Related ArticlesTRPA1 Channel Activation Inhibits Motor Activity in the Mouse Colon. Front Neurosci. 2020;14:471 Authors: Hassan AA, Sleet B, Cousins Z, Keating CD Abstract There is a growing awareness of the role that TRP channels play in regulating sensory and motor functions in the gastrointestinal tract. In this study we used an in-vitro murine model of colonic peristaltic-like complexes (CPMCs) to evaluate the role of exogenous and endogenous TRPA1...
Wed Jun 17, 2020 13:12
Related ArticlesFunctional Segregation of the Middle Temporal Visual Motion Area Revealed With Coactivation-Based Parcellation. Front Neurosci. 2020;14:427 Authors: Gao J, Zeng M, Dai X, Yang X, Yu H, Chen K, Hu Q, Xu J, Cheng B, Wang J Abstract Traditionally, the visual motion area (MT) is considered as a brain region specialized for visual motion perception. However, accumulating evidence showed that MT is also related to various functions, suggesting...
Wed Jun 17, 2020 13:12
Related ArticlesCurrent and potential pharmacological treatment options for insomnia in patients with alcohol use disorder in recovery. Neuropsychopharmacol Rep. 2020 Jun 15;: Authors: Roehrs TA, Auciello J, Tseng J, Whiteside G Abstract Alcohol use disorder (AUD) is characterized by dysfunction in motivational, mood-stress regulation, and sleep systems that interact in complex ways to heighten the risk of relapse during abstinence. Emerging data suggest...
Wed Jun 17, 2020 17:04
Related ArticlesA Case of Hypoglycemia Associated With the Ketogenic Diet and Alcohol Use. J Endocr Soc. 2020 Jun 01;4(6):bvaa045 Authors: Spoke C, Malaeb S Abstract The ketogenic diet, which has become an increasingly popular diet, severely restricts carbohydrate intake to shunt metabolism towards fatty acid oxidation and production of ketones as a fuel source. There have been many studies illustrating the positive effects of a ketogenic diet in weight...
Wed Jun 17, 2020 13:04
Related ArticlesFunctional implications of pH-induced conformational changes in the Sphingosine kinase 1. Spectrochim Acta A Mol Biomol Spectrosc. 2020 Jan 15;225:117453 Authors: Gupta P, Khan FI, Roy S, Anwar S, Dahiya R, Alajmi MF, Hussain A, Rehman MT, Lai D, Hassan MI Abstract Sphingosine kinase 1 (SphK1) catalyzes the conversion of sphingosine to sphingosine-1-phosphate that acts as a bioactive signalling molecule, and regulates various cellular...
Wed Jun 17, 2020 13:04
Related ArticlesThe Biosynthesis of Flavin Cofactors in Listeria monocytogenes. J Mol Biol. 2019 07 12;431(15):2762-2776 Authors: Sebastián M, Arilla-Luna S, Bellalou J, Yruela I, Medina M Abstract Listeria monocytogenes is riboflavin auxotrophic, but it has two genes envisaged to transform riboflavin into FMN and FAD after its uptaked by specialized transporters. One encodes a bifunctional type I FAD synthase (FADS, herein LmFADS-1), while the other...
Wed Jun 17, 2020 13:04
Background The current body of knowledge shows that there is very little research into the occurrence and scale of asymmetry or postural defects in table tennis. It is interesting which regions of the spine are exposed to the greatest changes in the shape of its curvatures and whether the asymmetrical position of the shoulder and pelvic girdles in table tennis players changes when adopting the ready position. Consequently, can overload occur in certain parts of the spine and can the asymmetry deepen...
Wed Jun 17, 2020 03:00
Background Visual processing of food plays an important role in controlling eating behaviors. Several studies have developed image databases of food to investigate visual food processing. However, few databases include non-Western foods and objective nutrition information on the foods. Methods We developed an image database of Japanese food samples that has detailed nutrition information, including calorie, carbohydrate, fat and protein contents. To validate the database, we presented...
Wed Jun 17, 2020 03:00
Grazing, one of the primary utilization modes of grassland, is the main cause of grassland degradation. Historical overgrazing results in dwarf phenotype and decreased photosynthesis of perennial plants. However, it remains unknown what the mechanism underlying of this legacy effect is, and the role of stomata in the resulting decreased photosynthesis also remains unclear. To address these questions, differences in stomatal density, length and width on both adaxial and abaxial epidermis were compared...
Wed Jun 17, 2020 03:00
Coronavirus disease 2019 has become a worldwide pandemic. By April 7, 2020, approximately 1,279,722 confirmed cases were reported worldwide including those in Asia, European Region, African Region and Region of the Americas. Rapid and accurate detection of Severe Acute Respiratory Syndrome Virus 2 (SARS-CoV-2) is critical for patient care and implementing public health measures to control the spread of infection. In this study, we developed and validated a rapid total nucleic acid extraction method...
