Abstract Purpose To analyze the surgical outcomes in terms of postoperative wound complications in a small case series of six patients treated with lateral cervical approach (LCA) for salvage total laryngectomy (STL) without prophylactic use of the pectoralis major myocutaneous flap (PMMF) or free flaps. Methods Between September 2018 and August...
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Abstract There is still controversy on the role of hyperinsulinemia and endogenous antisecretory factor (EAF) in Meniere’s disease. In the literature, there is no mention on glucose uptake or specially processed cereals (SPC). Nevertheless, the role of EAF and its inhibition by SPC should be taken into account in future research. In case of patients not responding to medical treatment and dietary changes, intratympanic (IT) treatment has been suggested. In Italy, generalists...
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Abstract Objective Septal deviation is an important cause of impaired nasal breathing among pediatric patients. A widespread solution to septal deviation is septoplasty. However, there are certain controversies surrounding the effect of this technique on pediatric patients and its influence on the growth centers of the nose. The objective of this review is to study if there is a strong and valid evidence in the literature that supports...
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Abstract Background Benign paroxysmal positional vertigo (BPPV) is the most common cause of peripheral vertigo and its recurrence is fairly common. Several studies correlated the pathophysiological role of different comorbidities—such as diabetes, osteoporosis, vascular, psychiatric and autoimmune diseases—in the development and recurrence of BPPV. The aim of this study is to analyse the pharmacological history of patients with idiopathic...
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Abstract Purpose The advent of endoscopic otosurgery provides reduced tissue destruction with theoretically improved views, yet a quantification of the difference of exposure between microscopic and endoscopic approaches has not yet been performed in human specimens. The objective of this study was to assess the difference in views of cadaveric tympanic membranes when inspected with operating microscopes or endoscopes. ...
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Abstract Objective In this study, it was aimed to evaluate and compare biochemical and histopathological effects of platelet-rich plasma (PRP), ozone and hyperbaric oxygen (HBO) on wound healing which was formed experimentally in oral cavity of rats. Materials and methods In this study, thirty-six Wistar Hannover rats with weight of 250–350 g,...
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What is social change, and where is it coming from? How can we see it when it happens, and is there ever any moment of time where there is no change? Societies never stagnate, of course, but is there something like accelerated change or the beginning of social change? What are the conditions for it? And how can we not only recognise it when it happens but also relate it to a readership? These questions shaped our discussions during two terms in the seminar rooms of the Chair of Social Anthropology,...
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In late june 2017, Arnos Yong's Renewing Christian Theology: Systematics for a Global Christianity (Baylor University Press, 2014) was the subject of a specially organized Theology Forum at the University of Bern, Switzerland. Four of the discussants wrote up their reflections, and the author then penned a rejoinder. The following reviews, followed by a response from the author, track some of the questions and conversations being catalyzed by the ongoing development of Pentecostal theology, particularly...
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Inflammasome-induced pyroptosis comprises a key cell-autonomous immune process against intracellular bacteria, namely the generation of dying cell structures. These so-called pore-induced intracellular traps (PITs) entrap and weaken intracellular microbes. However, the immune importance of pyroptosis against extracellular pathogens remains unclear. Here, we report that Type-3 secretion system (T3SS)-expressing Pseudomonas aeruginosa ( P. aeruginosa ) escaped PIT immunity by inducing a NLRC4 inflammasome-dependent...
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We describe a versatile method for chromosomal gene editing based on classical consecutive single-crossovers. The method exploits rapid plasmid construction using Gibson assembly, a convenient E. coli donor strain, and efficient dual-negative selection for improved suicide vector resolution. We used this method to generate in frame deletions, insertions and point mutations in Salmonella enterica with limited hands-on time. Similar strategies allowed efficient gene editing also in Pseudomonas aeruginosa...
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Altered lipid metabolism in macrophages is associated with various important inflammatory conditions. Although lipid metabolism is an important target for therapeutic intervention, the metabolic requirement involved in lipid accumulation during pro-inflammatory activation of macrophages remains incompletely characterized. We show here that macrophage activation with IFNγ results in increased aerobic glycolysis, iNOS-dependent inhibition of respiration, and accumulation of triacylglycerol. Surprisingly,...
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Abstract The current study has investigated whether pure malingering, in which reported symptoms are nonexistent, partial malingering, in which existent symptoms are exaggerated, and genuine symptoms could be differentiated by applying the verifiability approach (VA) and the Self-Report Symptom Inventory (SRSI). The logic behind the VA is that deceivers’ statements contain more non-verifiable information, whereas truth tellers’ accounts include more verifiable details. The SRSI...
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Abstract Despite the potential of teledermatology to increase access to dermatology services and improve patient care, it is not widely practised in Australia. In an effort to increase uptake of teledermatology by Australian dermatologists and support best practice, guidelines for teledermatology for the Australian context have been developed by The University of Queensland's Centre for Online Health in collaboration with The Australasian College of Dermatologists’ E‐Health Committee. The guidelines...
