What would our babies say if they could speak? Would we ever put them down if we knew?
07:45
Journal of Cutaneous Medicine and Surgery, Ahead of Print.
Mon Jun 22, 2020 11:11
Journal of Cutaneous Medicine and Surgery, Ahead of Print.
Mon Jun 22, 2020 10:39
Journal of Cutaneous Medicine and Surgery, Ahead of Print.
Mon Jun 22, 2020 10:27
East African lake cichlids are one of the most impressive examples of an adaptive radiation. Independently in Lake Victoria, Tanganyika, and Malawi, several hundreds of species arose within the last 10 million...
Mon Jun 22, 2020 03:00
Abstract Neutrophils are the most abundant leukocytes in the blood. Moreover, neutrophils form the first line of host immune defense against bacterial and fungal invasion, and also play an important part in inflammatory and immune system responses. Intravesical bacillus Calmette–Guérin (BCG) has been shown to reduce and delay tumor progression to muscle-invasive disease after transurethral resection of bladder tumors (TRUBTs). Following...
03:00
Frequently the results generated when testing novel anti-tumor immunotherapies in vitro do not correlate with data collected in in vivo models and/or in clinical settings. It is our hypothesis that this discrepancy is caused by the use of in vitro conditions, such as normoxia, a two-dimensional surface, optimal growth media and lack of cell complexity and heterogeneity. These conditions do not accurately reflect the tumor microenvironment (TME) that the tested immunotherapeutic strategies experience...
Mon Jun 22, 2020 16:18
PURPOSE BRAFV600E mutations portend poor prognosis in metastatic colorectal cancer (mCRC); however, the true prevalence and prognosis are unknown, as unwell patients may not undergo BRAF sequencing. PATIENTS AND METHODS We reviewed a population-based cohort of 1898 patients with CRC that underwent reflexive immunohistochemistry (IHC) mismatch repair (MMR) & BRAFV600E testing. Outcomes among IHC detected BRAFV600E mCRC (BRAFIHC) were compared to patients with next generation sequencing identified...
Mon Jun 22, 2020 16:18
The 2019 Accelerating Anticancer Agent Development (AAADV) Workshop assembled a panel of experts for an in-depth discussion session to present "Novel Therapeutic Interventions Early in the Disease Trajectory." The panel reviewed the limitations of evaluating investigational cancer therapeutics solely in advanced metastatic and relapsed/refractory disease settings, and recommended strategies for drug evaluation earlier in the disease course, including in the first line in combination with standard...
Mon Jun 22, 2020 16:18
PURPOSE: Plasma genotyping may identify mutations in potentially "actionable" cancer genes, such as BRCA1/2, but their clinical significance is not well defined. We evaluated the characteristics of somatically acquired BRCA1/2 mutations in patients with MBC. METHODS: Patients with MBC undergoing routine cell-free DNA (cfDNA) next generation sequencing (73 gene panel) before starting a new therapy were included. Somatic BRCA1/2 mutations were classified as known germline-pathogenic mutations or novel...
Mon Jun 22, 2020 16:18
Jewel wasps in the genus of Nasonia are parasitoids with haplodiploidy sex determination, rapid development and are easy to culture in the laboratory. They are excellent models for insect genetics, genomics, epigenetics, development, and evolution. Nasonia vitripennis (Nv) and N. giraulti (Ng) are closely-related species that can be intercrossed, particularly after removal of the intracellular bacterium Wolbachia, which serve as a powerful tool to map and positionally clone morphological, behavioral,...
Mon Jun 22, 2020 22:52
Crops are hosts to numerous plant pathogenic microorganisms. Maize has several major disease issues; thus, breeding multiple disease resistant (MDR) varieties is critical. While the genetic basis of resistance to multiple fungal pathogens has been studied in maize, less is known about the relationship between fungal and bacterial resistance. In this study, we evaluated a disease resistance introgression line (DRIL) population for the foliar disease Goss's bacterial wilt and blight (GW) and conducted...
Mon Jun 22, 2020 22:52
Three national audiology assiociations sent a joint letter to the Centers for Medicare and Medicaid (CMS) requesting the removal of the Medicare physician order requirement. The Academy of Doctors of Audiology (ADA), the American Academy of Audiology (AAA), and the American Speech-Language-Hearing Association (ASHA) sent the letter on June 2."Our organizations request that CMS remove the requirement under Medicare that beneficiaries obtain a physician order prior to an appointment with an audiologist...
Mon Jun 22, 2020 14:57
British Journal of Cancer, Published online: 23 June 2020; doi:10.1038/s41416-020-0952-1YES1 amplification confers trastuzumab–emtansine (T-DM1) resistance in HER2-positive cancer
03:00
British Journal of Cancer, Published online: 23 June 2020; doi:10.1038/s41416-020-0945-0Gremlin-1 augments the oestrogen-related receptor α signalling through EGFR activation: implications for the progression of breast cancer
03:00
01:13
01:13
Repurposing anticancer drugs for COVID-19-induced inflammation, immune dysfunction, and coagulopathy
British Journal of Cancer, Published online: 22 June 2020; doi:10.1038/s41416-020-0948-xRepurposing anticancer drugs for COVID-19-induced inflammation, immune dysfunction, and coagulopathy
Mon Jun 22, 2020 03:00
Repurposing anticancer drugs for COVID-19-induced inflammation, immune dysfunction, and coagulopathy
Mon Jun 22, 2020 03:00
British Journal of Cancer, Published online: 22 June 2020; doi:10.1038/s41416-020-0944-1Correction: Molecular subtypes of oropharyngeal cancer show distinct immune microenvironment related with immune checkpoint blockade response
Mon Jun 22, 2020 03:00
Mon Jun 22, 2020 03:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03105
Mon Jun 22, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03699
Mon Jun 22, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05186
Mon Jun 22, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05749
Mon Jun 22, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01562
Mon Jun 22, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04715
Mon Jun 22, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02052
Mon Jun 22, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02257
Mon Jun 22, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04758
Mon Jun 22, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04677
Mon Jun 22, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01570
Mon Jun 22, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03730
Fri Jun 19, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03860
Fri Jun 19, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04710
Fri Jun 19, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02290
Fri Jun 19, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04144
Fri Jun 19, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c06516
Fri Jun 19, 2020 07:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου