Ultraconserved elements (UCEs) are stretches of hundreds of nucleotides with highly conserved cores flanked by variable regions. Although the selective forces responsible for the preservation of UCEs are unknown, they are nonetheless believed to contain phylogenetically meaningful information from deep to shallow divergence events. Phylogenetic applications of UCEs assume selection as being largely invariant across the entire locus, including its variable flanking regions. We present a Wright-Fisher...
Wed Jun 17, 2020 03:00
Molecular analyses of closely related taxa have increasingly revealed the importance of higher-order genetic interactions in explaining the observed pattern of reproductive isolation between populations. Indeed, both empirical and theoretical studies have linked the process of speciation to complex genetic interactions. Gene Regulatory Networks (GRNs) capture the inter-dependencies of gene expression and encode information about an individual's phenotype and development at the molecular level. As...
Wed Jun 17, 2020 03:00
Abstract Emm55 is a bacterial gene derived from Streptococcus pyogenes (S. pyogenes) that was cloned into a plasmid DNA vaccine (pAc/emm55). In this study, we investigated the anti-tumor efficacy of pAc/emm55 in a B16 murine melanoma model. Intralesional (IL) injections of pAc/emm55 significantly delayed tumor growth compared to the pAc/Empty group. There was a significant increase in the CD8+ T cells infiltrating into the tumors after pAc/emm55 treatment compared to the control...
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Future Oncology, Ahead of Print.
Wed Jun 17, 2020 04:29
Neonatal varicella mostly results from maternal varicella. The disease can cause presentation ranging from mild symptoms to varicella pneumonia, hepatitis, meningoencephalitis, or fatality. If the mother develops symptoms implying varicella 4–5 days antepartum to 2 days postpartum, the mortality rate of the baby may reach 20%. We report a case of neonatal varicella from maternal varicella. The patient’s mother initially developed maculopapular rash over her trunk 1 day after giving birth; she had...
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Related ArticlesToxicity of the herbicides used on herbicide-tolerant crops, and societal consequences of their use in France. Drug Chem Toxicol. 2020 Jun 16;:1-24 Authors: Bourdineaud JP Abstract In France, the implementation of mutant herbicide-tolerant crops and the use of the related herbicides - sulfonylureas and imidazolinones - have triggered a strong societal reaction illustrated by the intervening actions of environmentalist groups illegally...
Wed Jun 17, 2020 20:20
Related ArticlesCharacterization and neuroprotective properties of alkaloid extract of Vernonia amygdalina Delile in experimental models of Alzheimer's disease. Drug Chem Toxicol. 2020 Jun 16;:1-10 Authors: Oboh G, Adedayo BC, Adetola MB, Oyeleye IS, Ogunsuyi OB Abstract This study emphasized on the neuroprotective properties of bitter leaf alkaloid-rich extract (BLAE) using transgenic fruit fly (Drosophila melanogaster [D. melanogaster]) model and scopolamine-induced...
Wed Jun 17, 2020 20:20
Related ArticlesCo-drug of isoniazid and sulfur containing antioxidant for attenuation of hepatotoxicity and treatment of tuberculosis. Drug Chem Toxicol. 2020 Jun 16;:1-11 Authors: Bhilare NV, Dhaneshwar SS, Mahadik KR, Dasgupta A Abstract The prolonged use of isoniazid (INH) - a highly effective drug in the treatment of tuberculosis - causes fatal liver injury. In order to overcome this adverse effect, a unique amide codrug was designed by covalently...
Wed Jun 17, 2020 20:20
Related ArticlesTucumã (Astrocaryum aculeatum) extract: phytochemical characterization, acute and subacute oral toxicity studies in Wistar rats. Drug Chem Toxicol. 2020 Jun 14;:1-12 Authors: Guex CG, Cassanego GB, Dornelles RC, Casoti R, Engelmann AM, Somacal S, Maciel RM, Duarte T, Borges WS, Andrade CM, Emanuelli T, Danesi CC, Ribeiro EE, Bauermann LF Abstract Natural products are often used by the population to treat and/or prevent several disorders....
Wed Jun 17, 2020 14:23
Related ArticlesMiconazole and terbinafine induced reactive oxygen species accumulation and topical toxicity in human keratinocytes. Drug Chem Toxicol. 2020 Jun 14;:1-5 Authors: Lam PL, Wong MM, Hung LK, Yung LH, Tang JC, Lam KH, Chung PY, Wong WY, Ho YW, Wong RS, Gambari R, Chui CH Abstract There are an estimated 1 billion cases of superficial fungal infection globally. Fungal pathogens form biofilms within wounds and delay the wound healing process....