Wed Jun 17, 2020 03:00
Reduction of the greenhouse effect is primarily associated with the reduction of greenhouse gas (GHG) emissions. Carbon dioxide (CO2) is one of the gases that increases the greenhouse effect - it is responsible for about half of the greenhouse effect. Significant sources of CO2 are wastewater treatment plants (WWTPs) and waste management, with about 3% contribution to global emissions. CO2 is produced mainly in the aerobic stage of wastewater purification and is a consequence of activated sludge...
Wed Jun 17, 2020 03:00
Given their complexity, targeted care and management of different areas and tree species are necessary for enhancing the natural regeneration of forests. Thus, an understanding of changes in the overstory and understory is essential for ensuring successful regeneration. Promoting the natural regeneration of Larix principis-rupprechtii plantations is considered challenging; indeed, regional sustainable development through natural regeneration of many stands has often been considered unattainable....
Wed Jun 17, 2020 03:00
Noise induced hearing loss (NIHL) is accompanied by a reduction of cochlear hair cells and spiral ganglion neurons. Different approaches have been applied to prevent noise induced apoptosis / necrosis. Physical intervention is one technique currently under investigation. Specific wavelengths within the near-infrared light (NIR)-spectrum are known to influence cytochrome-c-oxidase activity, which leads in turn to a decrease in apoptotic mechanisms. It has been shown recently that NIR can significantly...
Wed Jun 17, 2020 03:00
Background Increasing bodies of evidence reveal that targeting a programmed cell death protein 1 (PD-1) monoclonal antibody is a promising immunotherapy for lung adenocarcinoma. Although PD receptor ligand 1 (PDL1) expression is widely recognized as the most powerful predictive biomarker for anti-PD-1 therapy, its regulatory mechanisms in lung adenocarcinoma remain unclear. Therefore, we conducted this study to explore differentially expressed genes (DEGs) and elucidate the regulatory...
Wed Jun 17, 2020 03:00
Oral squamous cell carcinoma (OSCC) has always been one of the most aggressive and invasive cancers among oral and maxillofacial malignancies. As the morbidity and mortality of the disease have increased year by year, the search for a promising diagnostic and prognostic biomarker for the disease is becoming increasingly urgent. Tumorous and adjacent tissues were collected from three OSCC sufferers and we obtained 229 differentially expressed genes (DEGs) between tumor and normal tissues via high-throughput...
Wed Jun 17, 2020 03:00
Endophytic fungi have been emerged as fruitful resources for producing structurally fascinating and biologically active secondary metabolites. However, endophytic fungi from medicinal plants of Qinling Mountains–the most important natural climatic boundary between the subtropical and warm temperate zones of China with an astonishingly high level of biodiversity–have rarely been explored as potential sources of novel fungal species and active secondary metabolites. In this study, a total of 371 fungal...
Wed Jun 17, 2020 03:00
Related ArticlesEndoscopic "Quick" Septoplasty in Preservation Rhinoplasty. Ann Plast Surg. 2020 Jun 12;: Authors: DʼAscanio L, Ori M, Finocchi V, Vione N, Capalbo M, Ricci G Abstract BACKGROUND: Preservation rhinoplasty (PR) is revolutionizing rhinoplasty surgery, based on new anatomical studies, advanced tip suture techniques, and refinement of surgical techniques. Septal surgery is a fundamental preparatory stage during PR, especially for the dorsal...
Wed Jun 17, 2020 16:58
Related ArticlesComparison of translabyrinthine and retrosigmoid approach for treating vestibular schwannoma: A meta-analysis. Clin Neurol Neurosurg. 2020 Jun 06;196:105994 Authors: Jun W, Gao YL, Yu HG, Huang QL, Long XQ, Liu GH, Ting X, Zhong XY, Zhou YF Abstract BACKGROUND: To date, the literature directly comparing the translabyrinthine approach and retrosigmoid approach in the operation of patients with vestibular schwannoma was limited. We aimed...
Wed Jun 17, 2020 16:58
Abstract Purpose To identify laypersons’ most preferred tooth shade as a function of observer and patient factors, namely patients’ skin shade and observers’ socio‐demographics. Materials and Methods Two online surveys using computer‐designed perioral images with different shades of the skin and teeth were distributed to participants in Montreal (Canada) and San Francisco (USA). The first survey (n=120) was designed to assess public preferences of tooth shade value, hue and chroma as a...
Tue Jun 16, 2020 21:44
Abstract Purpose To review the primary additive manufacturing (AM) technologies used to fabricate metals in implant dentistry and compare them to conventional casting and subtractive methods. Methods The literature on metal AM technologies was reviewed, and the AM procedures and their current applications in implant dentistry were collated and described. Collection of published articles about metal AM in dental field data sources: MEDLINE, EMBASE, EBSCO, and Web of Science searched. All...
Tue Jun 16, 2020 20:50
Tue Jun 16, 2020 14:19
Tue Jun 16, 2020 20:44
Background and Objectives Chronic wound repair is a major problem in wound treatment. Recently, several studies have suggested that carbon dioxide (CO2) laser can be used to improve the healing of chronic wounds. The aim of the present study was to preliminarily investigate the efficacy of laser debridement in treating chronic wound through a comparison of traditional instrument/surgical debridement with the ultrapulsed CO2 laser debridement in terms of wound healing, wound infection control, and...
