Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Critically ill patients are known to have a variety of electrolyte abnormalities. Lactic acidosis can frequently be seen secondary to shock states and is usually treated with aggressive volume resuscitation. Interestingly, hypophosphatemia is a potential cause of resistant lactic acidosis, which may not be as commonly identified or considered. We present a case of a 42-year-old man admitted twice...
Tue Jun 16, 2020 15:03
Abstract Malignant renal tumours represent 5% of childhood cancers and include types with likely different aetiology: Wilms tumour (WT), rhabdoid renal tumour, kidney sarcomas, and renal carcinomas. WT is the most common renal tumour in children, previously shown to vary internationally and with ethnicity. Using the comprehensive database of the International Incidence of Childhood Cancer study (IICC), we analysed global variations and time trends in incidence of renal tumour types in children (age...
Tue Jun 16, 2020 12:05
Abstract Ovarian cancer has a poor survival rate and, understandably, women often want to know whether there is anything they can do to improve their prognosis. Our goal was to investigate the association between a healthy lifestyle pre‐ and post‐diagnosis and survival in a cohort of Australian women with invasive epithelial ovarian cancer. We calculated a healthy lifestyle index (HLI) based on women's self‐reported smoking status, height, weight, physical activity, diet and alcohol consumption...
Tue Jun 16, 2020 12:05
Abstract Helicobacter pylori infection induces inflammation of the gastric mucosa, which may progress to precancerous lesions and gastric cancer. The gastric histo‐pathological damages may be associated to some virulence genes of the bacterium, notably vacA and cagA genes. To establish correlations between these genes and the lesions, biopsies from 1303 adults consenting patients that were previously analyzed by PCR to characterize vacA ‐s ‐m, −i regions and cagA 3′ region polymorphism, were...
Tue Jun 16, 2020 12:05
ABSTRACT Vaccination against human papillomavirus (HPV) has been introduced as a public health initiative in many countries, including Denmark since October 2008. It is important to monitor post‐implementation effectiveness of HPV‐vaccination at the population‐level. We studied HPV‐prevalence after first invitation to screening at age 23 years in women offered the quadrivalent HPV‐vaccine at the age of 14 years. Randomly selected screening samples from women born in 1994 in four out of five Danish...
Tue Jun 16, 2020 12:05
Abstract Identification of glomerular lesions and structures is a key point for pathological diagnosis, treatment instructions and prognosis evaluation in kidney diseases. These time‐consuming tasks require a more accurate and reproducible quantitative analysis method. We established derivation and validation cohorts composed of 400 Chinese patients with Immunoglobulin A nephropathy (IgAN) retrospectively. Deep convolutional neural networks and biomedical image processing algorithms were implemented...
Tue Jun 16, 2020 22:15
Abstract Introduction Anatomic cruciate ligament reconstruction is known to be correlated with better clinical results. The aim of the study was to provide a simple method to enable anatomic results in the setting of PCL reconstruction. We, therefore, assessed the tibial and femoral insertion site of the posterior cruciate ligament (PCL) by the use of an objective coordinate system in an anatomical study. We also sought to show reproducibility...
Wed Jun 17, 2020 03:00
"Yes, hello?" Her voice was breathy and anxious — that of someone who’d been waiting all day for this call. It was 10:30 p.m. "Hi, Ms. A. it’s Dr. Stuart. I’m sorry to be calling so late. I wanted to give you an update on how your husband is doing." These daily — or rather, nightly — phone calls…
Tue Jun 16, 2020 03:00
See this image from 100 micron cadaveric MRI , done on 7Tesla MRI recently published in scientific data recently. Isn’t it beautiful?That’s the privilege we have as students of medicine , learning about the human body , how it works , it has fascinated artists over the years and it is privilege and blessing to be learning all this. Quoting Ayn Rand (The Fountainhead) here Now take a human body. Why wouldn't you like to see a human body with a curling tail with a crest of ostrich feathers at the...
Wed Jun 17, 2020 09:02
Related ArticlesIntrathecal use of gadobutrol for gadolinium-enhanced MR cisternography in the evaluation of patients with otorhinorrhea. Neuroradiology. 2020 Jun 13;: Authors: Dogan SN, Salt V, Korkmazer B, Arslan S, Islak C, Kocer N, Kizilkilic O Abstract PURPOSE: Intrathecal gadolinium-enhanced MR cisternography (IGE-MRC) has a high sensitivity to detect accurate localization of cerebrospinal fluid (CSF) leakage in otorhinorrhea patients. Our purpose...
Wed Jun 17, 2020 08:54
Summary Temozolomide (TMZ) generates DNA adducts that are repaired by direct DNA and base excision repair mechanisms. Methoxyamine (MX, TRC-102) potentiates TMZ activity by binding to apurinic and apyrimidinic (AP) sites after removal of N3-methyladenine and N7-methylguanine, inhibiting site recognition of AP endonuclease. We conducted a phase I trial to determine the maximum tolerated dose and dose-limiting toxicities (DLTs) of intravenous MX when given with oral TMZ. Patients...
Wed Jun 17, 2020 03:00
Horm Metab ResDOI: 10.1055/a-1192-5447© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Tue Jun 16, 2020 02:00
Exp Clin Endocrinol Diabetes 2020; 128: 355-357DOI: 10.1055/a-1163-7355© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Tue Jun 16, 2020 02:00
Exp Clin Endocrinol Diabetes 2020; 128: 358-374DOI: 10.1055/a-1175-4610The wide spectrum of novel applications for the LC-MS/MS-based analysis of thyroid hormone metabolites (THM) in blood samples and other biological specimen highlights the perspectives of this novel technology. However, thorough development of pre-analytical sample workup and careful validation of both pre-analytics and LC-MS/MS...
Tue Jun 16, 2020 02:00
Exp Clin Endocrinol Diabetes 2020; 128: 479-487DOI: 10.1055/a-1144-2636Determination of the levels of thyroid-stimulating hormone (TSH) and free thyroid hormones (fTHs) is crucial for assessing thyroid function. However, as a result of inter-individual genetic variability and different environmental factors individual set points exist for TSH and fTHs and display considerable variation. Furthermore,...
Tue Jun 16, 2020 02:00
Covid-19 has become the singular priority of our health care delivery system — disrupting patient care processes, halting many research activities, and profoundly affecting medical education. Graduate medical education (GME) programs have had to interrupt typical training experiences, given the…
Tue Jun 16, 2020 03:00
Surgical Infections, Ahead of Print.
Mon Jun 15, 2020 10:00
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