Wed Jun 17, 2020 14:23
Related ArticlesThe protective effect of fluted pumpkin seeds against atrazine-induced testicular injury. Drug Chem Toxicol. 2020 Jun 14;:1-11 Authors: Abarikwu SO, Oleribe AL, Mgbudom-Okah CJ, Onuah CL, Chikwendu CS, Onyeike EN Abstract The present study evaluated the protective effect of fluted pumpkin seeds (FPS) on atrazine (ATZ)-induced testicular damage. Twenty adult male Wistar rats were divided into four groups of five animals each. The control...
Wed Jun 17, 2020 14:23
Related ArticlesCyclophosphamide, a cancer chemotherapy drug-induced early onset of reproductive senescence and alterations in reproductive performance and their prevention in mice. Drug Chem Toxicol. 2020 Jun 15;:1-7 Authors: Athira VR, Shivanandappa T, Yajurvedi HN Abstract Although, cyclophosphamide (CP) treatment is known to cause degeneration of the ovarian follicular reserve, which may have a serious consequence of the onset of early reproductive...
Wed Jun 17, 2020 14:23
Publication date: Available online 16 June 2020Source: Reports of Practical Oncology & RadiotherapyAuthor(s): Federico Maldonado Magos, Francisco Javier Lozano Ruiz, Sandra Ileana Pérez Álvarez, Onix Garay Villar, Cesar Cárdenas Pérez, María Yicel Bautista, Gabriela Núñez Guardado
Wed Jun 17, 2020 14:22
Publication date: Available online 16 June 2020Source: American Journal of OtolaryngologyAuthor(s): Luke J. Pasick, Jane Y. Tong, Daniel A. Benito, Punam Thakkar, Joseph F. Goodman, Arjun S. Joshi
Wed Jun 17, 2020 14:21
Related ArticlesTargeting Autophagy In Disease: Recent Advances In Drug Discovery. Expert Opin Drug Discov. 2020 Jun 16;:1-19 Authors: Kim D, Hwang HY, Kwon HJ Abstract INTRODUCTION: Small molecules targeting autophagy have been highly implicated as new therapeutic agents to treat diseases of interest. With the increasing demand for autophagy-targeting drugs, this review attempts to provide an efficient strategy to explore major autophagy-based human...
Wed Jun 17, 2020 18:22
Related ArticlesWhy do SARS-COV vaccines not exist? The pharma scientific intelligence and business model must be revisited! Expert Opin Drug Discov. 2020 Jun 16;:1-3 Authors: Boudjelal M, Nehdi A, Islam I PMID: 32543297 [PubMed - as supplied by publisher]
Wed Jun 17, 2020 18:22
Related ArticlesPeptide-based targeting of connexins and pannexins for therapeutic purposes. Expert Opin Drug Discov. 2020 Jun 15;:1-10 Authors: Caufriez A, Böck D, Martin C, Ballet S, Vinken M Abstract INTRODUCTION: Connexin and pannexin (hemi)channels play an important role in paracrine and autocrine signaling pathways. The opening of these cellular pores is linked to a wide range of diseases. Therefore, pharmacological closing of connexin and pannexin...
Wed Jun 17, 2020 18:22
Related ArticlesParallel Processing of Sound Dynamics across Mouse Auditory Cortex via Spatially Patterned Thalamic Inputs and Distinct Areal Intracortical Circuits. Cell Rep. 2019 04 16;27(3):872-885.e7 Authors: Liu J, Whiteway MR, Sheikhattar A, Butts DA, Babadi B, Kanold PO Abstract Natural sounds have rich spectrotemporal dynamics. Spectral information is spatially represented in the auditory cortex (ACX) via large-scale maps. However, the representation...
Wed Jun 17, 2020 14:19
Related ArticlesAerosolization During Common Ventilation Scenarios. Otolaryngol Head Neck Surg. 2020 Jun 16;:194599820933595 Authors: Xiao R, Workman AD, Puka E, Juang J, Naunheim MR, Song PC Abstract Otolaryngologists are at increased risk for exposure to suspected aerosol-generating procedures during the ongoing coronavirus disease 2019 (COVID-19) pandemic. In the present study, we sought to quantify differences in aerosol generation during common...
