Abstract Objective Lasers which can reduce epithelium thickness will enhance the penetration of topical drugs. To date, no study has assessed the efficacy of this technique in the oral mucosa. The aim of this study was the evaluation of efficacy of this technique in increasing the effect of topical anesthesia in the oral mucosa. Materials and methods On 20...
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Abstract Objectives To test the polymerization stress of nine self-adhesive resin composite cements (G-CEM, iCEM, Bifix SE, Maxcem Elite, PANAVIA SA, SoloCem, SmartCem 2, SpeedCEM, RelyX Unicem 2) and one glass ionomer cement (control group; Ketac Cem). Materials and methods The crack propagation of a feldspar ceramic (n = 130) was determined by measuring...
Mon Jun 15, 2020 03:00
Abstract Objectives The absence of bleeding on probing (BOP) is a good predictor of disease stability. This study investigated whether detection of hemoglobin (Hb) in gingival crevicular fluid (GCF) indicates minute signs of periodontal disease, even in BOP (−) cases. Materials and methods GCF was collected from gingival sulci of 152 sound maxillary and mandibular...
Mon Jun 15, 2020 03:00
Abstract Objectives In reconstructive surgery, flap monitoring is crucial for early identification of perfusion problems. Using hyperspectral imaging (HSI), this clinical study aimed to develop a non-invasive, objective approach for perfusion monitoring of free and pedicled flaps. Material and methods HSI of 22 free (FF) and 8 pedicled flaps (PF) in 30 patients...
Mon Jun 15, 2020 03:00
Abstract Objectives This study aimed to survey dentists in Germany to identify their favored materials for the fabrication of tooth-supported single crowns (SCs) depending on the location of the abutment teeth and the preparation margin. Materials and methods The survey included questions regarding demographic characteristics of dentists/their dental practice...
Tue Jun 16, 2020 03:00
Abstract Objectives The aim of this study was to evaluate diagnoses of temporomandibular (TMJ) disc displacement by comparing evaluations done on the basis of central sagittal scans only, the most often used in temporomandibular disorder (TMD) patients, with a multisection evaluation done with both sagittal and coronal scans. Materials and methods Multisection...
Wed Jun 17, 2020 03:00
Abstract Objective Nutraceutical agents have been demonstrated as adjuncts for the treatment of several inflammatory diseases. The present study analyzed and compared new nutraceutical agent as an adjunct to Scaling and root planing (SRP) versus SRP alone for the treatment of periodontitis. Materials and methods Sixty-six patients with moderate periodontitis...
Wed Jun 17, 2020 03:00
Abstract Objective This study evaluates whether endodontic cavity access into molars influences the chemomechanical preparation of curved root canals. Materials and methods Twenty mesiobuccal canals of maxillary molars were randomly divided into two experimental groups (n = 10), according to the type of endodontic access analyzed (conventional and minimally...
Tue Jun 16, 2020 03:00
Abstract Objectives Currently, procedural sedation in the clinical setting relies heavily on the use of pulse oximetry to monitor hypoxemia. Different studies suggest that incidence of hypoxemia and incidence of arterial oxygen desaturation are reduced by early intervention via capnography monitoring. The aim of this article was to discuss the importance of implementing capnography monitoring during procedural sedations performed in a...
Tue Jun 16, 2020 03:00
High Altitude Medicine &Biology, Ahead of Print.
Tue Jun 16, 2020 10:00
High Altitude Medicine &Biology, Ahead of Print.
Tue Jun 16, 2020 10:00
LaryngorhinootologieDOI: 10.1055/a-1190-4907Gemäß der S2k-Leitlinie „Gastroösophageale Refluxkrankheit (engl. GERD)“ von 05/2014 wird bei der extraösophagealen GERD-Manifestation (z. B. mit Ausbildung eines Kontaktgranuloms, KG) eine empirische Protonenpumpeninhibitor (PPI)-Therapie in doppelter Standarddosis (z. B. Pantoprazol 40 mg 2-mal/Tag) über 8 Wochen angeraten. Valide Studiendaten existieren hierzu jedoch nicht.Im Rahmen einer prospektiven Studie von 05/2015–12/2019 erhielten 39 Patienten...
