Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Tue Jun 16, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Tue Jun 16, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Tue Jun 16, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Tue Jun 16, 2020 10:00
Related ArticlesNegative impact of high body mass index on cetuximab-mediated cellular cytotoxicity against human colon carcinoma cells. J Chemother. 2020 Jun 16;:1-4 Authors: Campiotti L, Gariboldi MB, Mortara L, Noonan DM, Gallo D, Nigro O, Monti E, Piantanida E Abstract This study assessed the relationship between the ability of Natural Killer (NK) cells to activate antibody-dependent cellular cytotoxicity against human HT29 colorectal cancer cells...
Wed Jun 17, 2020 18:08
Related ArticlesBacteremia with Staphylococcus pseudintermedius in a 4 month old pediatric oncology patient. J Chemother. 2020 Jun 15;:1-3 Authors: Blondeau LD, Rubin JE, Deneer H, Kanthan R, Sanche S, Beshard N, Mpofu C, Blondeau JM Abstract Staphylococcus pseudintermedius colonizes and is a pathogen of dogs and is being increasingly recognized from specimens from humans with various infections. We describe a case of S. pseudintermedius bacteremia in...
Wed Jun 17, 2020 14:06
Publication date: August 2020Source: World Neurosurgery, Volume 140Author(s): Gorky Medhi, Subhendu Parida, Patrick Nicholson, Satya Bhusan Senapati, Bimal Prasad Padhy, Vitor Mendes Pereira
Wed Jun 17, 2020 14:02
Publication date: August 2020Source: World Neurosurgery, Volume 140Author(s): Lorenzo Giammattei, Nicolas Penet, Stefania Padovan, Mihaela Florea, Yohan Ducos, Paolo di Russo, Sebastien Froelich
Wed Jun 17, 2020 14:02
Related ArticlesIntralesional cryotherapy versus Cryotherapy spray for the treatment of recalcitrant plantar warts: a prospective, randomized study. J Dermatolog Treat. 2020 Jun 16;:1-19 Authors: Albalat W, Attwa E, Ebrahim HM Abstract Back ground: Recalcitrant planter warts are representing a therapeutic challenge. Intralesional cryotherapy (ILC) has emerged as a promising therapeutic option in recalcitrant planter warts treatment.Objective: To compare...
Wed Jun 17, 2020 17:58
Related ArticlesHerpes Zoster (shingles) complicating the course of COVID19 infection. J Dermatolog Treat. 2020 Jun 16;:1-7 Authors: Elsaie ML, Nada HA Abstract Different skin presentations and patterns of cutaneous signs were reported in COVID19 patients. Varicella-zoster virus (VZV) infection is responsible for two very common skin conditions. Varicella (chichkenpox) is the initial presentation for infection with VZV and is characterized by a diffuse...
Wed Jun 17, 2020 17:58
Related ArticlesPsoriasis and risk of the COVID-19 infection: Is there a role for Angiotensin Converting Enzyme (ACE)? J Dermatolog Treat. 2020 Jun 16;:1-7 Authors: Shahidi-Dadras M, Tabary M, Robati RM, Araghi F, Dadkhahfar S Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first appeared in Wuhan, China in December 2019 resulting in the COVID-19 pandemic. It has been shown that SARS-CoV-2 spike protein shares a high similarity...
Wed Jun 17, 2020 17:58
Related ArticlesLaser safety in isotretinoin use: online survey of public perception. J Dermatolog Treat. 2020 Jun 14;:1-4 Authors: AlKhowailed M, AlWayili S, Altalhab S, AlJasser MI, Al-Hargan A Abstract Background: The safety of laser therapy in patients taking isotretinoin is controversial. Recent evidence suggests that laser during isotretinoin treatment is safe. Our study aims to assess public perception and willingness to undergo laser intervention...
