Antibiotics, Vol. 9, Pages 328: Characterization of Extremely Drug-Resistant and Hypervirulent Acinetobacter baumannii AB030 Antibiotics doi: 10.3390/antibiotics9060328 Authors: Manu Singh P. Malaka De Silva Yasser Al-Saadi Jacek Switala Peter C. Loewen Georg Hausner Wangxue Chen Ismael Hernandez Santiago Castillo-Ramirez Ayush Kumar Acinetobacter baumannii is an important nosocomial bacterial pathogen. Multidrug-resistant isolates of A. baumannii are reported...
Wed Jun 17, 2020 03:00
Antibiotics, Vol. 9, Pages 330: Multimodal Role of Amino Acids in Microbial Control and Drug Development Antibiotics doi: 10.3390/antibiotics9060330 Authors: Idrees Mohammad Karodia Rahman Amino acids are ubiquitous vital biomolecules found in all kinds of living organisms including those in the microbial world. They are utilised as nutrients and control many biological functions in microorganisms such as cell division, cell wall formation, cell growth and metabolism, intermicrobial...
Wed Jun 17, 2020 03:00
Antibiotics, Vol. 9, Pages 331: Fluoroquinolone Versus Nonfluoroquinolone Treatment of Bloodstream Infections Caused by Chromosomally Mediated AmpC-Producing Enterobacteriaceae Antibiotics doi: 10.3390/antibiotics9060331 Authors: Gunter Barber Wagner Stover Objectives: Chromosomally mediated AmpC-producing Enterobacteriaceae (CAE) display high susceptibility to fluoroquinolones; minimal clinical data exist supporting comparative clinical outcomes. The objective of this study...
Wed Jun 17, 2020 03:00
Antibiotics, Vol. 9, Pages 329: Optimizing Antibiotic Treatment Strategies for Neonates and Children: Does Implementing Extended or Prolonged Infusion Provide any Advantage? Antibiotics doi: 10.3390/antibiotics9060329 Authors: Paola Costenaro Chiara Minotti Elena Cuppini Elisa Barbieri Carlo Giaquinto Daniele Donà Optimizing the use of antibiotics has become mandatory, particularly for the pediatric population where limited options are currently available. Selecting the...
Wed Jun 17, 2020 03:00
Antioxidants, Vol. 9, Pages 531: Isosamidin from Peucedanum japonicum Roots Prevents Methylglyoxal-Induced Glucotoxicity in Human Umbilical Vein Endothelial Cells via Suppression of ROS-Mediated Bax/Bcl-2 Antioxidants doi: 10.3390/antiox9060531 Authors: Moon Ho Do Jae Hyuk Lee Jongmin Ahn Min Jee Hong Jinwoong Kim Sun Yeou Kim Methylglyoxal (MGO) is a highly reactive metabolite of glucose. Elevated levels of MGO induce the generation of reactive oxygen species (ROS) and...
Wed Jun 17, 2020 03:00
Antioxidants, Vol. 9, Pages 532: Pro-Oxidant Actions of Carotenoids in Triggering Apoptosis of Cancer Cells: A Review of Emerging Evidence Antioxidants doi: 10.3390/antiox9060532 Authors: Shin Song Oh Keum Saini Carotenoids are well known for their potent antioxidant function in the cellular system. However, in cancer cells with an innately high level of intracellular reactive oxygen species (ROS), carotenoids may act as potent pro-oxidant molecules and trigger ROS-mediated...
Wed Jun 17, 2020 03:00
Antioxidants, Vol. 9, Pages 529: Terpenoids as Potential Geroprotectors Antioxidants doi: 10.3390/antiox9060529 Authors: Proshkina Plyusnin Babak Lashmanova Maganova Koval Platonova Shaposhnikov Moskalev Terpenes and terpenoids are the largest groups of plant secondary metabolites. However, unlike polyphenols, they are rarely associated with geroprotective properties. Here we evaluated the conformity of the biological effects of terpenoids with the criteria...
Wed Jun 17, 2020 03:00
Antioxidants, Vol. 9, Pages 530: Andrographis paniculata and Its Bioactive Diterpenoids Against Inflammation and Oxidative Stress in Keratinocytes Antioxidants doi: 10.3390/antiox9060530 Authors: Mussard Jousselin Cesaro Legrain Lespessailles Esteve Berteina-Raboin Toumi Andrographis paniculata was widely used in traditional herbal medicine to treat various diseases. This study explored the potential anti-aging activity of Andrographis paniculata in cutaneous...
