Abstract Purpose The craniometrics of head circumference (HC) and ventricular size are part of the clinical assessment of infants with hydrocephalus and are often utilized in conjunction with other clinical and radiological parameters to determine the success of treatment. We aimed to assess the effect of endoscopic third ventriculostomy (ETV) and shunting on craniometric measurements during the follow-up of a cohort of infants...
Abstract Introduction Neurenteric cysts (NEC) are rare benign tumors of the central nervous system. Even more rare are the NEC at the ventral foramen magnum in children that are misdiagnosed. They cause distortion of the vertebrobasilar vascular system and cervicomedullary neural structures and are adherent to the latter. The inferior portion lies ventral to the upper most dentate ligament. This has implications in the surgical...
Abstract Introduction Quadrigeminal arachnoid cyst (QAC) associated with encephalocele is rare; and while some treatments have been developed in recent years, no definite therapeutic approach for QAC has been established. Endoscopic treatment for arachnoid cyst is gaining popularity because it is relatively less invasive to the normal brain tissues. Case presentation...
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Malignant transformation of basal cell adenoma is extremely rare. We report the case of a 63-year-old Chinese woman, who had noticed a slowing growing mass in her right parotid gland with slight pain for 1 month. Based on physical and ultrasound examinations, a diagnosis of benign salivary gland tumour was made before the surgery. A frozen biopsy was performed, and the diagnosis was basal cell adenoma, with the tumour cells infiltrating the capsule. Routine histopathological examination was performed...
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Abstract Purpose The aim of this study was to evaluate the prevalence and clinical correlates of impaired sleep quality and excessive daytime sleepiness among patients receiving methadone for opioid use disorder (OUD). Methods Patients receiving methadone (n = 164) completed surveys assessing sleep quality (Pittsburgh Sleep Quality Index [PSQI]), daytime...
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The Haribo Goldbear's century-old recipe has evolved over time. Today, a gummy in Germany might taste different than one in Singapore, Brazil, or the US. (Stan Horaczek/)A hundred years ago, the first Haribo factory cranked up its confectionery machines on the banks of Germany’s Rhine River. Started by 27-year-old Hans Riegel, the business stayed modest and local—until the founder made a marvelous culinary discovery. The exact formula to his bear-shaped success remains a secret to this day, but it’s...
Human color vision depends on three types of cones—special cells sensitive to red, blue, or green light. However, many birds, reptiles, and fish have an additional kind of cone that can pick up ultraviolet light. (Noah Whiteman/)Hummingbirds can see an impressive array of colors that are invisible—or appear very different—to the human eye, scientists reported June 15 in the journal Proceedings of the National Academy of Sciences. In a series of experiments involving sugar water and LED tubes, the...
Can you hear me now? No? Good. (cetteup via Unsplash/)Anyone who works with power tools knows hearing protection is an integral part of the game. Don’t protect your ears, and you can plan on spending your later years shouting over the dinner table. But what protection is best for you varies. Do you want to listen to music while you’re working? Do you need ear protection for a concert or for a child? Whatever your situation, there’s a solution available for purchase.Listen to a podcast while you work....
Get accurate readings. (Kelly Sikkema via Unsplash/)When your kid is getting sick or has a teething fever, it’s important for you to feel safe, secure, and informed. Being a parent is hard enough without having to pin down your squirm-ball to take their temperature. These thermometers will give you an accurate reading of your baby’s temperature no matter the circumstances. If your baby has not been their usually bouncy self, maybe they are just being fussy or having an off-day. A thermometer will...
Brooms for an efficient sweep. (Neal E. Johnson via Unsplash/)The modern broom owes a whole lot to the bygone corn husk and natural fiber designs that first cropped up in the late 1700s. Today, there’s a perfect broom out there for cleaning every type of debris off of every surface, from cereal on kitchen floors to muddy puddles in a basement. Some styles are interchangeable, and others are for specific uses, but if you dedicate different brooms for their appropriate rooms, you can work smarter and...