Wed Jun 17, 2020 14:01
Related ArticlesShort-term stress-related increasing cases of alopecia areata during the COVID-19 pandemic. J Dermatolog Treat. 2020 Jun 13;:1-4 Authors: Kutlu Ö, Aktaş H, İmren IG, Metin A PMID: 32538230 [PubMed - as supplied by publisher]
Wed Jun 17, 2020 14:01
Related ArticlesTopical finasteride for the treatment of male androgenetic alopecia and female pattern hair loss: a review of the current literature. J Dermatolog Treat. 2020 Jun 13;:1-21 Authors: Suchonwanit P, Iamsumang W, Leerunyakul K Abstract Background: Androgenetic alopecia (AGA) is a frequently encountered dermatological concern that impacts a patient's self-esteem and quality of life. Finasteride is a selective 5-alpha reductase inhibitor that...
Wed Jun 17, 2020 14:01
Related ArticlesSecukinumab Retreatment Associated Psoriasis Flare with Pustules. J Dermatolog Treat. 2020 Jun 13;:1-9 Authors: El-Komy M, Amer M, Mostafa A, ElKalioby M Abstract This case report describes a patient with plaque psoriasis and psoriatic arthritis who experienced IL-17A blocking antibody secukinumab treatment-interruption followed by re-treatment. The patient showed heterogeneous responses; significant improvement at initial introduction...
Wed Jun 17, 2020 14:01
Related ArticlesCombined microneedling with topical application of platelet-rich plasma versus microneedling alone in the treatment of stria distensae: clinicopathological analysis. J Dermatolog Treat. 2020 Jun 13;:1-39 Authors: Abdel-Motaleb AA, Zedan H, Mostafa MM, Abu-Dief EE, Gebril SM, Hussein M Abstract Background: Striae distensae (SD) are common skin conditions. Objectives: This study was done to test the hypothesis that "the use of microneedling...
Wed Jun 17, 2020 14:01
Related ArticlesEmerging treatments for bullous pemphigoid. J Dermatolog Treat. 2020 Jun 13;:1-31 Authors: Garrido PM, Queirós CS, Travassos AR, Borges-Costa J, Filipe P Abstract Bullous pemphigoid (BP) is the most common autoimmune blistering disease. It is characterized by an immune response against the hemidesmossomal anchoring proteins BP180 and BP230. BP mainly affects elderly patients, with an increasing incidence over the past two decades. High...
Wed Jun 17, 2020 14:01
Related ArticlesAcute smell and taste loss in outpatients: all infected with SARS-CoV-2? Rhinology. 2020 Jun 15;: Authors: Renaud M, Leon A, Trau G, Fath L, Ciftci S, Bensimon Y, Venkatasamy A, Debry C Abstract During SARS-CoV-2 pandemic, our region (Alsace, East of France) became a Covid-19 cluster quite early in Europe. Loss of smell and taste was quickly flagged by the Ears-Nose and Throat scientific community as a potential warning signs of SARS-CoV-2...
Wed Jun 17, 2020 16:01
Zinc-depletion associates with tissue eosinophilia and collagen depletion in chronic rhinosinusitis.
Related ArticlesZinc-depletion associates with tissue eosinophilia and collagen depletion in chronic rhinosinusitis. Rhinology. 2020 Jun 15;: Authors: Suzuki M, Ramezanpour M, Cooksley C, Lee TJ, Jeong B, Kao S, Suzuki T, Psaltis AJ, Nakamaru Y, Homma A, Wormald PJ, Vreugde S Abstract BACKGROUND: Zinc plays an important role in many biological processes. Reduced zinc levels have been found in chronic rhinosinusitis (CRS) patients, however, its role in...
Wed Jun 17, 2020 16:01
Related ArticlesParental concern as an indicator of the severity of Obstructive Sleep Apnea in children. Int J Pediatr Otorhinolaryngol. 2020 May 28;136:110144 Authors: Lavi M, Tauman R, Greenfeld M, Fishman G, Wasserzug O, DeRowe A Abstract INTRODUCTION: An accepted screening question for Obstructive Sleep Apnea (OSA) in children is "Does your child snore". However, this has no correlation to severity. The purpose of this study is to evaluate a simple...