Wed Jun 17, 2020 03:00
Atmosphere, Vol. 11, Pages 645: Assessment of Gaseous and Particulate Emissions of a Euro 6d-Temp Diesel Vehicle Driven >1300 km Including Six Diesel Particulate Filter Regenerations Atmosphere doi: 10.3390/atmos11060645 Authors: Victor Valverde Barouch Giechaskiel Diesel-fueled vehicles have classically had high particulate and NOx emissions. The introduction of Diesel Particulate Filters (DPFs) and Selective Catalytic Reduction for NOx (SCR) systems have decreased the Particle...
Wed Jun 17, 2020 03:00
Atmosphere, Vol. 11, Pages 644: Contrasting Signals of the Westerly Index and North Atlantic Oscillation over the Drought Sensitivity of Tree-Ring Chronologies from the Mediterranean Basin Atmosphere doi: 10.3390/atmos11060644 Authors: Pablo Casas-Gómez Raúl Sánchez-Salguero Pedro Ribera Juan C. Linares Extreme drought events are becoming increasingly frequent and extended, particularly in Mediterranean drought-prone regions. In this sense, atmospheric oscillations patterns,...
Wed Jun 17, 2020 03:00
Bioengineering, Vol. 7, Pages 59: Human Mesenchymal Stem Cells Overexpressing Interleukin 2 Can Suppress Proliferation of Neuroblastoma Cells in Co-Culture and Activate Mononuclear Cells In Vitro Bioengineering doi: 10.3390/bioengineering7020059 Authors: Daria S. Chulpanova Valeriya V. Solovyeva Victoria James Svetlana S. Arkhipova Marina O. Gomzikova Ekaterina E. Garanina Elvira R. Akhmetzyanova Leysan G. Tazetdinova Svetlana F. Khaiboullina Albert A. Rizvanov ...
Wed Jun 17, 2020 03:00
Biology, Vol. 9, Pages 132: Unreported Cases for Age Dependent COVID-19 Outbreak in Japan Biology doi: 10.3390/biology9060132 Authors: Quentin Griette Pierre Magal Ousmane Seydi We investigate the age structured data for the COVID-19 outbreak in Japan. We consider a mathematical model for the epidemic with unreported infectious patient with and without age structure. In particular, we build a new mathematical model and a new computational method to fit the data by using age classes...
Wed Jun 17, 2020 03:00
Biomedicines, Vol. 8, Pages 165: Varespladib Inhibits the Phospholipase A2 and Coagulopathic Activities of Venom Components from Hemotoxic Snakes Biomedicines doi: 10.3390/biomedicines8060165 Authors: Chunfang Xie Laura-Oana Albulescu Kristina B. M. Still Julien Slagboom Yumei Zhao Zhengjin Jiang Govert W. Somsen Freek J. Vonk Nicholas R. Casewell Jeroen Kool Phospholipase A2 (PLA2) enzymes are important toxins found in many snake venoms, and they can exhibit...
Wed Jun 17, 2020 03:00
Biomedicines, Vol. 8, Pages 163: Air Contamination in Different Departments of a Tertiary Hospital. Assessment of Microbial Load and of Antimicrobial Susceptibility Biomedicines doi: 10.3390/biomedicines8060163 Authors: Athanasios Tselebonis Evangelia Nena Maria Panopoulou Christos Kontogiorgis Eugenia Bezirtzoglou Theodoros Constantinidis Air contamination in the hospital setting can be a reason for the spread of nosocomial infection among susceptible patients. The aim...
Wed Jun 17, 2020 03:00
Biomedicines, Vol. 8, Pages 164: β-Caryophyllene Reduces the Inflammatory Phenotype of Periodontal Cells by Targeting CB2 Receptors Biomedicines doi: 10.3390/biomedicines8060164 Authors: Giacomo Picciolo Giovanni Pallio Domenica Altavilla Mario Vaccaro Giacomo Oteri Natasha Irrera Francesco Squadrito Human gingival fibroblasts (GF) and human oral mucosa epithelial cells (EC) with an inflammatory phenotype represent a valuable experimental paradigm to explore the curative...
Wed Jun 17, 2020 03:00
Biomolecules, Vol. 10, Pages 920: Profiling and Role of Bioactive Molecules from Puntius sophore (Freshwater/Brackish Fish) Skin Mucus with Its Potent Antibacterial, Antiadhesion, and Antibiofilm Activities Biomolecules doi: 10.3390/biom10060920 Authors: Patel Ashraf Siddiqui Ashraf Sachidanandan Snoussi Adnan Hadi Epidermal fish mucus comprises of diverse bioactive metabolites which plays an immense role in defense mechanisms and other important cellular...