Wed Jun 17, 2020 20:16
Related ArticlesAuthor Reply to: "Comment on 'The Prevalence of Olfactory and Gustatory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis'". Otolaryngol Head Neck Surg. 2020 Jun 16;:194599820934760 Authors: Tong JY, Wong A, Zhu D, Fastenberg JH, Tham T PMID: 32539660 [PubMed - as supplied by publisher]
Wed Jun 17, 2020 20:16
Related ArticlesLong-Term Otitis Media Outcomes in Infants With Early Tympanostomy Tubes. Otolaryngol Head Neck Surg. 2020 Jun 16;:194599820931414 Authors: Luu K, Park J, Shaffer AD, Chi DH Abstract OBJECTIVE: To review the otologic outcomes of infants who failed the newborn hearing screen (NBHS) and received early tympanostomy tubes for otitis media with effusion (OME). STUDY DESIGN: Retrospective case series. SETTING: Tertiary...
Wed Jun 17, 2020 20:16
Related ArticlesDouble-Layered (Cartilage Island + Extra Perichondrium) Graft for Type 1 Tympanoplasty. Otolaryngol Head Neck Surg. 2020 Jun 16;:194599820931400 Authors: Ismi O, Gorur K, Gur H, Ozcan C, Vayisoglu Y Abstract OBJECTIVE: To compare the graft success rates and hearing results of single-layered (composite island) grafting (SLG) vs double-layered (composite plus second layer of perichondrium) grafting (DLG) for over-under type 1 tympanoplasty...
Wed Jun 17, 2020 20:16
Related ArticlesOlfactory and Oral Manifestations of COVID-19: Sex-Related Symptoms-A Potential Pathway to Early Diagnosis. Otolaryngol Head Neck Surg. 2020 Jun 16;:194599820934380 Authors: Biadsee A, Biadsee A, Kassem F, Dagan O, Masarwa S, Ormianer Z Abstract OBJECTIVE: The coronavirus disease 2019 (COVID-19) pandemic poses a threat to global health. Early diagnosis is an essential key to limit the outbreak of the virus. STUDY DESIGN:...
Wed Jun 17, 2020 20:16
Related ArticlesOlfactory and Gustatory Dysfunction as an Early Identifier of COVID-19 in Adults and Children: An International Multicenter Study. Otolaryngol Head Neck Surg. 2020 Jun 16;:194599820934376 Authors: Qiu C, Cui C, Hautefort C, Haehner A, Zhao J, Yao Q, Zeng H, Nisenbaum EJ, Liu L, Zhao Y, Zhang D, Levine CG, Cejas I, Dai Q, Zeng M, Herman P, Jourdaine C, de With K, Draf J, Chen B, Jayaweera DT, Denneny JC, Casiano R, Yu H, Eshraghi AA, Hummel T, Liu X,...
Wed Jun 17, 2020 20:16
Related ArticlesCharacteristics and Frequency of Children With Severe Obstructive Sleep Apnea Undergoing Elective Polysomnography. Otolaryngol Head Neck Surg. 2020 Jun 16;:194599820931084 Authors: Bains A, Abraham E, Hsieh A, Rubin BR, Levi JR, Cohen MB Abstract OBJECTIVE: To determine the prevalence and demographics features of pediatric patients with severe obstructive sleep apnea (OSA) who would not undergo preoperative polysomnography (PSG) under...
Wed Jun 17, 2020 20:16
Related ArticlesAssessing National Utilization Trends and Outcomes of Robotic and Endoscopic Thyroidectomy in the United States. Otolaryngol Head Neck Surg. 2020 Jun 16;:194599820927699 Authors: Jacobs D, Torabi SJ, Gibson C, Rahmati R, Mehra S, Judson BL Abstract OBJECTIVE: We aimed to evaluate trends and outcomes of surgical approaches to thyroid surgery. We hypothesized that there have been changes over time in the utilization of approaches to...
Wed Jun 17, 2020 20:16
Related ArticlesNatural History and Consequences of Nonunion in Mandibular and Maxillary Free Flaps. Otolaryngol Head Neck Surg. 2020 Jun 16;:194599820931069 Authors: Swendseid B, Kumar A, Sweeny L, Zhan T, Goldman RA, Krein H, Heffelfinger RN, Luginbuhl AJ, Curry JM Abstract OBJECTIVE: To describe the natural history of bone segment union in head and neck free flap procedures and detail the association of poor segment union with postoperative complications....
