Antibiotics, Vol. 9, Pages 327: A Novel Derivative of Thioridazine Shows Low Toxicity and Efficient Activity against Gram-Positive Pathogens Antibiotics doi: 10.3390/antibiotics9060327 Authors: Jørgensen Saaby Andersson Kromann Sheikhsamani Permin Ronco Svenningsen Christensen Olsen Thioridazine hydrochloride (HCl) has been suggested as a promising antimicrobial helper compound for the treatment of infections with antimicrobial-resistant bacteria....
Mon Jun 15, 2020 03:00
Antibodies, Vol. 9, Pages 23: Targeting Dendritic Cells with Antigen-Delivering Antibodies for Amelioration of Autoimmunity in Animal Models of Multiple Sclerosis and Other Autoimmune Diseases Antibodies doi: 10.3390/antib9020023 Authors: Courtney A. Iberg Daniel Hawiger The specific targeting of dendritic cells (DCs) using antigen-delivering antibodies has been established to be a highly efficient protocol for the induction of tolerance and protection from autoimmune processes in...
Mon Jun 15, 2020 03:00
Antioxidants, Vol. 9, Pages 524: Toxicity of Necrostatin-1 in Parkinson’s Disease Models Antioxidants doi: 10.3390/antiox9060524 Authors: Alegre-Cortés Muriel-González Canales-Cortés Uribe-Carretero Martínez-Chacón Aiastui López de Munain Niso-Santano Gonzalez-Polo Fuentes Yakhine-Diop Parkinson’s disease (PD) is a neurodegenerative disorder that is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta....
Mon Jun 15, 2020 03:00
Arts, Vol. 9, Pages 69: Disrupting Heteronormative Temporality through Queer Dramaturgies: Fun Home, Hadestown and A Strange Loop Arts doi: 10.3390/arts9020069 Authors: Sarah K. Whitfield This article considers how André De Shields performance in Hadestown (2019), and the musicals Fun Home (2015) and A Strange Loop (2019) can be seen to respond to the present moment and argues that they disrupt heteronormative temporality through queer dramaturgy. It explores musicals that...
Mon Jun 15, 2020 03:00
Atmosphere, Vol. 11, Pages 635: A Qualitative Study of the Ionospheric Weak Response to Super Geomagnetic Storms Atmosphere doi: 10.3390/atmos11060635 Authors: Haimeng Li Zhou Chen Lianqi Xie Fan Li The ionospheric response to a geomagnetic storm is a geophysical process. Although strong geomagnetic storms input more energy into the Earth’s upper atmosphere, the ionospheric response often does not reflect the same level of variation as the geomagnetic storm, and the...
Mon Jun 15, 2020 03:00
Atmosphere, Vol. 11, Pages 634: Registration of Atmospheric-Electric Effects from Volcanic Clouds on the Kamchatka Peninsula (Russia) Atmosphere doi: 10.3390/atmos11060634 Authors: Pavel P. Firstov Evgeniy I. Malkin Rinat R. Akbashev Gennadiy I. Druzhin Nina V. Cherneva Robert H. Holzworth Vladimir N. Uvarov Ivan E. Stasiy The paper is devoted to the description of observations over atmospheric and electric effects from volcanic eruptions on Kamchatka peninsula (Russia)...
Mon Jun 15, 2020 03:00
Atmosphere, Vol. 11, Pages 633: Using High-Density Rain Gauges to Validate the Accuracy of Satellite Precipitation Products over Complex Terrains Atmosphere doi: 10.3390/atmos11060633 Authors: Linfei Yu Yongqiang Zhang Yonghui Yang Topography and precipitation intensity are important factors that affect the quality of satellite precipitation products (SPPs). A clear understanding of the accuracy performance of SPPs over complex terrains and its relationship with topography is valuable...
Mon Jun 15, 2020 03:00
Atmosphere, Vol. 11, Pages 632: A Lagrangian Advection Scheme for Solving Cloud Droplet Diffusion Growth Atmosphere doi: 10.3390/atmos11060632 Authors: Lei Wei Jiming Sun Hengchi Lei Li Dong Wenhao Hu Cloud drop diffusion growth is a fundamental microphysical process in warm clouds. In the present work, a new Lagrangian advection scheme (LAS) is proposed for solving this process. The LAS discretizes cloud drop size distribution (CDSD) with movable bins. Two types of prognostic...