Wed Jun 17, 2020 03:00
Biomolecules, Vol. 10, Pages 921: Adenosine-5′-Phosphosulfate- and Sulfite Reductases Activities of Sulfate-Reducing Bacteria from Various Environments Biomolecules doi: 10.3390/biom10060921 Authors: Kushkevych Abdulina Kováč Dordević Vítězová Iutynska Rittmann A comparative study of the kinetic characteristics (specific activity, initial and maximum rate, and affinity for substrates) of key enzymes of assimilatory sulfate reduction (APS reductase and dissimilatory...
Wed Jun 17, 2020 03:00
Biomolecules, Vol. 10, Pages 919: Preclinical Efficacy and Safety of an Anti-Human VEGFA and Anti-Human NRP1 Dual-Targeting Bispecific Antibody (IDB0076) Biomolecules doi: 10.3390/biom10060919 Authors: Ko Kwon Kim Min Shin Yang Lee Lee Hong Kim Although bevacizumab (Avastin®) has been approved as an antiangiogenic agent against some cancers, the efficacy is transient and unsatisfactory in other cancers most likely owing to the presence of...
Wed Jun 17, 2020 03:00
Biomolecules, Vol. 10, Pages 918: Effects of Biogenic Zinc Oxide Nanoparticles on Growth and Oxidative Stress Response in Flax Seedlings vs. In Vitro Cultures: A Comparative Analysis Biomolecules doi: 10.3390/biom10060918 Authors: Afifa Zaeem Samantha Drouet Sumaira Anjum Razia Khurshid Muhammad Younas Jean Philippe Blondeau Duangjai Tungmunnithum Nathalie Giglioli-Guivarc’h Christophe Hano Bilal Haider Abbasi Linum usitatissimum biosynthesizes lignans and...
Wed Jun 17, 2020 03:00
Biomolecules, Vol. 10, Pages 917: Against Repurposing Methadone for Glioblastoma Therapy Biomolecules doi: 10.3390/biom10060917 Authors: Tatjana Vatter Lukas Klumpp Katrin Ganser Nicolai Stransky Daniel Zips Franziska Eckert Stephan M. Huber Methadone, which is used as maintenance medication for outpatient treatment of opioid dependence or as an analgesic drug, has been suggested by preclinical in vitro and mouse studies to induce cell death and sensitivity to chemo-...
Wed Jun 17, 2020 03:00
Biomolecules, Vol. 10, Pages 916: Chemical Composition and Immunomodulatory Activity of Hypericum perforatum Essential Oils Biomolecules doi: 10.3390/biom10060916 Authors: Igor A. Schepetkin Gulmira Özek Temel Özek Liliya N. Kirpotina Andrei I. Khlebnikov Mark T. Quinn Hypericum L. (Hypericaceae) extracts have been used for their therapeutic effects; however, not much is known about the immunomodulatory activity of essential oils extracted from this plant. We isolated...
Wed Jun 17, 2020 03:00
Biomolecules, Vol. 10, Pages 915: Emerging Roles of RNA 3′-end Cleavage and Polyadenylation in Pathogenesis, Diagnosis and Therapy of Human Disorders Biomolecules doi: 10.3390/biom10060915 Authors: Jamie Nourse Stefano Spada Sven Danckwardt A crucial feature of gene expression involves RNA processing to produce 3′ ends through a process termed 3′ end cleavage and polyadenylation (CPA). This ensures the nascent RNA molecule can exit the nucleus and be translated...
Wed Jun 17, 2020 03:00
Biomolecules, Vol. 10, Pages 914: The Structure of Blood Coagulation Factor XIII Is Adapted to Oxidation Biomolecules doi: 10.3390/biom10060914 Authors: Alexandra Vasilyeva Lyubov Yurina Alexander Shchegolikhin Maria Indeykina Anna Bugrova Alexey Kononikhin Eugene Nikolaev Mark Rosenfeld The blood coagulation factor XIII (FXIII) plays a critical role in supporting coagulation and fibrinolysis due to both the covalent crosslinking of fibrin polymers, rendering them...
Wed Jun 17, 2020 03:00
Biosensors, Vol. 10, Pages 69: A Novel Efficient FEM Thin Shell Model for Bio-Impedance Analysis Biosensors doi: 10.3390/bios10060069 Authors: Jiawei Tang Mingyang Lu Yuedong Xie Wuliang Yin In this paper, a novel method for accelerating eddy currents calculation on a cell model using the finite element method (FEM) is presented. Due to the tiny thickness of cell membrane, a full-mesh cell model requires a large number of mesh elements and hence intensive computation resources...
