Abstract Myriad radiation effects, including benefits and detriments, complicate justifying and optimizing radiation exposures. The purpose of this study was to develop a comprehensive conceptual framework and corresponding quantitative methods to aggregate the detriments and benefits of radiation exposures to individuals, groups, and populations. In this study, concepts from the ICRP for low dose were integrated with clinical techniques focused on high dose to develop a comprehensive...
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Conditions: Melanoma; Lung Cancer; Head and Neck Cancer; Urogenital Neoplasms; Breast CancerIntervention: Drug: ImmunotherapySponsors: Fondazione IRCCS Istituto Nazionale dei Tumori, Milano; Karolinska University Hospital; St Vincent's University Hospital, Ireland; Oslo University HospitalNot yet recruiting
Wed Jun 17, 2020 19:00
Condition: Esophageal Squamous Cell CarcinomaIntervention: Drug: Pembrolizumab InjectionSponsors: Ruijin Hospital; Fujian Medical University Union Hospital; Zhejiang University; The First Affiliated Hospital of Anhui Medical University; The First Affiliated Hospital of Nanchang UniversityNot yet recruiting
Wed Jun 17, 2020 19:00
Condition: Advanced Gastric or Gastroesophageal Junction AdenocarcinomaInterventions: Drug: QL1604; Drug: Nab-paclitaxel; Drug: PaclitaxelSponsor: Qilu Pharmaceutical Co., Ltd.Not yet recruiting
Wed Jun 17, 2020 19:00
Conditions: Head and Neck Neoplasms; Squamous Cell Carcinoma; Squamous Skin CarcinomaIntervention: Radiation: Stereotactic Body Radiotherapy (SBRT)Sponsors: McMaster University; Juravinski Cancer Centre FoundationNot yet recruiting
Wed Jun 17, 2020 19:00
Publication date: Available online 16 June 2020Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Yujiro Yokoyama, Hisato Takagi, Toshiki Kuno
Wed Jun 17, 2020 19:26
To rapidly communicate short reports of innovative responses to Covid-19 around the world, along with a range of current thinking on policy and strategy relevant to the pandemic, the Journal has initiated the Covid-19 Notes series. Covid-19 has arrived at our clinic, GHESKIO, in Port-au-Prince,…
Tue Jun 16, 2020 03:00
"Yes, hello?" Her voice was breathy and anxious — that of someone who’d been waiting all day for this call. It was 10:30 p.m. "Hi, Ms. A. it’s Dr. Stuart. I’m sorry to be calling so late. I wanted to give you an update on how your husband is doing." These daily — or rather, nightly — phone calls…
Tue Jun 16, 2020 03:00
Covid-19 has become the singular priority of our health care delivery system — disrupting patient care processes, halting many research activities, and profoundly affecting medical education. Graduate medical education (GME) programs have had to interrupt typical training experiences, given the…
Tue Jun 16, 2020 03:00
Abstract Introduction Conflicting results have been reported in the association between glioblastoma proximity to the subventricular zone (SVZ) and enrichment of cancer stem cell properties. Here, we examined this hypothesis using magnetic resonance (MR) images derived from 217 The Cancer Imaging Archive (TCIA) glioblastoma subjects. Methods Pre-operative...
Mon Jun 15, 2020 03:00
Abstract Purpose Immunotherapy has demonstrated efficacy in treatment of intracranial metastasis from melanoma, calling into question the role of intracranial radiotherapy (RT). Herein, we assessed the utilization patterns of intracranial RT in patients with melanoma brain metastasis and compared outcomes in patients treated with immunotherapy alone versus immunotherapy in addition to intracranial RT. ...
Mon Jun 15, 2020 03:00
Abstract Introduction Beyond focal radiation, there is no consensus standard therapy for pediatric high-grade glioma (pHGG) and outcomes remain dismal. We describe the largest molecularly-characterized cohort of children with pHGG treated with a 3-drug maintenance regimen of temozolomide, irinotecan, and bevacizumab (TIB) following radiation. Methods ...
Tue Jun 16, 2020 03:00
We use a lottery analogy to show how sexual reproduction is advantageous in populations that contain abundant genetic variation. Since it has been shown that most eukaryotic species are genetically polymorphic, our model can explain the ubiquity of sex among such species. The model also indicates that classic population genetics theory is applicable to ecological studies of natural selection acting on standing genetic variation.
Wed Jun 17, 2020 03:00
Virus evolution drives the annual influenza epidemics in human population worldwide. However, it has been challenging to evaluate the mutation effect of the influenza virus on evading the population immunity. In this study, we introduce a novel statistical and computational approach to measure the dynamic molecular determinants underlying epidemics by the effective mutations (EMs), and account for the time of waning mutation advantage against herd immunity by the effective mutation periods (EMPs)....