Mon Jun 15, 2020 03:00
Biology, Vol. 9, Pages 127: Lymphoid Tissue in Teleost Gills: Variations on a Theme Biology doi: 10.3390/biology9060127 Authors: Rességuier Dalum Pasquier Zhang Koppang Boudinot Wiegertjes In bony fish, the gill filaments are essential for gas exchanges, but also are vulnerable to infection by water-borne microorganisms. Omnipresent across fish, gill-associated lymphoid tissues (GIALT) regulate interactions with local microbiota and halt infection by pathogens....
Mon Jun 15, 2020 03:00
Biomedicines, Vol. 8, Pages 162: 17β-Estradiol Promotes Proinflammatory and Procoagulatory Phenotype of Innate Immune Cells in the Presence of Antiphospholipid Antibodies Biomedicines doi: 10.3390/biomedicines8060162 Authors: Gayane Manukyan Anush Martirosyan Ludek Slavik Jana Ulehlova Martin Dihel Tomas Papajik Eva Kriegova Antiphospholipid syndrome (APS) is the most common cause of acquired thrombophilia and recurrent spontaneous miscarriages associated with extended...
Mon Jun 15, 2020 03:00
Biomedicines, Vol. 8, Pages 160: New Pyrimidinone-Fused 1,4-Naphthoquinone Derivatives Inhibit the Growth of Drug Resistant Oral Bacteria Biomedicines doi: 10.3390/biomedicines8060160 Authors: Kyungmin Kim Daseul Kim Hyunjin Lee Tae Hoon Lee Ki-Young Kim Hakwon Kim Background: Dental caries is considered to be a preventable disease, and various antimicrobial agents have been developed for the prevention of dental disease. However, many bacteria show resistance to existing...
Mon Jun 15, 2020 03:00
Biomedicines, Vol. 8, Pages 161: Distribution of Helicobacter pylori and Periodontopathic Bacterial Species in the Oral Cavity Biomedicines doi: 10.3390/biomedicines8060161 Authors: Tamami Kadota Masakazu Hamada Ryota Nomura Yuko Ogaya Rena Okawa Narikazu Uzawa Kazuhiko Nakano The oral cavity may serve as a reservoir of Helicobacter pylori. However, the factors required for H. pylori colonization are unknown. Here, we analyzed the relationship between the presence of...
Mon Jun 15, 2020 03:00
Biomolecules, Vol. 10, Pages 909: Multimarker Approach to Identify Patients with Coronary Artery Disease at High Risk for Subsequent Cardiac Adverse Events: The Multi-Biomarker Study Biomolecules doi: 10.3390/biom10060909 Authors: Giurgea Zlabinger Gugerell Lukovic Syeda Mandic Pavo Mester-Tonczar Traxler-Weidenauer Spannbauer Kastner Müller Anvari Bergler-Klein Gyöngyösi In our prospective non-randomized, single-center cohort...
Mon Jun 15, 2020 03:00
Biomolecules, Vol. 10, Pages 908: MicroRNA Alterations in a Tg501 Mouse Model of Prion Disease Biomolecules doi: 10.3390/biom10060908 Authors: Toivonen Sanz-Rubio López-Pérez Marín-Moreno Bolea Osta Badiola Zaragoza Espinosa Torres Martín-Burriel MicroRNAs (miRNAs) may contribute to the development and pathology of many neurodegenerative diseases, including prion diseases. They are also promising biomarker candidates due to their stability in...
Mon Jun 15, 2020 03:00
Biomolecules, Vol. 10, Pages 907: Structural Basis of Specific Glucoimidazole and Mannoimidazole Binding by Os3BGlu7 Biomolecules doi: 10.3390/biom10060907 Authors: Bodee Nutho Salila Pengthaisong Anupong Tankrathok Vannajan Sanghiran Lee James R. Ketudat Cairns Thanyada Rungrotmongkol Supot Hannongbua β-Glucosidases and β-mannosidases hydrolyze substrates that differ only in the epimer of the nonreducing terminal sugar moiety, but most such enzymes...
Mon Jun 15, 2020 03:00
Biomolecules, Vol. 10, Pages 906: 1H Nuclear Magnetic Resonance of Pig Seminal Plasma Reveals Intra-Ejaculate Variation in Metabolites Biomolecules doi: 10.3390/biom10060906 Authors: Yentel Mateo-Otero Pol Fernández-López Sergi Gil-Caballero Beatriz Fernandez-Fuertes Sergi Bonet Isabel Barranco Marc Yeste In pigs, ejaculate is expelled in fractions, mainly the sperm-rich fraction (SRF) and the post-SRF (PSRF), which differ in both sperm content and origin. In addition,...