Wed Jun 17, 2020 02:00
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British Journal of Cancer, Published online: 18 June 2020; doi:10.1038/s41416-020-0900-0Clinical and pathological associations of PTEN expression in ovarian cancer: a multicentre study from the Ovarian Tumour Tissue Analysis Consortium
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British Journal of Cancer, Published online: 18 June 2020; doi:10.1038/s41416-020-0919-2Concurrent chemo-radiotherapy with proton therapy: reduced toxicity with comparable oncological outcomes vs photon chemo-radiotherapy
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British Journal of Cancer, Published online: 17 June 2020; doi:10.1038/s41416-020-0946-zCorrection: Association between the National Cancer Screening Programme (NSCP) for gastric cancer and oesophageal cancer mortality
Wed Jun 17, 2020 03:00
Wed Jun 17, 2020 03:00
Related ArticlesTubeimoside I induces autophagy in HepG2 cells by activating the AMP-activated protein kinase signaling pathway. Oncol Lett. 2020 Jul;20(1):623-630 Authors: Ruan C, You L, Qiu Y, Cui X, Wu D Abstract Tubeimoside I (TBMS) is a natural compound with antitumor properties. However, the detailed mechanism underlying the function of TBMS in liver cancer has not been fully elucidated. In the present study, TBMS was shown to suppress cell proliferation...
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Related ArticlesSPAG6 silencing induces autophagic cell death in SKM-1 cells via the AMPK/mTOR/ULK1 signaling pathway. Oncol Lett. 2020 Jul;20(1):551-560 Authors: Zhang M, Luo J, Luo X, Liu L Abstract As a member of the cancer-testis antigen family, sperm-associated antigen 6 (SPAG6) has been reported to be associated with the pathogenesis of myelodysplastic syndromes (MDS). Previous studies have demonstrated that SPAG6 is upregulated in bone marrow...
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Related ArticlesEnsemble classification for predicting the malignancy level of pulmonary nodules on chest computed tomography images. Oncol Lett. 2020 Jul;20(1):401-408 Authors: Xiao N, Qiang Y, Zia MB, Wang S, Lian J Abstract Early identification and classification of pulmonary nodules are essential for improving the survival rates of individuals with lung cancer and are considered to be key requirements for computer-assisted diagnosis. To address...
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Related ArticlesCombination treatment of gemcitabine and sorafenib exerts a synergistic inhibitory effect on non-small cell lung cancer in vitro and in vivo via the epithelial-to-mesenchymal transition process. Oncol Lett. 2020 Jul;20(1):346-356 Authors: Jiang S, Wang R, Zhang X, Wu F, Li S, Yuan Y Abstract Standard chemotherapy is commonly used in clinical practice for the treatment of non-small cell lung cancer (NSCLC). However, its therapeutic efficacy...
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Related ArticlesIdentification of genes associated with gastric cancer survival and construction of a nomogram to improve risk stratification for patients with gastric cancer. Oncol Lett. 2020 Jul;20(1):215-225 Authors: Ding Y, Chen Y, Wu M, Li L, Huang Y, Wang H, Wang H, Yu X, Xu N, Teng L Abstract The present study aimed to identify genes associated with gastric cancer survival and improve risk stratification for patients with gastric cancer. Transcriptomic...
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Related ArticlesLeveraging methylation to identify the potential causal genes associated with survival in lung adenocarcinoma and lung squamous cell carcinoma. Oncol Lett. 2020 Jul;20(1):193-200 Authors: Liu L, Zeng P, Yang S, Yuan Z Abstract Understanding the different genetic landscape between lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) is important for understanding the underlying molecular mechanism, which may facilitate the...
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Facial Plast Surg 2020; 36: 305-308DOI: 10.1055/s-0040-1713117Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents | Full text
Wed Jun 17, 2020 02:00
Facial Plast Surg 2020; 36: 317-328DOI: 10.1055/s-0040-1712473This article discusses the periocular anatomy region thoroughly because its knowledge in detail is of paramount importance for any surgeon dedicated to periocular surgery or any practitioner who dedicate their practice to aesthetic medicine. Mastering the anatomical details permits obtaining consistently good results with the minimal amount of complications possible.[...]Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001,...
Wed Jun 17, 2020 02:00
Facial Plast Surg 2020; 36: 297-304DOI: 10.1055/s-0040-1713116Restoration of the inner nasal lining is an essential factor in successful nasal reconstruction. Among various methods, free full-thickness skin grafting represents a readily available and feasible technique. A prerequisite for success is a secure and immobile fixation to the undersurface of the nourishing forehead flap. This retrospective study aims to evaluate the results of multiple quilting sutures to secure free full-thickness skin...