Wed Jun 17, 2020 03:00
The several hundreds of species of bdelloid rotifers are notorious because they represent an ancient clade comprising only asexual lineages. Moreover, most bdelloid species have the ability to withstand complete desiccation and high doses of ionizing radiation, being able to repair their DNA after massive genome breakage. To better understand the impact of long-term asexuality and DNA breakage on genome evolution, a telomere-to-tolemere reference genome assembly of a bdelloid species is critical....
Wed Jun 17, 2020 03:00
Host plant specialization across herbivorous insects varies dramatically, but the underlying evolutionary mechanisms are little-known. The milkweed bugs (Heteroptera: Lygaeinae) are ancestrally associated with plants of the Apocynaceae from which they commonly sequester cardiac glycosides for defense, facilitated by resistant Na+/K+-ATPases and adaptations for transport, storage and discharge of toxins. Here, we show that three Lygaeinae species independently colonized four novel non-apocynaceous...
Wed Jun 17, 2020 03:00
A thorough reconstruction of historical processes is essential for a comprehensive understanding of processes shaping patterns of genetic diversity. Indeed, past and current conditions influencing effective population size have important evolutionary implications for the efficacy of selection, increased accumulation of deleterious mutations, and loss of adaptive potential. Here, we gather extensive genome-wide data that represent the extant diversity of the Coho salmon (Oncorhynchus kisutch) to address...
Tue Jun 16, 2020 03:00
Despite holding a central role for fertilisation success, reproductive traits often show elevated rates of evolution and diversification. The rapid evolution of seminal fluid proteins (Sfps) within populations is predicted to cause mis-signalling between the male ejaculate and female reproductive tract between populations resulting in postmating prezygotic (PMPZ) isolation. Crosses between populations of Drosophila montana show PMPZ isolation in the form of reduced fertilisation success in both noncompetitive...
Tue Jun 16, 2020 03:00
Chitinases enzymatically hydrolyze chitin, a highly abundant biomolecule with many potential industrial and medical uses in addition to their natural biological roles. Fungi are a rich source of chitinases, however the phylogenetic and functional diversity of fungal chitinases are not well understood. We surveyed fungal chitinases from 373 publicly available genomes, characterized domain architecture, and conducted phylogenetic analyses of the glycoside hydrolase family 18 (GH18) domain. This large-scale...
Tue Jun 16, 2020 03:00
Related ArticlesCurrent knowledge of pituitary adenylate cyclase activating polypeptide (PACAP) in articular cartilage. Histol Histopathol. 2020 Jun 16;:18233 Authors: Lauretta G, Ravalli S, Szychlinska MA, Castorina A, Maugeri G, D'Amico AG, D'Agata V, Musumeci G Abstract Pituitary adenylate cyclase activating polypeptide (PACAP) is an evolutionally well conserved neuropeptide, mainly expressed by neuronal and peripheral cells. It proves to be an interesting...
Wed Jun 17, 2020 19:16
Abstract Background Radiation dose at CT should be as low as possible without compromising diagnostic quality. Objective To assess the potential for maximum dose reduction of pediatric lung dual-source CT with spectral shaping and advanced iterative reconstruction (ADMIRE). Materials and...
Wed Jun 17, 2020 03:00
Abstract Background Very-low-birth-weight (VLBW) preterm neonates are vulnerable to patent ductus arteriosus (PDA), which might be related to high-resistance flow in the superior mesenteric artery (SMA), with decreased diastolic flow in situations of marked intestinal hypoperfusion. No previous studies have evaluated the portal vein and superior mesenteric vein (SMV) parameters to assess the PDA hemodynamic repercussions. ...
Tue Jun 16, 2020 03:00
Abstract Background Pancreas atrophy and the loss of T1-weighted signal intensity by magnetic resonance imaging (MRI) are findings of chronic pancreatitis. Objective The purpose of this study was to test published normal values and cutoffs for pancreas thickness and the pancreas:spleen T1-weighted signal intensity ratio in children without pancreatic...