Mon Jun 15, 2020 03:00
Biosensors, Vol. 10, Pages 64: Pectobacterium atrosepticum Biosensor for Monitoring Blackleg and Soft Rot Disease of Potato Biosensors doi: 10.3390/bios10060064 Authors: Mahdis Hashemi Tameh Elisabetta Primiceri Maria Serena Chiriacò Palmiro Poltronieri Masoud Bahar Giuseppe Maruccio Pectobacterium atrosepticum (Pba) is a quarantine and threatening phytopathogen known as the causal agent of blackleg and soft rot disease of potatoes in many areas. Its early detection is...
Mon Jun 15, 2020 03:00
Brain Sciences, Vol. 10, Pages 373: Uniportal Full Endoscopic Posterolateral Transforaminal Lumbar Interbody Fusion with Endoscopic Disc Drilling Preparation Technique for Symptomatic Foraminal Stenosis Secondary to Severe Collapsed Disc Space: A Clinical and Computer Tomographic Study with Technical Note Brain Sciences doi: 10.3390/brainsci10060373 Authors: Wu Kim Lee Kim Lee Jeon Raorane Jang Background: Severe collapsed disc secondary to degenerative spinal...
Mon Jun 15, 2020 03:00
Brain Sciences, Vol. 10, Pages 372: Familial Hemiplegic Migraine with an ATP1A4 Mutation: Clinical Spectrum and Carbamazepine Efficacy Brain Sciences doi: 10.3390/brainsci10060372 Authors: Giangennaro Coppola Grazia Maria Giovanna Pastorino Luigi Vetri Floriana D’Onofrio Francesca Felicia Operto An Italian family with familial hemiplegic migraine (FHM) with the absence of mutations in the known genes associated with this disorder, namely ATP1A2, ATP1A3, CACNA1A, and SCN1A,...
Mon Jun 15, 2020 03:00
Brain Sciences, Vol. 10, Pages 371: Experimental and Clinical Treatment of Subarachnoid Hemorrhage after the Rupture of Saccular Intracranial Aneurysms Brain Sciences doi: 10.3390/brainsci10060371 Authors: Serge Marbacher John H. Zhang The Special Issue “Experimental and Clinical Treatment of Subarachnoid Hemorrhage after the Rupture of Saccular Intracranial Aneurysms” provides an excellent insight into the many facets of aneurysmal subarachnoid hemorrhage [...]
Mon Jun 15, 2020 03:00
Cancers, Vol. 12, Pages 1578: Low Prevalence of HER2-Positive Breast Carcinomas among Screening Detected Breast Cancers Cancers doi: 10.3390/cancers12061578 Authors: M. Ángeles López-García Irene Carretero-Barrio Belén Pérez-Míes Miguel Chiva Carolina Castilla Begoña Vieites José Palacios Conflicting results have been reported regarding the prevalence of screen-detected human epidermal growth factor receptor 2 (HER2)-positive breast carcinomas and non-screen detected...
Mon Jun 15, 2020 03:00
Cancers, Vol. 12, Pages 1586: Ubiquilin Networking in Cancers Cancers doi: 10.3390/cancers12061586 Authors: Salinee Jantrapirom Luca Lo Piccolo Dumnoensun Pruksakorn Saranyapin Potikanond Wutigri Nimlamool Ubiquilins or UBQLNs, members of the ubiquitin-like and ubiquitin-associated domain (UBL-UBA) protein family, serve as adaptors to coordinate the degradation of specific substrates via both proteasome and autophagy pathways. The UBQLN substrates reveal great diversity and...
Mon Jun 15, 2020 03:00
Cancers, Vol. 12, Pages 1585: Use of a Luciferase-Expressing Orthotopic Rat Brain Tumor Model to Optimize a Targeted Irradiation Strategy for Efficacy Testing with Temozolomide Cancers doi: 10.3390/cancers12061585 Authors: Alexandra M. Mowday Natasja G. Lieuwes Rianne Biemans Damiënne Marcus Behzad Rezaeifar Brigitte Reniers Frank Verhaegen Jan Theys Ludwig J. Dubois Glioblastoma multiforme (GBM) is a common and aggressive malignant brain cancer with a mean survival...
Mon Jun 15, 2020 03:00
Cancers, Vol. 12, Pages 1584: Blood Flow Measurements Enable Optimization of Light Delivery for Personalized Photodynamic Therapy Cancers doi: 10.3390/cancers12061584 Authors: Yi Hong Ong Joann Miller Min Yuan Malavika Chandra Mirna El Khatib Sergei A. Vinogradov Mary E. Putt Timothy C. Zhu Keith A. Cengel Arjun G. Yodh Theresa M. Busch Fluence rate is an effector of photodynamic therapy (PDT) outcome. Lower light fluence rates can conserve tumor perfusion...