Wed Jun 17, 2020 20:03
Publication date: Available online 17 June 2020Source: European Journal of Surgical OncologyAuthor(s): Federico Ghidinelli, Anna Bianchi
Wed Jun 17, 2020 13:59
Publication date: Available online 17 June 2020Source: European Journal of Surgical OncologyAuthor(s): Francesco Carli, Gabriele Baldini
Wed Jun 17, 2020 13:59
Related ArticlesKnowledge, attitudes and practices of faculty on mentorship: an exploratory interpretivist study at a sub-Saharan African medical school. BMC Med Educ. 2020 Jun 15;20(1):192 Authors: Mubuuke AG, Mbalinda SN, Munabi IG, Kateete D, Opoka RB, Kiguli S Abstract BACKGROUND: Mentorship has become a routine part of undergraduate training in health professions education. Although many health professions training institutions have successfully...
Wed Jun 17, 2020 18:00
Related ArticlesWhat occupational therapists' say about their competencies' enactment, maintenance and development in practice? A two-phase mixed methods study. BMC Med Educ. 2020 Jun 15;20(1):191 Authors: Rochette A, Brousseau M, Vachon B, Engels C, Amari F, Thomas A Abstract BACKGROUND: Understanding how professional competencies are actually enacted in clinical practice can help university programs better prepare their graduates. The study aimed to...
Wed Jun 17, 2020 18:00
Tue Jun 16, 2020 20:18
Tue Jun 16, 2020 19:58
Abstract Ectropion is a rather frequent complication of ichthyosis with negative functional and esthetic impact. Lid surgery can provide significant improvement. We report on a series of four ichthyosis patients with ongoing bilateral eye problems despite intense medical treatment (mean age 27.8 ± 14.1 years). All patients suffered from lagophthalmos. Two of the patients had only lower lid ectropion. In two of the patients’ ectropion was forming on the upper lid in addition to the lower lid when...
Tue Jun 16, 2020 18:09
Tue Jun 16, 2020 18:05
Abstract A novel coronavirus (severe acute respiratory syndrome corononavirus‐2; SARS‐CoV‐2) has affected millions of people across the world. The coronavirus disease (COVID‐19) resulting from SARS‐CoV‐2 manifests in variable clinical severity, featuring both respiratory and extra‐respiratory symptoms. Dermatological manifestations of COVID‐19 are sparsely reported. To study the various dermatological findings in SARS‐CoV‐2 positive patients in Indian population. This article is protected by copyright....
Tue Jun 16, 2020 18:03
Abstract The effectiveness of AbobotulinumtoxinA (BoNT‐ABO) depends on numerous factors, including the amount of dose, presence of autoantibody and number of injected muscles. In this study, we aimed to investigate the effect of the BoNT‐ABO in different dilutions, age groups, and frequency of sessions. A total of 60 patients with upper facial wrinkles were included in the study. A 500‐unit vial of BoNT‐ABO was reconstituted with 2.5 mL preservative‐free normal saline for 30 patients and 4 mL saline...
Tue Jun 16, 2020 18:03
Abstract Ultraviolet (UV) irradiation to the eye induces photoimmunosuppression. In here, we examined the effect of green odor against immunosuppression of contact hypersensitivity in the eye induced by UVB irradiation. Systemic immunosuppression was induced in ICR mice sensitized with 0.5% oxazolone through the skin by a single exposure to UVB. Consecutive green odor treatment significantly counteracted UVB irradiation‐induced immunosuppression of the contact hypersensitivity (CHS) response. The...
Tue Jun 16, 2020 17:15
Abstract Psoriasis is a chronic disease, mediated by the human immune system, based on a polygenic vulnerability, with cutaneous and systemic manifestations and substantial negative effects on the quality of life of patients. The physical and psychological impact of psoriasis affect all areas of patient's functioning. Likewise, the prevalence of depression and anxiety in patients with psoriasis is significantly higher than in the general population, and the quality of life is lower if compared to...