The selfie is a must-have skill for the solo traveler. ( Artem Beliaikin / Unsplash/)Selfies (or self-portraits) have a long and illustrious history. Renowned artists such as Van Gogh, Rembrandt, and Carvaggio frequently painted themselves—sometimes hundreds of times—and Robert Cornelius gave the format new life in 1839, when he shot the first photographic selfie in history. Our fascination with our own reflection is clearly nothing new—it’s just that our ability to depict it has never been more...
Meet the Kampfmittelaufklärung und-identifizierung. (Gerd Benndorf/Bundeswehr/)The KAI is the newest tool at the disposal of the German Army—it’s a vehicle with a 33-foot long, multi-jointed, 1.9-ton steel arm. The burly appendage is designed to detect and identify unexploded ordnance from a safe distance. It has sufficient dexterity so that a soldier could use it, and the sensors and tools at its end, to check out what could be a bomb under a bridge or elsewhere, hopefully without exploding it....
Sweet seats for your bathroom. (Sidekix Media via Unsplash/)A smart toilet can come in many forms, from the entire appliance to an attachable seat. Not only aesthetically pleasing—they make using the restroom more convenient, hygienic, and comfortable. While top-of-the-line toilets can be fairly pricey, we have tried to include a range of options and price points. You won’t be disappointed by the many features we have found and the major benefits of upgrading your commode. These toilets are intelligent,...
Good morning! (Clay Banks via Unsplash/)Intense coffee connoisseurs can be precious about the brands and regions they devote themselves to, and even a casual coffee drinker understands that a good cup of joe needs to start with quality beans.No matter what roast you prefer, there is a bean that will deliver the sophisticated flavor and bracing caffeine boost you want from your morning (or afternoon or evening or late night) coffee. Here are some of the best we’ve found.Not a gentle wake-up. (Amazon/)If...
Anti-Black bias can even shared by Black people. (Clay Banks via Unsplash/)In a world where many people actively work to fight against systemic racism and even more claim to be “woke,” the science of implicit bias reveals why most of us still have work to do. Implicit biases are like puppeteers lurking inside our heads, coloring our every action with unconscious stereotyping and prejudice.Humans begin forming simple mental links in infancy: We learn to associate highchairs with mealtime, parents...
Fuss over your floofy friend. (Sara Kurfeß via Unsplash/)Deciding with your vet whether or not Sampson or Nugget needs regular claw trims is simple. Getting your canine pal to offer a paw is another thing entirely. If you’re determined to avoid the cost of regular visits to the groomers, you’ll need a good pair of nail clippers or a nail grinder, along with plenty of comforting words for pacifying your pooch. With patience, skill, and the right tools, get the job done in the comfort of your own home...
Have the tools to get the job done right. (cetteup vis Unsplash/)Maybe you need to cut down a dead tree. Maybe you need to build a deer stand. Maybe you need to repair the seat in your boat. Whatever the situation, these four tools will have your back. Sure, you might need another, more specialized tool one day, but make sure you have these in your arsenal.Cut it down. (Amazon/)You need a chainsaw, but it can be hard to know which one. Consider this 24-inch, 460 Rancher gas chainsaw. It has a 2-cycle...
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Background and Objectives. Thoracic aortic aneurysm (TAA) is a silent disease characterised by aortic wall expansion and vascular smooth muscle cell (VSMC) dedifferentiation from contractile to synthetic phenotype. Long noncoding RNAs (lncRNAs) involved in VSMC phenotypic regulation could be considered as potential diagnostic indicators and therapeutic targets of TAA. In vitro studies show that lncRNAs CARMN, LUCAT1, MALAT1, and SMILR are associated with the VSMC phenotypic state. Our aim was to...
Background. Thyroid carcinoma (THCA) is one of the most common malignancies of the endocrine system, which is usually treated by surgery combined with iodine-131 (I131) radiotherapy. Aims. This study is aimed at exploring the potential targets of I131 radiotherapy in THCA. Methods. The RNA-sequencing data of THCA in The Cancer Genome Atlas database (including 568 THCA samples) was downloaded. The differentially expressed genes (DEGs) between the tumour samples whether or not subjected to I131 radiotherapy...