Mon Jun 15, 2020 03:00
Cancers, Vol. 12, Pages 1587: Current Strategies for Treating NSCLC: From Biological Mechanisms to Clinical Treatment Cancers doi: 10.3390/cancers12061587 Authors: Junnan Li Hang Kwok The identification of specific epidermal growth factor receptor (EGFR)-activating mutations heralded a breakthrough in non-small-cell lung cancer (NSCLC) treatments, with the subsequent development of EGFR-tyrosine kinase inhibitor (TKIs) becoming the first-line therapy for patients harboring EGFR mutations....
Mon Jun 15, 2020 03:00
Cancers, Vol. 12, Pages 1582: The Deubiquitinase USP4 Stabilizes Twist1 Protein to Promote Lung Cancer Cell Stemness Cancers doi: 10.3390/cancers12061582 Authors: Fengtian Li Qingyong Hu Tao He Jing Xu Yong Yi Siyi Xie Liangping Ding Mengyuan Fu Rongtian Guo Zhi-Xiong Jim Xiao Mengmeng Niu Lung cancer stem cells (CSCs) play a pivotal role in tumor development, drug resistance, metastasis and recurrence of lung cancer. Thus, it is of great importance to study...
Mon Jun 15, 2020 03:00
Cancers, Vol. 12, Pages 1583: Obesity and the Impact on Cutaneous Melanoma: Friend or Foe? Cancers doi: 10.3390/cancers12061583 Authors: Lorey K. Smith Shaghayegh Arabi Emily J. Lelliott Grant A. McArthur Karen E. Sheppard Excess body weight has been identified as a risk factor for many types of cancers, and for the majority of cancers, it is associated with poor outcomes. In contrast, there are cancers in which obesity is associated with favorable outcomes and this has been...
Mon Jun 15, 2020 03:00
Cancers, Vol. 12, Pages 1580: Assessment of the Extent of Resection in Surgery of High-Grade Glioma—Evaluation of Black Blood Sequences for Intraoperative Magnetic Resonance Imaging at 3 Tesla Cancers doi: 10.3390/cancers12061580 Authors: Tom Finck Jens Gempt Sandro M. Krieg Bernhard Meyer Claus Zimmer Benedikt Wiestler Jan S. Kirschke Nico Sollmann Achieving an optimal extent of resection (EOR) whilst keeping lasting neurological decline to a minimum is paramount...
Mon Jun 15, 2020 03:00
Cancers, Vol. 12, Pages 1581: Cancer and SARS-CoV-2 Infection: Diagnostic and Therapeutic Challenges
Cancers, Vol. 12, Pages 1581: Cancer and SARS-CoV-2 Infection: Diagnostic and Therapeutic Challenges Cancers doi: 10.3390/cancers12061581 Authors: Alessandro Allegra Giovanni Pioggia Alessandro Tonacci Caterina Musolino Sebastiano Gangemi In late December 2019, a new infectious viral disease appeared. A new betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), has been recognized as the pathogen responsible for this infection. Patients affected by...
Mon Jun 15, 2020 03:00
Cancers, Vol. 12, Pages 1579: Advances in Deubiquitinating Enzyme Inhibition and Applications in Cancer Therapeutics Cancers doi: 10.3390/cancers12061579 Authors: Ainsley Mike Antao Apoorvi Tyagi Kye-Seong Kim Suresh Ramakrishna Since the discovery of the ubiquitin proteasome system (UPS), the roles of ubiquitinating and deubiquitinating enzymes (DUBs) have been widely elucidated. The ubiquitination of proteins regulates many aspects of cellular functions such as protein degradation...
Mon Jun 15, 2020 03:00
Cancers, Vol. 12, Pages 1577: 8th Edition Tumor, Node, and Metastasis T-Stage Prognosis Discrepancies: Solid Component Diameter Predicts Prognosis Better than Invasive Component Diameter Cancers doi: 10.3390/cancers12061577 Authors: Kazuhito Funai Akikazu Kawase Kiyomichi Mizuno Sin Koyama Norihiko Shiiya The biggest change in the 8th edition of the tumor, lymph node, and metastasis (TNM) classification is the recommendation of the solid component diameter and invasive size...
Mon Jun 15, 2020 03:00
Cancers, Vol. 12, Pages 1576: Sorafenib Resistance in Hepatocellular Carcinoma: The Relevance of Genetic Heterogeneity Cancers doi: 10.3390/cancers12061576 Authors: Loraine Kay D. Cabral Claudio Tiribelli Caecilia H. C. Sukowati Despite advances in biomedicine, the incidence and the mortality of hepatocellular carcinoma (HCC) remain high. The majority of HCC cases are diagnosed in later stages leading to the less than optimal outcome of the treatments. Molecular targeted therapy...