Tue Jun 16, 2020 16:58
Related ArticlesDynamic representations in networked neural systems. Nat Neurosci. 2020 Jun 15;: Authors: Ju H, Bassett DS Abstract A group of neurons can generate patterns of activity that represent information about stimuli; subsequently, the group can transform and transmit activity patterns across synapses to spatially distributed areas. Recent studies in neuroscience have begun to independently address the two components of information processing:...
Wed Jun 17, 2020 14:52
Related ArticlesMicrobiological detoxification of mycotoxins: Focus on Mechanisms and Advances. Infect Disord Drug Targets. 2020 Jun 16;: Authors: Abdi M, Asadi A, Maleki F, Kouhsari E, Fattahi A, Ohadi E, Lotfali E, Ahmadi A, Ghafouri Z Abstract Some fungal species of the genera Aspergillus, Penicillium, and Fusarium secretes toxic metabolites known as mycotoxins, has become a global concern that is toxic to different species of animals and humans....
Wed Jun 17, 2020 17:55
Related ArticlesPDB-1 from Potentilla discolor Bunge induces apoptosis and autophagy by downregulating the PI3K/Akt/mTOR signaling pathway in A549 cells. Biomed Pharmacother. 2020 Jun 13;129:110378 Authors: Zhang RR, Meng NN, Liu C, Li KL, Wang MX, Lv ZB, Chen SY, Guo X, Wang XK, Wang Q, Sun JY Abstract PDB-1 is a new C-27-carboxylated-lupane-triterpenoid derivative isolated from Potentilla discolor Bunge. In our previous research, PDB-1 was suggested...
Wed Jun 17, 2020 14:48
Related ArticlesDirect targeting of HSP90 with daurisoline destabilizes β-catenin to suppress lung cancer tumorigenesis. Cancer Lett. 2020 Jun 13;: Authors: Huang XH, Yan X, Zhang QH, Hong P, Zhang WX, Liu YP, Xu W, Li B, He QY Abstract Lung cancer is the most frequent cancer worldwide with a poor prognosis. Identification of novel cancer targets and useful therapeutic strategies without toxicity are urgently needed. In this study, we screened natural...
Wed Jun 17, 2020 14:48
Related ArticlesReview of rationale and progress towards targeting cyclin-dependent kinase 2 (CDK2) for male contraception1. Biol Reprod. 2020 Jun 16;: Authors: Faber EB, Wang N, Georg GI Abstract Cyclin-dependent kinase 2 (CDK2) is a member of the larger cell cycle regulating CDK family of kinases, activated by binding partner cyclins as its name suggests. Despite its canonical role in mitosis, CDK2 knockout mice are viable but sterile, suggesting...
Wed Jun 17, 2020 14:48
Related ArticlesFull length RTEL1 is required for the elongation of the single-stranded telomeric overhang by telomerase. Nucleic Acids Res. 2020 Jun 15;: Authors: Awad A, Glousker G, Lamm N, Tawil S, Hourvitz N, Smoom R, Revy P, Tzfati Y Abstract Telomeres cap the ends of eukaryotic chromosomes and distinguish them from broken DNA ends to suppress DNA damage response, cell cycle arrest and genomic instability. Telomeres are elongated by telomerase...
Wed Jun 17, 2020 14:48
Related ArticlesmiR-133a-3p promotes apoptosis and induces cell cycle arrest by targeting CREB1 in retinoblastoma. Arch Med Sci. 2020;16(4):941-956 Authors: Li J, Liu X, Wang W, Li C Abstract Introduction: Retinoblastoma (RB) is a malignant tumor that is derived from photoreceptors. It is common in children under 3 years old with a family genetic predisposition. MicroRNA-133a-3p (miR-133a-3p) is one of the tumor-related miRNAs that interprets a critical...