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Στη δύσκολη περίοδο της πανδημίας του κορωνοϊού, το Εθνικό Σύστημα Υγείας, με τους έμπειρους γιατρούς, σημείωσε ακόμια μία μικρή νίκη. Αυτή τη φορά οι γιατροί έσωσαν ένα 10χρονο αγόρι, τον Οδυσσέα, ο οποίος το βράδυ της περασμένης Κυριακής, κατάπιε ένα καρύδι, κάποια κομμάτια του οποίου έφραξαν τον πνεύμονά του. Ο Οδυσσέας εισήχθη στο Καραμανδάνειο Νοσοκομείο Παίδων Πατρών, όπου αφαιρέθηκε στο χειρουργείο ένα κομμάτι και στη συνέχεια μεταφέρθηκε σε σοβαρή κατάσταση από το ΕΚΑΒ διασωληνωμένος στο Πανεπιστημιακό...
Wed Jun 17, 2020 16:27
«Οι άνθρωποι είμαστε φύσει κοινωνικά όντα. Ίσως γι’αυτό νιώθουμε ικανοποίηση σώματος και πνεύματος όταν προσφέρουμε στους άλλους», αναφέρει ο Eric Kim, καθηγητής στην Ιατρική Σχολή T. H. Chan του Πανεπιστημίου Χάρβαρντ και επικεφαλής ερευνητής μιας νέας μελέτης για τη μακροζωία που δημοσιεύθηκε στο American Journal of Preventive Medicine. Κατά τη διάρκεια της μελέτης, η ομάδα του Δρ. Kim εξέτασε σχεδόν 13.000 ανθρώπους άνω των 50 ετών, οι οποίοι συμμετείχαν σε εθνική μελέτη για τη Συνταξιοδότηση...
Wed Jun 17, 2020 13:01
Μια ανατρεπτική, θα λέγαμε, έρευνα εξέτασε τη σχέση της ψυχοθεραπείας με τη φλεγμονή, στοχεύοντας στην εύρεση της ψυχοθεραπευτικής μεθόδου που μπορεί να μειώσει τη φλεγμονή αποτελεσματικά. Η ανασκόπηση 56 τυχαιοποιημένων κλινικών δοκιμών έδειξε ότι οι συμπεριφοριστικές ψυχοθεραπείες μπορούν να είναι αποτελέσουν μια εναλλακτική μη φαρμακευτική προσέγγιση για τη μείωση της φλεγμονής που προκαλεί ασθένειες. Τα αποτελέσματα της ανάλυσης, που δημοσιεύθηκαν στο JAMA Psychiatry, διαπίστωσαν ότι η γνωσιακή-συμπεριφοριστική...
Wed Jun 17, 2020 12:46
Ελληνική επιστημονική ομάδα ανακοίνωσε σε διεθνές επιστημονικό περιοδικό ότι βρήκε σπάνια χρωμοσωμική αλλοίωση που αποκαλύπτει έναν κοινό αρχαίο πρόγονο για 13 ελληνικές, άγνωστες μεταξύ τους, οικογένειες. Σύμφωνα με όσα αναφέρονται στο άρθρο του Journal of Human Genetics παρατηρήθηκε ότι αυτή η σπάνια γενετική αλλοίωση που σχετίζεται με την υπογονιμότητα, εντοπίζεται μόνο στον ελληνικό πληθυσμό και ξεκίνησε από το ίδιο άτομο πριν από εκατοντάδες χρόνια. Η επιστημονική ομάδα του τμήματος Γενετικής...
Wed Jun 17, 2020 11:46
Μεγάλο ερευνητικό ενδιαφέρον υπάρχει στη διεθνή βιβλιογραφία, λόγω των αντικρουομένων αποτελεσμάτων, σχετικά με την επίδραση του καπνίσματος στους θανάτους από λοίμωξη Covid-19. Η ερευνητική ομάδα των καθηγητών Κώστα Τούτουζα και Δημήτρη Τούσουλη, στην Α’ Πανεπιστημιακή Καρδιολογική Κλινική της Ιατρικής Σχολής του Εθνικού και Καποδιστριακού Πανεπιστημίου Αθηνών, στο Ιπποκράτειο Νοσοκομείο Αθηνών, διεξήγαγε μία συστηματική ανασκόπηση και μετα-ανάλυση των μελετών που εξετάζουν τη σχέση του καπνίσματος...