Wed Jun 17, 2020 20:16
Related ArticlesIntranasal Corticosteroid Therapy: Systematic Review and Meta-analysis of Reported Safety and Adverse Effects in Adults. Otolaryngol Head Neck Surg. 2020 Jun 16;:194599820931455 Authors: Donaldson AM, Choby G, Kim DH, Marks LA, Lal D Abstract OBJECTIVES: To address concerns related to the safety profile of both Food and Drug Administration (FDA)-approved and non-FDA-approved intranasal corticosteroid (INCS) use in the adult population....
Wed Jun 17, 2020 20:16
Related ArticlesPostmortem investigation of a human cortical visual prosthesis that was implanted for 36 years. J Neural Eng. 2020 Jun 15;: Authors: Towle V, Pytel P, Lane F, Plass J, Frim DM, Troyk PR Abstract Postmortem analysis of the brain from a blind human subject that had a cortical visual prosthesis implanted for 36 years (Dobelle, 2000) provides insight into the optimal design characteristics of a successful human cortical visual prosthesis,...
Wed Jun 17, 2020 18:15
Related ArticlesIn Vitro Expansion of Corneal Endothelial Cells for Transplantation. Methods Mol Biol. 2020;2145:17-27 Authors: Santerre K, Xu I, Thériault M, Proulx S Abstract The corneal endothelium forms a leaky barrier between the corneal stroma and the aqueous humor of the anterior chamber. This cell monolayer maintains the corneal stroma in a state of relative dehydration, a process called deturgescence, which is required in order to obtain corneal...
Wed Jun 17, 2020 20:12
Related ArticlesPentosan polysulfate sodium-induced pigmentary maculopathy with non-leaking cystoid macular edema successfully treated with anti-VEGF therapy. Retin Cases Brief Rep. 2020 Jun 05;: Authors: De Larochellière E, Bourgault S Abstract PURPOSE: To report a case of non-leaking cystoid macular edema (CME) associated with pentosan polysulfate sodium (PPS)-induced pigmentary maculopathy. METHODS: Multimodal imaging, including optical coherence...
Wed Jun 17, 2020 20:12
Related ArticlesComparing serum protein levels can aid in differentiating HPV-negative and -positive oropharyngeal squamous cell carcinoma patients. PLoS One. 2020;15(6):e0233974 Authors: Dickinson A, Saraswat M, Syrjänen S, Tohmola T, Silén R, Randén-Brady R, Carpén T, Hagström J, Haglund C, Mattila P, Mäkitie A, Joenväärä S, Silén S Abstract BACKGROUND: The surrogate immunohistochemical marker, p16INK4a, is used in clinical practice to determine the...
Wed Jun 17, 2020 18:14
Related ArticlesP2Y2 receptors mediate nucleotide-induced EGFR phosphorylation and stimulate proliferation and tumorigenesis of head and neck squamous cell carcinoma cell lines. Oral Oncol. 2020 Jun 12;109:104808 Authors: Woods LT, Jasmer KJ, Muñoz Forti K, Shanbhag VC, Camden JM, Erb L, Petris MJ, Weisman GA Abstract OBJECTIVES: To assess functional expression of the P2Y2 nucleotide receptor (P2Y2R) in head and neck squamous cell carcinoma (HNSCC) cell...
Wed Jun 17, 2020 18:14
Related ArticlesThe knockdown of SNHG3 inhibits the progression of laryngeal squamous cell carcinoma by miR-340-5p/YAP1 axis and Wnt/β-catenin pathway. Neoplasma. 2020 Jun 16;: Authors: Kang R, Yao DF, Xu GZ, Zhou YH Abstract Laryngeal squamous cell carcinoma (LSCC) is a common malignancy of the head and neck. Long noncoding RNAs (lncRNAs) play essential roles in the development and treatment of LSCC. However, the role and regulatory mechanism of lncRNA...
Wed Jun 17, 2020 14:09
Related ArticlesNew Medical Device and Therapeutic Approvals in Otolaryngology: State of the Art Review of 2019. OTO Open. 2020 Apr-Jun;4(2):2473974X20932506 Authors: Rameau A, Hong RS, Djalilian H, Erbele ID, Phillips KM, Capasso R, Rose AS, Brenner MJ, Santa Maria PL Abstract Objective: To review new devices and drugs relevant to otolaryngology-head and neck surgery that were approved by the US Food and Drug Administration (FDA) in 2019. ...