Wed Jun 17, 2020 14:48
Related ArticlesMDL-800, an allosteric activator of SIRT6, suppresses proliferation and enhances EGFR-TKIs therapy in non-small cell lung cancer. Acta Pharmacol Sin. 2020 Jun 15;: Authors: Shang JL, Ning SB, Chen YY, Chen TX, Zhang J Abstract Sirtuin 6 (SIRT6), a member of the sirtuin family, is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase that is involved in various physiological and pathological processes. SIRT6 is generally...
Wed Jun 17, 2020 14:48
Related ArticlesSenescence as a therapeutically relevant response to CDK4/6 inhibitors. Oncogene. 2020 Jun 15;: Authors: Wagner V, Gil J Abstract Cyclin-dependent kinases 4 and 6 (CDK4/6) phosphorylate and inhibit retinoblastoma (RB) family proteins. Hyperphosphorylated RB releases E2F transcription factors, activating a transcriptional program that initiates S phase. Due to the critical role that this pathway has in regulating cell cycle progression,...
Wed Jun 17, 2020 14:48
Related ArticlesE2F1 sumoylation as a protective cellular mechanism in oxidative stress response. Proc Natl Acad Sci U S A. 2020 Jun 15;: Authors: Graves JD, Lee YJ, Liu K, Li G, Lin FT, Lin WC Abstract Oxidative stress is a ubiquitous threat to all aerobic organisms and has been implicated in numerous pathological conditions such as cancer. Here we demonstrate a pivotal role for E2F1, a cell cycle regulatory transcription factor, in cell tolerance...
Wed Jun 17, 2020 14:48
Related ArticlesAsiatic acid ameliorates acute hepatic injury by reducing endoplasmic reticulum stress and triggering hepatocyte autophagy. Biomed Pharmacother. 2020 Jun 12;129:110375 Authors: Pang X, Qiao Q, Vonglorkham S, Feng Z, Pang L, Chen S, Wang D, Lao L, Lin X, Wei J Abstract Endoplasmic reticulum stress (ERS), mutual crosstalk between autophagy and apoptosis-related signaling pathway, plays an important role in the process of acute liver...
Wed Jun 17, 2020 14:48
Related ArticlesCannabinoid CP55940 selectively induces apoptosis in Jurkat cells and in ex vivo T-cell acute lymphoblastic leukemia through H2O2 signaling mechanism. Leuk Res. 2020 May 26;95:106389 Authors: Soto-Mercado V, Mendivil-Perez M, Jimenez-Del-Rio M, Fox JE, Velez-Pardo C Abstract T-cell acute lymphoblastic leukemia (T-ALL) is a highly heterogeneous malignant hematological disorder arising from T-cell progenitors. This study was aimed to...
Wed Jun 17, 2020 14:48
Related ArticlesTargeting the oncogene LSF with either the small molecule inhibitor FQI1 or siRNA causes mitotic delays with unaligned chromosomes, resulting in cell death or senescence. BMC Cancer. 2020 Jun 15;20(1):552 Authors: Willoughby JLS, George K, Roberto MP, Chin HG, Stoiber P, Shin H, Pedamallu CS, Schaus SE, Fitzgerald K, Shah J, Hansen U Abstract BACKGROUND: The oncogene LSF (encoded by TFCP2) has been proposed as a novel therapeutic...
Wed Jun 17, 2020 14:48
Related ArticlesHIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137. Elife. 2020 Jun 15;9: Authors: Zhang F, Bieniasz PD Abstract The HIV-1 Vpr accessory protein induces ubiquitin/proteasome-dependent degradation of many cellular proteins by recruiting them to a cullin4A-DDB1-DCAF1 complex. In so doing, Vpr enhances HIV-1 gene expression and induces (G2/M) cell cycle arrest. However, the identities of Vpr target...