Wed Jun 17, 2020 11:11
Προκαταρκτικές αλλά ιδιαίτερα ενθαρρυντικές είναι οι αναλύσεις τυχαιοποιημένης μελέτης από την Κίνα, με πλάσμα από αναρρώσαντες ασθενείς με COVID-19, που δημοσιεύτηκε στο περιοδικό JAMA, όπως αναφέρουν οι γιατροί της Θεραπευτικής Κλινικής της Ιατρικής Σχολής του ΕΚΠΑ, Μαρία Γαβριατοπούλου, Ιωάννης Ντάνασης και Θάνος Δημόπουλος (καθηγητής Θεραπευτικής και πρύτανης ΕΚΠΑ), συνοψίζοντας τα ευρήματά της. Πρόκειται για την πρώτη τυχαιοποιημένη κλινική δοκιμή θεραπείας με πλάσμα από αναρρώσαντες ασθενείς...
Wed Jun 17, 2020 10:29
Ένα νέφος αιωρούμενων σταγονιδίων, που μπορεί να είναι μολυσμένα με κορωνοϊό, παράγεται όταν κάποιος τραβά το καζανάκι έχοντας ανοικτό το καπάκι της λεκάνης. Τα σταγονίδια φτάνουν σε ύψος έως σχεδόν ενός μέτρου από το καπάκι και αιρωούνται για τουλάχιστον ένα λεπτό, με συνέπεια είτε να τα εισπνεύσει κανείς είτε να καθίσουν πάνω σε επιφάνειες, κάτι που μπορεί να ευνοήσει την εξάπλωση της νόσου του κορωνοϊού, σύμφω με μελέτη Κινέζων επιστημόνων. Προηγούμενες μελέτες έχουν δείξει ότι τα σωματίδια...
Wed Jun 17, 2020 09:40
Τη συμβολή της ασπιρίνης στην αποτροπή εμφάνισης καρκίνου του παχέος εντέρου ανέδειξε έρευνα με επικεφαλής ερευνητές από τα Πανεπιστήμια Newcastle και Leeds του Ηνωμένου Βασιλείου. Μάλιστα, ο κίνδυνος παραμένει χαμηλός έως και δέκα χρόνια μετά την ολοκλήρωση της αγωγής. Η διεθνής μελέτη CAPP2 διεξήχθη σε ασθενείς με σύνδρομο Lynch (κληρονομικός μη-πολυποδιακός ορθοκολικός καρκίνος – HNPCC), μια κληρονομική πάθηση που αυξάνει τις πιθανότητες εμφάνισης καρκίνου του παχέος εντέρου, του ορθού και άλλων...
Wed Jun 17, 2020 08:00
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Abstract Purpose We compared the sexual function in women with classic forms of congenital adrenal hyperplasia (CAH) and polycystic ovary syndrome (PCOS) to find if the cause of androgen excess determines sexual functioning. Methods Hundred and four women (21 with CAH, 63 with PCOS and 20 healthy controls) aged 18–40 years were included into the study....
Abstract Purpose To investigate the long-term safety (primary endpoint) and effectiveness (secondary endpoint) of the somatropin biosimilar Omnitrope®. Methods PATRO Children is an ongoing, multicenter, observational, post-marketing surveillance study. Children who received Omnitrope® for any indication were included. Adverse events (AEs) were evaluated...
Abstract Purpose Covid-19 is a pandemic of unprecedented proportion, whose understanding and management is still under way. In the emergency setting new or available therapies to contrast the spread of COVID-19 are urgently needed. Elderly males, especially those affected by previous diseases or with comorbidities, are more prone to develop interstitial pneumonia that can deteriorate evolving to ARDS (acute respiratory distress syndrome)...