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Abstract High‐frequency ultrasonography (HFUS) represents a useful adjunct for dermatologists in the diagnosis of capillary malformation‐arteriovenous malformation (CM‐AVM) syndrome. We present a paediatric case series of 6 patients with confirmed RASA1 gene mutation in whom HFUS demonstrated AVM beneath cutaneous CM‐like lesions greater than 1.5 cm.
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Abstract We describe our connectomics pipeline for processing anterograde tracer injection data for the brain of the common marmoset (Callithrix jacchus). Brain sections were imaged using a batch slide scanner (NanoZoomer 2.0-HT) and we used artificial intelligence to precisely segment the tracer signal from the background in the fluorescence images. The shape of each brain was reconstructed by reference to a block-face and all data were mapped into a common 3D brain space with...
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The clinical implementation of artificial intelligence (AI) may take longer...Read more on AuntMinnieEurope.comRelated Reading: AI, radiomics accurately characterize thyroid nodules Cloud computing isn't the answer to all our prayers Can AI help detect tuberculosis on chest x-rays? Hype over AI may be putting patients' lives at risk Europe seeks to harness power of AI in COVID-19 crisis
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Background: Breast carcinoma is the most common malignant disease in the female population and one of the leading causes of death among women worldwide. One crucial hallmark of cancer is chronic inflammation where the immunosuppressive environment is dominant. The immunosuppressive environment is largely achieved by the interaction of tumor cells and infiltrating leukocytes. Summary: Usually, human macrophages and natural killer cells are involved in antitumor immunity. The therapeutic potential...
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Abstract Background There is no consensus in the literature regarding the impression procedures in the presence of multiple and angulated implants. Methods Three maxillary master models with 6 implants bilaterally positioned in anterior, premolar and molar regions were fabricated. In model 1, all implants were placed in parallel; in models 2...
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Summary One of the key features of acute myeloid leukemia (AML) is the arrest of differentiation at the early progenitor stage of myelopoiesis. Therefore, the identification of new agents that could overcome this differentiation block and force leukemic cells to enter the apoptotic pathway is essential for the development of new treatment strategies in AML. Regarding this, herein we report the pro-differentiation activity of the pan-Bcl-2 inhibitor, obatoclax. Obatoclax promoted...
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Fault diagnosis plays a very important role in ensuring the safe and reliable operations of machines. Currently, the deep learning-based fault diagnosis is attracting increasing attention. However, fault diagnosis under variable working conditions has been a significant challenge due to the domain discrepancy problem. This problem is also unavoidable in deep learning-based fault diagnosis methods. This paper contributes to the ongoing investigation by proposing a new approach for the fault diagnosis...
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“La telefonata è arrivata sabato sera: per un mero errore di prescrizione un giovane ragazzo, in lotta contro un tumore, sarebbe rimasto senza medicinale”. Il Dott. Raffaele Marzano affida ad un post Facebook il racconto di una...
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Coronavirus (severe acute respiratory syndrome coronavirus 2) outbreak is a public health emergency and a global pandemic. During the present coronavirus disease (COVID-19) crisis, telemedicine has been recommended to screen suspected patients to limit risk of exposure and maximise medical staff protection. We constructed the protective physical barrier with telemedicine technology to limit COVID-19 exposure in ED. Our hospital is an urban community hospital with annual ED volume of approximately...
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The phone rings. A text, a call—‘Are you okay? Is it really that bad?’ It’s 4am and none of us are sleeping. My white noise machine can’t silence the sirens that fill the night. It echoes the same repetitive message: COVID-19. It’s here, it’s been here and we haven’t reached the peak yet.We’re emergency physicians on the frontline of this global pandemic. Lynn moved to New York to start her medical career. She studied, trained and stayed in the NYP Columbia-Cornell family. An original New Yorker,...
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Dear Editor,Up to 20:40 14 April 2020, there have been 50 008 diagnosed covid-19 cases in Wuhan. Among them, 2579 patients died. The number of covid-19 cases in Wuhan increased from 4100 to 49 122 during February and became stable in March, and about 20% of them required intensive care unit (ICU) admission. More than 10 hospitals were newly built after February 2020 for admission of all the patients. Unfortunately, there was a shortage of ICU beds and medical staff in Wuhan, due to the large number...
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BackgroundThirteen episodes of oesophageal food impaction (EFI) per 100 000 people present to a medical setting each year. Several pharmacological interventions meant to relieve such impactions have been explored; none have proven superior.ObjectivesPerform a single-arm feasibility study of oral nitroglycerin solution for EFI.MethodsTwenty adult patients presenting to a single urban tertiary medical centre thought to have EFI were given up to three doses of 0.4 mg nitroglycerin solution orally and...
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BACKGROUND:Prescribing of levothyroxine and rates of thyroid function testing may be sensitive to minor changes in the upper limit of the reference range for thyroid-stimulating hormone (TSH) that increase the proportion of abnormal results. We evaluated the population-level change in levothyroxine prescribing and TSH testing after a minor planned decrease in the upper limit of the reference range for TSH in a large urban centre with a single medical laboratory. METHODS:Using provincial administrative...
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