) swab for the quantitative assessment of SARS-CoV-2 RNA level...
Thu Jun 11, 2020 03:00
Mon Jun 15, 2020 18:58
Abstract Objective Grief reactions in bereaved caregivers of cancer patients have been identified individually as distinct prolonged grief disorder (PGD)‐ and major depressive disorder (MDD)‐symptom trajectories, but no research has examined whether patterns of change (trajectories) for PGD and MDD symptoms synchronize during bereavement. We conducted a secondary analysis study to investigate the construct distinctiveness of PGD and MDD by simultaneously identifying and examining similarities...
Mon Jun 15, 2020 18:57
Abstract Objectives Numerous authors have expressed their interest in adjustment and social support in the context of cancer. However, none of the previous studies has directly examined the models describing the links between daily social support and adjustment fluctuation, particularly at the relational level. This study aimed to verify the additive and buffering models of daily received support regarding the relational level of patient‐caregiver relationship, that is, the relationship‐related...
Mon Jun 15, 2020 18:57
Abstract Objective Suicidal ideation is common in cancer patients and may be associated with hopelessness, demoralization, and depression. This study aims to investigate the serial multiple mediation of demoralization and depression in the relationship between hopelessness and suicidal ideation in cancer patients. Methods A total of 244 cancer patients were investigated by using the following standardized self‐reported questionnaires: Self‐rating Idea of Suicide scale (SIOSS), Beck Hopelessness...
Mon Jun 15, 2020 18:56
Abstract Objective To synthesise qualitative evidence related to barriers and facilitators of flexible sigmoidoscopy screening (FSS) intention and uptake, particularly within low sociodemographic uptake groups. FSS uptake is lower amongst women, lower socio‐economic status (SES), and Asian ethnic groups within the United Kingdom (UK) and United States of America. Methods 12 168 articles were identified from searches of four databases: EMBASE, MEDLINE, PsycINFO, and Web of Science. Eligibility...
Mon Jun 15, 2020 18:56
Abstract Objective Androgen deprivation therapy (ADT) enhances survival of advanced prostate cancer patients and is therefore used as a concomitant therapy. However, ADT has been reported to cause negative side effects on cognition and emotional processing. So far, research referred to the effects of short‐term treatment. Since the brain may adapt to androgen deprivation, we were especially interested in the long‐term effects of ADT on cognitive and socio‐economic decision‐making. Methods...
Mon Jun 15, 2020 18:55
Related ArticlesIntrathecal use of gadobutrol for gadolinium-enhanced MR cisternography in the evaluation of patients with otorhinorrhea. Neuroradiology. 2020 Jun 13;: Authors: Dogan SN, Salt V, Korkmazer B, Arslan S, Islak C, Kocer N, Kizilkilic O Abstract PURPOSE: Intrathecal gadolinium-enhanced MR cisternography (IGE-MRC) has a high sensitivity to detect accurate localization of cerebrospinal fluid (CSF) leakage in otorhinorrhea patients. Our purpose...
Mon Jun 15, 2020 20:37
Abstract Introduction High-grade neuroepithelial tumor with BCOR alteration (HGNET BCOR) has been recently classified as a new category of tumors among those previously known as PNET. They are molecularly characterized by the mutation of the BCOR gene, a corepressor of BCL6 a gene (which has an important role in immune responses). Only case reports and very small series have been published so far; therefore, their behavior and management...
Mon Jun 15, 2020 03:00
Abstract Purpose The hallmark of neurofibromatosis type 2 (NF2) is the presence of bilateral vestibular schwannomas (VS) which however have not yet developed or grown to large size in children and young adolescents. Therefore, early diagnosis in pediatric patients without family history of NF2 has to be made by signs and symptoms not related to VS which will be reviewed in this study. ...
Mon Jun 15, 2020 03:00
Publication date: Available online 14 June 2020Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Niels Christian Pausch, Tabea Pankow, Bernd Lethaus, Alexander Karl Bartella, Dirk Halama
Mon Jun 15, 2020 20:13
Related ArticlesReflux and dental disorders in the pediatric population: A systematic review. Int J Pediatr Otorhinolaryngol. 2020 Jun 08;136:110166 Authors: Lechien JR, Calvo-Henriquez C, Chiesa-Estomba CM, Barillari MR, Trozzi M, Meucci D, Peer S, Ben Abdelouahed F, Schindler A, Saussez S Abstract OBJECTIVES: To investigate the role of laryngopharyngeal reflux (LPR) or gastroesophageal reflux disease (GERD) in the development of dental disorders in...