Wed Jun 17, 2020 13:49
Related ArticlesParis Saponin VII Induces Apoptosis and Cell Cycle Arrest in Erythroleukemia Cells by a Mitochondrial Membrane Signaling Pathway. Anticancer Agents Med Chem. 2020 Jun 15;: Authors: Lin X, Gajendran B, Varier KM, Liu W, Song J, Rao Q, Wang C, Qiu J, Ni W, Qin X, Wen M, Liu H, Li Y Abstract BACKGROUND AND PURPOSE: Leukemia considered a top-listed ailment, according to WHO, which contributes to the death of a major population of the...
Wed Jun 17, 2020 13:49
Related ArticlesmiR-485-5p improves the progression of ovarian cancer by targeting SRC in vitro and in vivo. Neoplasma. 2020 Jun 16;: Authors: Yang Y, Liu J, Qian X, Li Y, Wang Y, Xu X Abstract miR-485-5p is involved in many tumors, but its role in ovarian cancer has been rarely reported. This paper mainly studied the expression and mechanism of miR-485-5p in ovarian cancer. The expression of miR-485-5p in ovarian cancer was compared with that in...
Wed Jun 17, 2020 13:49
Related ArticlesLncRNA UCA1 Antagonizes Arsenic-Induced Cell Cycle Arrest through Destabilizing EZH2 and Facilitating NFATc2 Expression. Adv Sci (Weinh). 2020 Jun;7(11):1903630 Authors: Dong Z, Gao M, Li C, Xu M, Liu S Abstract Arsenic (As) is a widespread metalloid contaminant, and its internal exposure is demonstrated to cause serious detrimental health problems. Albeit considerable studies are performed to interrogate the molecular mechanisms responsible...
Wed Jun 17, 2020 13:49
Related ArticlesTubeimoside I induces autophagy in HepG2 cells by activating the AMP-activated protein kinase signaling pathway. Oncol Lett. 2020 Jul;20(1):623-630 Authors: Ruan C, You L, Qiu Y, Cui X, Wu D Abstract Tubeimoside I (TBMS) is a natural compound with antitumor properties. However, the detailed mechanism underlying the function of TBMS in liver cancer has not been fully elucidated. In the present study, TBMS was shown to suppress cell proliferation...
Wed Jun 17, 2020 13:49
Related ArticlesCombination treatment of gemcitabine and sorafenib exerts a synergistic inhibitory effect on non-small cell lung cancer in vitro and in vivo via the epithelial-to-mesenchymal transition process. Oncol Lett. 2020 Jul;20(1):346-356 Authors: Jiang S, Wang R, Zhang X, Wu F, Li S, Yuan Y Abstract Standard chemotherapy is commonly used in clinical practice for the treatment of non-small cell lung cancer (NSCLC). However, its therapeutic efficacy...
Wed Jun 17, 2020 13:49
Related ArticlesPromoter hypermethylation influences the suppressive role of long non-coding RNA MEG3 in the development of multiple myeloma. Exp Ther Med. 2020 Jul;20(1):637-645 Authors: Yu W, Shi Q, Wu C, Shen X, Chen L, Xu J Abstract Methylation is a fundamental regulator of gene transcription. Long non-coding RNA maternally expressed 3 (MEG3) inhibits cell proliferation in various types of cancer. However, the molecular mechanisms of MEG3 methylation...
Wed Jun 17, 2020 13:49
Related ArticlesBioinformatics analysis reveals meaningful markers and outcome predictors in HBV-associated hepatocellular carcinoma. Exp Ther Med. 2020 Jul;20(1):427-435 Authors: Zhang L, Makamure J, Zhao D, Liu Y, Guo X, Zheng C, Liang B Abstract Hepatocellular carcinoma (HCC) is the most common type of malignant neoplasm of the liver with high morbidity and mortality. Extensive research into the pathology of HCC has been performed; however, the molecular...
Wed Jun 17, 2020 13:49
Related ArticlesInhibition of fatty acid synthase (FASN) affects the proliferation and apoptosis of HepG2 hepatoma carcinoma cells via the β-catenin/C-myc signaling pathway. Ann Hepatol. 2020 Mar 31;: Authors: Zhang W, Huang J, Tang Y, Yang Y, Hu H Abstract INTRODUCTION AND OBJECTIVES: Research in the last few years has proven that inhibition of fatty acid synthase (FASN) suppresses the migration and invasion of hepatoma carcinoma cells. This study...