Wed Jun 17, 2020 02:00
Facial Plast Surg 2020; 36: 309-316DOI: 10.1055/s-0040-1712472Preservation of the facial nerve is crucial in any type of facial procedure. This is even more important when performing plastic surgery on the face. An intricate knowledge of the course of the facial nerve is a requisite prior to performing facelifts, regardless of the technique used. The complex relationship of the ligaments and the facial nerve may put the nerve at an increased risk of damage, especially if its anatomy is not fully...
Wed Jun 17, 2020 02:00
Facial Plast Surg 2020; 36: 329-334DOI: 10.1055/s-0040-1712538Dorsal preservation rhinoplasty in cases of a convex or overprojected noses has significant advantages over resection and reconstruction of the dorsum. Analysis of the subdorsal septum in relation to the radix osteotomy to achieve a drop or hinge of the natural dorsum is important in avoiding possible complications involving the skull base, frontal sinus, and subsequent radix position. In the majority of patients, simple cut release of...
Wed Jun 17, 2020 02:00
Facial Plast Surg 2020; 36: 215-216DOI: 10.1055/s-0040-1712540Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents | Full text
Wed Jun 17, 2020 02:00
Abstract The host innate immune response stands at the first line of defense against the outburst of pathogen invasion and their byproduct release. The balanced and coordinated expression of genes in normal immune responses is compromised in the progress of endotoxemia with exacerbated inflammation and massive cell death. In the present study, we identified cyclin-dependent kinase 9 (CDK9), the functional subunit of the positive transcription...
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Abstract The liver is one of the most vulnerable organs during sepsis. Current studies have proven that microRNAs play important roles in injury and inflammation. The current study aimed to investigate the role of miR-103 in septic liver injury. The sepsis model was established by cecal ligation and puncture in mice. Then, the mice were divided into four groups: normal group, sepsis group, sepsis + miR-103a-3p agomir group, and sepsis...
Wed Jun 17, 2020 03:00
Human T cells are often subdivided into distinct subtypes, including Th1, Th2, Th17 and Treg cells, that are thought to carry out distinct functions in the body. Typically, T cell subpopulations are defined by the expression of distinct gene repertoires; however, there is variability between studies regarding the methods used for isolation and the markers used to define each T cell subtype. Therefore, how reliably studies can be compared to one another remains an open question. Moreover, previous...
Wed Jun 17, 2020 19:40
Metazoan replication-dependent histone pre-mRNAs are cleaved at the 3’ end by U7 snRNP, an RNA-guided endonuclease that contains U7 snRNA, seven proteins of the Sm ring, FLASH and four polyadenylation factors: symplekin, CPSF73, CPSF100 and CstF64. A fully recombinant U7 snRNP was recently reconstituted from all 13 components for functional and structural studies and shown to accurately cleave histone pre-mRNAs. Here, we analyzed the activity of recombinant U7 snRNP in more detail. We demonstrate...
Wed Jun 17, 2020 17:36
AbstractThe global pandemic of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 remains a challenge for prevention due to asymptomatic or paucisymptomatic patients. Anecdotal and preliminary evidence from multiple institutions shows that these patients present with a sudden onset of anosmia without rhinitis. We aim to review the pathophysiology of anosmia related to viral upper respiratory infections and the prognostic implications. Current evidence suggests that SARS-CoV-2-related anosmia...
Wed Jun 17, 2020 03:00
Insulin/insulin-like growth factor signaling (IIS) is a conserved mechanism to regulate animal physiology in response to nutrition. IIS activity controls gene expression, but only a subset of transcriptional regulators (TRs) targeted by the IIS pathway is currently known. Here we report the results of an unbiased screen for Drosophila TRs phosphorylated in an IIS-dependent manner. To conduct the screen, we built a library of 857 V5/Strep-tagged TRs under the control of Copper-inducible metallothionein...
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Radiation therapy (RT) is highly effective due to its ability to physically focus the treatment to target the tumor while sparing normal tissue and its ability to be combined with systemic therapy. This systemic therapy can be utilized before RT as an adjuvant or induction treatment, during RT as a radiation "sensitizer," or following RT as a part of combined modality therapy. As part of a unique concept of using radiation as "focused biology" we investigated how tumors and normal tissues adapt...
Wed Jun 17, 2020 16:35
Purpose: Gene-expression-based molecular subtypes of high-grade serous tubo-ovarian cancer (HGSOC), demonstrated across multiple studies, may provide improved stratification for molecularly targeted trials. However, evaluation of clinical utility has been hindered by non-standardized methods which are not applicable in a clinical setting. We sought to generate a clinical-grade minimal gene-set assay for classification of individual tumor specimens into HGSOC subtypes and confirm previously reported...
Wed Jun 17, 2020 16:35
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