Nature Communications, Published online: 22 June 2020; doi:10.1038/s41467-020-16910-5DNA polymerase epsilon (Pol ε) is responsible for leading strand synthesis during DNA replication. Here the authors use Cryo-EM to describe the architecture of the Pol ε holoenzyme and to provide an atomic model for the leading strand replisome.
Mon Jun 22, 2020 03:00
Nature Communications, Published online: 22 June 2020; doi:10.1038/s41467-020-16851-zExtravasated erythrocytes in cerebrospinal fluid (CSF) contribute to the pathogenesis of subarachnoid haemorrhage (SAH). Here, the authors show that meningeal lymphatics drain extravasated erythorcytes and that blockage of this drainage aggravates SAH severity.
Mon Jun 22, 2020 03:00
Nature Communications, Published online: 22 June 2020; doi:10.1038/s41467-020-16489-xKinship behavior in rodents has been documented in the laboratory setting but the neural mechanisms that mediate kinship behavior are not known. Here, the authors show that the lateral septum has a key role in organizing mammalian kinship behavior.
Mon Jun 22, 2020 03:00
Nature Communications, Published online: 22 June 2020; doi:10.1038/s41467-020-16960-9Separation of ethylene from C2 ternary mixture with high working capacity is a challenging task. Here, the authors report a Th-azole framework (Azole-Th-1) for highly efficient purification of ethylene from C2H4/C2H6 and C2H4/C2H2/C2H6 mixtures, respectively.
Mon Jun 22, 2020 03:00
Nature Communications, Published online: 22 June 2020; doi:10.1038/s41467-020-16835-zHelium is generally considered too inert to be present in giant ice planet mantles. The authors, by first-principles calculations and crystal structure searches, find stable ammonia–helium compounds at the conditions of Uranus and Neptune’s upper mantles, with possible implications in the planet composition models.
Mon Jun 22, 2020 03:00
Nature Communications, Published online: 22 June 2020; doi:10.1038/s41467-020-16975-2G protein-coupled receptors (GPCRs) can couple to more than one G protein subtype, and the coupling efficiency varies depending on the GPCR-G protein pair. Here authors use hydrogen/deuterium exchange mass spectrometry and mutagenesis to study the structural mechanism underlying primary and secondary Gi/o coupling.
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Related Articles The neurological insights of the emerging coronaviruses. J Clin Neurosci. 2020 Jun 11;: Authors: Msigwa SS, Wang Y, Li Y, Cheng X Abstract Emerging Viral diseases are incredibly infectious and proficient in inducing pandemics. Unlike the previous emerging coronaviruses (ECoVs) which neurological complexities were uncommon, with neurological features exhibition at 14-25 days post-onset, yet with critical outcomes exhibiting >50%...
Mon Jun 22, 2020 17:26
Recent research indicates that hard corals in a process that is termed phase shift are often replaced by soft corals in reefs. The simultaneous occurrence of local (i.e. organic eutrophication as highly under-investigated parameter) and global (i.e. ocean warming) factors may facilitate these phase shifts as hard corals are negatively affected by both ocean warming and organic eutrophication. Knowledge about soft coral responses to environmental change remains incomplete, although these organisms...
Mon Jun 22, 2020 03:00
Monkeypox (MPX) is a zoonotic disease similar to smallpox. Its fatality rate is about 11% and it is endemic to the Central and West African countries. In this paper, we analyze a compartmental model of MPX dynamics. Our goal is to see whether MPX can be controlled and eradicated by voluntary vaccinations. We show that there are three equilibria—disease free, fully endemic and previously neglected semi-endemic (with disease existing only among humans). The existence of semi-endemic equilibrium has...
Mon Jun 22, 2020 03:00
Asparagus africanus Lam. is a plant used traditionally to treat different ailments. Currently, scanty information is available on its safety. The aim of this study is to determine the acute toxicity of the methanolic extract on vital organs and its associated biochemical parameters. Fifteen female Sprague-Dawley rats were divided into five groups. Group I served as normal control, groups II, III, IV, and V were orally administered single dose of crude extract dissolved in distilled water at 5 mg/kg...
Mon Jun 22, 2020 03:00
The study is based on new material from the collections of the Naturalis Biodiversity Centre in Leiden (RNHM) and the Hungarian Natural History Museum (HNHM) and addresses issues in two genera: Epeus Peckham & Peckham, 1886 and Ptocasius Simon, 1885 from Thailand. Both genera are of Asian/Indomalayan origin, the latter with a diversity hotspot in the subtropical valleys of the Himalayas. Based on morphological data, we propose three new species of Epeus (Epeus daiqini sp. nov. (♂♀), Epeus pallidus...