Tue Jun 16, 2020 03:00
Publication date: July 2020Source: Journal of Cranio-Maxillofacial Surgery, Volume 48, Issue 7Author(s):
Wed Jun 17, 2020 19:08
Publication date: July 2020Source: Journal of Cranio-Maxillofacial Surgery, Volume 48, Issue 7Author(s):
Wed Jun 17, 2020 19:08
Publication date: July 2020Source: Journal of Cranio-Maxillofacial Surgery, Volume 48, Issue 7Author(s):
Wed Jun 17, 2020 19:08
Publication date: Available online 17 June 2020Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Zhiyang Liu, Qianyang Xie, Chi Yang, Minjie Chen, Guo Bai, Ahmed Abdelrehem
Wed Jun 17, 2020 19:08
Cerato-platanins (CPs) form a family of fungal small secreted cysteine-rich proteins (SSCPs) and are of particular interest not only because of their surface activity but also their abundant secretion by fungi. We performed an evolutionary analysis of 283 CPs from 157 fungal genomes with the focus on the environmental opportunistic plant-beneficial and mycoparasitic fungus Trichoderma. Our results revealed a long evolutionary history of CPs in Dikarya fungi that have undergone several events of lateral...
Wed Jun 17, 2020 18:00
Oral allergy syndrome (OAS) is one of the most common IgE-mediated allergic reactions. It is characterized by a number of symptoms induced by the exposure of the oral and pharyngeal mucosa to allergenic protei...
Wed Jun 17, 2020 03:00
Publication date: September 2020Source: Biomedicine & Pharmacotherapy, Volume 129Author(s): Wei Li, Tinghong Pan, Wei Jiang, Hongying Zhao
Wed Jun 17, 2020 19:04
Publication date: September 2020Source: Biomedicine & Pharmacotherapy, Volume 129Author(s): Kunbei Lai, Yajun Gong, Wenbo Zhao, Longhui Li, Chuangxin Huang, Fabao Xu, Xiaojing Zhong, Chenjin Jin
Wed Jun 17, 2020 19:04
Publication date: September 2020Source: Biomedicine & Pharmacotherapy, Volume 129Author(s): Xiangyan Wu, Aling Shen, Liya Bao, Meizhu Wu, Xiaoying Lin, Huai Wang, Youqin Chen, Qiaoyan Cai, Shan Lin, Xueling Zhou, Yan Lu, Meizhong Peng, Daxin Chen, Jianfeng Chu, Jun Peng
Wed Jun 17, 2020 19:04
Publication date: September 2020Source: Biomedicine & Pharmacotherapy, Volume 129Author(s): Kailiang Li, Hongchao Han, Wenjing Gu, Chunyuan Cao, Pengyuan Zheng
Wed Jun 17, 2020 19:04
Publication date: September 2020Source: Biomedicine & Pharmacotherapy, Volume 129Author(s): Chao Dong, Hong Yang, Yongkui Wang, Xu Yan, Dongzhe Li, Zhengming Cao, Yongming Ning, Chunlin Zhang
Wed Jun 17, 2020 19:04
Publication date: September 2020Source: Biomedicine & Pharmacotherapy, Volume 129Author(s): Ye Zhou, Meng Zhang, Zhilei Zhang, Yuming Jia, Chong Zhang, Li Peng
Wed Jun 17, 2020 19:04
Publication date: September 2020Source: Biomedicine & Pharmacotherapy, Volume 129Author(s): Huipeng Li, Huayu Zhang, Guohua Wang, Zhinian Chen, Youmin Pan
Wed Jun 17, 2020 19:04
Publication date: September 2020Source: Biomedicine & Pharmacotherapy, Volume 129Author(s): Xiao-Hong Li, Yan-Ru Liu, Da-Hai Jiang, Zhi-Shu Tang, Da-Wei Qian, Zhong-Xing Song, Lin Chen, Xin-Bo Shi, Ning-Juan Yang, Ya-Feng Yan, Ai-Bing Chang
Wed Jun 17, 2020 19:04
Publication date: September 2020Source: Biomedicine & Pharmacotherapy, Volume 129Author(s): Xuedong He, Lu Zhao, Weihe Zhong, Hsin-Yi Chen, Xiaoting Shan, Ning Tang, Calvin Yu-Chian Chen
Wed Jun 17, 2020 19:04
Publication date: September 2020Source: Biomedicine & Pharmacotherapy, Volume 129Author(s): Yicheng Yang, Fan Lin, Zhiqiang Xiao, Bo Sun, Zhiyao Wei, Bingyang Liu, Lin Xue, Changming Xiong
Wed Jun 17, 2020 19:04
Publication date: September 2020Source: Biomedicine & Pharmacotherapy, Volume 129Author(s): Mateusz Niedzielski, Marlena Broncel, Paulina Gorzelak-Pabiś, Ewelina Woźniak
Wed Jun 17, 2020 19:04
Publication date: September 2020Source: Biomedicine & Pharmacotherapy, Volume 129Author(s): Jiansong Han, Xinquan Gu, Yang Li, Qiaoli Wu
Wed Jun 17, 2020 19:04
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