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Objectives. To investigate the physical properties of the modified microgroove (MG) and antibacterial nanocoated surfaces. In addition, the biological interactions of the modified surfaces with human gingival fibroblasts (HGFs) and the antibacterial activity of the surfaces against Porphyromonas gingivalis were studied. Methods. The titanium nitride (TiN) and silver (Ag) coatings were deposited onto the smooth and MG surfaces using magnetron sputtering. A smooth titanium surface (Ti-S) was used as...
Background. Breast cancer is the common malignancy with high morbidity and mortality in women. S-phase kinase-associated protein 2 (Skp2) has been characterized to play an oncogenic role in the breast carcinogenesis and progression. Therefore, inactivation of Skp2 in breast cancer might be a novel approach for fighting breast malignancy. A natural compound diosgenin has been reported to exert anticancer activity in a variety of human cancers. However, the underlying mechanism has not been fully determined....
Background. Brown adipose tissue generates heat instead of storing energy. It is important in the regulation of body weight, and individual variation in adaptive thermogenesis can be attributed to variations in the amount or activity of BAT. Objective. The objective of this study was to systematically review different articles to assess the prevalence of BAT and its associated factors and relation with obesity and diabetes mellitus. Methods. A systematic review and meta-analysis were employed on...
p2 of rice stripe virus may translocate from the nucleus to the cytoplasm and recruit nucleolar functions to promote virus systemic movement. Cajal bodies (CBs) are nuclear components associated with the nucleolus, which play a major role in plant virus infection. Coilin, a marker protein of CBs, is essential for CB formation and function. Coilin contains three domains, the N-terminal, the center, and the C-terminal fragments. Using yeast two-hybrid, colocalization, and bimolecular fluorescence complementation...
Background. Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer, which represents the 9th most frequently diagnosed cancer. However, the molecular mechanism of occurrence and development of ccRCC is indistinct. Therefore, the research aims to identify the hub biomarkers of ccRCC using numerous bioinformatics tools and functional experiments. Methods. The public data was downloaded from the Gene Expression Omnibus (GEO) database, and the differently expressed genes...
High risk human Papillomavirus (HPV) infections ultimately cause cervical cancer. Human Immunodeficiency Virus (HIV) infected women often present with multiple high-risk HPV infections and are thus at a higher risk of developing cervical cancer. However, information on the circulating high-risk HPV genotypes in Kenya in both HIV-infected and HIV-uninfected women is still scanty. This study is aimed at determining the phylogeny and the HPV genotypes in women with respect to their HIV status and at...
Objective. To investigate the value of coagulation indicators D-dimer (DD), prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), and fibrinogen (Fg) in predicting the severity and prognosis of COVID-19. Methods. A total of 115 patients with confirmed COVID-19, who were admitted to Tianyou Hospital of Wuhan University of Science and Technology between January 18, 2020, and March 5, 2020, were included. The dynamic changes of DD, PT, APTT, and Fg were tested, and...
Background. Early detection of dengue epidemics is a vital aspect in control programmes. Predictions based on larval indices of disease vectors are widely used in dengue control, with defined threshold values. However, there is no set threshold in Sri Lanka at the national or regional levels for Aedes larval indices. Therefore, the current study aimed at developing threshold values for vector indices in two dengue high-risk districts in Sri Lanka. Methods. Monthly vector indices (House Index [HI],...