Wed Jun 17, 2020 03:00
Biosensors, Vol. 10, Pages 68: Plant Part-Derived Carbon Dots for Biosensing Biosensors doi: 10.3390/bios10060068 Authors: Muhammad Zulfajri Hani Nasser Abdelhamid Sudewi Sandhiya Dayalan Akhtar Rasool Ahsan Habib Genin Gary Huang Carbon dots (CDs) are a new cluster of carbon atoms with particle size less than 10 nm. CDs also exhibit interesting fluorescence (FL) properties. CDs are attractive because of their fascinating characteristics including low toxicity, good...
Wed Jun 17, 2020 03:00
Biosensors, Vol. 10, Pages 67: Recent Advances in Cellulose-Based Biosensors for Medical Diagnosis Biosensors doi: 10.3390/bios10060067 Authors: Samir Kamel Tawfik A. Khattab Cellulose has attracted much interest, particularly in medical applications such as advanced biosensing devices. Cellulose could provide biosensors with enhanced biocompatibility, biodegradability and non-toxicity, which could be useful for biosensors. Thus, they play a significant role in environmental monitoring,...
Wed Jun 17, 2020 03:00
Biosensors, Vol. 10, Pages 66: Magnetic Bead-Based Electrochemical Immunoassays On-Drop and On-Chip for Procalcitonin Determination: Disposable Tools for Clinical Sepsis Diagnosis Biosensors doi: 10.3390/bios10060066 Authors: Águeda Molinero-Fernández María Moreno-Guzmán Miguel Ángel López Alberto Escarpa Procalcitonin (PCT) is a known protein biomarker clinically used for the early stages of sepsis diagnosis and therapy guidance. For its reliable determination, sandwich format...
Wed Jun 17, 2020 03:00
Brain Sciences, Vol. 10, Pages 383: Pathological Findings in Chronic Inflammatory Demyelinating Polyradiculoneuropathy: A Single-Center Experience Brain Sciences doi: 10.3390/brainsci10060383 Authors: Marco Luigetti Angela Romano Andrea Di Paolantonio Giulia Bisogni Salvatore Rossi Amelia Conte Francesca Madia Mario Sabatelli Objective: Segmental demyelination is the pathological hallmark of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), but other...
Wed Jun 17, 2020 03:00
Brain Sciences, Vol. 10, Pages 384: Mini-Review on the Possible Interconnections between the Gut-Brain Axis and the Infertility-Related Neuropsychiatric Comorbidities Brain Sciences doi: 10.3390/brainsci10060384 Authors: Gabriela Simionescu Ovidiu-Dumitru Ilie Alin Ciobica Bogdan Doroftei Radu Maftei Delia Grab Jack McKenna Nitasha Dhunna Ioannis Mavroudis Emil Anton Both the gut-brain axis (GBA) and the hypothalamic–pituitary–adrenal (HPA)...
Wed Jun 17, 2020 03:00
Brain Sciences, Vol. 10, Pages 382: Behavioral and Autonomic Responses in Treating Children with High-Functioning Autism Spectrum Disorder: Clinical and Phenomenological Insights from Two Case Reports Brain Sciences doi: 10.3390/brainsci10060382 Authors: Lucia Billeci Ettore Caterino Alessandro Tonacci Maria Luisa Gava In this study, we aimed to evaluate the process applied in subjects with Autism Spectrum Disorder (ASD) to elaborate and communicate their experiences of daily...
Wed Jun 17, 2020 03:00
Brain Sciences, Vol. 10, Pages 381: Importance of the Role of ω-3 and ω-6 Polyunsaturated Fatty Acids in the Progression of Brain Cancer Brain Sciences doi: 10.3390/brainsci10060381 Authors: Mayra Montecillo-Aguado Belen Tirado-Rodriguez Zhen Tong Owen M. Vega Mario Morales-Martínez Shaheen Abkenari José Pedraza-Chaverri Sara Huerta-Yepez Brain cancer is one of the most malignant types of cancer in both children and adults. Brain cancer patients tend to have a poor...
Wed Jun 17, 2020 03:00
Cancers, Vol. 12, Pages 1606: Automated Classification of Significant Prostate Cancer on MRI: A Systematic Review on the Performance of Machine Learning Applications Cancers doi: 10.3390/cancers12061606 Authors: Jose M. Castillo T. Muhammad Arif Wiro J. Niessen Ivo G. Schoots Jifke F. Veenland Significant prostate carcinoma (sPCa) classification based on MRI using radiomics or deep learning approaches has gained much interest, due to the potential application in assisting...