Mon Jun 22, 2020 03:00
Background Glaesserella parasuis (G. parasuis) is a respiratory pathogen of swine and the etiological agent of Glässer’s disease. The structural organization of genetic information, antibiotic resistance genes, potential pathogenicity, and evolutionary relationships among global G. parasuis strains remain unclear. The aim of this study was to better understand patterns of genetic variation, antibiotic resistance factors, and virulence mechanisms of this pathogen. ...
Mon Jun 22, 2020 03:00
Background Jainemys pisdurensis comb. nov. is an extinct pleurodiran turtle from the Late Cretaceous (Maastrichtian) of India, previously referred to Carteremys and Shweboemys. The holotype, an eroded skull, had been collected near the village of Pisdura, south of Nagpur, in Maharashtra State, while all referred shell material originates from coeval sediments exposed at the nearby village of Dongargaon. Initial estimates believed this turtle to either be an early representative of Podocnemididae...
Mon Jun 22, 2020 03:00
The objective of the work was to demonstrate the relationship between the natural environmental characteristics of a reservoir and its catchment and severity of trophic degradation. The shallow, highly-silted Rzeszów Reservoir (SE Poland) was the object of study. The impact on degradation of internal supply from accumulated bottom sediments was also assessed, using water and sediment sampled in 2013 and 2014. A high value for trophic state was identified for the reservoir on the basis of TSI indexes,...
Mon Jun 22, 2020 03:00
Background Maternal malnutrition is a critical factor in determining the risk of obesity and glucose intolerance in offspring. However, little is known about the effects of a maternal high-fat diet (HFD) on the β cell phenotype in offspring, which is a major factor in glucose homeostasis, especially during the early life of offspring. Methods Dams were randomly fed a HFD (60% kcal from fat) or a chow diet before pregnancy...
Mon Jun 22, 2020 03:00
Related Articles Pertuzumab, trastuzumab, and docetaxel for Chinese patients with previously untreated HER2-positive locally recurrent or metastatic breast cancer (PUFFIN): a phase III, randomized, double-blind, placebo-controlled study. Breast Cancer Res Treat. 2020 Jun 20;: Authors: Xu B, Li W, Zhang Q, Shao Z, Li Q, Wang X, Li H, Sun T, Yin Y, Zheng H, Feng J, Zhang H, Lei G, Restuccia E Abstract PURPOSE: The Chinese bridging study PUFFIN...
Mon Jun 22, 2020 17:15
Publication date: Available online 22 June 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Marco Caminati, Carlo Lombardi, Claudio Micheletto, Elena Roca, Barbara Bigni, Fabiana Furci, Domenico Girelli, Gianenrico Senna, Ernesto Crisafulli
Mon Jun 22, 2020 13:17
Publication date: Available online 22 June 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Wojciech Francuzik, Franziska Ruëff, Andrea Bauer, Maria Beatrice Bilò, Victoria Cardona, George Christoff, Sabine Dölle-Bierke, Luis Ensina, Montserat Fernandes-Rivas, Thomas Hawranek, Johnathan O’B Hourihane, Thilo Jakob, Nicos G. Papadopoulus, Claudia Pföhler, Iwona Poziomkowska-Gęsicka, Xavier Van der Brempt, Kathrin Scherer Hofmeier, Regina Treudler, Nicola Wagner, Bettina Wedi
Mon Jun 22, 2020 13:17
Publication date: Available online 22 June 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Junqing Yue, Lu Qin, Cong Zhang, Min Xie
Mon Jun 22, 2020 13:17
Publication date: Available online 22 June 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Oreste Gallo, Chiara Bruno, Luca Giovanni Locatello
Mon Jun 22, 2020 13:17
Publication date: Available online 22 June 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Valentin Navel, Frédéric Chiambaretta, Frédéric Dutheil
Mon Jun 22, 2020 13:17
Abstract Introduction Considerable advances in melanoma have been realized through immunotherapy. The principal aim was to determine whether primary tumor characteristics or Next Generation Sequencing (NGS) could serve as markers of immunotherapy response. Methods and Results The study cohort consisted of 67 patients who received immunotherapy for recurrent or metastatic melanoma and for whom primary tumor biopsies and pathology reports were available. A subset of 59 patient tumors were...