Mon Jun 15, 2020 03:00
Cancers, Vol. 12, Pages 1575: Therapeutic Efficacy of ABN401, a Highly Potent and Selective MET Inhibitor, Based on Diagnostic Biomarker Test in MET-Addicted Cancer Cancers doi: 10.3390/cancers12061575 Authors: Jooseok Kim Kyung Eui Park Yoo-Seong Jeong YeongMun Kim Hayeon Park Ji-Hye Nam Kyungsoo Jung Woo Sung Son Hun Soon Jung Jong-Hwa Lee Seong Hoon Jeong Nam Ah Kim Jae Du Ha Sung Yun Cho Yoon-La Choi Suk-Jae Chung Jun Young Choi Sungyoul...
Mon Jun 15, 2020 03:00
Cells, Vol. 9, Pages 1467: Nanospheres Loaded with Curcumin Improve the Bioactivity of Umbilical Cord Blood-Mesenchymal Stem Cells via c-Src Activation During the Skin Wound Healing Process Cells doi: 10.3390/cells9061467 Authors: Do-Wan Kim Chang-Hyung Choi Jong Pil Park Sei-Jung Lee Curcumin, a hydrophobic polyphenol derived from turmeric, has been used a food additive and as a herbal medicine for the treatment of various diseases, but the clinical application of curcumin...
Mon Jun 15, 2020 03:00
Cells, Vol. 9, Pages 1464: Ongoing Research on the Role of Gintonin in the Management of Neurodegenerative Disorders Cells doi: 10.3390/cells9061464 Authors: Muhammad Ikram Rahat Ullah Amjad Khan Myeong Ok Kim Neurodegenerative disorders, namely Parkinson’s disease (PD), Huntington’s disease (HD), Alzheimer’s disease (AD), and multiple sclerosis (MS), are increasingly major health concerns due to the increasingly aged population worldwide. These...
Mon Jun 15, 2020 03:00
Cells, Vol. 9, Pages 1465: The Use of Three-Dimensional DNA Fluorescent In Situ Hybridization (3D DNA FISH) for the Detection of Anaplastic Lymphoma Kinase (ALK) in Non-Small Cell Lung Cancer (NSCLC) Circulating Tumor Cells Cells doi: 10.3390/cells9061465 Authors: Arutha Kulasinghe Yenkai Lim Joanna Kapeleris Majid Warkiani Ken O’Byrne Chamindie Punyadeera Tumor tissue biopsy is often limited for non-small cell lung cancer (NSCLC) patients and alternative sources of tumoral...
Mon Jun 15, 2020 03:00
Cells, Vol. 9, Pages 1466: Emerging Roles of Post-Translational Modifications in Nucleotide Excision Repair Cells doi: 10.3390/cells9061466 Authors: Barbara N. Borsos Hajnalka Majoros Tibor Pankotai Nucleotide excision repair (NER) is a versatile DNA repair pathway which can be activated in response to a broad spectrum of UV-induced DNA damage, such as bulky adducts, including cyclobutane-pyrimidine dimers (CPDs) and 6–4 photoproducts (6–4PPs). Based on the...
Mon Jun 15, 2020 03:00
Cells, Vol. 9, Pages 1463: EDMD-Causing Emerin Mutant Myogenic Progenitors Exhibit Impaired Differentiation Using Similar Mechanisms Cells doi: 10.3390/cells9061463 Authors: Ashvin Iyer James M. Holaska Mutations in the gene encoding emerin (EMD) cause Emery–Dreifuss muscular dystrophy (EDMD1), an inherited disorder characterized by progressive skeletal muscle wasting, irregular heart rhythms and contractures of major tendons. The skeletal muscle defects seen in EDMD are...
Mon Jun 15, 2020 03:00
Children, Vol. 7, Pages 62: Bilateral Pulmonary Embolism in a 12-Year-Old Girl with Steroid-Resistant Nephrotic Syndrome Children doi: 10.3390/children7060062 Authors: Osama Y. Safdar Rahaf H. Rajab Rand G. Alghanemi Gazal A. Tantawi Noora A. Alsulami Aeshah A. Alsayed Abdullah K. Habiballah Nephrotic syndrome is the most common glomerular disease among children. Although most cases respond to steroid therapy, approximately 10–20% of patients exhibit resistance...
Mon Jun 15, 2020 03:00
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