Tue Jun 16, 2020 18:59
Thyroid fine‐needle aspiration cytology (FNA) and histopathology can be subjective areas of medical diagnosis and subject to different interpretations. On the basis of the authors' personal experience, 12 recommendations with potential to improve clinical decision making, ensure quality, and reduce diagnostic error in thyroid FNAC and histopathology are presented. 1) use a standardized reporting terminology for thyroid FNAC; 2) understand and explain to service users the limitations of cytology and...
Tue Jun 16, 2020 15:49
Tue Jun 16, 2020 15:34
New England Journal of Medicine, Ahead of Print.
Tue Jun 16, 2020 07:00
Facial expressions are important for intentional display of emotions in social interaction. For people with severe paralysis, the ability to intentionally display emotions can be impaired. Current brain‐computer interfaces (BCIs) allow for linguistic communication but are cumbersome for expressing emotions. Here, we investigated the feasibility of a BCI to display emotions by decoding facial expressions. We used electrocorticographic recordings from the sensorimotor cortex of people with refractory...
Wed Jun 17, 2020 11:45
The formation of discrete macrocycles wrapped around single‐walled carbon nanotubes (SWCNTs) has recently emerged as an appealing strategy to functionalize these carbon nanomaterials and modify their properties. Here, we demonstrate that the reversible disulfide exchange reaction, which proceeds under mild conditions, is ideally suited to install relatively large amounts of mechanically interlocked disulfide macrocycles on the one‐dimensional nanotubes. Presumably as a result of error‐correction...
Tue Jun 16, 2020 22:00
Copper‐catalyzed borylative multicomponent reactions (MCRs) involving olefins and C–N electrophiles are a powerful tool to rapidly build up molecular complexity. The products from these reactions contain multiple functionalities, such as amino, cyano and boronate groups, that are ubiquitous in medicinal and process chemistry programs. Copper‐catalyzed MCRs are particularly attractive because they use a relatively abundant and non‐toxic catalyst to selectively deliver high‐value products from simple...
Tue Jun 16, 2020 20:29
Modification of the external surfaces of metal organic frameworks offers a new level of control over their adsorption behavior. We have previously shown that capping of MOFs with ethylenediamine (EDA) can effectively retain small gaseous molecules [Nat. Comm. 2016, 7, 13871] at room temperature. Here, we report a temperature‐induced variation in the capping‐layer gate opening mechanism through a combination of in situ IR experiments and ab initio simulations of the capping layer. We find an atypical...
Tue Jun 16, 2020 18:53
The shape and size of self‐assembled structures upon local organization of their molecular building blocks are hard to predict in the presence of long‐range interactions. Combining small‐angle X‐ray/neutron scattering data, theoretical modelling, and com‐ puter simulations, we investigate sodium dodecyl sulfate (SDS) in a broad range of concentrations and ionic strengths. Computer simulations indicate that micellar shape changes are associated with different binding of the counterions. Employing...
Tue Jun 16, 2020 18:32
The smart self‐protection is essential to avoid the safety issue of energy storage devices. However, conventional strategies based on sol‐gel transition electrolytes often suffer from unstable self‐recovery performance. Herein, smart separators based on thermal‐gated poly(N‐isopropylacrylamide) (PNIPAM) hydrogel electrolytes were developed for rechargeable zinc‐ion batteries (ZIBs). Such PNIPAM‐based separators not only display a pore structure evolution from opened to closed state, but also exhibit...
Tue Jun 16, 2020 17:23
Herein, we report the synthesis of specific silica supported Co/Co3O4 core‐shell based nanoparticles prepared by template synthesis of cobalt‐pyromellitic acid on silica and subsequent pyrolysis. The optimal catalyst material allows for general and selective hydrogenation of pyridines, quinolines and other heteroarenes including acridine, phenanthroline, naphthyridine, quinoxaline, imidazo[1,2‐a]pyridine, and indole under comparably mild reaction conditions. In addition, recycling of these Co‐nanoparticles...
Tue Jun 16, 2020 16:59
We report an Umpolung strategy of enol ethers to generate oxy‐allyl cation equivalents based on the use of hypervalent iodine reagents. Under mild basic conditions, the addition of nucleophiles to aryloxy‐substituted vinylbenziodoxolone (VBX) reagents, easily available in two steps from silyl alkynes, resulted in the stereoselective formation of substituted aryl enol ethers. The reaction was most efficient with phenols as nucleophiles, but preliminary results were also achieved for C‐ and N‐ nucleophiles....
Tue Jun 16, 2020 15:26
We present a robust protocol based on iterations of free energy perturbation (FEP) calculations, chemical synthesis, biophysical mapping and X‐ray crystallography to reveal the binding mode of an antagonist series to the adenosine A 2A receptor (AR). Eight A 2A AR binding site mutations from biophysical mapping experiments were initially analysed with sidechain FEP simulations, performed on alternate binding modes. The results distinctively supported one binding mode, which was subsequently used...
Tue Jun 16, 2020 15:25
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