Wed Jun 17, 2020 13:49
Related ArticlesFolate-induced nanostructural changes of oligochitosan nanoparticles and their fate of cellular internalization by melanoma. Carbohydr Polym. 2020 Sep 15;244:116488 Authors: Musalli AH, Talukdar PD, Roy P, Kumar P, Wong TW Abstract This study examined the effects of folate environment of oligochitosan nanoparticles on their cellular internalization profiles in human melanoma cells. The conjugates and nanoparticles of oligochitosan-folate,...
Wed Jun 17, 2020 13:49
Related ArticlesCharacteristics of Immune Checkpoint Inhibitors Trials Associated With Inclusion of Patients With HIV: A Systematic Review and Meta-analysis. JAMA Netw Open. 2019 11 01;2(11):e1914816 Authors: Sorotsky H, Hogg D, Amir E, Araujo DV PMID: 31702796 [PubMed - indexed for MEDLINE]
Wed Jun 17, 2020 13:49
Related ArticlesSourcing the immune system to induce immunogenic cell death in Kras-colorectal cancer cells. Br J Cancer. 2019 10;121(9):768-775 Authors: Cirone M, Lotti LV, Granato M, Renzo LD, Biunno I, Cattaneo M, Verginelli F, Vespa S, Davies D, Wells V, Mariani-Costantini R, Mallucci L Abstract BACKGROUND: Current approaches aimed at inducing immunogenic cell death (ICD) to incite an immune response against cancer neoantigens are based on the use...
Wed Jun 17, 2020 13:49
Related ArticlesLong noncoding RNA BCAR4 promotes glioma cell proliferation via EGFR/PI3K/AKT signaling pathway. J Cell Physiol. 2019 12;234(12):23608-23617 Authors: Wei L, Yi Z, Guo K, Long X Abstract Long noncoding RNA Breast Cancer Antiestrogen Resistance 4 (BCAR4) has been identified to be oncogenic in several cancers. In our study, we demonstrated that BCAR4 expression was significantly upregulated in glioma tissues compared with paired nontumor...
Wed Jun 17, 2020 13:49
Related ArticlesDesign and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia. J Med Chem. 2019 06 13;62(11):5414-5433 Authors: Guo Z, Zhang Z, Yang H, Cao D, Xu X, Zheng X, Chen D, Wang Q, Li Y, Li J, Du Z, Wang X, Chen L, Ding J, Shen J, Geng M, Huang X, Xiong B Abstract PRMT4 is a type I protein arginine methyltransferase and plays important roles in various cellular processes. Overexpression...
Wed Jun 17, 2020 13:49
Related ArticlesCalcium-activated nucleotidase 1 silencing inhibits proliferation, migration, and invasion in human clear cell renal cell carcinoma. J Cell Physiol. 2019 12;234(12):22635-22647 Authors: Liu X, Yang Z, Luo X, Luo J, Fu W, Fang Z, Xia D, Li L, Xu J Abstract Calcium-activated nucleotidase 1 (CANT1, belongs to the apyrase family, is widely expressed in various organs. However, the biological function of CANT1 remains poorly explored. In...
Wed Jun 17, 2020 13:49
Related Articlesc-Myc Is a Major Determinant for Antitumor Activity of Aurora A Kinase Inhibitor MLN8237 in Thyroid Cancer. Thyroid. 2018 12;28(12):1642-1654 Authors: Li Y, Li X, Pu J, Yang Q, Guan H, Ji M, Shi B, Chen M, Hou P Abstract Background: c-Myc is overexpressed in different types of cancer, including thyroid cancer, and has been considered undruggable. There is evidence showing that MLN8237, a type of aurora A kinase (AURKA) inhibitor,...
Wed Jun 17, 2020 13:49
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