Sun Jun 21, 2020 15:33
Related Articles Clinical Practice Guidelines for Bladder Cancer 2019 update by the Japanese Urological Association: Summary of the revision. Int J Urol. 2020 Jun 21;: Authors: Matsumoto H, Shiraishi K, Azuma H, Inoue K, Uemura H, Eto M, Ohyama C, Ogawa O, Kikuchi E, Kitamura H, Shinohara N, Takahashi S, Tsuzuki T, Nakagawa M, Narumi Y, Nishiyama H, Habuchi T, Hinotsu S, Fujii Y, Fujimoto K, Fujimoto H, Mizowaki T, Matsuyama H Abstract OBJECTIVES:...
Mon Jun 22, 2020 15:08
Related Articles Parosteal osteosarcoma associated with a low-grade component mimicking well-differentiated liposarcoma: a case report. Skeletal Radiol. 2020 Jun 21;: Authors: Sohier P, Rodrigues M, Anract P, Feydy A, Larousserie F Abstract Parosteal osteosarcomas and well-differentiated liposarcomas are both well-differentiated locally aggressive tumors. They both have simple karyotypes with amplification of the 12q13-15 regions including MDM2...
Mon Jun 22, 2020 15:08
Related Articles Prospective evaluation of the impact of human papilloma virus status and small node size on the diagnostic accuracy of 18F-fluorodeoxyglucose positron emission tomography/computed tomography for primary head and neck squamous cell carcinoma. ANZ J Surg. 2020 Jun 21;: Authors: Lee J, Emmett L, Tang R, Ho B, Earls P, Matthews T, Gallagher R Abstract BACKGROUND: Fluorodeoxyglucose-positron emission tomography/computed tomography...
Mon Jun 22, 2020 14:37
Related Articles Predictors for failure of supraglottic superimposed high frequency jet ventilation during endoscopic upper airway surgery in pediatric patients. Paediatr Anaesth. 2020 Jun 21;: Authors: Plate C, Krenz G, Molenbuur B, Dikkers FG, Eindhoven GB, Wachters JE, van Dijk B, Halmos GB Abstract Airway surgery in pediatric patients is challenging with regard to balancing surgical exposure with ventilation requirements, as during...
Mon Jun 22, 2020 14:37
Related Articles Correlations Between Progression-free Survival, Objective Response Rate, and Overall Survival in Clinical Trials of PD-1/PD-L1 Immune Checkpoint Blockade: A Meta-analysis. Clin Pharmacol Ther. 2020 Jun 21;: Authors: Ye J, Ji X, Dennis PA, Abdullah H, Mukhopadhyay P Abstract PD-1/PD-L1 immune checkpoint blockade (ICB) has improved overall survival (OS) in solid tumor trials; however, parallel improvements in RECIST-based...
Mon Jun 22, 2020 14:37
Related Articles Fraction-Variant Beam Orientation Optimization for Intensity-Modulated Proton Therapy. Med Phys. 2020 Jun 21;: Authors: Gu W, O'Connor D, Ruan D, Zou W, Dong L, Sheng K Abstract PURPOSE: To achieve a superior balance between dosimetry and the delivery efficiency of intensity modulated proton therapy (IMPT) using as few beams as possible in a single fraction, we optimally vary beams in different fractions. METHODS:...
Mon Jun 22, 2020 14:37
Related Articles High detection sensitivity and reliable morphological correlation of PET with a silicon photomultiplier for primary tongue squamous cell carcinoma. Ann Nucl Med. 2020 Jun 20;: Authors: Kojima I, Takanami K, Ogawa T, Sakamoto M, Nagai H, Miyashita H, Iikubo M Abstract OBJECTIVE: A positron emission tomography (PET) scanner using a silicon photomultiplier (SiPM PET) in place of a photomultiplier tube significantly improves...
Mon Jun 22, 2020 14:37
Related Articles Galectin-3 Expression in High-Risk HPV-Positive and Negative Head & Neck Squamous Cell Carcinomas and Regional Lymph Node Metastases. Head Neck Pathol. 2020 Jun 20;: Authors: Coppock JD, Mills AM, Stelow EB Abstract Despite higher stages at presentation, patients with high-risk (HR) HPV-related (HPV+) head and neck squamous cell carcinomas (HNSCCs) have better survival rates compared to those with non-HPV-related (HPV-)...
Mon Jun 22, 2020 14:37
Related Articles Label-Free Semiquantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics Analysis of Laryngeal/Hypopharyngeal Squamous Cell Carcinoma on Formalin-Fixed, Paraffin-Embedded Tissue Samples - a Pilot Study. Pathol Oncol Res. 2020 Jun 21;: Authors: Burian A, Lujber L, Gerlinger I, Jarai T, Orosz E, Turiak L, Acs A, Hegedus Z, Peter AK, Tornoczki T, Gombos K, Mark L Abstract Squamous cell carcinoma (SCC) of the head...
Mon Jun 22, 2020 14:37
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