Wed Jun 17, 2020 03:00
Cancers, Vol. 12, Pages 1607: Overcoming Platinum and PARP-Inhibitor Resistance in Ovarian Cancer Cancers doi: 10.3390/cancers12061607 Authors: Michelle McMullen Katherine Karakasis Ainhoa Madariaga Amit M. Oza Platinum chemotherapy remains the cornerstone of treatment for epithelial ovarian cancer (OC) and Poly (ADP-ribose) polymerase inhibitors (PARPi) now have an established role as maintenance therapy. The mechanisms of action of these agents is, in many ways, complementary,...
Wed Jun 17, 2020 03:00
Cancers, Vol. 12, Pages 1600: Role of Anillin in Tumour: From a Prognostic Biomarker to a Novel Target Cancers doi: 10.3390/cancers12061600 Authors: Nguyen Minh Tuan Chang Hoon Lee Anillin (ANLN), an actin-binding protein, reportedly plays a vital role in cell proliferation and migration, particularly in cytokinesis. Although there have been findings pointing to a contribution of ANLN to the development of cancer, the association of ANLN to cancer remains not fully understood. Here,...
Wed Jun 17, 2020 03:00
Cancers, Vol. 12, Pages 1601: Cisplatin Resistance in Testicular Germ Cell Tumors: Current Challenges from Various Perspectives Cancers doi: 10.3390/cancers12061601 Authors: João Lobo Carmen Jerónimo Rui Henrique Testicular germ cell tumors share a marked sensitivity to cisplatin, contributing to their overall good prognosis. However, a subset of patients develop resistance to platinum-based treatments, by still-elusive mechanisms, experiencing poor quality of life due to multiple...
Wed Jun 17, 2020 03:00
Cancers, Vol. 12, Pages 1604: Deep Learning for the Classification of Small-Cell and Non-Small-Cell Lung Cancer Cancers doi: 10.3390/cancers12061604 Authors: Mark Kriegsmann Christian Haag Cleo-Aron Weis Georg Steinbuss Arne Warth Christiane Zgorzelski Thomas Muley Hauke Winter Martin E. Eichhorn Florian Eichhorn Joerg Kriegsmann Petros Christopolous Michael Thomas Mathias Witzens-Harig Peter Sinn Moritz von Winterfeld Claus Peter Heussel Felix...
Wed Jun 17, 2020 03:00
Cancers, Vol. 12, Pages 1603: A Novel JAK1 Mutant Breast Implant-Associated Anaplastic Large Cell Lymphoma Patient-Derived Xenograft Fostering Pre-Clinical Discoveries Cancers doi: 10.3390/cancers12061603 Authors: Danilo Fiore Luca Vincenzo Cappelli Paul Zumbo Jude M. Phillips Zhaoqi Liu Shuhua Cheng Liron Yoffe Paola Ghione Federica Di Maggio Ahmet Dogan Inna Khodos Elisa de Stanchina Joseph Casano Clarisse Kayembe Wayne Tam Doron Betel Robin...
Wed Jun 17, 2020 03:00
Cancers, Vol. 12, Pages 1602: Purine Metabolites in Tumor-Derived Exosomes May Facilitate Immune Escape of Head and Neck Squamous Cell Carcinoma Cancers doi: 10.3390/cancers12061602 Authors: Nils Ludwig Delbert G. Gillespie Torsten E. Reichert Edwin K. Jackson Theresa L. Whiteside Body fluids of patients with head and neck squamous cell carcinoma (HNSCC) are enriched in exosomes that reflect properties of the tumor. The aim of this study was to determine whether purine metabolites...
Wed Jun 17, 2020 03:00
Cancers, Vol. 12, Pages 1599: Whole Exome Sequencing of Multi-Regional Biopsies from Metastatic Lesions to Evaluate Actionable Truncal Mutations Using a Single-Pass Percutaneous Technique Cancers doi: 10.3390/cancers12061599 Authors: Valerie Heong Darwin Tay Shane Ee Goh Bernard Wee Tuan Zea Tan Ross Soo Brendan Pang Diana Lim Anil Gopinathan Samuel Ow Cheng Ean Chee Boon Cher Goh Soo Chin Lee Wei Peng Yong Andrea Wong Mohamed Feroz Mohd Omar Richie...
Wed Jun 17, 2020 03:00
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