Mon Jun 15, 2020 20:08
Samsung is releasing its top-of-the-line RS85 Prestige diagnostic ultrasound system. The device sports Samsung’s latest hardware and software technologies, such as Crystal Architecture, to produce high quality ultrasound images. Moreover, the system can run a dozen or so intelligent software features that fine tune image quality in specific situations and provide measurements, assessments of blood flow, and other useful metrics. Some of the capabilities of the RS85 Prestige include...
Mon Jun 15, 2020 19:30
As of early May 2020, over 4.7 million people have been confirmed to be infected with the SARS-CoV-2 coronavirus[1], and governments are scrambling to contain its spread. The high R0 value (a measure of contagiousness- estimated to be between 2.0 and 3.02) of SARS-CoV-2 means that those infected copiously spread the virus and develop complications suddenly. As a result, health care systems are overwhelmed, and the effective delivery of medical care to all patients has become a challenge worldwide....
Mon Jun 15, 2020 18:35
Vitamin D and its cognate intracellular nuclear receptor, namely, vitamin D receptor (VDR), are involved in the regulation of a variety of body metabolic processes, immune function, and oncogenesis. A large number of studies demonstrated the association of low vitamin D levels and variations in five common single nucleotide polymorphisms (SNPs), FokI, BsmI, Tru9I, ApaI, and TaqI, with the risk of several cancers, including colorectal cancers. However, these associations vary among different populations....
Mon Jun 15, 2020 16:50
The mechanism of RP11-838N2.3 promoting cisplatin resistance in lung adenocarcinoma (LAD) was unclear. The RP11-838N2.3 expression level in cells and LAD tissues was detected by qPCR. We constructed lentivirus-mediated GV303 overexpression and GV248 shRNA vector targeting RP11-838N2.3, then infected A549 and A549/DDP cell and furtherly analyzed cell biology. High-throughput gene chip analysis showed that RP11-838N2.3 was significantly upregulated in A549/DDP (). The qPCR results showed that the expression...
Mon Jun 15, 2020 16:50
Aim. To study demographic and clinical characteristics and to give a comparative description of the functional and hemodynamic status, profile of concomitant pathology in patients with various forms of pulmonary arterial hypertension (PAH), and chronic thromboembolic pulmonary hypertension (CTEPH) according to the Russian National Registry. Methods. During the period from January 01, 2012, till January 01, 2019, 1105 patients aged >18 years with verified diagnosis of PAH and CTEPH, who were subsequently...
Mon Jun 15, 2020 16:35
In recent years, the prevalence of human immunodeficiency virus (HIV) infection among Chinese university students has increased significantly, and HIV transmission among men who have sex with men (MSM) comprises more than half of the new cases. There is still a lack of research investigating the incidence of male-to-male sex, the attitudes towards MSM, and the awareness of HIV/AIDS among university students in Guangxi, one of the HIV high-risk areas in China. Therefore, we performed a cross-sectional...
Mon Jun 15, 2020 16:35
One of the well-studied phase II drug metabolizing enzymes is N-acetyltransferase 2 (NAT2) which has an essential role in the detoxification and metabolism of several environmental toxicants and many therapeutic drugs like isoniazid (antituberculosis, TB) and antimicrobial sulfonamides. According to the variability in the acetylation rate among different ethnic groups, individuals could be classified into slow, intermediate, and fast acetylators; these variabilities in the acetylation rate are a...
Mon Jun 15, 2020 15:05
Purpose. The aim of this study was to report the histopathology of failed free vascularized fibular grafting (FVFG) for osteonecrosis of the femoral head (ONFH) after a mean follow-up of 11.5 years (ranged from 10.6 to 14.2 years). Methods. Six hips of 5 patients with a history of steroid use, aged 34–67 years, were in stage II of ONFH as classified by the Ficat and Arlet classification at the time of FVFG treatment. Grafting failure led to osteoarthritis of the hip joint during a mean of 11.5 years...
Mon Jun 15, 2020 10:50
Evidences abound that HSF1 and ALDH2 are of cardioprotective effect, yet there is still no report on whether HSF1 can regulate ALDH2 to delay the occurrence of heart failure. We first established the pressure overload-induced heart failure model of mice by transverse aortic constriction (TAC) and discovered that, in the forming period of heart failure, changes of HSF1 and ALDH2 expression recorded the consistent trend. When HSF1 was upregulated/downregulated to delay/promote the occurrence of heart...
Mon Jun 15, 2020 10:50
Protein-protein interactions (PPIs) are important for almost all cellular processes, including metabolic cycles, DNA transcription and replication, and signaling cascades. The experimental methods for identifying PPIs are always time-consuming and expensive. Therefore, it is important to develop computational approaches for predicting PPIs. In this paper, an improved model is proposed to use a machine learning method in the study of protein-protein interactions. With the consideration of the factors...
Mon Jun 15, 2020 10:05
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