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Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00704H, CommunicationK. Sudhakara Prasad, Yousef Abugalyon, Chunqiang Li, Feng Xu, XiuJun James LiA low-cost, sensitive, and disposable paper-based immunosensor for instrument-free colorimetric detection of a pancreatic cancer biomarker PEAK1 was reported for the first time by capitalizing the catalytic properties of gold...The content of this RSS Feed (c) The Royal Society of Chemistry
Wed Jun 17, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00938E, Communication Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Nidhi Juthani, Patrick S DoyleWe report a platform utilizing a reporter enzyme, which produces a chromogenic indigo precipitate that preferentially localizes within a hydrogel microparticle. The 3D network of the hydrogel maintains the rapid...The content of this RSS Feed (c) The Royal Society of Chemistry
Wed Jun 17, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00997K, PaperXia Zhong, Minghui Jiang, Yanmei Lei, Yaqin Chai, Ying Zhuo, Ruo YuanPerylene and its derivatives, as classical organic polycyclic aromatic hydrocarbons (PAHs) ECL materials, have attracted extensive attention due to their excellent photoelectric activity and good structural controllability. As is well...The content of this RSS Feed (c) The Royal Society of Chemistry
Wed Jun 17, 2020 02:00
An unexpected discovery of 1,4-benzoquinone as a lipophilic mediator for toxicity detection in water
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00991A, PaperDengbin Yu, Jiantao Li, Zhichao Kang, Ling Liu, Jingting He, Hongwen YU, Shaojun DongSince most toxicological risk assessments are based on individual single-species tests, there is uncertainty in extrapolating these results to ecosystem assessments. Herein, we successfully developed a mediated microbial electrochemical biosensor...The content of this RSS Feed (c) The Royal Society of Chemistry
Wed Jun 17, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00928H, PaperZhihui Dai, Junyao Li, Mengyang Zhang, Huaisheng Wang, Jie Wu, Ruixue Zheng, JIahui Zhang, Yan Li, Zhaoyin WangIn this work, a method for quantifying the activity of formamidopyrimidine DNA glucosylase (Fpg) is designed based on phosphate group (P)-modulated multi-enzyme catalysis and fluorescent copper nanoclusters (CuNCs). By eliminating...The content of this RSS Feed (c) The Royal Society of Chemistry
Wed Jun 17, 2020 02:00
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Neopenda, a medical device startup based in Chicago that has been featured on Medgadget previously, has recently adapted its wearable vital signs monitor, originally developed for newborns, to be used with pediatric and adult patients in response to the COVID-19 pandemic. To date, the neoGuard has been utilized as a monitoring solution for newborn infants in hospitals in Uganda. The wearable wirelessly streams vital signs, such as respiration rate, to a phone or tablet computer, allowing healthcare...
Medtronic won the European Union CE Mark for its Micra AV pacemaker that’s delivered into the heart, where it resides without requiring any leads, using a minimally invasive transcatheter procedure. The device is indicated for patients suffering from AV block, a condition that prevents proper electrical signal transfer between the atria and the ventricle. Micra AV addresses this condition by continuously monitoring the physical movement of the heart, using a built-in accelerometer,...
After a long wait, the FDA has finally cleared Abbott’s FreeStyle Libre 2 continuous glucose monitor in the U.S. for any patients with diabetes over four years of age. The system provides low and high glucose level alarms, which let patients know in real-time if they’re falling outside of their normal range and it doesn’t require any fingersticks to calibrate it. Such technology can allow for significant improvements in patient comfort while offering exciting new capabilities for improved glucose...
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To rapidly communicate short reports of innovative responses to Covid-19 around the world, along with a range of current thinking on policy and strategy relevant to the pandemic, the Journal has initiated the Covid-19 Notes series. Covid-19 has arrived at our clinic, GHESKIO, in Port-au-Prince,…
Tue Jun 16, 2020 03:00
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The world has been looking toward South Korea for guidance, and the reasoning is obvious. Even though the country’s exponential growth of COVID-19 infections in late February was not met with widespread quarantine or lockdown, the Korean government’s swift response, prodigious amount of testing, and pointed quarantine regulation guidelines resulted in a steady decrease in infections and a low mortality rate. [pquote]I call this banal security—the making of security, and the destruction it professes...
Frances Kvietok Dueñas is the recipient of the 2019 Council on Anthropology and Education Frederick Erickson Outstanding Dissertation Award. Here, she recounts findings from the ethnographic study that is the basis of her award-winning dissertation, “Youth bilingualism, identity and Quechua language planning and policy in the urban Peruvian Andes.” Diana walked around her rowdy Quechua classroom, trying to encourage her high school students to perform a Quechua song, a graded assignment. More than...
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