Wed Jun 17, 2020 14:09
Related ArticlesA Concentric Tube Robot System for Rigid Bronchoscopy: A Feasibility Study on Central Airway Obstruction Removal. Ann Biomed Eng. 2020 Jan;48(1):181-191 Authors: Gafford JB, Webster S, Dillon N, Blum E, Hendrick R, Maldonado F, Gillaspie EA, Rickman OB, Herrell SD, Webster RJ Abstract New robotic systems have recently emerged to assist with peripheral lung access, but a robotic system for rigid bronchoscopy has yet to be developed. We...
Wed Jun 17, 2020 14:09
Related ArticlesLiquid-type non-thermal atmospheric plasma ameliorates vocal fold scarring by modulating vocal fold fibroblast. Exp Biol Med (Maywood). 2019 07;244(10):824-833 Authors: Won HR, Song EH, Won JE, Lee HY, Kang SU, Shin YS, Kim CH PMID: 31088117 [PubMed - indexed for MEDLINE]
Wed Jun 17, 2020 14:09
Publication date: August 2020Source: Cancer Epidemiology, Volume 67Author(s): Derrick C. Gibson, John D. Prochaska, Xiaoying Yu, Sapna Kaul
Wed Jun 17, 2020 14:09
Publication date: August 2020Source: Cancer Epidemiology, Volume 67Author(s): Wasil Jastaniah, Mohammed F. Essa, Walid Ballourah, Ibrahim Abosoudah, Saad Al Daama, Ali H. Algiraigri, Ibrahim Al Ghemlas, Mohammad Alshahrani, Abdulrahman Alsultan
Wed Jun 17, 2020 14:09
Publication date: August 2020Source: Cancer Epidemiology, Volume 67Author(s): Abram Bunya Kamiza, Steve Kamiza, Christopher George Mathew
Wed Jun 17, 2020 14:09
Related ArticlesPerfusion-driven Intravoxel Incoherent Motion (IVIM) MRI in Oncology: Applications, Challenges, and Future Trends. Magn Reson Med Sci. 2020 Jun 15;: Authors: Iima M Abstract Recent developments in MR hardware and software have allowed a surge of interest in intravoxel incoherent motion (IVIM) MRI in oncology. Beyond diffusion-weighted imaging (and the standard apparent diffusion coefficient mapping most commonly used clinically), IVIM...
Wed Jun 17, 2020 14:28
Related ArticlesMetastasis-directed Therapy Prolongs Efficacy of Systemic Therapy and Improves Clinical Outcomes in Oligoprogressive Castration-resistant Prostate Cancer. Eur Urol Oncol. 2020 Jun 11;: Authors: Deek MP, Taparra K, Phillips R, Velho PI, Gao RW, Deville C, Song DY, Greco S, Carducci M, Eisenberger M, DeWeese TL, Denmeade S, Pienta K, Paller CJ, Antonarakis ES, Olivier KR, Park SS, Tran PT, Stish BJ Abstract BACKGROUND: Available therapies...
Wed Jun 17, 2020 14:28
Related ArticlesFeasibility, Acceptability, and Clinical Implementation of an Immersive Virtual Reality Intervention to Address Psychological Well-Being in Children and Adolescents With Cancer. J Pediatr Oncol Nurs. 2020 Jul/Aug;37(4):265-277 Authors: Tennant M, McGillivray J, Youssef GJ, McCarthy MC, Clark TJ Abstract Objective: Virtual reality (VR), a novel and highly immersive technology, offers promise in addressing potential psychological impacts...
Wed Jun 17, 2020 14:28
Related ArticlesTechnologies for circulating tumor cell separation from whole blood. J Hematol Oncol. 2019 05 14;12(1):48 Authors: Bankó P, Lee SY, Nagygyörgy V, Zrínyi M, Chae CH, Cho DH, Telekes A Abstract The importance of early cancer diagnosis and improved cancer therapy has been clear for years and has initiated worldwide research towards new possibilities in the care strategy of patients with cancer using technological innovations. One of the...
Wed Jun 17, 2020 14:28
Related ArticlesParaffin Immunofluorescence Increases Light-Chain Detection in Extra-Renal Light Chain Amyloidosis and Other Light-Chain-Associated Diseases. Arch Pathol Lab Med. 2020 Jun 15;: Authors: Gibier JB, Perbet R, Lopez B, Colombat M, Dubois R, Humez S, Terriou L, Copin MC, Gnemmi V Abstract CONTEXT.—: Distinguishing the different types of amyloid is clinically important, because treatments and outcomes are different. Mass spectrometry is the...
Wed Jun 17, 2020 14:27
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